PT2030622E - Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico - Google Patents
Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico Download PDFInfo
- Publication number
- PT2030622E PT2030622E PT08167618T PT08167618T PT2030622E PT 2030622 E PT2030622 E PT 2030622E PT 08167618 T PT08167618 T PT 08167618T PT 08167618 T PT08167618 T PT 08167618T PT 2030622 E PT2030622 E PT 2030622E
- Authority
- PT
- Portugal
- Prior art keywords
- progesterone
- dosage
- indication
- treatment
- brain injury
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 5
- 229960003387 progesterone Drugs 0.000 title abstract 2
- 239000000186 progesterone Substances 0.000 title abstract 2
- 208000030886 Traumatic Brain injury Diseases 0.000 title 1
- 230000009529 traumatic brain injury Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 208000001738 Nervous System Trauma Diseases 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 3
- 208000028412 nervous system injury Diseases 0.000 abstract 3
- 206010030113 Oedema Diseases 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000016273 neuron death Effects 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66472805P | 2005-03-24 | 2005-03-24 | |
US72966305P | 2005-10-24 | 2005-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2030622E true PT2030622E (pt) | 2011-06-02 |
Family
ID=36987966
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT06748657T PT1868614E (pt) | 2005-03-24 | 2006-03-24 | Regime de dosagem para o tratamento de uma lesão cerebral traumática com progesterona |
PT08167618T PT2030622E (pt) | 2005-03-24 | 2006-03-24 | Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT06748657T PT1868614E (pt) | 2005-03-24 | 2006-03-24 | Regime de dosagem para o tratamento de uma lesão cerebral traumática com progesterona |
Country Status (16)
Country | Link |
---|---|
US (4) | US20090221544A1 (pt) |
EP (5) | EP1871382B1 (pt) |
JP (5) | JP5394059B2 (pt) |
AT (2) | ATE520404T1 (pt) |
AU (2) | AU2006226774B2 (pt) |
CA (2) | CA2602950C (pt) |
CY (2) | CY1111478T1 (pt) |
DE (1) | DE602006020353D1 (pt) |
DK (2) | DK2030622T3 (pt) |
ES (2) | ES2392454T3 (pt) |
HK (3) | HK1112579A1 (pt) |
HR (2) | HRP20110198T1 (pt) |
PL (2) | PL2030622T3 (pt) |
PT (2) | PT1868614E (pt) |
RS (1) | RS52471B (pt) |
WO (2) | WO2006102644A2 (pt) |
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US9527881B2 (en) | 2008-02-26 | 2016-12-27 | Emory University | Steroid analogues for neuroprotection |
EP2331571B1 (en) | 2008-09-18 | 2015-08-26 | Northwestern University | Nmda receptor modulators and uses thereof |
US20110306579A1 (en) * | 2009-01-30 | 2011-12-15 | Emory University | Methods of neuroprotection using neuroprotective steroids and a vitamin d |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
US20110262502A1 (en) * | 2010-02-08 | 2011-10-27 | Prairie Pharmaceuticals LLC | Pulmonary delivery of 17-hydroxyprogesterone caproate (17-hpc) |
ES2773079T3 (es) | 2010-02-08 | 2020-07-09 | Shenzhen Evergreen Therapeutics Co Ltd | Métodos para el uso de progestágeno como sensibilizador de glucocorticoides |
US10987361B2 (en) | 2010-02-08 | 2021-04-27 | Shenzhen Evergreen Therapeutics Co., Ltd. | Treating auto-immune and auto-inflammatory diseases |
US10993879B2 (en) * | 2010-02-08 | 2021-05-04 | Shenzhen Evergreen Therapeutics Co., Ltd. | Pulmonary delivery of progestogen |
TW201138782A (en) | 2010-04-26 | 2011-11-16 | Besins Healthcare Lu Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
MX357761B (es) * | 2011-04-27 | 2018-07-23 | Univ Northwestern | Métodos para tratar la enfermedad de alzheimer, enfermedad de huntington, autismo u otros trastornos. |
WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
SG10201606063RA (en) * | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
US20130210785A1 (en) | 2012-02-15 | 2013-08-15 | Emory University | Progesterone analogs and uses related thereto |
MX356427B (es) | 2012-02-29 | 2018-05-29 | Braun Melsungen Ag | Emulsion que contiene hormona. |
RU2498826C1 (ru) * | 2012-05-14 | 2013-11-20 | Федеральное государственное бюджетное учреждение науки Комплексный научно-исследовательский институт им. Х.И. Ибрагимова Российской академии наук | Способ лечения больных с черепно-мозговой травмой |
IL304912A (en) | 2012-08-21 | 2023-10-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
EP2925327B1 (en) | 2012-11-30 | 2024-01-10 | The Regents of The University of California | Allopregnanolone for treating, reducing or mitigating symptoms of post-partum depression |
SI3514158T1 (sl) | 2013-01-29 | 2023-03-31 | Aptinyx Inc. | Spirolaktamski modulatorji NMDA-receptorja in njihove uporabe |
JP6531042B2 (ja) | 2013-01-29 | 2019-06-12 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体モジュレーターおよびその使用 |
EA201591404A1 (ru) | 2013-01-29 | 2016-01-29 | Аптиникс Инк. | Спиролактамные модуляторы рецептора nmda и их применение |
EA201591405A1 (ru) | 2013-01-29 | 2017-05-31 | Аптиникс Инк. | Спиролактамные модуляторы nmda-рецептора и их применение |
KR20150110787A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
WO2015023593A1 (en) | 2013-08-12 | 2015-02-19 | Emory University | Progesterone phosphate analogs and uses related thereto |
JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
US10231979B2 (en) * | 2015-08-07 | 2019-03-19 | Indiana University Research And Technology Corporation | Modulation of inflammation using progesterone metabolites |
WO2017156103A1 (en) | 2016-03-08 | 2017-09-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
PE20190174A1 (es) | 2016-05-19 | 2019-02-01 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
IL264496B (en) | 2016-08-01 | 2022-09-01 | Aptinyx Inc | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
WO2018026798A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
BR112019001921A2 (pt) | 2016-08-01 | 2019-05-14 | Aptinyx Inc. | moduladores do receptor nmda de espiro-lactama e seus usos |
US10918637B2 (en) | 2016-08-01 | 2021-02-16 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CA3031537A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2019215058A1 (en) | 2018-01-31 | 2020-09-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EP3918336A1 (en) * | 2019-01-31 | 2021-12-08 | University of Geneva | Prospective markers in traumatic brain injury (tbi) |
JP2022523564A (ja) | 2019-03-04 | 2022-04-25 | アイオーカレンツ, インコーポレイテッド | 機械学習を使用するデータ圧縮および通信 |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
KR20240144112A (ko) * | 2021-12-02 | 2024-10-02 | 마블바이옴 인코포레이티드 | 미주신경 관련 질환, 장애 및 병태를 치료하기 위한 마이크로바이옴 조성물, 성분 또는 대사산물의 방법 및 용도 |
WO2024059056A1 (en) * | 2022-09-12 | 2024-03-21 | Emory University | Methods of managing traumatic brain injury |
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AU2006226774B2 (en) * | 2005-03-24 | 2010-12-02 | Emory University | Methods for the treatment of central nervous system injury via a tapered administration of progesterone |
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2006
- 2006-03-24 AU AU2006226774A patent/AU2006226774B2/en not_active Ceased
- 2006-03-24 ES ES06748657T patent/ES2392454T3/es active Active
- 2006-03-24 EP EP06739662A patent/EP1871382B1/en active Active
- 2006-03-24 JP JP2008503262A patent/JP5394059B2/ja not_active Expired - Fee Related
- 2006-03-24 CA CA2602950A patent/CA2602950C/en not_active Expired - Fee Related
- 2006-03-24 DK DK08167618.1T patent/DK2030622T3/da active
- 2006-03-24 AU AU2006226811A patent/AU2006226811B2/en not_active Ceased
- 2006-03-24 US US11/909,276 patent/US20090221544A1/en not_active Abandoned
- 2006-03-24 WO PCT/US2006/010984 patent/WO2006102644A2/en active Application Filing
- 2006-03-24 PT PT06748657T patent/PT1868614E/pt unknown
- 2006-03-24 EP EP08167618A patent/EP2030622B1/en active Active
- 2006-03-24 DK DK06748657.1T patent/DK1868614T3/da active
- 2006-03-24 EP EP11177154.9A patent/EP2431042B1/en active Active
- 2006-03-24 PT PT08167618T patent/PT2030622E/pt unknown
- 2006-03-24 CA CA2601715A patent/CA2601715C/en not_active Expired - Fee Related
- 2006-03-24 DE DE602006020353T patent/DE602006020353D1/de active Active
- 2006-03-24 EP EP06748657A patent/EP1868614B1/en active Active
- 2006-03-24 EP EP12163432A patent/EP2494976A1/en not_active Withdrawn
- 2006-03-24 WO PCT/US2006/010797 patent/WO2006102596A2/en active Application Filing
- 2006-03-24 PL PL08167618T patent/PL2030622T3/pl unknown
- 2006-03-24 PL PL06748657T patent/PL1868614T3/pl unknown
- 2006-03-24 ES ES11177154T patent/ES2428313T3/es active Active
- 2006-03-24 AT AT06739662T patent/ATE520404T1/de not_active IP Right Cessation
- 2006-03-24 US US11/909,278 patent/US20090325920A1/en not_active Abandoned
- 2006-03-24 RS RS20120433A patent/RS52471B/en unknown
- 2006-03-24 JP JP2008503227A patent/JP5295755B2/ja not_active Expired - Fee Related
- 2006-03-24 AT AT08167618T patent/ATE499104T1/de active
-
2008
- 2008-06-25 HK HK08107067.5A patent/HK1112579A1/xx not_active IP Right Cessation
- 2008-06-30 HK HK08107230.7A patent/HK1112581A1/xx not_active IP Right Cessation
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2009
- 2009-08-14 HK HK09107489.4A patent/HK1128242A1/xx not_active IP Right Cessation
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2011
- 2011-03-17 HR HR20110198T patent/HRP20110198T1/hr unknown
- 2011-05-20 CY CY20111100496T patent/CY1111478T1/el unknown
- 2011-08-17 JP JP2011178655A patent/JP2011225629A/ja not_active Withdrawn
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2012
- 2012-04-24 US US13/454,503 patent/US20120245133A1/en not_active Abandoned
- 2012-07-16 US US13/550,148 patent/US8614203B2/en active Active
- 2012-08-30 HR HRP20120688TT patent/HRP20120688T1/hr unknown
- 2012-10-25 CY CY20121101012T patent/CY1113253T1/el unknown
-
2013
- 2013-07-12 JP JP2013146680A patent/JP2013234191A/ja not_active Withdrawn
- 2013-12-20 JP JP2013263682A patent/JP5496407B2/ja not_active Expired - Fee Related
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