CN1078475A - 一种改进的将取代的甾族3-卤素-3，5-二烯衍生物转化为取代的甾族3，5-二烯-3-羧酸衍生物的方法及所用中间物 - Google Patents

一种改进的将取代的甾族3-卤素-3，5-二烯衍生物转化为取代的甾族3，5-二烯-3-羧酸衍生物的方法及所用中间物 Download PDF

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Publication number
CN1078475A
CN1078475A CN 93102531 CN93102531A CN1078475A CN 1078475 A CN1078475 A CN 1078475A CN 93102531 CN93102531 CN 93102531 CN 93102531 A CN93102531 A CN 93102531A CN 1078475 A CN1078475 A CN 1078475A
Authority
CN
China
Prior art keywords
compound
diene
formula
carboxylic acid
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 93102531
Other languages
English (en)
Chinese (zh)
Inventor
N·H·贝恩
F·F·奥因斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1078475A publication Critical patent/CN1078475A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN 93102531 1992-02-07 1993-02-06 一种改进的将取代的甾族3-卤素-3，5-二烯衍生物转化为取代的甾族3，5-二烯-3-羧酸衍生物的方法及所用中间物 Pending CN1078475A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83228092A 1992-02-07 1992-02-07
US832,280 1992-02-07

Publications (1)

Publication Number Publication Date
CN1078475A true CN1078475A (zh) 1993-11-17

Family

ID=25261209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 93102531 Pending CN1078475A (zh) 1992-02-07 1993-02-06 一种改进的将取代的甾族3-卤素-3，5-二烯衍生物转化为取代的甾族3，5-二烯-3-羧酸衍生物的方法及所用中间物

Country Status (23)

Country Link
EP (1) EP0643724A4 (ja)
JP (1) JPH07505140A (ja)
KR (1) KR950700319A (ja)
CN (1) CN1078475A (ja)
AP (1) AP9600790A0 (ja)
AU (1) AU666177B2 (ja)
BG (1) BG98955A (ja)
BR (1) BR9305837A (ja)
CA (1) CA2129342A1 (ja)
CZ (1) CZ188794A3 (ja)
FI (1) FI943660A0 (ja)
HU (1) HUT68303A (ja)
IL (1) IL104602A (ja)
MA (1) MA22788A1 (ja)
MX (1) MX9300676A (ja)
NO (1) NO942925L (ja)
NZ (1) NZ249382A (ja)
OA (1) OA10090A (ja)
RU (1) RU94045824A (ja)
SI (1) SI9300065A (ja)
TW (1) TW327175B (ja)
WO (1) WO1993016097A1 (ja)
ZA (1) ZA93801B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206413D0 (en) * 1992-03-24 1992-05-06 Smithkline Beecham Corp N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA883034B (en) * 1987-04-29 1989-03-29 Smithkline Beckman Corp Steroid 5-alpha-reductase inhibitors
IL104601A0 (en) * 1992-02-07 1993-07-08 Smithkline Beecham Corp Process for the preparation of steroidal dienes

Also Published As

Publication number Publication date
CA2129342A1 (en) 1993-08-19
MX9300676A (es) 1994-07-29
NZ249382A (en) 1996-05-28
AU666177B2 (en) 1996-02-01
EP0643724A1 (en) 1995-03-22
HU9402303D0 (en) 1994-10-28
CZ188794A3 (en) 1994-12-15
WO1993016097A1 (en) 1993-08-19
TW327175B (en) 1998-02-21
NO942925L (no) 1994-08-08
AU3612693A (en) 1993-09-03
EP0643724A4 (en) 1995-05-10
NO942925D0 (ja) 1994-08-05
MA22788A1 (fr) 1993-10-01
OA10090A (en) 1996-12-18
BR9305837A (pt) 1997-02-18
BG98955A (bg) 1995-06-30
JPH07505140A (ja) 1995-06-08
FI943660A (fi) 1994-08-05
HUT68303A (en) 1995-06-28
FI943660A0 (fi) 1994-08-05
RU94045824A (ru) 1996-07-10
SI9300065A (en) 1993-09-30
KR950700319A (ko) 1995-01-16
IL104602A0 (en) 1993-07-08
AP9600790A0 (en) 1996-04-30
ZA93801B (en) 1993-11-05
IL104602A (en) 1997-07-13

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