CN107334802A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera Download PDFInfo
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- CN107334802A CN107334802A CN201710738578.0A CN201710738578A CN107334802A CN 107334802 A CN107334802 A CN 107334802A CN 201710738578 A CN201710738578 A CN 201710738578A CN 107334802 A CN107334802 A CN 107334802A
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- Prior art keywords
- gerbera
- freeze
- squeezing
- crude slice
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera.The technique is cleaned, eluted after the harvesting of gerbera medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Gerbera powder decoction pieces prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine gerbera medicine materical crude slice.
Background technology
Chinese medicine gerbera is the herb of feverfew gerbera.The effect of with clearing heat and promoting diuresis, removing toxicity for detumescence.Clinic cures mainly
Cough with lung heat, damp-heat dysentery, heat gonorrhea, rheumatic arthritis, carbuncle furuncle poison etc..
The processing mode of conventional gerbera medicine materical crude slice is：After harvesting, impurity is removed, is dried, directly packing storage and transport.
These dry gerbera Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy, so as to cause the decline of medical material quanlity and
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting
Agent prescription and ensure its clinical efficacy.
At present, in the market has Chinese medicine manufactured granule pieces sale after extraction.Due to granule pieces preparation process
In, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted.
Further, since the gerbera medicinal material of extraction is also to dry and stored by long-time, therefore, its raw material easily pollutes and gone mouldy
Situation be also be difficult avoid.In order to ensure the clinic of gerbera medicinal material is effective, steady quality, a kind of new gerbera drink
Piece and its preparation technology urgently develop.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera ".This technique can be most
The polarity and the nonpolar active ingredient that retain in gerbera medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring big fourth
The steady quality and clinical safety of careless medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in gerbera picking time, is cleaned, is cut into the section of 1 ~ 2cm length, adds the water of 0.5 ~ 1 times of amount of medicinal material weight,
Stirring 15 ~ 30 minutes, takes advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, squeezing
Take juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200
Mesh screen, obtain gerbera concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains relative density as 1.05 ~ 1.25
Medicinal extract.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as-
15 DEG C ~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, crosses 60 ~ 100 mesh
Sieve, packaging, produce the fresh squeezing freeze-dried powder medicine materical crude slice of gerbera.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of gerbera is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, it is printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh gerbera medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being freeze-dried, resulting powder decoction pieces,
The active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume,
Quality is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By the gerbera medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stirring 15
Minute, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Gained medicine
Slag is squeezed with squeezer again, leaching concoction.Above-mentioned 3 gerbera concoctions are merged, with 60 mesh screens, filtrate decompression concentrates,
Temperature is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.It will freeze
Knot thing is freeze-dried after taking out, and temperature is set as -18 DEG C, pressure 0.09Mpa, and the time is 24 hours.Collect lyophilized products,
Crush, cross 60 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the gerbera medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 points
Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction
Squeezed again with squeezer, leaching concoction.Above-mentioned 3 gerbera concoctions are merged, with 100 mesh screens, filtrate decompression concentration, temperature
Degree is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.By scars
It is freeze-dried after taking-up, temperature is set as -40 DEG C, pressure 0.09Mpa, and the time is 48 hours.Collect lyophilized products, powder
It is broken, 100 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera, it is characterised in that：Gathered in gerbera picking time Its herb, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain gerbera concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera according to claim 1, it is characterised in that： By the gerbera concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the leaching that relative density is 1.05 ~ 1.25 Cream, put in -20 DEG C ~ -80 DEG C refrigerators and freeze 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set It is set to 0.06 ~ 0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, crushes, and crosses 60 ~ 100 mesh sieves, packaging, produces gerbera Fresh squeezing freeze-dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738578.0A CN107334802A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738578.0A CN107334802A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera |
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| Publication Number | Publication Date |
|---|---|
| CN107334802A true CN107334802A (en) | 2017-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738578.0A Pending CN107334802A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN105998130A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738578.0A patent/CN107334802A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN105998130A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| PB01 | Publication | ||
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Application publication date: 20171110 |