CN1067682C - 抗肿瘤化合物、药物组合物、其制备方法以及其用于治疗的方法 - Google Patents

抗肿瘤化合物、药物组合物、其制备方法以及其用于治疗的方法 Download PDF

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Publication number
CN1067682C
CN1067682C CN94192117A CN94192117A CN1067682C CN 1067682 C CN1067682 C CN 1067682C CN 94192117 A CN94192117 A CN 94192117A CN 94192117 A CN94192117 A CN 94192117A CN 1067682 C CN1067682 C CN 1067682C
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China
Prior art keywords
phenyl
group
amino
methyl
silyl
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Expired - Fee Related
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CN94192117A
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English (en)
Chinese (zh)
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CN1123547A (zh
Inventor
I·大岛
E·邦巴德里
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Indena SpA
Research Foundation of the State University of New York
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Indena SpA
Research Foundation of the State University of New York
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN94192117A 1993-03-26 1994-03-24 抗肿瘤化合物、药物组合物、其制备方法以及其用于治疗的方法 Expired - Fee Related CN1067682C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/040,189 1993-03-26
US08/040,189 US5475011A (en) 1993-03-26 1993-03-26 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Publications (2)

Publication Number Publication Date
CN1123547A CN1123547A (zh) 1996-05-29
CN1067682C true CN1067682C (zh) 2001-06-27

Family

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CN94192117A Expired - Fee Related CN1067682C (zh) 1993-03-26 1994-03-24 抗肿瘤化合物、药物组合物、其制备方法以及其用于治疗的方法

Country Status (19)

Country Link
US (3) US5475011A (enExample)
EP (1) EP0690856B1 (enExample)
JP (2) JP3157165B2 (enExample)
KR (1) KR100223720B1 (enExample)
CN (1) CN1067682C (enExample)
AT (1) ATE229018T1 (enExample)
AU (1) AU676041B2 (enExample)
CA (1) CA2158147C (enExample)
CZ (1) CZ288924B6 (enExample)
DE (1) DE69431833T2 (enExample)
DK (1) DK0690856T3 (enExample)
ES (1) ES2190440T3 (enExample)
HU (1) HUT73848A (enExample)
NO (1) NO311722B1 (enExample)
PL (2) PL179587B1 (enExample)
PT (1) PT690856E (enExample)
RU (1) RU2137764C1 (enExample)
SK (1) SK282317B6 (enExample)
WO (1) WO1994022856A1 (enExample)

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Also Published As

Publication number Publication date
CA2158147A1 (en) 1994-10-13
DK0690856T3 (da) 2003-03-31
HUT73848A (en) 1996-09-30
CZ248095A3 (en) 1996-03-13
JPH11322737A (ja) 1999-11-24
KR960701045A (ko) 1996-02-24
EP0690856A4 (enExample) 1996-02-07
KR100223720B1 (ko) 1999-10-15
ATE229018T1 (de) 2002-12-15
SK118395A3 (en) 1996-06-05
US5705508A (en) 1998-01-06
HU9502642D0 (en) 1995-11-28
PL179587B1 (pl) 2000-09-29
NO311722B1 (no) 2002-01-14
ES2190440T3 (es) 2003-08-01
NO953796D0 (no) 1995-09-25
US5475011A (en) 1995-12-12
CA2158147C (en) 1999-10-05
AU6491694A (en) 1994-10-24
EP0690856B1 (en) 2002-12-04
JP3145993B2 (ja) 2001-03-12
AU676041B2 (en) 1997-02-27
US5599820A (en) 1997-02-04
WO1994022856A1 (en) 1994-10-13
JPH08508497A (ja) 1996-09-10
DE69431833T2 (de) 2003-11-06
EP0690856A1 (en) 1996-01-10
PL310827A1 (en) 1996-01-08
DE69431833D1 (de) 2003-01-16
NO953796L (no) 1995-11-15
JP3157165B2 (ja) 2001-04-16
RU2137764C1 (ru) 1999-09-20
CZ288924B6 (cs) 2001-09-12
PT690856E (pt) 2003-04-30
SK282317B6 (sk) 2002-01-07
PL180708B1 (pl) 2001-03-30
CN1123547A (zh) 1996-05-29

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