YU2704A - 2- (3, 5-BIS-TRIFLUORMETIL-FENIL) -N-[6-(1, 1-DIOKSO-1λ6-TI0M0RF0LIN-4-IL)-4-(2-METIL- ILI 4-FLUOR-2-METIL- SUPSTITUISAN) -FENIL-PIRIDIN-3-IL]-N-METIL-IZOBUTIRAMID - Google Patents

2- (3, 5-BIS-TRIFLUORMETIL-FENIL) -N-[6-(1, 1-DIOKSO-1λ6-TI0M0RF0LIN-4-IL)-4-(2-METIL- ILI 4-FLUOR-2-METIL- SUPSTITUISAN) -FENIL-PIRIDIN-3-IL]-N-METIL-IZOBUTIRAMID

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Publication number
YU2704A
YU2704A YU2704A YUP2704A YU2704A YU 2704 A YU2704 A YU 2704A YU 2704 A YU2704 A YU 2704A YU P2704 A YUP2704 A YU P2704A YU 2704 A YU2704 A YU 2704A
Authority
YU
Yugoslavia
Prior art keywords
methyl
phenyl
isobutyramide
thiomorpholin
dioxo
Prior art date
Application number
YU2704A
Other languages
English (en)
Inventor
Theresa Maria Ballard
Torsten Hoffmann
Sonia Maria Poli
Patrick Schnider
Andrew Sleihht
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU2704A publication Critical patent/YU2704A/sh

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
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    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • AHUMAN NECESSITIES
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    • A61P27/02Ophthalmic agents
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na jedinjenja 2-(3,5-bis-trifluormetil-fenil)-N-[6-(1,1-dsiokso-1λ6-tiomorfolin-4-il)-4-o-tolil-piridin-3-il]-N-metil-izobutiramid i 2-(3,5-bis-trifluormetil-fenil)-N-[6-(1,1-dsiokso-1λ6-tiomorfolin-4-il)-4-(4-fluor-2-metil-fenil)-piridin-3-il]-N-metil-iobutiramid, koja se mogu primeniti za lecenje migrene, reumatoidnog artritisa, astme, bronhijalne hiperaktivnosti, zapaljive bolesti creva (utrobe) ili za lecenje poremecaja ukljucujuci Parkinsonovu bolest, briznost (anksioznost), depresiju, bol, glavobolju, Alchajmerovu bolest, multipla sklerozu, edeme, alergijski rinitis, Kronovu bolest, povredu oka, ocne zapaljive bolesti, psihozu, bolesti kretanja, indukovano povracanje, emezu, nezadrzavanje mokrenja, psihoimunoloske ili psihosomatske poremecaje, rak (kancer), simptome uskracivanja adiktivnih lekova (droga) iz opijata ili nikotina, traumatsku povredu mozga ili benignu prostatsku hiperplaziju.
YU2704A 2001-07-31 2002-07-26 2- (3, 5-BIS-TRIFLUORMETIL-FENIL) -N-[6-(1, 1-DIOKSO-1λ6-TI0M0RF0LIN-4-IL)-4-(2-METIL- ILI 4-FLUOR-2-METIL- SUPSTITUISAN) -FENIL-PIRIDIN-3-IL]-N-METIL-IZOBUTIRAMID YU2704A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01118412 2001-07-31

Publications (1)

Publication Number Publication Date
YU2704A true YU2704A (sh) 2006-08-17

Family

ID=8178193

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2704A YU2704A (sh) 2001-07-31 2002-07-26 2- (3, 5-BIS-TRIFLUORMETIL-FENIL) -N-[6-(1, 1-DIOKSO-1λ6-TI0M0RF0LIN-4-IL)-4-(2-METIL- ILI 4-FLUOR-2-METIL- SUPSTITUISAN) -FENIL-PIRIDIN-3-IL]-N-METIL-IZOBUTIRAMID

Country Status (30)

Country Link
US (1) US6849624B2 (sh)
EP (1) EP1414525B1 (sh)
JP (1) JP4700908B2 (sh)
KR (1) KR100577101B1 (sh)
CN (1) CN1289497C (sh)
AR (1) AR034921A1 (sh)
AT (1) ATE430600T1 (sh)
BR (1) BR0211523A (sh)
CA (1) CA2452502C (sh)
DE (1) DE60232246D1 (sh)
EA (1) EA006238B1 (sh)
EC (1) ECSP044963A (sh)
ES (1) ES2324209T3 (sh)
GT (1) GT200200159A (sh)
HK (1) HK1069136A1 (sh)
HR (1) HRP20040039A2 (sh)
HU (1) HUP0400398A3 (sh)
MA (1) MA27055A1 (sh)
MX (1) MXPA04000917A (sh)
MY (1) MY128464A (sh)
NO (1) NO20040404L (sh)
NZ (1) NZ530579A (sh)
PA (1) PA8551601A1 (sh)
PE (1) PE20030276A1 (sh)
PL (1) PL366986A1 (sh)
UA (1) UA77685C2 (sh)
UY (1) UY27403A1 (sh)
WO (1) WO2003011860A2 (sh)
YU (1) YU2704A (sh)
ZA (1) ZA200400652B (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100599134B1 (ko) * 2001-04-23 2006-07-12 에프. 호프만-라 로슈 아게 양성 전립선 비대증에 대한 nk-1 수용체 길항물질의 용도
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
ES2285233T3 (es) 2002-12-20 2007-11-16 Niconovum Ab Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable.
ATE366576T1 (de) * 2003-01-31 2007-08-15 Hoffmann La Roche Neue kristallmodifikation von 2-(3,5-bis- trifluormethyl-phenyl)-n-6-(1,1-dioxo-1lamda-6-
JP4580426B2 (ja) 2004-07-06 2010-11-10 エフ.ホフマン−ラ ロシュ アーゲー Nk−1受容体拮抗薬の合成において中間体として使用されるカルボキサミド誘導体の製造方法
CA2601935C (en) * 2005-02-22 2013-04-09 F. Hoffmann-La Roche Ag Nk1 antagonists
KR20070094666A (ko) 2005-02-25 2007-09-20 에프. 호프만-라 로슈 아게 약제 물질 분산성이 향상된 정제
WO2007104573A2 (en) 2006-03-16 2007-09-20 Niconovum Ab Improved snuff composition
GB0808747D0 (en) 2008-05-14 2008-06-18 Glaxo Wellcome Mfg Pte Ltd Novel compounds
US10383894B2 (en) * 2010-03-17 2019-08-20 Lutran Industries, Inc. Human medicinal treatment using salt of peroxymonosulfuric acid
KR20160078997A (ko) 2013-11-08 2016-07-05 깃세이 야쿠힌 고교 가부시키가이샤 카복시메틸피페리딘 유도체
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
US10463655B2 (en) 2015-03-04 2019-11-05 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
CN112218636A (zh) * 2018-06-08 2021-01-12 万达制药公司 使用川地匹坦进行治疗的方法

Family Cites Families (7)

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JPS6435115A (en) * 1987-07-31 1989-02-06 Nippon Seiko Kk Bearing device
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
BR9408442A (pt) 1993-12-29 1997-08-05 Merck Sharp & Dohme Composto composição farmacêutica processos para tratamento ou prevenção de distúrbios fisiológicos associados com um excesso de taquiquininas e para a preparação do composto e de uso do composto
TW385308B (en) 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
US5972938A (en) 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
ATE496032T1 (de) 1999-02-24 2011-02-15 Hoffmann La Roche 4-phenylpyridinderivate und deren verwendung als nk-1 rezeptorantagonisten
KR100599134B1 (ko) * 2001-04-23 2006-07-12 에프. 호프만-라 로슈 아게 양성 전립선 비대증에 대한 nk-1 수용체 길항물질의 용도

Also Published As

Publication number Publication date
UY27403A1 (es) 2003-04-30
GT200200159A (es) 2003-05-16
HUP0400398A2 (hu) 2004-09-28
UA77685C2 (en) 2007-01-15
HUP0400398A3 (en) 2010-06-28
WO2003011860A2 (en) 2003-02-13
ES2324209T3 (es) 2009-08-03
CN1289497C (zh) 2006-12-13
ECSP044963A (es) 2004-03-23
NO20040404L (no) 2004-01-29
CA2452502A1 (en) 2003-02-13
PA8551601A1 (es) 2003-06-30
HRP20040039A2 (en) 2004-06-30
HK1069136A1 (en) 2005-05-13
MXPA04000917A (es) 2004-04-02
KR20040029386A (ko) 2004-04-06
MY128464A (en) 2007-02-28
EP1414525B1 (en) 2009-05-06
PL366986A1 (en) 2005-02-07
KR100577101B1 (ko) 2006-05-10
MA27055A1 (fr) 2004-12-20
WO2003011860A3 (en) 2003-09-04
CN1537025A (zh) 2004-10-13
NZ530579A (en) 2006-02-24
US20030064983A1 (en) 2003-04-03
EA006238B1 (ru) 2005-10-27
JP4700908B2 (ja) 2011-06-15
DE60232246D1 (de) 2009-06-18
US6849624B2 (en) 2005-02-01
EA200400109A1 (ru) 2004-08-26
ZA200400652B (en) 2005-04-28
BR0211523A (pt) 2004-09-14
EP1414525A2 (en) 2004-05-06
ATE430600T1 (de) 2009-05-15
PE20030276A1 (es) 2003-03-29
AR034921A1 (es) 2004-03-24
JP2005500354A (ja) 2005-01-06
AU2002355652B2 (en) 2007-07-05
CA2452502C (en) 2011-02-15

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