CN109219606B - 食欲素受体调节剂的卤素取代的哌啶 - Google Patents
食欲素受体调节剂的卤素取代的哌啶 Download PDFInfo
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- CN109219606B CN109219606B CN201780022666.9A CN201780022666A CN109219606B CN 109219606 B CN109219606 B CN 109219606B CN 201780022666 A CN201780022666 A CN 201780022666A CN 109219606 B CN109219606 B CN 109219606B
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662294940P | 2016-02-12 | 2016-02-12 | |
US62/294,940 | 2016-02-12 | ||
US201662336102P | 2016-05-13 | 2016-05-13 | |
US62/336,102 | 2016-05-13 | ||
PCT/US2017/017408 WO2017139603A1 (fr) | 2016-02-12 | 2017-02-10 | Pipéridines halosubstituées en tant que modulateurs de récepteur des orexines |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109219606A CN109219606A (zh) | 2019-01-15 |
CN109219606B true CN109219606B (zh) | 2021-10-01 |
Family
ID=59563558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780022666.9A Active CN109219606B (zh) | 2016-02-12 | 2017-02-10 | 食欲素受体调节剂的卤素取代的哌啶 |
Country Status (32)
Country | Link |
---|---|
US (3) | US10894789B2 (fr) |
EP (1) | EP3414241B1 (fr) |
JP (1) | JP6883045B2 (fr) |
KR (1) | KR20180107232A (fr) |
CN (1) | CN109219606B (fr) |
AU (1) | AU2017217931B2 (fr) |
BR (1) | BR112018016446B1 (fr) |
CA (1) | CA3013927C (fr) |
CL (1) | CL2018002121A1 (fr) |
CO (1) | CO2018009290A2 (fr) |
CR (1) | CR20180429A (fr) |
DK (1) | DK3414241T3 (fr) |
DO (1) | DOP2018000179A (fr) |
EA (1) | EA036542B9 (fr) |
ES (1) | ES2923790T3 (fr) |
HR (1) | HRP20220906T1 (fr) |
HU (1) | HUE059280T2 (fr) |
IL (1) | IL260788B (fr) |
LT (1) | LT3414241T (fr) |
MX (1) | MX2018009656A (fr) |
MY (1) | MY195239A (fr) |
PH (1) | PH12018501708A1 (fr) |
PL (1) | PL3414241T3 (fr) |
PT (1) | PT3414241T (fr) |
RS (1) | RS63471B1 (fr) |
SG (1) | SG11201806368VA (fr) |
SI (1) | SI3414241T1 (fr) |
SV (1) | SV2018005731A (fr) |
TN (1) | TN2018000280A1 (fr) |
TW (1) | TWI710557B (fr) |
WO (1) | WO2017139603A1 (fr) |
ZA (1) | ZA201805839B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI710557B (zh) * | 2016-02-12 | 2020-11-21 | 美商伊歐拉斯治療學公司 | 作為食慾素受體調節劑之經鹵素取代之六氫吡啶 |
CA3074059A1 (fr) | 2017-09-01 | 2019-03-07 | Chronos Therapeutics Limited | Derives de 2-azabicyclo[3.1.1]heptane et de 2-azabicyclo[3.2.1]octane substitues en tant qu'antagonistes du recepteur de l'orexine |
WO2019063605A1 (fr) * | 2017-09-28 | 2019-04-04 | Boehringer Ingelheim International Gmbh | Nouveaux n-(2,2-difluoroéthyl)-n-[(pyrimidinylamino)propanyl]arylcarboxamides |
US20210169883A1 (en) * | 2018-07-27 | 2021-06-10 | Icahn School Of Medicine At Mount Sinai | Method of treating aggression with orexin receptor antagonists |
CN114502551B (zh) | 2019-11-01 | 2023-08-22 | 优迈特株式会社 | 含氟嘧啶化合物及其制备方法 |
Citations (4)
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CN101874030A (zh) * | 2007-09-24 | 2010-10-27 | 埃科特莱茵药品有限公司 | 用作食欲素受体拮抗剂的吡咯烷和哌啶 |
WO2013127913A1 (fr) * | 2012-03-01 | 2013-09-06 | Rottapharm S.P.A. | Composés de 4,4-difluoro-pipéridine |
CN104220065A (zh) * | 2012-02-07 | 2014-12-17 | Eolas治疗公司 | 取代的脯氨酸/哌啶用作食欲素受体拮抗剂 |
WO2015123355A1 (fr) * | 2014-02-12 | 2015-08-20 | Eolas Therapeutics, Inc. | Prolines/pipéridines substituées en tant qu'antagonistes du récepteur de l'orexine |
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WO2013127913A1 (fr) * | 2012-03-01 | 2013-09-06 | Rottapharm S.P.A. | Composés de 4,4-difluoro-pipéridine |
WO2015123355A1 (fr) * | 2014-02-12 | 2015-08-20 | Eolas Therapeutics, Inc. | Prolines/pipéridines substituées en tant qu'antagonistes du récepteur de l'orexine |
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