CN107106574A - 神经活性类固醇、组合物及其用途 - Google Patents

神经活性类固醇、组合物及其用途 Download PDF

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Publication number
CN107106574A
CN107106574A CN201580060650.8A CN201580060650A CN107106574A CN 107106574 A CN107106574 A CN 107106574A CN 201580060650 A CN201580060650 A CN 201580060650A CN 107106574 A CN107106574 A CN 107106574A
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CN
China
Prior art keywords
neuroactive steroid
dose
infusion
hour
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580060650.8A
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English (en)
Chinese (zh)
Inventor
S.J.凯恩斯
H.卡胡恩
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Sage Therapeutics Inc
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Sage Therapeutics Inc
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Filing date
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Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Priority to CN202311453621.0A priority Critical patent/CN117679426A/zh
Publication of CN107106574A publication Critical patent/CN107106574A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580060650.8A 2014-09-08 2015-09-08 神经活性类固醇、组合物及其用途 Pending CN107106574A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311453621.0A CN117679426A (zh) 2014-09-08 2015-09-08 神经活性类固醇、组合物及其用途

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462047599P 2014-09-08 2014-09-08
US62/047,599 2014-09-08
US201562170596P 2015-06-03 2015-06-03
US62/170,596 2015-06-03
US201562213015P 2015-09-01 2015-09-01
US62/213,015 2015-09-01
PCT/US2015/048937 WO2016040322A1 (en) 2014-09-08 2015-09-08 Neuroactive steroids, compositions, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311453621.0A Division CN117679426A (zh) 2014-09-08 2015-09-08 神经活性类固醇、组合物及其用途

Publications (1)

Publication Number Publication Date
CN107106574A true CN107106574A (zh) 2017-08-29

Family

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Family Applications (2)

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CN201580060650.8A Pending CN107106574A (zh) 2014-09-08 2015-09-08 神经活性类固醇、组合物及其用途
CN202311453621.0A Pending CN117679426A (zh) 2014-09-08 2015-09-08 神经活性类固醇、组合物及其用途

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Country Status (18)

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US (3) US20170348327A1 (enExample)
EP (1) EP3191101B1 (enExample)
JP (3) JP6837430B2 (enExample)
KR (2) KR102491549B1 (enExample)
CN (2) CN107106574A (enExample)
AU (3) AU2015315333A1 (enExample)
BR (1) BR112017004535A2 (enExample)
CA (1) CA2960611C (enExample)
CO (1) CO2017003396A2 (enExample)
IL (2) IL285703B2 (enExample)
JO (2) JOP20200195A1 (enExample)
MX (2) MX382123B (enExample)
PE (2) PE20221050A1 (enExample)
PH (1) PH12017500427A1 (enExample)
RU (2) RU2020127610A (enExample)
SG (2) SG11201701815SA (enExample)
TW (3) TW202329978A (enExample)
WO (1) WO2016040322A1 (enExample)

Cited By (7)

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WO2020103952A1 (zh) * 2018-11-22 2020-05-28 南京诺瑞特医药科技有限公司 神经活性类固醇的新制剂
CN112512505A (zh) * 2018-04-17 2021-03-16 马特恩制药股份公司 用于鼻内递送孕烯醇酮的组合物和方法
CN112533611A (zh) * 2018-06-12 2021-03-19 萨奇治疗股份有限公司 19-去甲基c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
CN113939299A (zh) * 2019-05-10 2022-01-14 腾盛博药生物科技有限公司 含有别孕烷醇酮、加奈索酮或祖拉诺醇酮的药物组合物及其用途
CN113939298A (zh) * 2018-12-14 2022-01-14 普拉西斯精密医药公司 用于治疗抑郁症的方法
CN115487138A (zh) * 2021-06-18 2022-12-20 北京万全德众医药生物技术有限公司 别孕烯醇酮注射剂及其制备方法
CN116348095A (zh) * 2020-08-17 2023-06-27 腾盛博药生物科技有限公司 含有神经活性类固醇的药物组合物及其用途

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WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
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US11410755B2 (en) * 2014-11-06 2022-08-09 Ieso Digital Health Limited Computer-based system for providing psychological therapy
SMT202000276T1 (it) 2014-11-27 2020-07-08 Sage Therapeutics Inc Composizioni e metodi per trattare disturbi del snc
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WO2016164763A1 (en) 2015-04-10 2016-10-13 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
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WO2017156103A1 (en) 2016-03-08 2017-09-14 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
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CN112341511A (zh) * 2019-08-09 2021-02-09 南京诺瑞特医药科技有限公司 3-羟基-5-孕烷-20-酮衍生物及其用途
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US20230091716A1 (en) * 2020-02-12 2023-03-23 Glia, Llc Progesterone Combinations
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US11969434B1 (en) 2022-08-29 2024-04-30 Lipocine Inc. Oral allopregnanolone compositions and methods of use
US12208103B1 (en) 2021-05-07 2025-01-28 Lipocine Inc. Compositions and methods for treating CNS disorders
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EP4583902A2 (en) * 2022-09-07 2025-07-16 Oxeia Biopharmaceuticals, Inc. Treatment of mild traumatic brain injury
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