GT200200159A - 2-(3,5-bis-trifluorometil-fenil)-n-[6-(1,1-dioxo-1lambda6-tiomorfolin-4-il)-4-(2-metil o 4-fluoro-2-metil substituido)fenil-piridin-3-il]-n-metil-isobutiramida - Google Patents
2-(3,5-bis-trifluorometil-fenil)-n-[6-(1,1-dioxo-1lambda6-tiomorfolin-4-il)-4-(2-metil o 4-fluoro-2-metil substituido)fenil-piridin-3-il]-n-metil-isobutiramidaInfo
- Publication number
- GT200200159A GT200200159A GT200200159A GT200200159A GT200200159A GT 200200159 A GT200200159 A GT 200200159A GT 200200159 A GT200200159 A GT 200200159A GT 200200159 A GT200200159 A GT 200200159A GT 200200159 A GT200200159 A GT 200200159A
- Authority
- GT
- Guatemala
- Prior art keywords
- metal
- isobutiramida
- tiomorfolin
- 1lambda6
- trifluorometil
- Prior art date
Links
- 239000002184 metal Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL (I) EN DONDE R1,F3,SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON ANTAGONISTAS ALTAMENTE SELECTIVOS DEL RECEPTOR DE LA NEUROQUININA 1 (NK1, SUBSTANCIA P) POR LO QUE SON DE UTILIDAD EN CUADROS DE MIGRAÑA, ARTRITIS REUMATOIDE, ASMA, PSICOSIS, SINTOMAS DE ABSTINENCIA DE DROGAS ADICTIVAS DE OPIACEOS O NICOTINA, ENTRE OTROS, DESCRITOS EN LA SOLICITUD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01118412 | 2001-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200200159A true GT200200159A (es) | 2003-05-16 |
Family
ID=8178193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200200159A GT200200159A (es) | 2001-07-31 | 2002-07-31 | 2-(3,5-bis-trifluorometil-fenil)-n-[6-(1,1-dioxo-1lambda6-tiomorfolin-4-il)-4-(2-metil o 4-fluoro-2-metil substituido)fenil-piridin-3-il]-n-metil-isobutiramida |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6849624B2 (es) |
| EP (1) | EP1414525B1 (es) |
| JP (1) | JP4700908B2 (es) |
| KR (1) | KR100577101B1 (es) |
| CN (1) | CN1289497C (es) |
| AR (1) | AR034921A1 (es) |
| AT (1) | ATE430600T1 (es) |
| BR (1) | BR0211523A (es) |
| CA (1) | CA2452502C (es) |
| DE (1) | DE60232246D1 (es) |
| EA (1) | EA006238B1 (es) |
| EC (1) | ECSP044963A (es) |
| ES (1) | ES2324209T3 (es) |
| GT (1) | GT200200159A (es) |
| HK (1) | HK1069136A1 (es) |
| HR (1) | HRP20040039A2 (es) |
| HU (1) | HUP0400398A3 (es) |
| MA (1) | MA27055A1 (es) |
| MX (1) | MXPA04000917A (es) |
| MY (1) | MY128464A (es) |
| NO (1) | NO20040404L (es) |
| NZ (1) | NZ530579A (es) |
| PA (1) | PA8551601A1 (es) |
| PE (1) | PE20030276A1 (es) |
| PL (1) | PL366986A1 (es) |
| UA (1) | UA77685C2 (es) |
| UY (1) | UY27403A1 (es) |
| WO (1) | WO2003011860A2 (es) |
| YU (1) | YU2704A (es) |
| ZA (1) | ZA200400652B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60210760T2 (de) * | 2001-04-23 | 2006-11-23 | F. Hoffmann-La Roche Ag | Verwendung von nk-1-rezeptorantagonisten gegen benigne prostatahyperplasie |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| PT1578422E (pt) | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
| CN100562320C (zh) * | 2003-01-31 | 2009-11-25 | 弗·哈夫曼-拉罗切有限公司 | 2-(3,5-二-三氟甲基-苯基)-N-[6-(1,1-二氧代-1λ6-硫代吗啉-4-基)-4-(4-氟-2-甲基-苯基)-吡啶-3-基]-N-甲基-异丁酰胺的新晶体变体 |
| ATE500224T1 (de) | 2004-07-06 | 2011-03-15 | Hoffmann La Roche | Herstellungsverfahren für carboxamid-pyridin- derivate als zwischenprodukte bei der synthese von nk-1-rezeptor-antagonisten |
| CN101128429B (zh) * | 2005-02-22 | 2012-03-21 | 弗·哈夫曼-拉罗切有限公司 | Nk1拮抗物 |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| JP5694645B2 (ja) | 2006-03-16 | 2015-04-01 | ニコノヴァム エービーＮｉｃｏｎｏｖｕｍ Ａｂ | 改善された嗅ぎたばこ組成物 |
| GB0808747D0 (en) | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
| US10383894B2 (en) * | 2010-03-17 | 2019-08-20 | Lutran Industries, Inc. | Human medicinal treatment using salt of peroxymonosulfuric acid |
| KR20160078997A (ko) | 2013-11-08 | 2016-07-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | 카복시메틸피페리딘 유도체 |
| TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
| DK3265087T3 (da) | 2015-03-04 | 2020-10-19 | Vanda Pharmaceuticals Inc | Fremgangsmåde til behandling med tradipitant |
| CN112218636A (zh) * | 2018-06-08 | 2021-01-12 | 万达制药公司 | 使用川地匹坦进行治疗的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6435115A (en) * | 1987-07-31 | 1989-02-06 | Nippon Seiko Kk | Bearing device |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| EP1462450B1 (en) | 1993-12-29 | 2007-06-13 | MERCK SHARP & DOHME LTD. | Substituted morpholine derivatives and their use as therapeutic agents |
| TW385308B (en) | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| DK1035115T3 (da) | 1999-02-24 | 2005-01-24 | Hoffmann La Roche | 4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister |
| DE60210760T2 (de) * | 2001-04-23 | 2006-11-23 | F. Hoffmann-La Roche Ag | Verwendung von nk-1-rezeptorantagonisten gegen benigne prostatahyperplasie |
-
2002
- 2002-07-17 US US10/196,795 patent/US6849624B2/en not_active Expired - Fee Related
- 2002-07-25 PE PE2002000667A patent/PE20030276A1/es not_active Application Discontinuation
- 2002-07-26 CA CA2452502A patent/CA2452502C/en not_active Expired - Fee Related
- 2002-07-26 PL PL02366986A patent/PL366986A1/xx not_active Application Discontinuation
- 2002-07-26 YU YU2704A patent/YU2704A/sh unknown
- 2002-07-26 UA UA2004021462A patent/UA77685C2/uk unknown
- 2002-07-26 EP EP02791471A patent/EP1414525B1/en not_active Expired - Lifetime
- 2002-07-26 MX MXPA04000917A patent/MXPA04000917A/es active IP Right Grant
- 2002-07-26 JP JP2003517052A patent/JP4700908B2/ja not_active Expired - Fee Related
- 2002-07-26 NZ NZ530579A patent/NZ530579A/en unknown
- 2002-07-26 WO PCT/EP2002/008311 patent/WO2003011860A2/en active IP Right Grant
- 2002-07-26 DE DE60232246T patent/DE60232246D1/de not_active Expired - Lifetime
- 2002-07-26 CN CNB028151100A patent/CN1289497C/zh not_active Expired - Fee Related
- 2002-07-26 PA PA20028551601A patent/PA8551601A1/es unknown
- 2002-07-26 HU HU0400398A patent/HUP0400398A3/hu unknown
- 2002-07-26 KR KR1020047001322A patent/KR100577101B1/ko not_active IP Right Cessation
- 2002-07-26 AT AT02791471T patent/ATE430600T1/de active
- 2002-07-26 EA EA200400109A patent/EA006238B1/ru not_active IP Right Cessation
- 2002-07-26 ES ES02791471T patent/ES2324209T3/es not_active Expired - Lifetime
- 2002-07-26 BR BR0211523-9A patent/BR0211523A/pt not_active Application Discontinuation
- 2002-07-29 AR ARP020102847A patent/AR034921A1/es not_active Application Discontinuation
- 2002-07-29 MY MYPI20022848A patent/MY128464A/en unknown
- 2002-07-30 UY UY27403A patent/UY27403A1/es not_active Application Discontinuation
- 2002-07-31 GT GT200200159A patent/GT200200159A/es unknown
-
2004
- 2004-01-15 HR HR20040039A patent/HRP20040039A2/hr not_active Application Discontinuation
- 2004-01-27 ZA ZA200400652A patent/ZA200400652B/xx unknown
- 2004-01-29 EC EC2004004963A patent/ECSP044963A/es unknown
- 2004-01-29 NO NO20040404A patent/NO20040404L/no unknown
- 2004-01-30 MA MA27507A patent/MA27055A1/fr unknown
-
2005
- 2005-02-28 HK HK05101662A patent/HK1069136A1/xx not_active IP Right Cessation
Also Published As
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