CN110167510B - 减轻胶囊壳中的应力以降低破裂倾向的方法 - Google Patents

减轻胶囊壳中的应力以降低破裂倾向的方法 Download PDF

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Publication number
CN110167510B
CN110167510B CN201780070689.7A CN201780070689A CN110167510B CN 110167510 B CN110167510 B CN 110167510B CN 201780070689 A CN201780070689 A CN 201780070689A CN 110167510 B CN110167510 B CN 110167510B
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China
Prior art keywords
capsule shell
capsule
hard capsule
shell
capsules
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Expired - Fee Related
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CN201780070689.7A
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English (en)
Chinese (zh)
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CN110167510A (zh
Inventor
莱斯特·大卫·富勒
诺顿·哈特
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RP Scherer Technologies LLC
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RP Scherer Technologies LLC
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/10—Temperature; Pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B11/00—Machines or apparatus for drying solid materials or objects with movement which is non-progressive
    • F26B11/02—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in moving drums or other mainly-closed receptacles
    • F26B11/04—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in moving drums or other mainly-closed receptacles rotating about a horizontal or slightly-inclined axis
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/004—Nozzle assemblies; Air knives; Air distributors; Blow boxes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/02—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure
    • F26B21/04—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure partly outside the drying enclosure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/08—Humidity
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/12—Velocity of flow; Quantity of flow, e.g. by varying fan speed, by modifying cross flow area
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/90—Capsules

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Disintegrating Or Milling (AREA)
CN201780070689.7A 2016-12-08 2017-12-08 减轻胶囊壳中的应力以降低破裂倾向的方法 Expired - Fee Related CN110167510B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662431569P 2016-12-08 2016-12-08
US62/431,569 2016-12-08
PCT/US2017/065398 WO2018107080A1 (en) 2016-12-08 2017-12-08 A method to relieve stress in capsule shells to reduce propensity to break

Publications (2)

Publication Number Publication Date
CN110167510A CN110167510A (zh) 2019-08-23
CN110167510B true CN110167510B (zh) 2021-12-14

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780070689.7A Expired - Fee Related CN110167510B (zh) 2016-12-08 2017-12-08 减轻胶囊壳中的应力以降低破裂倾向的方法
CN201780069164.1A Active CN109923360B (zh) 2016-12-08 2017-12-08 在受控环境中加速干燥软胶囊

Family Applications After (1)

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US (3) US11026865B2 (OSRAM)
EP (2) EP3551158B1 (OSRAM)
JP (2) JP7129977B2 (OSRAM)
KR (2) KR102475555B1 (OSRAM)
CN (2) CN110167510B (OSRAM)
AU (2) AU2017371180B2 (OSRAM)
BR (1) BR112019010069A2 (OSRAM)
CA (2) CA3041560A1 (OSRAM)
CO (2) CO2019005095A2 (OSRAM)
ES (1) ES2927068T3 (OSRAM)
IL (2) IL266695B (OSRAM)
MX (2) MX2019005956A (OSRAM)
RU (2) RU2745334C9 (OSRAM)
WO (2) WO2018107019A1 (OSRAM)

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KR102328603B1 (ko) 2021-11-18
ES2927068T3 (es) 2022-11-02
US12161605B2 (en) 2024-12-10
RU2019112049A3 (OSRAM) 2021-01-21
AU2017374037A1 (en) 2019-05-16
MX2019005956A (es) 2019-07-10
EP3551158B1 (en) 2024-07-10
EP3551950A4 (en) 2020-06-03
EP3551158C0 (en) 2024-07-10
EP3551158A4 (en) 2020-06-03
RU2019113369A3 (OSRAM) 2021-03-18
RU2745334C9 (ru) 2021-05-24
JP7129977B2 (ja) 2022-09-02
IL266694B2 (en) 2023-03-01
BR112019010069A2 (pt) 2019-08-20
NZ752946A (en) 2025-03-28
EP3551158A1 (en) 2019-10-16
KR20190069576A (ko) 2019-06-19
RU2765074C2 (ru) 2022-01-25
EP3551950B1 (en) 2022-06-22
IL266694A (en) 2019-07-31
IL266695A (en) 2019-07-31
KR20190084990A (ko) 2019-07-17
BR112019010644A2 (pt) 2019-10-01
CO2019005095A2 (es) 2019-05-31
CO2019005238A2 (es) 2019-05-31
US20200069524A1 (en) 2020-03-05
CN109923360B (zh) 2022-02-11
AU2017371180B2 (en) 2023-05-11
JP2020500643A (ja) 2020-01-16
JP2020501101A (ja) 2020-01-16
RU2745334C2 (ru) 2021-03-24
AU2017374037B2 (en) 2023-02-23
CN110167510A (zh) 2019-08-23
CA3041560A1 (en) 2018-06-14
RU2019112049A (ru) 2021-01-12
US20200069525A1 (en) 2020-03-05
CA3045127A1 (en) 2018-06-14
WO2018107019A1 (en) 2018-06-14
CN109923360A (zh) 2019-06-21
JP7013465B2 (ja) 2022-01-31
IL266694B (en) 2022-11-01
EP3551950A1 (en) 2019-10-16
US11026865B2 (en) 2021-06-08
US20250025377A1 (en) 2025-01-23
AU2017371180A1 (en) 2019-05-23
MX2019005930A (es) 2019-07-08
RU2019113369A (ru) 2021-01-13
WO2018107080A1 (en) 2018-06-14
IL266695B (en) 2022-09-01
KR102475555B1 (ko) 2022-12-07

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