CN1083442C - 四氮杂大环的制备方法 - Google Patents

四氮杂大环的制备方法 Download PDF

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Publication number
CN1083442C
CN1083442C CN97195647A CN97195647A CN1083442C CN 1083442 C CN1083442 C CN 1083442C CN 97195647 A CN97195647 A CN 97195647A CN 97195647 A CN97195647 A CN 97195647A CN 1083442 C CN1083442 C CN 1083442C
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CN
China
Prior art keywords
formula
compound
decahydro
scheme
bromine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN97195647A
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English (en)
Chinese (zh)
Other versions
CN1222147A (zh
Inventor
M·阿格瑟
G·里帕
A·斯卡拉
V·瓦尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
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Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of CN1222147A publication Critical patent/CN1222147A/zh
Application granted granted Critical
Publication of CN1083442C publication Critical patent/CN1083442C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN97195647A 1996-06-21 1997-06-09 四氮杂大环的制备方法 Expired - Lifetime CN1083442C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001257A IT1284046B1 (it) 1996-06-21 1996-06-21 Processo per la preparazione di tetraazamacrocicli
ITMI96A001257 1996-06-21

Publications (2)

Publication Number Publication Date
CN1222147A CN1222147A (zh) 1999-07-07
CN1083442C true CN1083442C (zh) 2002-04-24

Family

ID=11374458

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97195647A Expired - Lifetime CN1083442C (zh) 1996-06-21 1997-06-09 四氮杂大环的制备方法

Country Status (16)

Country Link
US (3) US5880281A (enExample)
EP (1) EP0914320B1 (enExample)
JP (1) JP4308323B2 (enExample)
CN (1) CN1083442C (enExample)
AT (1) ATE223389T1 (enExample)
AU (1) AU3256497A (enExample)
CA (1) CA2258768C (enExample)
CZ (1) CZ295406B6 (enExample)
DE (1) DE69715211T2 (enExample)
ES (1) ES2183185T3 (enExample)
HU (1) HU223439B1 (enExample)
IN (1) IN183348B (enExample)
IT (1) IT1284046B1 (enExample)
NO (1) NO310621B1 (enExample)
WO (1) WO1997049691A1 (enExample)
ZA (1) ZA975425B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1284046B1 (it) * 1996-06-21 1998-05-08 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1290457B1 (it) * 1997-04-04 1998-12-03 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1291673B1 (it) * 1997-04-28 1999-01-19 Bracco Spa Processo per la preparazione di 1,4,7,10 - tetraazaciclododecano
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
DE19809542A1 (de) * 1998-03-05 1999-09-09 Clariant Gmbh Quaternäre polycyclische Polyammoniumsalze und Verfahren zu deren Herstellung
DE19809543A1 (de) * 1998-03-05 1999-09-09 Clariant Gmbh Verfahren zur Herstellung von makropolycyclischen Polymaninen
DE19856481C1 (de) * 1998-12-02 2000-07-06 Schering Ag Verfahren zur Herstellung von Cyclen
US6156890A (en) * 1999-01-15 2000-12-05 Schering Aktiengesellschaft Process for the production of cyclene
IT1309601B1 (it) * 1999-03-09 2002-01-24 Bracco Spa Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
CA2410906C (en) * 2000-06-02 2012-10-02 Board Of Regents, The University Of Texas System Ethylenedicysteine (ec)-drug conjugates
FR2810035B1 (fr) * 2000-06-13 2004-04-16 Air Liquide Procede de preparation de tetraaza macrocycles et nouveaux composes
FR2856063B1 (fr) * 2003-06-13 2005-10-07 Air Liquide Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
US7498432B2 (en) 2003-06-25 2009-03-03 Board Of Trustees Of Michigan State University Method of synthesis of 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosane (1) and 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosa, 4, 6, 13, 15, 21, 23-hexaene (2)
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
DE102004003710A1 (de) * 2004-01-24 2005-08-11 Clariant Gmbh Verwendung von Übergangsmetallkomplexen als Bleichkatalysatoren in Wasch- und Reinigungsmitteln
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
WO2008064040A2 (en) * 2006-11-22 2008-05-29 The Board Of Regents Of The University Of Texas System Methods and compositions using chelator-antibody conjugates
WO2008119036A2 (en) 2007-03-27 2008-10-02 Radiomedix Inc. Compositions for targeted imaging and therapy
US11473032B2 (en) 2010-02-02 2022-10-18 Fuchs Petrolub Se Constant velocity joint having a boot
WO2012177701A2 (en) 2011-06-20 2012-12-27 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents
CN103360333B (zh) * 2013-07-22 2016-03-30 厦门市华兴化工有限公司 一种高纯度轮环藤宁的制备方法
CN104387336B (zh) * 2014-10-24 2016-04-27 上海应用技术学院 1,4,7,10-四氮杂环十二烷及其纳滤膜的制备方法
IL271681A (en) 2018-07-18 2020-01-30 Vyripharm Entpr Llc Systems and methods for integrated and comprehensive management of cannabis products
CN113956262B (zh) * 2021-10-18 2023-03-07 苏州百灵威超精细材料有限公司 一种四氮杂环烷类化合物及其中间体的合成方法
CN113801123B (zh) * 2021-10-18 2022-12-09 苏州百灵威超精细材料有限公司 一种1,4,8,11-四氮杂环十四烷类化合物及其中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485818A (en) * 1968-04-05 1969-12-23 Jerome B Thompson 1,4,7,10-tetraazacyclododecene and 1,4,7,10,13 - pentaazacyclopentadecene and process for their manufacture
US3932451A (en) * 1973-11-27 1976-01-13 E. I. Du Pont De Nemours & Company 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids
EP0427595A1 (en) * 1989-11-09 1991-05-15 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for the synthesis of cyclic polynitrogenated compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587451A (en) * 1993-11-26 1996-12-24 The Dow Chemical Company Process for preparing polyazamacrocycles
GB9504922D0 (en) * 1995-03-10 1995-04-26 Nycomed As Process
IT1284046B1 (it) * 1996-06-21 1998-05-08 Bracco Spa Processo per la preparazione di tetraazamacrocicli

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485818A (en) * 1968-04-05 1969-12-23 Jerome B Thompson 1,4,7,10-tetraazacyclododecene and 1,4,7,10,13 - pentaazacyclopentadecene and process for their manufacture
US3932451A (en) * 1973-11-27 1976-01-13 E. I. Du Pont De Nemours & Company 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids
EP0427595A1 (en) * 1989-11-09 1991-05-15 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for the synthesis of cyclic polynitrogenated compounds

Also Published As

Publication number Publication date
HUP9903380A3 (en) 2001-07-30
CZ295406B6 (cs) 2005-08-17
ES2183185T3 (es) 2003-03-16
DE69715211D1 (de) 2002-10-10
IN183348B (enExample) 1999-11-27
US6013793A (en) 2000-01-11
NO310621B1 (no) 2001-07-30
CZ421098A3 (cs) 1999-06-16
NO985992L (no) 1999-02-22
CA2258768C (en) 2009-03-10
CN1222147A (zh) 1999-07-07
ZA975425B (en) 1998-01-26
ITMI961257A0 (enExample) 1996-06-21
US5880281A (en) 1999-03-09
DE69715211T2 (de) 2003-08-07
WO1997049691A1 (en) 1997-12-31
US6114521A (en) 2000-09-05
HU223439B1 (hu) 2004-07-28
CA2258768A1 (en) 1997-12-31
EP0914320B1 (en) 2002-09-04
NO985992D0 (no) 1998-12-18
JP4308323B2 (ja) 2009-08-05
ATE223389T1 (de) 2002-09-15
AU3256497A (en) 1998-01-14
JP2000512642A (ja) 2000-09-26
IT1284046B1 (it) 1998-05-08
EP0914320A1 (en) 1999-05-12
ITMI961257A1 (it) 1997-12-21

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C06 Publication
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SE01 Entry into force of request for substantive examination
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Owner name: BRACCO INTERNATIONAL B.V.

Free format text: FORMER OWNER: BRACCO S. P. A.

Effective date: 20031128

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20031128

Address after: Holland ah Mostedan

Patentee after: Bracco International B. V.

Address before: Milan Italy

Patentee before: Bracco S. P. A.

CX01 Expiry of patent term

Granted publication date: 20020424

CX01 Expiry of patent term