CA2248143C - Process to prepare oxazolidinones - Google Patents

Process to prepare oxazolidinones Download PDF

Info

Publication number
CA2248143C
CA2248143C CA002248143A CA2248143A CA2248143C CA 2248143 C CA2248143 C CA 2248143C CA 002248143 A CA002248143 A CA 002248143A CA 2248143 A CA2248143 A CA 2248143A CA 2248143 C CA2248143 C CA 2248143C
Authority
CA
Canada
Prior art keywords
process according
phenyl
alkyl
phi
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002248143A
Other languages
English (en)
French (fr)
Other versions
CA2248143A1 (en
Inventor
Bruce A. Pearlman
William R. Perrault
Michael R. Barbachyn
Peter R. Manninen
Dana S. Toops
David J. Houser
Thomas J. Fleck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Priority to CA002557862A priority Critical patent/CA2557862A1/en
Publication of CA2248143A1 publication Critical patent/CA2248143A1/en
Application granted granted Critical
Publication of CA2248143C publication Critical patent/CA2248143C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002248143A 1996-04-11 1997-03-28 Process to prepare oxazolidinones Expired - Fee Related CA2248143C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002557862A CA2557862A1 (en) 1996-04-11 1997-03-28 Process to prepare 5-aminomethyl substituted oxazolidinones

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1549996P 1996-04-11 1996-04-11
US60/015,499 1996-04-11
PCT/US1997/003458 WO1997037980A1 (en) 1996-04-11 1997-03-28 Process to prepare oxazolidinones

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002557862A Division CA2557862A1 (en) 1996-04-11 1997-03-28 Process to prepare 5-aminomethyl substituted oxazolidinones

Publications (2)

Publication Number Publication Date
CA2248143A1 CA2248143A1 (en) 1997-10-16
CA2248143C true CA2248143C (en) 2008-10-07

Family

ID=21771765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002248143A Expired - Fee Related CA2248143C (en) 1996-04-11 1997-03-28 Process to prepare oxazolidinones

Country Status (24)

Country Link
US (1) US5837870A (enExample)
EP (2) EP1114819B1 (enExample)
JP (2) JP2000508312A (enExample)
KR (1) KR100530297B1 (enExample)
CN (3) CN1082953C (enExample)
AT (2) ATE383347T1 (enExample)
AU (1) AU706117B2 (enExample)
CA (1) CA2248143C (enExample)
CZ (2) CZ298060B6 (enExample)
DE (2) DE69738457T2 (enExample)
DK (2) DK0892792T3 (enExample)
ES (2) ES2166073T3 (enExample)
HU (1) HUP0500044A3 (enExample)
NO (2) NO311837B1 (enExample)
NZ (1) NZ332278A (enExample)
PL (1) PL192691B1 (enExample)
PT (2) PT892792E (enExample)
RU (1) RU2176643C2 (enExample)
SG (1) SG85683A1 (enExample)
SI (1) SI0892792T1 (enExample)
SK (1) SK284703B6 (enExample)
TW (1) TW449593B (enExample)
WO (1) WO1997037980A1 (enExample)
ZA (1) ZA972983B (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
HUP0103082A3 (en) 1998-06-05 2002-12-28 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6403804B1 (en) * 1998-12-07 2002-06-11 Takasago International Corporation Process for preparing optically active oxazolidinone derivative
DK1149089T3 (da) 1999-02-01 2003-07-21 Upjohn Co Fremgangsmåde til fremstilling af tetrahydrothiopyran-o-fluorerede carbamater
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
US6444813B2 (en) 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) * 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) * 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ATE301474T1 (de) 2000-06-30 2005-08-15 Pharmacia & Upjohn Co Llc Zusammensetzungen zur behandlung baktrieller infektionen, welche ein oxazolidinonderivat, sulbactam und ampicillin enthalten
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
US6288239B1 (en) 2000-09-19 2001-09-11 Board Of Trustees Operating Michigan State University 5-trityloxymethyl-oxazolidinones and process for the preparation thereof
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
WO2002081470A1 (en) * 2001-04-07 2002-10-17 Astrazeneca Ab Oxazolidinones containing a sulfonimid group as antibiotics
EP1380121B1 (en) 2001-04-20 2007-09-26 Pharmacia & Upjohn Company LLC Process to prepare oxazolidinones
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
JP2005519996A (ja) * 2001-10-18 2005-07-07 ミシガン ステイト ユニバーシティー オキサゾリジノン類の製造方法及びその使用方法
AR038575A1 (es) * 2002-02-22 2005-01-19 Pharmacia Corp Formulacion oftalmica con nueva composicion de goma
US20040019012A1 (en) * 2002-02-22 2004-01-29 Singh Satish K. Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride
ES2803516T3 (es) 2003-10-16 2021-01-27 Symed Labs Ltd Una forma cristalina de linezolid
US7307163B2 (en) * 2004-04-19 2007-12-11 Symed Labs Limited Process for the preparation of linezolid and related compounds
PL1768967T3 (pl) * 2004-07-20 2009-09-30 Symed Labs Ltd Nowe związki pośrednie do wytwarzania linezolidu oraz związki pokrewne
BRPI0710312A2 (pt) * 2006-04-07 2011-08-09 Pfizer Prod Inc processo para preparar linezolida
CN100395270C (zh) * 2006-05-25 2008-06-18 湖北大学 线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途
EP2033960A3 (en) * 2007-09-04 2009-04-29 Dipharma Francis S.r.l. Linezolid crystalline hydrate form and linezolid salts
US20090093631A1 (en) * 2007-09-06 2009-04-09 Ben-Zion Dolitzky Processes for the preparation of a linezolid intermediate, linezolid hydroxide
EP2163547A1 (en) 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
JP5561462B2 (ja) * 2009-09-17 2014-07-30 日東化成株式会社 漁網防汚塗料組成物、該組成物を用いて形成される防汚塗膜、該塗膜の形成方法、および該塗膜を表面に有する漁網、漁網用具又は水中構造物
US20130137864A1 (en) 2009-12-26 2013-05-30 Jayaraman Venkat Raman Process for the preparation of linezolid
CN102822167A (zh) 2010-01-04 2012-12-12 埃南蒂亚有限公司 用于制备利伐沙班的方法及其中间体
EP2603505A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
EP2603506A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
EP2635589A1 (en) 2010-11-03 2013-09-11 Wockhardt Limited Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl]- 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester
US9567307B2 (en) * 2011-01-07 2017-02-14 The Regents Of The University Of California Amination of aryl alcohol derivatives
CN102153521B (zh) * 2011-01-31 2012-09-12 宁波市鄞州百特佳医药科技有限公司 一种用于制备利奈唑胺的中间体及其制备方法
PL2595968T3 (pl) 2011-02-24 2016-03-31 Lee Pharma Ltd Nowy sposób wytwarzania linezolidu i jego nowe produkty pośrednie
EP2593440A1 (en) 2011-02-24 2013-05-22 Lee Pharma Limited Anhydrous linezolid crystalline form-ii
CN102311402B (zh) * 2011-07-18 2013-08-21 苏州敬业医药化工有限公司 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法
CN102321042B (zh) * 2011-07-18 2013-12-04 苏州敬业医药化工有限公司 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法
WO2013072923A1 (en) 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
WO2013111048A1 (en) 2012-01-24 2013-08-01 Jubilant Life Sciences Limited Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
CN103626712B (zh) * 2012-08-23 2016-06-01 重庆药友制药有限责任公司 一种用于制备利奈唑胺的中间体及其制备方法
EP2917189B1 (en) 2012-11-09 2016-08-17 Synthon BV Process for making linezolid
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent
CN119119019B (zh) * 2024-09-11 2025-11-11 遵义医科大学 一种杂环磺酰胺/磺酸酯衍生物及其制备方法、应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA681830A (en) * 1964-03-10 X. Markley Francis Process for 5-(aryloxymethyl)-2-oxazolidinones
US3547951A (en) * 1969-06-17 1970-12-15 Waldo R Hardie 1,3-dioxolan-4-yl-alkyl guanidines
FR2315925A1 (fr) * 1975-07-04 1977-01-28 Nippon Chemiphar Co Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
JPS6014032B2 (ja) * 1978-01-20 1985-04-11 日本ケミフア株式会社東京 ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
JP2908510B2 (ja) * 1990-04-20 1999-06-21 イハラケミカル工業株式会社 ベンジルアミン類の製造方法
EP0677515A1 (en) * 1991-09-05 1995-10-18 Nippon Paint Co., Ltd. Method for preparing 2-oxazolidinone derivatives
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
CA2200433C (en) * 1994-10-26 2006-02-07 Douglas K. Hutchinson Phenyloxazolidinone antimicrobials
PT792273E (pt) * 1994-11-15 2003-06-30 Upjohn Co Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas
DE69614847T2 (de) * 1995-05-11 2002-04-04 Pharmacia & Upjohn Co., Kalamazoo Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone

Also Published As

Publication number Publication date
CN1319952C (zh) 2007-06-06
DE69709718D1 (de) 2002-02-21
NO984737D0 (no) 1998-10-09
HUP0500044A3 (en) 2005-09-28
US5837870A (en) 1998-11-17
CA2248143A1 (en) 1997-10-16
CN1215393A (zh) 1999-04-28
CZ200788A3 (cs) 2017-01-25
NO312728B1 (no) 2002-06-24
WO1997037980A1 (en) 1997-10-16
DK0892792T3 (da) 2002-04-02
ATE209193T1 (de) 2001-12-15
EP1114819A1 (en) 2001-07-11
DK1114819T3 (da) 2008-04-14
AU2318297A (en) 1997-10-29
PL329295A1 (en) 1999-03-15
DE69738457D1 (de) 2008-02-21
DE69738457T2 (de) 2008-12-24
CN1167701C (zh) 2004-09-22
NO20015253L (no) 1998-12-09
ZA972983B (en) 1998-10-08
ATE383347T1 (de) 2008-01-15
ES2298198T3 (es) 2008-05-16
RU2176643C2 (ru) 2001-12-10
SG85683A1 (en) 2002-01-15
EP0892792A1 (en) 1999-01-27
DE69709718T2 (de) 2002-06-20
NO984737L (no) 1998-12-09
EP1114819B1 (en) 2008-01-09
NO311837B1 (no) 2002-02-04
KR100530297B1 (ko) 2005-11-22
PT892792E (pt) 2002-05-31
PL192691B1 (pl) 2006-11-30
CN1496983A (zh) 2004-05-19
HU0500044D0 (en) 2005-03-29
CN1082953C (zh) 2002-04-17
PT1114819E (pt) 2008-02-28
ES2166073T3 (es) 2002-04-01
CZ298060B6 (cs) 2007-06-06
CZ287198A3 (cs) 1999-02-17
TW449593B (en) 2001-08-11
SI0892792T1 (en) 2002-06-30
CN1381454A (zh) 2002-11-27
NZ332278A (en) 2000-05-26
HK1061241A1 (en) 2004-09-10
KR20040066189A (ko) 2004-07-23
AU706117B2 (en) 1999-06-10
JP2000508312A (ja) 2000-07-04
SK284703B6 (sk) 2005-09-08
HK1018785A1 (en) 2000-01-07
NO20015253D0 (no) 2001-10-26
SK133698A3 (en) 1999-06-11
JP2008239621A (ja) 2008-10-09
EP0892792B1 (en) 2001-11-21

Similar Documents

Publication Publication Date Title
CA2248143C (en) Process to prepare oxazolidinones
EP1028940B1 (en) Process to produce oxazolidinones
CA2423599A1 (en) Methods of producing oxazolidinone compounds
KR100504304B1 (ko) 옥사졸리디논의제조방법
CA2557862A1 (en) Process to prepare 5-aminomethyl substituted oxazolidinones
KR19990024927A (ko) 옥사졸리디논 유도체 및 그의 제조방법 및 항균제 조성물
HUT74737A (en) Process for producing anthrapyrazolone derivatives

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed