CN109476762A - 多特异性抗原结合蛋白及其使用方法 - Google Patents

多特异性抗原结合蛋白及其使用方法 Download PDF

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Publication number
CN109476762A
CN109476762A CN201780044843.3A CN201780044843A CN109476762A CN 109476762 A CN109476762 A CN 109476762A CN 201780044843 A CN201780044843 A CN 201780044843A CN 109476762 A CN109476762 A CN 109476762A
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antigen
antibody
sdab
antigen binding
binding portion
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周传初
张亚峰
武术
柳振宇
李中道
章方良
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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CN201780044843.3A 2016-07-20 2017-07-20 多特异性抗原结合蛋白及其使用方法 Pending CN109476762A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2016/090703 WO2018014260A1 (en) 2016-07-20 2016-07-20 Multispecific antigen binding proteins and methods of use thereof
CNPCT/CN2016/090703 2016-07-20
PCT/CN2017/093644 WO2018014855A1 (en) 2016-07-20 2017-07-20 Multispecific antigen binding proteins and methods of use thereof

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CN109476762A true CN109476762A (zh) 2019-03-15

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US (2) US11447573B2 (https=)
EP (1) EP3487887A4 (https=)
JP (2) JP7115991B2 (https=)
KR (1) KR20190040483A (https=)
CN (1) CN109476762A (https=)
AU (1) AU2017300349A1 (https=)
BR (1) BR112019000970A2 (https=)
CA (1) CA3030933A1 (https=)
EA (1) EA201990331A1 (https=)
IL (1) IL264211A (https=)
MX (1) MX2019000730A (https=)
SG (1) SG11201811640SA (https=)
WO (2) WO2018014260A1 (https=)
ZA (1) ZA201900181B (https=)

Cited By (14)

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WO2020187202A1 (zh) * 2019-03-18 2020-09-24 江苏恒瑞医药股份有限公司 特异性结合vegf和ang2的双特异性抗体
WO2021013215A1 (zh) * 2019-07-23 2021-01-28 南京金斯瑞生物科技有限公司 抗cd47/抗lag-3双特异抗体及其制备方法和应用
CN112513097A (zh) * 2019-07-11 2021-03-16 武汉友芝友生物制药有限公司 四价对称双特异性抗体
WO2021218874A1 (zh) * 2020-04-27 2021-11-04 启愈生物技术(上海)有限公司 一种靶向人claudin和人PDL1蛋白的双特异抗体及其应用
WO2022002006A1 (zh) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 Fab-HCAb结构的结合蛋白
CN113968909A (zh) * 2020-07-22 2022-01-25 信达生物制药(苏州)有限公司 一种双特异性抗体的纯化方法
CN114573704A (zh) * 2021-03-10 2022-06-03 北京拓界生物医药科技有限公司 Pd-1/ctla-4结合蛋白及其医药用途
WO2022143801A1 (en) * 2020-12-30 2022-07-07 Wuxi Biologics (Shanghai) Co., Ltd. Multispecific antigen binding proteins
WO2023051656A1 (zh) * 2021-09-30 2023-04-06 贝达药业股份有限公司 双特异性抗体及其应用
CN115943161A (zh) * 2020-01-09 2023-04-07 拜奥穆尼克斯制药 结合mait和肿瘤细胞两者的多特异性抗体
JP2023531672A (ja) * 2020-06-30 2023-07-25 ハーバー・バイオメド・（シャンハイ）・カンパニー・リミテッド Ｈ２Ｌ２とＨＣＡｂ構造を有する結合タンパク質
WO2024032664A1 (zh) * 2022-08-09 2024-02-15 上海济煜医药科技有限公司 一种靶向pd-l1和vegf的抗体及其应用
WO2025016011A1 (en) * 2023-07-14 2025-01-23 Genor Biopharma Co., Ltd. Anti-PD-1/CTLA-4/VEGF ANTIBODIES AND USE THEREOF
TWI890689B (zh) * 2019-08-15 2025-07-21 美商再生元醫藥公司 用於細胞靶向之多特異性抗原結合分子及其用途

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SG11201909160WA (en) 2017-04-11 2019-10-30 Inhibrx Inc Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
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CN109970860A (zh) * 2017-12-27 2019-07-05 信达生物制药(苏州)有限公司 三链抗体、其制备方法及其用途
CN117050184A (zh) 2017-12-28 2023-11-14 南京传奇生物科技有限公司 针对tigit的单域抗体和其变体
KR20200118423A (ko) * 2018-01-08 2020-10-15 난징 레전드 바이오테크 씨오., 엘티디. 다중특이성 항원 결합 단백질 및 이의 사용 방법
CN111699200B (zh) 2018-01-15 2023-05-26 南京传奇生物科技有限公司 针对pd-1的单域抗体和其变体
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CN110357966A (zh) * 2018-04-09 2019-10-22 非同（成都）生物科技有限公司 具有延长的半衰期和增强的抗肿瘤效果的双特异性抗体
KR20260046525A (ko) 2018-04-11 2026-04-07 인히브릭스 바이오사이언스, 인크. 제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도
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JP7611820B2 (ja) 2018-10-11 2025-01-10 インヒブルクス バイオサイエンシズ インコーポレイテッド Ｄｌｌ３シングルドメイン抗体およびその治療用組成物
CN113166261A (zh) * 2018-10-11 2021-07-23 印希比股份有限公司 B7h3单域抗体及其治疗性组合物
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TWI756621B (zh) * 2019-01-25 2022-03-01 大陸商信達生物製藥（蘇州）有限公司 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體
JP2022525275A (ja) * 2019-03-28 2022-05-12 エービー ストゥーディオ インコーポレイテッド ヘテロ多量体タンパク質及びその使用法
EP3969484A4 (en) * 2019-05-17 2023-07-05 Nanjing GenScript Biotech Co., Ltd. ANTI-CD47/ANTI-PD-L1 MULTIPLE ANTIGEN BINDING PROTEINS AND METHODS OF USE
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WO2020259535A1 (zh) * 2019-06-25 2020-12-30 南京金斯瑞生物科技有限公司 抗cd47/抗tigit双特异抗体及其制备方法和应用
US12358987B2 (en) 2019-07-08 2025-07-15 Nanjing GenScript Biotech Co., Ltd. Anti-CD47/anti-PD-1 bispecific antibody, preparation method and use thereof
CN114096564A (zh) * 2019-07-16 2022-02-25 南京金斯瑞生物科技有限公司 抗cd47/抗ctla-4双特异抗体及其制备方法和应用
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JP7789002B2 (ja) 2020-01-29 2025-12-19 インヒブルクス バイオサイエンシズ インコーポレイテッド Ｃｄ２８シングルドメイン抗体ならびにその多価および多重特異性の構築物
EP4114953A4 (en) * 2020-03-05 2024-08-07 Merck Sharp & Dohme LLC Human-like heavy chain antibody variable domain (vhh) display libraries
MX2022012973A (es) 2020-04-26 2022-11-09 Biocytogen Pharmaceuticals Beijing Co Ltd Inmunoglobulinas modificadas.
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TW202220691A (zh) * 2020-07-27 2022-06-01 美商宏觀基因股份有限公司 用於使用ＰＤ—１ｘＣＴＬＡ—４雙特異性分子的方法
CN111944052B (zh) * 2020-08-26 2022-02-11 中国药科大学 抗TNF-α/PD-1双特异性抗体及其应用
WO2022048625A1 (en) * 2020-09-04 2022-03-10 Nanjing GenScript Biotech Co., Ltd. Multispecific antibodies targetting sars-cov-2 spike protein and uses thereof
JP7814759B2 (ja) * 2020-09-17 2026-02-17 上海霖羲致企業管理有限公司 二重特異性組換えタンパク質及びその使用
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JP2023550148A (ja) 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
KR20240099460A (ko) * 2021-11-11 2024-06-28 리제너론 파아마슈티컬스, 인크. Cd20-pd1 결합 분자 및 이의 사용 방법
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