ES2166073T3 - Procedimiento para preparar oxazolidinonas. - Google Patents
Procedimiento para preparar oxazolidinonas.Info
- Publication number
- ES2166073T3 ES2166073T3 ES97915865T ES97915865T ES2166073T3 ES 2166073 T3 ES2166073 T3 ES 2166073T3 ES 97915865 T ES97915865 T ES 97915865T ES 97915865 T ES97915865 T ES 97915865T ES 2166073 T3 ES2166073 T3 ES 2166073T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- hydroximethyl
- iii
- replaced
- oxazolidinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 2
- -1 OXAZOLIDINONE ALCOHOLS Chemical class 0.000 abstract 2
- NRKYWOKHZRQRJR-UHFFFAOYSA-N 2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F NRKYWOKHZRQRJR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1549996P | 1996-04-11 | 1996-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2166073T3 true ES2166073T3 (es) | 2002-04-01 |
Family
ID=21771765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97915865T Expired - Lifetime ES2166073T3 (es) | 1996-04-11 | 1997-03-28 | Procedimiento para preparar oxazolidinonas. |
| ES01302264T Expired - Lifetime ES2298198T3 (es) | 1996-04-11 | 1997-03-28 | Procedimiento para preparar oxazolidinonas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01302264T Expired - Lifetime ES2298198T3 (es) | 1996-04-11 | 1997-03-28 | Procedimiento para preparar oxazolidinonas. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5837870A (enExample) |
| EP (2) | EP1114819B1 (enExample) |
| JP (2) | JP2000508312A (enExample) |
| KR (1) | KR100530297B1 (enExample) |
| CN (3) | CN1082953C (enExample) |
| AT (2) | ATE383347T1 (enExample) |
| AU (1) | AU706117B2 (enExample) |
| CA (1) | CA2248143C (enExample) |
| CZ (2) | CZ298060B6 (enExample) |
| DE (2) | DE69709718T2 (enExample) |
| DK (2) | DK0892792T3 (enExample) |
| ES (2) | ES2166073T3 (enExample) |
| HU (1) | HUP0500044A3 (enExample) |
| NO (2) | NO311837B1 (enExample) |
| NZ (1) | NZ332278A (enExample) |
| PL (1) | PL192691B1 (enExample) |
| PT (2) | PT1114819E (enExample) |
| RU (1) | RU2176643C2 (enExample) |
| SG (1) | SG85683A1 (enExample) |
| SI (1) | SI0892792T1 (enExample) |
| SK (1) | SK284703B6 (enExample) |
| TW (1) | TW449593B (enExample) |
| WO (1) | WO1997037980A1 (enExample) |
| ZA (1) | ZA972983B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| WO1999064417A2 (en) | 1998-06-05 | 1999-12-16 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| US6403804B1 (en) * | 1998-12-07 | 2002-06-11 | Takasago International Corporation | Process for preparing optically active oxazolidinone derivative |
| DE60001807T2 (de) | 1999-02-01 | 2003-11-06 | Pharmacia & Upjohn Co., Kalamazoo | VERFAHREN ZU HERSTELLUNG VON o-FLUORIERTEN TETRAHYDROTHIOPYRAN CARBAMATEN |
| US6608081B2 (en) * | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| US6518285B2 (en) | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| US6444813B2 (en) | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| AR027261A1 (es) * | 2000-02-02 | 2003-03-19 | Upjohn Co | Linezolid forma cristalina ii |
| US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6544991B2 (en) | 2000-06-30 | 2003-04-08 | Pharmacia & Upjohn Company | Compositions and methods for treating bacterial infections |
| PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
| US6288239B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | 5-trityloxymethyl-oxazolidinones and process for the preparation thereof |
| PE20020578A1 (es) | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
| US20050032861A1 (en) * | 2001-04-07 | 2005-02-10 | Betts Michael John | Oxazolidines containing a sulfonimid group as antibiotics |
| PT1380121E (pt) | 2001-04-20 | 2007-11-21 | Pharmacia & Upjohn Co Llc | ''processo para preparar oxazolidinonas'' |
| ES2186550B2 (es) * | 2001-06-27 | 2003-11-16 | Vita Lab | Nuevos derivados de oxazolidinonas como antibacterianos. |
| WO2003106413A2 (en) * | 2001-10-18 | 2003-12-24 | Michigan State University | Process for the preparation of oxazolidinones and method of use thereof |
| BR0307893A (pt) * | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulação oftálmica com sistema de goma |
| MXPA04008173A (es) * | 2002-02-22 | 2004-11-26 | Pharmacia Corp | Formulaciones de farmaco antibiotico oftalmico que contienen un compuesto de ciclodextrina y cloruro de cetil piridinio. |
| EP2902386B1 (en) | 2003-10-16 | 2020-04-08 | Symed Labs Limited | A crystalline form of linezolid |
| DE602004009344T2 (de) * | 2004-04-19 | 2008-07-10 | Symed Labs Ltd., Hyderabad | Neues verfahren zur herstellung von linezolid und verwandten verbindungen |
| ATE429423T1 (de) * | 2004-07-20 | 2009-05-15 | Symed Labs Ltd | Neue zwischenprodukte für linezolid und verwandte verbindungen |
| KR20080104178A (ko) * | 2006-04-07 | 2008-12-01 | 화이자 프로덕츠 인코포레이티드 | 리네졸리드의 제조 방법 |
| CN100395270C (zh) * | 2006-05-25 | 2008-06-18 | 湖北大学 | 线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途 |
| EP2033960A3 (en) * | 2007-09-04 | 2009-04-29 | Dipharma Francis S.r.l. | Linezolid crystalline hydrate form and linezolid salts |
| US20090093631A1 (en) * | 2007-09-06 | 2009-04-09 | Ben-Zion Dolitzky | Processes for the preparation of a linezolid intermediate, linezolid hydroxide |
| EP2163547A1 (en) | 2008-09-16 | 2010-03-17 | Unión Químico Farmacéutica, S.A. (UQUIFA) | Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof |
| JP5561462B2 (ja) * | 2009-09-17 | 2014-07-30 | 日東化成株式会社 | 漁網防汚塗料組成物、該組成物を用いて形成される防汚塗膜、該塗膜の形成方法、および該塗膜を表面に有する漁網、漁網用具又は水中構造物 |
| WO2011077310A1 (en) | 2009-12-26 | 2011-06-30 | Alembic Limited | Process for the preparation of linezolid |
| EP2521723A1 (en) | 2010-01-04 | 2012-11-14 | Enantia, S.L. | Process for the preparation of rivaroxaban and intermediates thereof |
| CN103140487A (zh) | 2010-08-11 | 2013-06-05 | 斯索恩有限公司 | 制备利奈唑胺的方法 |
| EP2690100A1 (en) | 2010-08-11 | 2014-01-29 | Synhton B.V. | Process for making linezolid |
| JP2014500247A (ja) | 2010-11-03 | 2014-01-09 | ウォックハート リミテッド | リン酸モノ−（１−｛４−［（ｓ）―５−（アセチルアミノメチル）−２−オキソ−オキサゾリジン−３−イル］−２，６−ジフルオロフェニル｝−４−メトキシメチルピペリジン−４−イル）エステルの調製方法 |
| US9567307B2 (en) * | 2011-01-07 | 2017-02-14 | The Regents Of The University Of California | Amination of aryl alcohol derivatives |
| CN102153521B (zh) * | 2011-01-31 | 2012-09-12 | 宁波市鄞州百特佳医药科技有限公司 | 一种用于制备利奈唑胺的中间体及其制备方法 |
| CN103391927A (zh) * | 2011-02-24 | 2013-11-13 | 李药业有限公司 | 利奈唑胺及其新中间体的新制备方法 |
| US20140114065A1 (en) | 2011-02-24 | 2014-04-24 | Lee Phama Limited | Anhydrous linezolid crystalline form-ii |
| CN102321042B (zh) * | 2011-07-18 | 2013-12-04 | 苏州敬业医药化工有限公司 | 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法 |
| CN102311402B (zh) * | 2011-07-18 | 2013-08-21 | 苏州敬业医药化工有限公司 | 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法 |
| WO2013072923A1 (en) | 2011-09-19 | 2013-05-23 | Cadila Healthcare Limited | Process for the preparation of crystalline linezolid |
| WO2013111048A1 (en) | 2012-01-24 | 2013-08-01 | Jubilant Life Sciences Limited | Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent |
| CN103626712B (zh) * | 2012-08-23 | 2016-06-01 | 重庆药友制药有限责任公司 | 一种用于制备利奈唑胺的中间体及其制备方法 |
| WO2014071990A1 (en) | 2012-11-09 | 2014-05-15 | Synthon Bv | Process for making linezolid |
| WO2015173664A1 (en) | 2014-05-14 | 2015-11-19 | Wockhardt Limited | Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide |
| WO2021184339A1 (en) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| CN119119019B (zh) * | 2024-09-11 | 2025-11-11 | 遵义医科大学 | 一种杂环磺酰胺/磺酸酯衍生物及其制备方法、应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA681830A (en) * | 1964-03-10 | X. Markley Francis | Process for 5-(aryloxymethyl)-2-oxazolidinones | |
| US3547951A (en) * | 1969-06-17 | 1970-12-15 | Waldo R Hardie | 1,3-dioxolan-4-yl-alkyl guanidines |
| FR2315925A1 (fr) * | 1975-07-04 | 1977-01-28 | Nippon Chemiphar Co | Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique |
| FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
| LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
| JPS6014032B2 (ja) * | 1978-01-20 | 1985-04-11 | 日本ケミフア株式会社東京 | ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法 |
| US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
| FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
| US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
| JP2908510B2 (ja) * | 1990-04-20 | 1999-06-21 | イハラケミカル工業株式会社 | ベンジルアミン類の製造方法 |
| EP0530812B1 (en) * | 1991-09-05 | 1996-05-22 | Nippon Paint Co., Ltd. | Thermosetting resinous composition containing polyfunctional oxazolidinone component and polyamine component |
| DE69216251T2 (de) * | 1991-11-01 | 1997-05-15 | Pharmacia & Upjohn Co., Kalamazoo, Mich. | Substituierte aryl- und heteroaryl-phenyloxazolidinone |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| JPH0873455A (ja) * | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| EP0788498B1 (en) * | 1994-10-26 | 2001-08-16 | PHARMACIA & UPJOHN COMPANY | Phenyloxazolidinone antimicrobials |
| PT792273E (pt) * | 1994-11-15 | 2003-06-30 | Upjohn Co | Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas |
| ATE204874T1 (de) * | 1995-05-11 | 2001-09-15 | Upjohn Co | Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone |
-
1997
- 1997-03-28 AT AT01302264T patent/ATE383347T1/de not_active IP Right Cessation
- 1997-03-28 AU AU23182/97A patent/AU706117B2/en not_active Ceased
- 1997-03-28 US US08/828,923 patent/US5837870A/en not_active Expired - Fee Related
- 1997-03-28 SI SI9730273T patent/SI0892792T1/xx unknown
- 1997-03-28 DE DE69709718T patent/DE69709718T2/de not_active Expired - Fee Related
- 1997-03-28 EP EP01302264A patent/EP1114819B1/en not_active Expired - Lifetime
- 1997-03-28 PL PL329295A patent/PL192691B1/pl not_active IP Right Cessation
- 1997-03-28 KR KR10-2004-7009934A patent/KR100530297B1/ko not_active Expired - Fee Related
- 1997-03-28 PT PT01302264T patent/PT1114819E/pt unknown
- 1997-03-28 DK DK97915865T patent/DK0892792T3/da active
- 1997-03-28 WO PCT/US1997/003458 patent/WO1997037980A1/en not_active Ceased
- 1997-03-28 NZ NZ332278A patent/NZ332278A/xx unknown
- 1997-03-28 CN CN97193658A patent/CN1082953C/zh not_active Expired - Fee Related
- 1997-03-28 SK SK1336-98A patent/SK284703B6/sk unknown
- 1997-03-28 ES ES97915865T patent/ES2166073T3/es not_active Expired - Lifetime
- 1997-03-28 PT PT97915865T patent/PT892792E/pt unknown
- 1997-03-28 CZ CZ0287198A patent/CZ298060B6/cs not_active IP Right Cessation
- 1997-03-28 CN CNB031594743A patent/CN1319952C/zh not_active Expired - Fee Related
- 1997-03-28 CA CA002248143A patent/CA2248143C/en not_active Expired - Fee Related
- 1997-03-28 CN CNB011330031A patent/CN1167701C/zh not_active Expired - Fee Related
- 1997-03-28 DK DK01302264T patent/DK1114819T3/da active
- 1997-03-28 SG SG9905133A patent/SG85683A1/en unknown
- 1997-03-28 HU HU0500044A patent/HUP0500044A3/hu unknown
- 1997-03-28 CZ CZ2007-88A patent/CZ200788A3/cs unknown
- 1997-03-28 AT AT97915865T patent/ATE209193T1/de not_active IP Right Cessation
- 1997-03-28 RU RU98120398/04A patent/RU2176643C2/ru not_active IP Right Cessation
- 1997-03-28 ES ES01302264T patent/ES2298198T3/es not_active Expired - Lifetime
- 1997-03-28 EP EP97915865A patent/EP0892792B1/en not_active Expired - Lifetime
- 1997-03-28 DE DE69738457T patent/DE69738457T2/de not_active Expired - Fee Related
- 1997-03-28 JP JP9536189A patent/JP2000508312A/ja not_active Ceased
- 1997-04-02 TW TW086104216A patent/TW449593B/zh not_active IP Right Cessation
- 1997-04-08 ZA ZA972983A patent/ZA972983B/xx unknown
-
1998
- 1998-10-09 NO NO19984737A patent/NO311837B1/no unknown
-
2001
- 2001-10-26 NO NO20015253A patent/NO312728B1/no unknown
-
2008
- 2008-03-04 JP JP2008053675A patent/JP2008239621A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2166073T3 (es) | Procedimiento para preparar oxazolidinonas. | |
| BR0113930A (pt) | Compostos heterocìclicos de ligação aos receptores de quimiocina | |
| BRPI0410031A (pt) | variantes fc otimizadas e métodos para sua geração | |
| BR0307529A (pt) | Derivados de n-fenil-2-pirimidina-amina | |
| AR053946A2 (es) | Variante de alfa-amilasa de bacillus stearothermophilus original | |
| ITMI932113A1 (it) | Oligopeptidi ad attivita' fungicida | |
| GT199900150A (es) | 1,2,3,4-tetrahidroquinolinas 2-sustituidas 4-carboxiamino sustituidas. | |
| MY107158A (en) | 3-arylcarbonyl; -1h-indoles useful as therapeutic agents. | |
| BR9406552A (pt) | Processo e aparelho para exibir informações e modificar parâmetros associados a um sistema | |
| ES2105223T3 (es) | Compatibilizacion de mezclas elastomeras disimilares utilizando terpolimeros de etileno/acrilato/acido acrilico. | |
| HN1993004031A (es) | N - (4,6 dime) amin - 3 tri - 2 sulfo o una de sus sales utiles composicion herbicida que contiene el mismo y proceso para la produccion del compuesto. | |
| UY24006A1 (es) | Derivado del 2-(2-amino -1,6-dihidro-6-oxo-purin-9-il)metoxil-1,3-propanodiol. | |
| ES2113486T3 (es) | Produccion de organosilanos a partir de polisilanos. | |
| ES2162336T3 (es) | Modulo de espectroscopia de correlacion de fluorescencia para un microscopio. | |
| GT200200216A (es) | Derivados del 3-azabiciclo [3.1.0] hexano | |
| FR2709657B1 (fr) | Dispositif de désignation optique, notamment pour opération de microchirurgie. | |
| MX9602979A (es) | Compuestos heterociclicos terapeuticos. | |
| ES2104939T3 (es) | Procedimiento para la fabricacion de granulados de fertilizantes envueltos por una membrana. | |
| GT199700118A (es) | Procedimiento para piridinas sustituidas. | |
| ES2184089T3 (es) | Derivados de 2,4 - diaminopirimidina. | |
| BR0309850A (pt) | Ensaios de qualidade para células apresentando antìgeno | |
| DK0730493T3 (da) | Anvendelse af et polymermateriale på basis af modificerede hydrokolloider som indkapslingsmateriale | |
| ES2078591T3 (es) | Disco de apoyo. | |
| ATE350123T1 (de) | Niedrigtemperaturprozess zum extrahieren der hauptkomponenten aus pflanzen | |
| BRPI0401912A (pt) | Preparações que contêm aminóxidos e tensìdios aniÈnicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 892792 Country of ref document: ES |