ATE499104T1 - Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns - Google Patents

Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns

Info

Publication number
ATE499104T1
ATE499104T1 AT08167618T AT08167618T ATE499104T1 AT E499104 T1 ATE499104 T1 AT E499104T1 AT 08167618 T AT08167618 T AT 08167618T AT 08167618 T AT08167618 T AT 08167618T AT E499104 T1 ATE499104 T1 AT E499104T1
Authority
AT
Austria
Prior art keywords
brain
treatment
traumatic injury
nervous system
central nervous
Prior art date
Application number
AT08167618T
Other languages
English (en)
Inventor
Stuart W Hoffman
Arthur L Kellerman
Donald G Stein
David W Wright
Douglas W Lowery-North
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Application granted granted Critical
Publication of ATE499104T1 publication Critical patent/ATE499104T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
AT08167618T 2005-03-24 2006-03-24 Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns ATE499104T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66472805P 2005-03-24 2005-03-24
US72966305P 2005-10-24 2005-10-24

Publications (1)

Publication Number Publication Date
ATE499104T1 true ATE499104T1 (de) 2011-03-15

Family

ID=36987966

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06739662T ATE520404T1 (de) 2005-03-24 2006-03-24 Verfahren zur behandlung einer verletzung des zentralen nervensystems durch ausschleichende verabreichung von progesteron
AT08167618T ATE499104T1 (de) 2005-03-24 2006-03-24 Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06739662T ATE520404T1 (de) 2005-03-24 2006-03-24 Verfahren zur behandlung einer verletzung des zentralen nervensystems durch ausschleichende verabreichung von progesteron

Country Status (15)

Country Link
US (4) US20090221544A1 (de)
EP (5) EP2494976A1 (de)
JP (5) JP5394059B2 (de)
AT (2) ATE520404T1 (de)
AU (2) AU2006226774B2 (de)
CA (2) CA2602950C (de)
CY (2) CY1111478T1 (de)
DE (1) DE602006020353D1 (de)
DK (2) DK2030622T3 (de)
ES (2) ES2392454T3 (de)
HR (2) HRP20120688T1 (de)
PL (2) PL1868614T3 (de)
PT (2) PT2030622E (de)
RS (1) RS52471B (de)
WO (2) WO2006102596A2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473687B2 (en) * 2005-03-24 2009-01-06 Emory University Methods for the treatment of a traumatic central nervous system injury
PT2030622E (pt) * 2005-03-24 2011-06-02 Univ Emory Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico
EP2052724A1 (de) 2007-10-26 2009-04-29 sanofi-aventis Verwendung von Norgestimat als selektivem Hemmer der Ionenkanäle TRPC3, TRPC6 sowie TRPC6 und TRPC7
CA2716095C (en) 2008-02-26 2017-02-07 Emory University Steroid analogues for neuroprotection
RU2366466C1 (ru) * 2008-03-25 2009-09-10 Олег Васильевич Онысько Способ лечения черепно-мозговой травмы
KR101769999B1 (ko) 2008-09-18 2017-08-21 노오쓰웨스턴 유니버시티 Ｎｍｄａ 수용체 조절제 및 그의 용도
WO2010088409A2 (en) * 2009-01-30 2010-08-05 Emory University Methods of neuroprotection using neuroprotective steroids and a vitamin d
US8951968B2 (en) 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
US20110262502A1 (en) * 2010-02-08 2011-10-27 Prairie Pharmaceuticals LLC Pulmonary delivery of 17-hydroxyprogesterone caproate (17-hpc)
CN102811730B (zh) 2010-02-08 2014-07-09 杜涛 孕激素作为糖皮质激素增敏剂的使用
US10993879B2 (en) * 2010-02-08 2021-05-04 Shenzhen Evergreen Therapeutics Co., Ltd. Pulmonary delivery of progestogen
US10987361B2 (en) 2010-02-08 2021-04-27 Shenzhen Evergreen Therapeutics Co., Ltd. Treating auto-immune and auto-inflammatory diseases
TW201138782A (en) 2010-04-26 2011-11-16 Besins Healthcare Lu Sarl Low-oil pharmaceutical emulsion compositions comprising progestogen
SG194230A1 (en) * 2011-04-27 2013-12-30 Univ Northwestern Methods of treating alzheimer's disease, huntington's disease, autism, or other disorders
WO2013043985A1 (en) 2011-09-23 2013-03-28 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
WO2013112605A2 (en) * 2012-01-23 2013-08-01 Sage Therapeutics, Inc. Neuroactive steroid formulations and methods of treating cns disorders
US20130210785A1 (en) 2012-02-15 2013-08-15 Emory University Progesterone analogs and uses related thereto
MX356427B (es) 2012-02-29 2018-05-29 Braun Melsungen Ag Emulsion que contiene hormona.
RU2498826C1 (ru) * 2012-05-14 2013-11-20 Федеральное государственное бюджетное учреждение науки Комплексный научно-исследовательский институт им. Х.И. Ибрагимова Российской академии наук Способ лечения больных с черепно-мозговой травмой
IL275725B (en) 2012-08-21 2022-08-01 Sage Therapeutics Inc Treatment methods for epilepsy and status epilepticus
EP4335505A3 (de) 2012-11-30 2024-06-05 The Regents of The University of California Antikonvulsive aktivität von steroiden
MX2015009773A (es) 2013-01-29 2016-08-05 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
BR112015018087B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos
PE20151436A1 (es) 2013-01-29 2015-10-10 Naurex Inc Moduladores de receptores nmda de espiro-lactama y sus usos
CA2899010A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP6531042B2 (ja) 2013-01-29 2019-06-12 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
EP3033350B1 (de) 2013-08-12 2021-07-28 Emory University Progesteronphosphatanaloga und damit einhergehende verwendungen
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
US10231979B2 (en) * 2015-08-07 2019-03-19 Indiana University Research And Technology Corporation Modulation of inflammation using progesterone metabolites
SG11201807785VA (en) 2016-03-08 2018-10-30 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
PE20190174A1 (es) 2016-05-19 2019-02-01 Aptinyx Inc Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
AU2017306152A1 (en) 2016-08-01 2019-01-31 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10918637B2 (en) 2016-08-01 2021-02-16 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CN109661398B (zh) 2016-08-01 2022-07-05 阿普廷伊克斯股份有限公司 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途
SG11201900554YA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda modulators and methods of using same
BR112019001921A2 (pt) 2016-08-01 2019-05-14 Aptinyx Inc. moduladores do receptor nmda de espiro-lactama e seus usos
US11578072B2 (en) 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CN113366318A (zh) * 2019-01-31 2021-09-07 日内瓦大学 创伤性脑损伤(tbi)的前瞻性标志物
US11216742B2 (en) 2019-03-04 2022-01-04 Iocurrents, Inc. Data compression and communication using machine learning
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
JP2024542727A (ja) * 2021-12-02 2024-11-15 マーベルバイオーム・インコーポレイテッド 迷走神経関連疾患、障害、及び状態を治療するための方法、及び微生物叢組成物、成分、または代謝産物の使用
US20230293722A1 (en) * 2022-01-05 2023-09-21 Metaqor Llc Compositions and Methods for Treating Neurological-associated Disorders
WO2024059056A1 (en) * 2022-09-12 2024-03-21 Emory University Methods of managing traumatic brain injury

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5217085A (en) 1975-07-30 1977-02-08 Ono Pharmaceut Co Ltd Method of quantitative determination of free fatty acids in serum usin g fatty acid activating enzymes
US4404366A (en) * 1980-05-06 1983-09-13 Miles Laboratories, Inc. Beta-galactosyl-umbelliferone-labeled hapten conjugates
US4369250A (en) 1981-07-31 1983-01-18 Sherwood Medical Industries Inc. Fatty acid determination
JPH03500049A (ja) 1987-08-25 1991-01-10 ジー、ケルビン・ダブリュー ストレス、不安および発作活性の緩和のための組成物および方法
US5232917A (en) 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
US5120723A (en) * 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
USRE35517E (en) * 1987-08-25 1997-05-20 University Of Southern California Method, compositions, and compounds for modulating brain excitability
US5512429A (en) 1989-09-19 1996-04-30 British Technology Group Limited Assay for enzyme activity
GB9105707D0 (en) 1991-03-18 1991-05-01 Wilton David C Assay
US5114388A (en) * 1991-07-26 1992-05-19 True Fitness Technology, Inc. Stair simulator exerciser with adjustable incline
US5212167A (en) * 1991-09-12 1993-05-18 Trustees Of Boston University Modulation of receptor-mediated ion transport
US5206415A (en) * 1991-12-20 1993-04-27 Washington University Tricyclic steroid analogs
US5776923A (en) * 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
IL108371A (en) * 1993-01-19 2009-09-01 Endorech Inc Use of sex steroid precursors to prepare medicaments for treatment of vaginal atrophy
DE4311870C2 (de) 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
WO1995005826A1 (en) * 1993-08-20 1995-03-02 Jackson Meyer B Method for regulating neuropeptide hormone secretion
US5763431A (en) * 1993-08-20 1998-06-09 Jackson; Meyer B. Method for regulating neuropeptide hormone secretion
US5939545A (en) * 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
US5633011A (en) * 1994-08-04 1997-05-27 Alza Corporation Progesterone replacement therapy
FR2727117A1 (fr) * 1994-11-18 1996-05-24 Geffard Michel Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun
US5767117A (en) * 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
US5741899A (en) * 1995-02-02 1998-04-21 Cell Genesys, Inc. Chimeric receptors comprising janus kinase for regulating cellular pro liferation
KR19990022323A (ko) * 1995-06-06 1999-03-25 씨. 랜 낸시 안드로스탄 및 프레그난 시리즈의 신경활성 스테로이드
US5942241A (en) * 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
US5888996A (en) * 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
IL127189A0 (en) 1996-05-22 1999-09-22 Diversified Pharmaceuticals In Compositions methods and devices for the transdermal delivery of drugs
US5763492A (en) * 1996-10-01 1998-06-09 Duguesne University Of The Holy Ghost Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors
DK0981349T3 (da) 1997-05-02 2003-03-10 Wyeth Corp 5-alfa-pregnan-3-beta-ol-20-on-sulfat til behandling af tumorer og CNS sygdomme
US6245757B1 (en) * 1997-10-03 2001-06-12 Research Corporation Technologies, Inc. Use of progestins to treat ischemic event
US6174547B1 (en) * 1999-07-14 2001-01-16 Alza Corporation Dosage form comprising liquid formulation
US6268223B1 (en) 1999-08-27 2001-07-31 Viatech Imagin, Llc Assay for detecting damage to the central nervous system
US20020072509A1 (en) * 2000-10-11 2002-06-13 Stein Donald Gerald Methods for the treatment of a traumatic central nervous system injury
US7473687B2 (en) * 2005-03-24 2009-01-06 Emory University Methods for the treatment of a traumatic central nervous system injury
PT2030622E (pt) * 2005-03-24 2011-06-02 Univ Emory Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico

Also Published As

Publication number Publication date
JP2014055183A (ja) 2014-03-27
EP2431042A1 (de) 2012-03-21
PT2030622E (pt) 2011-06-02
HRP20120688T1 (hr) 2012-09-30
HRP20110198T1 (hr) 2011-04-30
HK1128242A1 (en) 2009-10-23
JP2008534512A (ja) 2008-08-28
AU2006226774B2 (en) 2010-12-02
PL1868614T3 (pl) 2013-01-31
PL2030622T3 (pl) 2011-07-29
DE602006020353D1 (de) 2011-04-07
EP2030622A1 (de) 2009-03-04
EP1871382A2 (de) 2008-01-02
ATE520404T1 (de) 2011-09-15
EP2431042B1 (de) 2013-06-26
EP1868614B1 (de) 2012-08-08
JP2008534515A (ja) 2008-08-28
JP5496407B2 (ja) 2014-05-21
JP5295755B2 (ja) 2013-09-18
HK1112579A1 (en) 2008-09-12
CY1111478T1 (el) 2015-08-05
CY1113253T1 (el) 2016-04-13
RS52471B (sr) 2013-02-28
ES2428313T3 (es) 2013-11-07
AU2006226811A1 (en) 2006-09-28
WO2006102596A2 (en) 2006-09-28
WO2006102644A9 (en) 2006-11-23
ES2392454T3 (es) 2012-12-10
DK1868614T3 (da) 2012-11-12
US20120245133A1 (en) 2012-09-27
CA2601715A1 (en) 2006-09-28
EP1871382B1 (de) 2011-08-17
EP1868614A2 (de) 2007-12-26
WO2006102644A2 (en) 2006-09-28
CA2602950C (en) 2012-10-30
DK2030622T3 (da) 2011-05-02
EP2030622B1 (de) 2011-02-23
JP2011225629A (ja) 2011-11-10
EP2494976A1 (de) 2012-09-05
CA2601715C (en) 2012-10-16
CA2602950A1 (en) 2006-09-28
US20120289491A1 (en) 2012-11-15
US20090221544A1 (en) 2009-09-03
AU2006226774A1 (en) 2006-09-28
PT1868614E (pt) 2012-11-23
WO2006102596A3 (en) 2007-01-18
JP2013234191A (ja) 2013-11-21
JP5394059B2 (ja) 2014-01-22
WO2006102644A3 (en) 2007-03-01
US20090325920A1 (en) 2009-12-31
AU2006226811B2 (en) 2010-11-25
US8614203B2 (en) 2013-12-24
HK1112581A1 (en) 2008-09-12

Similar Documents

Publication Publication Date Title
ATE499104T1 (de) Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns
Dedoncker et al. Combined transcranial direct current stimulation and psychological interventions: state of the art and promising perspectives for clinical psychology
Deutsch et al. Progesterone's role in neuroprotection, a review of the evidence
MX2020008680A (es) Terapia de combinacion con apilimod y agentes glutamatergicos.
WO2008039898A3 (en) Methods for the treatment of a traumatic central nervous system injury
PH12019502254A1 (en) Methods and systems for modulating stimuli to the brain with biosensors
EA201000603A1 (ru) ПРИМЕНЕНИЕ АНТИТЕЛ К TrkB ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНЫХ НАРУШЕНИЙ
BR112013007681A2 (pt) uso terapêutico de um agonista trl e terapia de combinação
WO2012106444A3 (en) Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia
WO2017190044A8 (en) Methods for detecting and treating pain using brain activity
MX2018012165A (es) Metodos de tratamiento de canceres pediatricos.
WO2003092617A3 (en) Combinations for the treatment of inflammatory skin disorders
WO2008033440A3 (en) Treatment of hyperproliferative diseases with anthraquinones
MX365366B (es) Formulaciones tópicas y orales que comprenden taurina y magnesio para la prevención y el tratamiento del acné.
RU2013122987A (ru) Способ лечения комбинированного радиационно-термического поражения
WO2017011356A3 (en) Mcj inhibitors for use in treating drug-induced diseases and conditions
WO2011140198A3 (en) Compounds and methods of treating brain disorders
ATE380554T1 (de) Verwendung von xenon mit hypothermie zur behandlung von neugeborenen-asphyxie
ATE485819T1 (de) Benzamidin derivative zur behandlung und vorbeugung von mucositis
WO2009111681A3 (en) Gallium compounds and methods of use to treat inflammatory bowel disease
BR112015008839A2 (pt) tratamento de tumores do sistema nervoso central
WO2011071981A3 (en) Anti-cytomegalovirus activity of artemisinin-derived dimers
ATE510530T1 (de) Verfahren zur verhinderung und/oder behandlung von altersflecken
WO2008128155A3 (en) SIRTUIN BASED METHODS AND COMPOSITIONS FOR TREATING β- CATENIN-RELATED CONDITIONS
WO2015051279A3 (en) Cxcr4 up- and down-regulation for treatment of diseases or disorders

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2030622

Country of ref document: EP