CN1082953C - 制备噁唑烷酮的方法 - Google Patents

制备噁唑烷酮的方法 Download PDF

Info

Publication number
CN1082953C
CN1082953C CN97193658A CN97193658A CN1082953C CN 1082953 C CN1082953 C CN 1082953C CN 97193658 A CN97193658 A CN 97193658A CN 97193658 A CN97193658 A CN 97193658A CN 1082953 C CN1082953 C CN 1082953C
Authority
CN
China
Prior art keywords
alkyl
phenyl
mixture
methanol
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97193658A
Other languages
English (en)
Chinese (zh)
Other versions
CN1215393A (zh
Inventor
B·A·佩尔曼
W·R·佩拉特
M·R·巴巴切恩
P·R·曼尼内
D·S·托普斯
D·J·霍瑟
T·J·弗雷克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of CN1215393A publication Critical patent/CN1215393A/zh
Application granted granted Critical
Publication of CN1082953C publication Critical patent/CN1082953C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN97193658A 1996-04-11 1997-03-28 制备噁唑烷酮的方法 Expired - Fee Related CN1082953C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1549996P 1996-04-11 1996-04-11
US60/015,499 1996-04-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB011330031A Division CN1167701C (zh) 1996-04-11 1997-03-28 制备噁唑烷酮胺的方法

Publications (2)

Publication Number Publication Date
CN1215393A CN1215393A (zh) 1999-04-28
CN1082953C true CN1082953C (zh) 2002-04-17

Family

ID=21771765

Family Applications (3)

Application Number Title Priority Date Filing Date
CN97193658A Expired - Fee Related CN1082953C (zh) 1996-04-11 1997-03-28 制备噁唑烷酮的方法
CNB031594743A Expired - Fee Related CN1319952C (zh) 1996-04-11 1997-03-28 制备唑烷酮胺的方法
CNB011330031A Expired - Fee Related CN1167701C (zh) 1996-04-11 1997-03-28 制备噁唑烷酮胺的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNB031594743A Expired - Fee Related CN1319952C (zh) 1996-04-11 1997-03-28 制备唑烷酮胺的方法
CNB011330031A Expired - Fee Related CN1167701C (zh) 1996-04-11 1997-03-28 制备噁唑烷酮胺的方法

Country Status (24)

Country Link
US (1) US5837870A (enExample)
EP (2) EP1114819B1 (enExample)
JP (2) JP2000508312A (enExample)
KR (1) KR100530297B1 (enExample)
CN (3) CN1082953C (enExample)
AT (2) ATE383347T1 (enExample)
AU (1) AU706117B2 (enExample)
CA (1) CA2248143C (enExample)
CZ (2) CZ298060B6 (enExample)
DE (2) DE69709718T2 (enExample)
DK (2) DK1114819T3 (enExample)
ES (2) ES2166073T3 (enExample)
HU (1) HUP0500044A3 (enExample)
NO (2) NO311837B1 (enExample)
NZ (1) NZ332278A (enExample)
PL (1) PL192691B1 (enExample)
PT (2) PT1114819E (enExample)
RU (1) RU2176643C2 (enExample)
SG (1) SG85683A1 (enExample)
SI (1) SI0892792T1 (enExample)
SK (1) SK284703B6 (enExample)
TW (1) TW449593B (enExample)
WO (1) WO1997037980A1 (enExample)
ZA (1) ZA972983B (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
SK18362000A3 (sk) 1998-06-05 2001-06-11 Astrazeneca Ab Oxazolidinónové deriváty, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú
EP1008590B1 (en) * 1998-12-07 2006-10-11 Takasago International Corporation Process for preparing optically active oxazolidinone derivatives
AU767579B2 (en) 1999-02-01 2003-11-20 Pharmacia & Upjohn Company Process to prepare cyclic-sulfur fluorine containing oxazolidinones
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
US6444813B2 (en) 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) * 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) * 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ES2245698T3 (es) 2000-06-30 2006-01-16 PHARMACIA & UPJOHN COMPANY LLC Composiciones para el tratamiento de infecciones bacterianas que contienen un compuesto de oxazolidinona, sulbactam y ampicilina.
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
US6288239B1 (en) 2000-09-19 2001-09-11 Board Of Trustees Operating Michigan State University 5-trityloxymethyl-oxazolidinones and process for the preparation thereof
AR031135A1 (es) 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
WO2002081470A1 (en) * 2001-04-07 2002-10-17 Astrazeneca Ab Oxazolidinones containing a sulfonimid group as antibiotics
CA2440600A1 (en) * 2001-04-20 2002-10-31 Pharmacia & Upjohn Company Process to prepare oxazolidinones
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
AU2002367959A1 (en) * 2001-10-18 2003-12-31 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
AU2003218059A1 (en) * 2002-02-22 2003-09-09 Pharmacia Corporation Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride
CA2477044A1 (en) * 2002-02-22 2003-09-04 Pharmacia Corporation Ophthalmic formulation with gum system
US7714128B2 (en) 2003-10-16 2010-05-11 Symed Labs Limited Crystalline form of linezolid
PL1737850T3 (pl) * 2004-04-19 2008-02-29 Symed Labs Ltd Nowy sposób wytwarzania linezolidu i związków pokrewnych
DE602004020812D1 (de) * 2004-07-20 2009-06-04 Symed Labs Ltd Neue zwischenprodukte für linezolid und verwandte verbindungen
KR20080104178A (ko) * 2006-04-07 2008-12-01 화이자 프로덕츠 인코포레이티드 리네졸리드의 제조 방법
CN100395270C (zh) * 2006-05-25 2008-06-18 湖北大学 线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途
EP2033960A3 (en) * 2007-09-04 2009-04-29 Dipharma Francis S.r.l. Linezolid crystalline hydrate form and linezolid salts
WO2009032294A2 (en) * 2007-09-06 2009-03-12 Teva Pharmaceutical Industries Ltd. Processes for the preparation of a linezolid intermediate, linezolid hydroxide
EP2163547A1 (en) 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
JP5561462B2 (ja) * 2009-09-17 2014-07-30 日東化成株式会社 漁網防汚塗料組成物、該組成物を用いて形成される防汚塗膜、該塗膜の形成方法、および該塗膜を表面に有する漁網、漁網用具又は水中構造物
CA2785620A1 (en) 2009-12-26 2011-06-30 Alembic Pharmaceuticals Limited Process for the preparation of linezolid
WO2011080341A1 (en) 2010-01-04 2011-07-07 Enantia, S.L. Process for the preparation of rivaroxaban and intermediates thereof
CN103140487A (zh) 2010-08-11 2013-06-05 斯索恩有限公司 制备利奈唑胺的方法
EP2603506A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
CN103391943A (zh) 2010-11-03 2013-11-13 沃克哈特有限公司 磷酸单-(1-{4-[(s)-5-(乙酰基氨基-甲基)-2-氧代-噁唑烷-3-基]-2,6-二氟苯基}-4-甲氧基甲基-哌啶-4-基)酯的制备方法
US9567307B2 (en) * 2011-01-07 2017-02-14 The Regents Of The University Of California Amination of aryl alcohol derivatives
CN102153521B (zh) * 2011-01-31 2012-09-12 宁波市鄞州百特佳医药科技有限公司 一种用于制备利奈唑胺的中间体及其制备方法
PT2595968E (pt) 2011-02-24 2015-12-31 Lee Pharma Ltd Novo processo de preparação de linezolide e seus novos intermediários
CN103402990A (zh) 2011-02-24 2013-11-20 李药业有限公司 无水利奈唑胺晶型-ii
CN102321042B (zh) * 2011-07-18 2013-12-04 苏州敬业医药化工有限公司 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法
CN102311402B (zh) * 2011-07-18 2013-08-21 苏州敬业医药化工有限公司 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法
WO2013072923A1 (en) 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
US20150025236A1 (en) 2012-01-24 2015-01-22 Jubilant Life Sciences Limited Process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
CN103626712B (zh) * 2012-08-23 2016-06-01 重庆药友制药有限责任公司 一种用于制备利奈唑胺的中间体及其制备方法
EP2917189B1 (en) 2012-11-09 2016-08-17 Synthon BV Process for making linezolid
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent
CN119119019B (zh) * 2024-09-11 2025-11-11 遵义医科大学 一种杂环磺酰胺/磺酸酯衍生物及其制备方法、应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025106A1 (en) * 1994-03-15 1995-09-21 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA681830A (en) * 1964-03-10 X. Markley Francis Process for 5-(aryloxymethyl)-2-oxazolidinones
US3547951A (en) * 1969-06-17 1970-12-15 Waldo R Hardie 1,3-dioxolan-4-yl-alkyl guanidines
FR2315925A1 (fr) * 1975-07-04 1977-01-28 Nippon Chemiphar Co Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
JPS6014032B2 (ja) * 1978-01-20 1985-04-11 日本ケミフア株式会社東京 ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
JP2908510B2 (ja) * 1990-04-20 1999-06-21 イハラケミカル工業株式会社 ベンジルアミン類の製造方法
DE69210919T2 (de) * 1991-09-05 1997-01-23 Nippon Paint Co Ltd Hitzehärtbare Harzmischung, enthaltend eine polyfunktionelle Oxazolidon-Komponente und eine Polyamin-Komponente
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
CN1068325C (zh) * 1994-10-26 2001-07-11 法玛西雅厄普约翰美国公司 苯基噁唑烷酮抗菌剂
ATE233766T1 (de) * 1994-11-15 2003-03-15 Upjohn Co Antibakterielle bizyklische oxazin und thiazin- oxazolidinone
FI974180A0 (fi) * 1995-05-11 1997-11-10 Upjohn Co Spirosyklisiä ja bisyklisiä diatsinyyli- ja karbatsinyylioksatsolidinoneja

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025106A1 (en) * 1994-03-15 1995-09-21 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
RU2176643C2 (ru) 2001-12-10
ZA972983B (en) 1998-10-08
DE69709718T2 (de) 2002-06-20
NO984737L (no) 1998-12-09
CN1496983A (zh) 2004-05-19
SG85683A1 (en) 2002-01-15
HK1061241A1 (en) 2004-09-10
ES2166073T3 (es) 2002-04-01
PL329295A1 (en) 1999-03-15
SK133698A3 (en) 1999-06-11
DK1114819T3 (da) 2008-04-14
NO312728B1 (no) 2002-06-24
ATE383347T1 (de) 2008-01-15
PL192691B1 (pl) 2006-11-30
EP1114819A1 (en) 2001-07-11
DE69709718D1 (de) 2002-02-21
AU706117B2 (en) 1999-06-10
CZ200788A3 (cs) 2017-01-25
EP1114819B1 (en) 2008-01-09
TW449593B (en) 2001-08-11
SI0892792T1 (en) 2002-06-30
HUP0500044A3 (en) 2005-09-28
SK284703B6 (sk) 2005-09-08
ES2298198T3 (es) 2008-05-16
KR100530297B1 (ko) 2005-11-22
NZ332278A (en) 2000-05-26
DE69738457D1 (de) 2008-02-21
ATE209193T1 (de) 2001-12-15
CN1319952C (zh) 2007-06-06
NO311837B1 (no) 2002-02-04
HU0500044D0 (en) 2005-03-29
NO984737D0 (no) 1998-10-09
WO1997037980A1 (en) 1997-10-16
CN1215393A (zh) 1999-04-28
CN1381454A (zh) 2002-11-27
PT1114819E (pt) 2008-02-28
JP2000508312A (ja) 2000-07-04
EP0892792A1 (en) 1999-01-27
CZ298060B6 (cs) 2007-06-06
KR20040066189A (ko) 2004-07-23
CA2248143C (en) 2008-10-07
EP0892792B1 (en) 2001-11-21
NO20015253L (no) 1998-12-09
PT892792E (pt) 2002-05-31
CA2248143A1 (en) 1997-10-16
CZ287198A3 (cs) 1999-02-17
HK1018785A1 (en) 2000-01-07
JP2008239621A (ja) 2008-10-09
US5837870A (en) 1998-11-17
DE69738457T2 (de) 2008-12-24
AU2318297A (en) 1997-10-29
CN1167701C (zh) 2004-09-22
DK0892792T3 (da) 2002-04-02
NO20015253D0 (no) 2001-10-26

Similar Documents

Publication Publication Date Title
CN1082953C (zh) 制备噁唑烷酮的方法
CN1036456C (zh) 氨基取代的吡唑
CN1310907C (zh) 杂环化合物和以其为有效成分的抗肿瘤药
CN1147471C (zh) 肾素抑制剂
CN1045088C (zh) 用作pnp抑制剂的嘌呤和鸟嘌呤化合物
CN102459232B (zh) 7-氮杂-螺[3.5]壬烷-7-甲酸酯衍生物、其制备及其治疗用途
CN1444570A (zh) 非甾体抗炎药
CN1275122A (zh) 制备噁唑烷酮的方法
CN1162312A (zh) 苯基噁唑烷酮抗菌剂
CN1688544A (zh) 作为蕈毒碱受体拮抗剂的含氟代和磺酰氨基的3,6－二取代的氮杂双环(3.1.0)己烷衍生物
CN1073944A (zh) 三取代四氢呋喃抗真菌剂
CN1910157A (zh) 对受体cbi有亲和性的n′－(1,5－二苯基－1h－吡唑－3－基)磺酰胺衍生物
CN1759093A (zh) 用于制备1,2－二氨基化合物的不使用叠氮化物的方法
CN1922162A (zh) 烷基哌嗪－和烷基高哌嗪－羧酸酯衍生物、其制备方法及其作为faah酶抑制剂的用途
CN1117965A (zh) 取代的4-苯基-吡啶酮和4-苯基-2-烷氧基吡啶
CN1064278A (zh) 4-脱氧-4-表鬼臼毒素衍生物或其药学上允许的盐
CN1922138A (zh) 芳氧基烷基氨基甲酸酯类衍生物,它们的制备方法与治疗用途
CN1219169A (zh) 取代苄胺及它们用于治疗抑郁症的用途
CN1191230C (zh) 神经氨酸苷酶抑制剂ro－64－0796的制备方法
CN1054980A (zh) 具有旋光活性的8-甲氧基喹诺酮羧酸衍生物，它们的制备方法以及它们的中间体
CN1037895A (zh) 杂脂族羧酰胺类化合物
CN1956951A (zh) 制备二苯基氮杂环丁烷酮衍生物的方法
CN1049662A (zh) 香豆素衍生物及其制备和在治疗脑血管失调中的应用
CN1437575A (zh) 氨甲基－苯基－环己酮衍生物
CN88102858A (zh) 可用作抗高血压剂的肼衍生物的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CI03 Correction of invention patent

Correction item: Claims

Correct: Replacement claim book, page 1-7

False: Claim Book 1-7, error

Number: 16

Volume: 18

COR Change of bibliographic data

Free format text: CORRECT: RIGHT-CLAIMING DOCUMENT; FROM: RIGHT-CLAIMING DOCUMENT THE FIRST 1-7 PAGES ERROR TO: REPLACEMENT RIGHT-CLAIMING DOCUMENT PAGE 1-7

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20020417