CN107432878A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush Download PDFInfo
- Publication number
- CN107432878A CN107432878A CN201710739224.8A CN201710739224A CN107432878A CN 107432878 A CN107432878 A CN 107432878A CN 201710739224 A CN201710739224 A CN 201710739224A CN 107432878 A CN107432878 A CN 107432878A
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- Prior art keywords
- scouring rush
- freeze
- squeezing
- crude slice
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush.The technique is cleaned, eluted after the harvesting of scouring rush's medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Common Scouring Rush Herb medicine materical crude slice prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine scouring rush's medicine materical crude slice.
Background technology
Chinese medicine scouring rush is the herb of Equisetaceae plant scouring rush.With clear liver and improve vision, stop blooding, inducing diuresis for treating strangurtia and other effects.It is clinical
It is mainly used in treating under anemopyretic cold, cough, red eye, swell pain, cloudiness, nosebleed epistaxis, hematuria, discharging fresh blood stool, stranguria, jaundice, band, bone
Folding etc..
The processing mode of conventional scouring rush's medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.This
Dry scouring rush's Hygienic Index can not be up to standard a bit, and medicinal material easily occurs and goes mouldy, so as to cause the decline of medical material quanlity and clinic
The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Just and ensure its clinical efficacy.
At present, in the market has Chinese medicine manufactured granule pieces sale after extraction.Due to granule pieces preparation process
In, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted.
Further, since scouring rush's medicinal material of extraction is also to dry and stored by long-time, therefore, the loss of active ingredient is also very
Big.In order to ensure the clinic of scouring rush's medicinal material is effective, steady quality, a kind of new scouring rush's medicine materical crude slice is urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush ".This technique can be maximum
The polarity and the nonpolar active ingredient that retain in scouring rush's medicinal material of limit, avoid medicinal material from being processed and storage and transport process in existing medicine materical crude slice
In the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring scouring rush's medicine materical crude slice
Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered picking time in scouring rush, is cleaned, is cut into the section of 1 ~ 2cm length, is added the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred
Mix 15 ~ 30 minutes, take advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and squeezing takes
Juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh twice
Filter is sieved through, obtains scouring rush's concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the leaching that relative density is 1.05 ~ 1.25
Cream.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as -15 DEG C
~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, and crosses 60 ~ 100 mesh sieves, bag
Dress, produce the fresh squeezing freeze-dried powder medicine materical crude slice of scouring rush.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of the included upper scouring rush of bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Fresh scouring rush's medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being freeze-dried, and resulting powder decoction pieces can
To retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume, matter
Amount is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By scouring rush's medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction
Squeezed again with squeezer, leaching concoction.Above-mentioned 3 scouring rush's concoctions are merged, with 60 mesh screens, filtrate decompression concentration, temperature
It is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.By scars
It is freeze-dried after taking-up, temperature is set as -18 DEG C, pressure 0.09Mpa, and the time is 24 hours.Collect lyophilized products, powder
It is broken, 60 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By scouring rush's medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 minutes,
Take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction are again
Squeezed with squeezer, leaching concoction.Above-mentioned 3 scouring rush's concoctions are merged, with 100 mesh screens, filtrate decompression concentration, temperature is set
It is set to 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.Scars are taken out
After be freeze-dried, temperature is set as -40 DEG C, pressure 0.09Mpa, and the time is 48 hours.Lyophilized products are collected, are crushed, mistake
100 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush, it is characterised in that：It is complete that picking time its is gathered in scouring rush Grass, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect Concoction is just squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, Press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain scouring rush's concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush according to claim 1, it is characterised in that：Will Scouring rush's concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 2, obtains the medicinal extract that relative density is 1.05 ~ 1.25, put- Freeze in 20 DEG C ~ -80 DEG C refrigerators 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set as 0.06 ~ 0.09MPa, time are 8 ~ 48 hours, collect lyophilized products, crush, and cross 60 ~ 100 mesh sieves, packaging, it is cold to produce the fresh squeezing of scouring rush Freeze dry powder decoction pieces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739224.8A CN107432878A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739224.8A CN107432878A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107432878A true CN107432878A (en) | 2017-12-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739224.8A Pending CN107432878A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of scouring rush |
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| Country | Link |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710739224.8A patent/CN107432878A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171205 |
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| WD01 | Invention patent application deemed withdrawn after publication |