PE20170904A1 - Esteroides neuroactivos, composiciones y usos de los mismos - Google Patents

Esteroides neuroactivos, composiciones y usos de los mismos

Info

Publication number
PE20170904A1
PE20170904A1 PE2017000428A PE2017000428A PE20170904A1 PE 20170904 A1 PE20170904 A1 PE 20170904A1 PE 2017000428 A PE2017000428 A PE 2017000428A PE 2017000428 A PE2017000428 A PE 2017000428A PE 20170904 A1 PE20170904 A1 PE 20170904A1
Authority
PE
Peru
Prior art keywords
alopregnona
alopregnone
alopregnolone
compositions
cyclodextrin
Prior art date
Application number
PE2017000428A
Other languages
English (en)
Inventor
Stephen Jay Kanes
Helen Colquhoun
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of PE20170904A1 publication Critical patent/PE20170904A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REFIERE A UN METODO PARA TRATAR EL TEMBLOR, LA DEPRESION Y EL TRASTORNO POR ANSIEDAD, EL CUAL COMPRENDE ADMINISTRAR A UN SUJETO UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN ESTEROIDE NEUROACTIVO TAL COMO PREGNANOLONA, ALOPREGNANOLONA, ALFADALONA, GANAXOLONA O ALFAXOLONA; DONDE EL ESTEROIDE NEUROACTIVO SE PROPORCIONA EN UNA COMPOSICION QUE COMPRENDE SULFO-BUTIL-ETER B-CICLODEXTRINA EN UNA CANTIDAD DE 1 A 30% EN PESO DE CICLODEXTRINA POR VOLUMEN DE COMPOSICION
PE2017000428A 2014-09-08 2015-09-08 Esteroides neuroactivos, composiciones y usos de los mismos PE20170904A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462047599P 2014-09-08 2014-09-08
US201562170596P 2015-06-03 2015-06-03
US201562213015P 2015-09-01 2015-09-01

Publications (1)

Publication Number Publication Date
PE20170904A1 true PE20170904A1 (es) 2017-07-12

Family

ID=55459478

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2017000428A PE20170904A1 (es) 2014-09-08 2015-09-08 Esteroides neuroactivos, composiciones y usos de los mismos
PE2022000301A PE20221050A1 (es) 2014-09-08 2015-09-08 Esteroides neuroactivos, composiciones y usos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2022000301A PE20221050A1 (es) 2014-09-08 2015-09-08 Esteroides neuroactivos, composiciones y usos de los mismos

Country Status (18)

Country Link
US (2) US20170348327A1 (es)
EP (1) EP3191101A4 (es)
JP (3) JP6837430B2 (es)
KR (2) KR20230015518A (es)
CN (2) CN117679426A (es)
AU (3) AU2015315333A1 (es)
BR (1) BR112017004535A2 (es)
CA (1) CA2960611A1 (es)
CO (1) CO2017003396A2 (es)
IL (2) IL285703B2 (es)
JO (2) JOP20200195A1 (es)
MX (2) MX2017003037A (es)
PE (2) PE20170904A1 (es)
PH (1) PH12017500427A1 (es)
RU (2) RU2020127610A (es)
SG (2) SG10202107866YA (es)
TW (3) TWI784261B (es)
WO (1) WO2016040322A1 (es)

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