CN107281237A - A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology - Google Patents
A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107281237A CN107281237A CN201710464581.8A CN201710464581A CN107281237A CN 107281237 A CN107281237 A CN 107281237A CN 201710464581 A CN201710464581 A CN 201710464581A CN 107281237 A CN107281237 A CN 107281237A
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- Prior art keywords
- ilex latifolia
- latifolia thunb
- materical crude
- crude slice
- medicine materical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh squeezing freeze-dried powder medicine materical crude slice of Ilex Latifolia Thunb and its preparation technology.The technique takes advantage of fresh squeezing, leaching concoction after the harvesting of Ilex Latifolia Thunb tender leaf.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried, and collects lyophilized products, is vacuum-packed after crushed.Broadleaf Holly Leaf medicine materical crude slice prepared by this method, remains the polarity and nonpolar active ingredient in medicinal material simultaneously to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine Ilex Latifolia Thunb medicine materical crude slice.
Background technology
Chinese medicine Ilex Latifolia Thunb for Holly bitter leaves tree tender leaf it is processed, dry form.This product is bitter, cold, with heat-clearing
Relieve summer heat, eyesight-improving intelligence-developing, promote the production of body fluid to quench thirst, be depressured fat-reducing, suppression cancer anti-cancer etc. multiple efficacies.
The processing mode of conventional Ilex Latifolia Thunb medicine materical crude slice is：Harvest after its tender leaf, dry, rubbing, packaging.Such medicine materical crude slice, body
Product is huge, and Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for the stable of its curative effect and reappear, or even give
Patient brings the harm of recessiveness.
In order to ensure Ilex Latifolia Thunb is clinical effectively, steady quality, a kind of new Ilex Latifolia Thunb medicine materical crude slice and its preparation technology are urgently
Exploitation.
The content of the invention
The invention discloses " a kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology ".This technique can be with
Retain the polarity and nonpolar active ingredient in Ilex Latifolia Thunb medicinal material to greatest extent, it is to avoid medicinal material is processed and stored up in existing medicine materical crude slice
The loss of active ingredient and the decline of medical material quanlity caused by during fortune, reduce pollution of the medicinal material by mould etc., to ensuring hardship
The steady quality and clinical safety of fourth tea-drinking piece effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in Ilex Latifolia Thunb picking time, fresh squeezing is taken advantage of, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, sheet frame pressure
Filter press filtration takes juice, and the remaining dregs of a decoction press extracting juice again, merge three concoctions, and 40 ~ 120 mesh screens obtain Ilex Latifolia Thunb concoction.Will
To Ilex Latifolia Thunb concoction the medicinal extract that relative density is 1.05 ~ 1.25 is concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C, and by this medicinal extract
Freeze in -20 ~ -80 DEG C of refrigerators 6 ~ 24 hours, then be freeze-dried, pressure is 0.06 ~ 0.09MPa, temperature is -15 ~ -40 DEG C,
Cooling time is 12 ~ 48 hours, is collected after lyophilized products, size-reduced, sieving, packaging.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Ilex Latifolia Thunb is enclosed in bag
Thin layer differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, be used as " identity card " of product.In addition, in the packaging bag of product,
Quick Response Code is printed on, can be linked by scanning and obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, character and micro-
The information such as diagnostic characteristics.
The present invention is advantageous in that：
The Ilex Latifolia Thunb tender leaf of fresh collection, cleans and is directly squeezed after washing, filter, be concentrated under reduced pressure, being freeze-dried, resulting powder
Last medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stablized, and is adjusted beneficial to accumulating and clinic, with very significant society's meaning
Justice and economic implications.
Embodiment
Embodiment 1
By the Ilex Latifolia Thunb tender leaf of fresh collection, clean, wash quickly, take advantage of using fresh herb squeezer pressure extracting juice.The gained dregs of a decoction add 3 times amount
Running water, stirs 20min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned 3 medicines
Juice merges, with 100 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set as 65 DEG C.It is in medicinal extract relative density obtained by concentration
When 1.15, medicinal extract is freezed 6 hours in -80 DEG C of refrigerators.Take out east knot thing, freeze-drying, pressure is 0.09Mpa, temperature for-
20 DEG C, dry 24 hours.Lyophilized products are taken out, low-temperature grinding crosses 80 mesh sieves, and moisture is not higher than 12%, packs, 1kg/ bags, plus
Enter packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the Ilex Latifolia Thunb tender leaf of fresh collection, clean, wash quickly, take advantage of using fresh herb squeezer pressure extracting juice.The gained dregs of a decoction add 5 times amount
Running water, stirs 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned 3 medicines
Juice merges, with 80 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set as 70 DEG C.It is in medicinal extract relative density obtained by concentration
When 1.10, medicinal extract is freezed 8 hours in -80 DEG C of refrigerators.Take out east knot thing, freeze-drying, pressure is 0.08Mpa, temperature for-
40 DEG C, dry 48 hours.Lyophilized products are taken out, low-temperature grinding crosses 60 mesh sieves, and moisture is not higher than 12%, packs, 1kg/ bags, plus
Enter packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, it is characterised in that：Adopted in Ilex Latifolia Thunb picking time
Collect its tender leaf, take advantage of fresh squeezing, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and plate and frame filter press press filtration takes juice, the remaining dregs of a decoction
Extracting juice is pressed again, merges three concoctions, and 40 ~ 120 mesh screens obtain Ilex Latifolia Thunb concoction.
2. a kind of Ilex Latifolia Thunb according to claim 1 is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, its feature exists
In：Obtained Ilex Latifolia Thunb concoction is concentrated under reduced pressure into the medicinal extract that relative density is 1.05 ~ 1.25 under the conditions of 40 ~ 75 DEG C, and will
This medicinal extract freezes 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then is freeze-dried, pressure be 0.06 ~ 0.09MPa, temperature be -15 ~ -
40 DEG C, cooling time is 12 ~ 48 hours, is collected after lyophilized products, size-reduced, sieving, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710464581.8A CN107281237A (en) | 2017-06-19 | 2017-06-19 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710464581.8A CN107281237A (en) | 2017-06-19 | 2017-06-19 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107281237A true CN107281237A (en) | 2017-10-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710464581.8A Pending CN107281237A (en) | 2017-06-19 | 2017-06-19 | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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| CN (1) | CN107281237A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115067409A (en) * | 2022-05-25 | 2022-09-20 | 贵州泰和现代生态农业科技有限公司 | Application of lobular broadleaf holly leaf instant powder in preparation of lipid-lowering health-care food |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687280A (en) * | 2016-02-11 | 2016-06-22 | 徐自升 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-06-19 CN CN201710464581.8A patent/CN107281237A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687280A (en) * | 2016-02-11 | 2016-06-22 | 徐自升 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN106109560A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Sophorae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115067409A (en) * | 2022-05-25 | 2022-09-20 | 贵州泰和现代生态农业科技有限公司 | Application of lobular broadleaf holly leaf instant powder in preparation of lipid-lowering health-care food |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171024 |
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| WD01 | Invention patent application deemed withdrawn after publication |