CN107108686B - 用于恶性肿瘤的rna干扰组合物和方法 - Google Patents

用于恶性肿瘤的rna干扰组合物和方法 Download PDF

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CN107108686B
CN107108686B CN201580071233.3A CN201580071233A CN107108686B CN 107108686 B CN107108686 B CN 107108686B CN 201580071233 A CN201580071233 A CN 201580071233A CN 107108686 B CN107108686 B CN 107108686B
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gst
composition
lipid
rnai
administration
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CN107108686A (zh
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应文斌
新津洋司郎
味吞宪二郎
B·马杰蒂
王丽
刘继华
R·亚达米
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Nitto Denko Corp
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CN201580071233.3A 2014-12-26 2015-12-28 用于恶性肿瘤的rna干扰组合物和方法 Active CN107108686B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2014266198 2014-12-26
JP2014-266198 2014-12-26
US201562184241P 2015-06-24 2015-06-24
US62/184,241 2015-06-24
US201562266661P 2015-12-13 2015-12-13
US62/266,661 2015-12-13
PCT/US2015/067560 WO2016106405A1 (en) 2014-12-26 2015-12-28 Rna interference compositions and methods for malignant tumors

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CN107108686B true CN107108686B (zh) 2021-07-16

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CN201580071233.3A Active CN107108686B (zh) 2014-12-26 2015-12-28 用于恶性肿瘤的rna干扰组合物和方法
CN201580071210.2A Pending CN108064153A (zh) 2014-12-26 2015-12-28 用于调节gst-pi基因的rna剂
CN201580071234.8A Pending CN108024961A (zh) 2014-12-26 2015-12-28 使用靶向Hsp47和p21的RNAi分子的恶性肿瘤治疗组合物和方法
CN201580071191.3A Active CN107106591B (zh) 2014-12-26 2015-12-28 用于gst-pi基因调节的rna干扰剂
CN201580071209.XA Active CN107106592B (zh) 2014-12-26 2015-12-28 用于p21基因调节的rna干扰剂
CN201580071081.7A Active CN108064155B (zh) 2014-12-26 2015-12-28 用于p21基因调节的rna剂
CN201580071232.9A Pending CN107106564A (zh) 2014-12-26 2015-12-28 用于治疗与kras突变相关的恶性肿瘤的方法和组合物

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CN201580071210.2A Pending CN108064153A (zh) 2014-12-26 2015-12-28 用于调节gst-pi基因的rna剂
CN201580071234.8A Pending CN108024961A (zh) 2014-12-26 2015-12-28 使用靶向Hsp47和p21的RNAi分子的恶性肿瘤治疗组合物和方法
CN201580071191.3A Active CN107106591B (zh) 2014-12-26 2015-12-28 用于gst-pi基因调节的rna干扰剂
CN201580071209.XA Active CN107106592B (zh) 2014-12-26 2015-12-28 用于p21基因调节的rna干扰剂
CN201580071081.7A Active CN108064155B (zh) 2014-12-26 2015-12-28 用于p21基因调节的rna剂
CN201580071232.9A Pending CN107106564A (zh) 2014-12-26 2015-12-28 用于治疗与kras突变相关的恶性肿瘤的方法和组合物

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US11045488B2 (en) * 2014-12-26 2021-06-29 Nitto Denko Corporation RNA interference agents for GST-π gene modulation
US10792299B2 (en) * 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US20180002702A1 (en) 2014-12-26 2018-01-04 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
ES2789049T3 (es) * 2014-12-26 2020-10-23 Nitto Denko Corp Agentes de interferencia de ARN para modulación génica de GST-pi
AU2016281685B2 (en) * 2015-06-24 2021-08-12 Nitto Denko Corporation Ionizable compounds and compositions and uses thereof
US10358647B2 (en) 2015-12-13 2019-07-23 Nitto Denko Corporation siRNA structures for high activity and reduced off target
TWI780046B (zh) 2016-05-10 2022-10-11 國立大學法人東京醫科齒科大學 炎症促進因子表現抑制劑、其有效成分之篩選方法、對於該方法為有用之表現匣、診斷藥及診斷方法
JP2019508379A (ja) * 2017-02-16 2019-03-28 日東電工株式会社 悪性腫瘍に対する治療方法及び治療用組成物
WO2019090359A1 (en) * 2017-11-06 2019-05-09 Nitto Denko Corporation Fusogenic compounds for delivery of biologically active molecules
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