ES2190440T3 - Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento. - Google Patents

Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento.

Info

Publication number
ES2190440T3
ES2190440T3 ES94912300T ES94912300T ES2190440T3 ES 2190440 T3 ES2190440 T3 ES 2190440T3 ES 94912300 T ES94912300 T ES 94912300T ES 94912300 T ES94912300 T ES 94912300T ES 2190440 T3 ES2190440 T3 ES 2190440T3
Authority
ES
Spain
Prior art keywords
treatment
pharmaceutical compositions
modes
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912300T
Other languages
English (en)
Spanish (es)
Inventor
Iwao Ojima
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Research Foundation of the State University of New York
Original Assignee
Indena SpA
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA, Research Foundation of the State University of New York filed Critical Indena SpA
Application granted granted Critical
Publication of ES2190440T3 publication Critical patent/ES2190440T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ES94912300T 1993-03-26 1994-03-24 Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento. Expired - Lifetime ES2190440T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/040,189 US5475011A (en) 1993-03-26 1993-03-26 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Publications (1)

Publication Number Publication Date
ES2190440T3 true ES2190440T3 (es) 2003-08-01

Family

ID=21909617

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912300T Expired - Lifetime ES2190440T3 (es) 1993-03-26 1994-03-24 Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento.

Country Status (19)

Country Link
US (3) US5475011A (enExample)
EP (1) EP0690856B1 (enExample)
JP (2) JP3157165B2 (enExample)
KR (1) KR100223720B1 (enExample)
CN (1) CN1067682C (enExample)
AT (1) ATE229018T1 (enExample)
AU (1) AU676041B2 (enExample)
CA (1) CA2158147C (enExample)
CZ (1) CZ288924B6 (enExample)
DE (1) DE69431833T2 (enExample)
DK (1) DK0690856T3 (enExample)
ES (1) ES2190440T3 (enExample)
HU (1) HUT73848A (enExample)
NO (1) NO311722B1 (enExample)
PL (2) PL179587B1 (enExample)
PT (1) PT690856E (enExample)
RU (1) RU2137764C1 (enExample)
SK (1) SK282317B6 (enExample)
WO (1) WO1994022856A1 (enExample)

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US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
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US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
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HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2386772C (en) * 1999-10-15 2009-01-13 Daiichi Pharmaceutical Co., Ltd. Pentacyclic taxane compound
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ATE432928T1 (de) * 2000-02-02 2009-06-15 Univ Florida State Res Found C10-taxanester als antitumormittel
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CZ20013429A3 (cs) 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxany substituované v poloze C7 karbonátem jako protinádorová činidla
PL350028A1 (en) 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) * 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
US6449899B1 (en) * 2001-03-08 2002-09-17 Council Of Scientific And Industrial Research Method for inducing improved seed germination in Podophyllum hexandrum Royle
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
RU2284328C2 (ru) * 2001-11-29 2006-09-27 Дайити Фармасьютикал Ко., Лтд. Кристаллы производных таксана и способ их получения
WO2004013093A2 (en) * 2002-08-02 2004-02-12 Immunogen, Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
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ITMI20021921A1 (it) 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
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PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
TW200533339A (en) * 2004-03-16 2005-10-16 Bristol Myers Squibb Co Therapeutic synergy of anti-cancer compounds
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US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
TW200640447A (en) * 2005-02-14 2006-12-01 Univ Florida State Res Found C10 cyclopropyl ester substituted taxane compositions
US8263793B2 (en) * 2005-03-31 2012-09-11 Accord Healthcare Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin III
EP2647641A1 (en) * 2005-11-04 2013-10-09 Accord Healthcare Inc. New methods for the preparation of taxanes using chiral auxiliaries
CN100516067C (zh) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 具有抗肿瘤活性的紫杉酚衍生物
US7615653B2 (en) * 2006-03-15 2009-11-10 The Research Foundation Of State University Of New York Anti-tuberculosis taxane compounds
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения
RU2547939C2 (ru) * 2007-12-26 2015-04-10 Биотест Аг Иммуноконъюгаты, направленные на cd138, и их применение
EP2238169A1 (en) * 2007-12-26 2010-10-13 Biotest AG Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
PL2240516T3 (pl) * 2007-12-26 2015-12-31 Biotest Ag Sposoby i środki do ulepszania nakierowania na komórki nowotworowe z ekspresją CD138
CN101952315B (zh) 2007-12-26 2015-04-01 生物测试股份公司 靶向cd138的试剂及其应用
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
US8242166B2 (en) * 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes
US8236319B2 (en) 2008-04-30 2012-08-07 Immunogen, Inc. Cross-linkers and their uses
CN104622809B (zh) 2008-05-23 2019-04-19 英属哥伦比亚大学 用于脂质体纳米颗粒的修饰的药物
CN101838281B (zh) * 2010-05-20 2015-02-18 上海博速医药科技有限公司 一种多西他赛手性侧链中间体的制备方法
WO2013018829A1 (ja) 2011-08-02 2013-02-07 アステラス製薬株式会社 薬剤の併用による癌治療方法
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JP6100627B2 (ja) * 2013-06-24 2017-03-22 株式会社パイロットコーポレーション 熱消色性筆記具インキ組成物及びそれを内蔵した筆記具
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物
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US9557445B2 (en) 2015-02-24 2017-01-31 Arkema France Optical diffusion blend materials for LED lighting
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN116143678A (zh) 2016-11-14 2023-05-23 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
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KR20240095442A (ko) 2021-11-03 2024-06-25 항저우 디에이씨 바이오테크 씨오, 엘티디 항체의 특이적 접합

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US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Also Published As

Publication number Publication date
CA2158147A1 (en) 1994-10-13
DK0690856T3 (da) 2003-03-31
HUT73848A (en) 1996-09-30
CZ248095A3 (en) 1996-03-13
JPH11322737A (ja) 1999-11-24
KR960701045A (ko) 1996-02-24
EP0690856A4 (enExample) 1996-02-07
KR100223720B1 (ko) 1999-10-15
ATE229018T1 (de) 2002-12-15
SK118395A3 (en) 1996-06-05
US5705508A (en) 1998-01-06
HU9502642D0 (en) 1995-11-28
PL179587B1 (pl) 2000-09-29
NO311722B1 (no) 2002-01-14
NO953796D0 (no) 1995-09-25
US5475011A (en) 1995-12-12
CA2158147C (en) 1999-10-05
AU6491694A (en) 1994-10-24
EP0690856B1 (en) 2002-12-04
JP3145993B2 (ja) 2001-03-12
AU676041B2 (en) 1997-02-27
US5599820A (en) 1997-02-04
WO1994022856A1 (en) 1994-10-13
CN1067682C (zh) 2001-06-27
JPH08508497A (ja) 1996-09-10
DE69431833T2 (de) 2003-11-06
EP0690856A1 (en) 1996-01-10
PL310827A1 (en) 1996-01-08
DE69431833D1 (de) 2003-01-16
NO953796L (no) 1995-11-15
JP3157165B2 (ja) 2001-04-16
RU2137764C1 (ru) 1999-09-20
CZ288924B6 (cs) 2001-09-12
PT690856E (pt) 2003-04-30
SK282317B6 (sk) 2002-01-07
PL180708B1 (pl) 2001-03-30
CN1123547A (zh) 1996-05-29

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