CN106109560A - A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof - Google Patents
A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof Download PDFInfo
- Publication number
- CN106109560A CN106109560A CN201610582899.1A CN201610582899A CN106109560A CN 106109560 A CN106109560 A CN 106109560A CN 201610582899 A CN201610582899 A CN 201610582899A CN 106109560 A CN106109560 A CN 106109560A
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- China
- Prior art keywords
- flos sophorae
- decoction pieces
- fresh squeezing
- preparation technology
- lyophilization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof.This technique, after Flos Sophorae medical material is gathered, cleans, drip washing, and takes advantage of fresh squeezing, leaching medicine juice.Medicinal residues add water stirring, filter squeezing.Concentrating under reduced pressure after the merging of gained medicine juice, lyophilization, collect lyophilized products, be vacuum-packed after crushed.Pagodatree Flower decoction pieces prepared by this method, remains the polarity in medical material and nonpolar effective ingredient the most simultaneously.Decoction pieces is beneficial to accumulating, convenient adjustment, and quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will have significant social meaning and economic benefit.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Flos Sophorae decoction pieces.
Background technology
Chinese medicine Flos Sophorae is leguminous plant Chinese scholartreeSophora japonicaL. dry flower and alabastrum.This product only has removing heat from blood
Blood, effect of purging liver-fire, it is used for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, controlling of the headache disease such as dizziness
Treat.
The processing mode of conventional Flos Sophorae decoction pieces is: summer, the flowers are in blossom to put or gathers time alabastrum is formed, and is dried, then storage of packing
Fortune.This type of decoction pieces, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for that formula is adjusted
With guarantee its clinical efficacy, even to patient bring recessiveness harm.
At present, granule pieces market also having Flos Sophorae medical material to make after extracting is sold.The preparation of granule pieces
Journey, extracts not only time consumption and energy consumption, and because conventional substantial amounts of water does solvent, the nonpolar effective ingredient in medical material is difficult to be extracted
Out.Additionally, due to the Flos Sophorae medical material extracted also is to be dried and through long-time storage, therefore, the loss of effective ingredient
Also it is the biggest.In order to ensure clinical effective, the steady quality of Flos Sophorae medical material, a kind of novel Flos Sophorae decoction pieces and preparation technology thereof
Urgently develop.
Summary of the invention
The invention discloses " a kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof ".This technique can be
The polarity retained in Flos Sophorae medical material of limits and nonpolar effective ingredient, it is to avoid medical material is in the processing of existing decoction pieces and accumulating
The loss of the effective ingredient caused in journey and the decline of medical material quanlity, reduce the medical material pollution by mycete etc., to guaranteeing that Flos Sophorae is drunk
Steady quality and the clinical safety of sheet effectively have great importance.
To achieve these goals, the technical scheme is that
After Flos Sophorae is gathered, cleaning, washing, take advantage of fresh squeezing, medicinal residues add the water of 1 ~ 5 times amount, stir 5 ~ 30min, filter press
Machine filter pressing extracting juice, remaining medicinal residues squeeze extracting juice again, merge three medicine juice, 40 ~ 120 mesh screen, obtain Flos Sophorae medicine juice.By obtain
Flos Sophorae medicine juice is evaporated to the extractum that relative density is 1.05 ~ 1.25 under the conditions of 40 ~ 75 DEG C, and by this extractum in-20 ~-
80 DEG C of refrigerators freeze 6 ~ 24 hours, then lyophilization, pressure is 0.06 ~ 0.09MPa, and temperature is-15 ~-40 DEG C, cooling time
It is 12 ~ 48 hours, after collecting lyophilized products, size-reduced, sieve, pack.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, decoction pieces manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication.Flos Sophorae is enclosed in Dai
Thin layer differentiates collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product.Additionally, in the packaging bag of product, print
There is Quick Response Code, former plant photo, medical material photo, decoction pieces photo, character and the micro-mirror obtaining product can be linked by scanning
The information such as other feature.
The invention have benefit that:
The Flos Sophorae medical material of fresh collection, directly squeeze after cleaning washing, filter, concentrating under reduced pressure, lyophilization, obtained powder
Decoction pieces, can retain the effective ingredient in medical material to greatest extent.This decoction pieces volume compares to tradition decoction pieces volume greatly
Reducing, vacuum packaging so that prepared slice quality is more stable, beneficially accumulating and clinical adjustment, have the most significant social meaning
And economic implications.
Detailed description of the invention
Embodiment 1
By the Flos Sophorae medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice.Gained medicinal residues add 3 times
The tap water of amount, stirs 20min, filter press squeezing extracting juice.Remaining medicinal residues squeeze extracting juice with squeezer again.By above-mentioned 3
Secondary medicine juice merges, and filters with 100 eye mesh screens.Filtrate reduced in volume, temperature is set as 65 DEG C.Concentrating gained extractum relative density
When being 1.15, extractum is freezed in-80 DEG C of refrigerators 6 hours.Taking out east knot thing, lyophilization, pressure is 0.09Mpa, temperature
For-20 DEG C, it is dried 24 hours.Taking out lyophilized products, low-temperature grinding, cross 80 mesh sieves, moisture is not higher than 12%, packs, 1kg/
Bag, adds packed antioxidant and desiccant, Vacuum Package, labeling.
Embodiment 2
By the Flos Sophorae medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice.Gained medicinal residues add 5 times
The tap water of amount, stirs 30min, filter press squeezing extracting juice.Remaining medicinal residues squeeze extracting juice with squeezer again.By above-mentioned 3
Secondary medicine juice merges, and filters with 80 eye mesh screens.Filtrate reduced in volume, temperature is set as 70 DEG C.Concentrating gained extractum relative density
When being 1.10, extractum is freezed in-80 DEG C of refrigerators 8 hours.Taking out east knot thing, lyophilization, pressure is 0.08Mpa, temperature
For-40 DEG C, it is dried 48 hours.Taking out lyophilized products, low-temperature grinding, cross 60 mesh sieves, moisture is not higher than 12%, packs, 1kg/
Bag, adds packed antioxidant and desiccant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (2)
1. a Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof, it is characterised in that: after Flos Sophorae is gathered, clean,
Washing, takes advantage of fresh squeezing, and medicinal residues add the water of 1 ~ 5 times amount, stirs 5 ~ 30min, and filter press filter pressing extracting juice, remaining medicinal residues are pressed again
Extracting juice, merges three medicine juice, 40 ~ 120 mesh screen, obtains Flos Sophorae medicine juice.
A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces the most according to claim 1 and preparation technology thereof, it is characterised in that:
The Flos Sophorae medicine juice obtained is evaporated to the extractum that relative density is 1.05 ~ 1.25 under the conditions of 40 ~ 75 DEG C, and by this extractum
Freezing 6 ~ 24 hours, then lyophilization in-20 ~-80 DEG C of refrigerators, pressure is 0.06 ~ 0.09MPa, and temperature is-15 ~-40 DEG C,
Cooling time is 12 ~ 48 hours, after collecting lyophilized products, size-reduced, sieves, packs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582899.1A CN106109560A (en) | 2016-07-23 | 2016-07-23 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582899.1A CN106109560A (en) | 2016-07-23 | 2016-07-23 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106109560A true CN106109560A (en) | 2016-11-16 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610582899.1A Pending CN106109560A (en) | 2016-07-23 | 2016-07-23 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281237A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107320515A (en) * | 2017-08-25 | 2017-11-07 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala |
| CN107320566A (en) * | 2017-08-25 | 2017-11-07 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade |
| CN107375352A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern |
| CN107375512A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of cordate houttuynia |
| CN107375419A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of elscholtiza |
| CN107375401A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gynostemma pentaphylla |
| CN107375394A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of fringed pink |
| CN107397768A (en) * | 2017-08-25 | 2017-11-28 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of ardisia japonica |
| CN107432878A (en) * | 2017-08-25 | 2017-12-05 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush |
| CN107441154A (en) * | 2017-08-25 | 2017-12-08 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Pogostemon cablin |
| CN107485694A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of lophatherum gracile |
| CN107714754A (en) * | 2017-08-25 | 2018-02-23 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gynostemma pentaphylla |
| CN112245350A (en) * | 2020-10-25 | 2021-01-22 | 刘鑫 | Process for extracting effective substances of fresh flowers for skin care products |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
-
2016
- 2016-07-23 CN CN201610582899.1A patent/CN106109560A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281237A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107320515A (en) * | 2017-08-25 | 2017-11-07 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Artemisia anomala |
| CN107320566A (en) * | 2017-08-25 | 2017-11-07 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of black nightshade |
| CN107375352A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of phoenix-tail fern |
| CN107375512A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of cordate houttuynia |
| CN107375419A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of elscholtiza |
| CN107375401A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gynostemma pentaphylla |
| CN107375394A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of fringed pink |
| CN107397768A (en) * | 2017-08-25 | 2017-11-28 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of ardisia japonica |
| CN107432878A (en) * | 2017-08-25 | 2017-12-05 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush |
| CN107441154A (en) * | 2017-08-25 | 2017-12-08 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Pogostemon cablin |
| CN107485694A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of lophatherum gracile |
| CN107714754A (en) * | 2017-08-25 | 2018-02-23 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gynostemma pentaphylla |
| CN112245350A (en) * | 2020-10-25 | 2021-01-22 | 刘鑫 | Process for extracting effective substances of fresh flowers for skin care products |
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Application publication date: 20161116 |