CN107028997A - A kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology - Google Patents
A kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107028997A CN107028997A CN201710465357.0A CN201710465357A CN107028997A CN 107028997 A CN107028997 A CN 107028997A CN 201710465357 A CN201710465357 A CN 201710465357A CN 107028997 A CN107028997 A CN 107028997A
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- Prior art keywords
- field thistle
- materical crude
- crude slice
- medicine materical
- fresh
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
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- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh squeezing spray-dried powders medicine materical crude slice of field thistle and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of field thistle medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, and collects spray drying product, is vacuum-packed after crushed.Field Thistle Herb medicine materical crude slice prepared by this method, remains the polarity and nonpolar active ingredient in medicinal material to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine field thistle medicine materical crude slice.
Background technology
Chinese medicine field thistle is feverfew field thistleCephalanoplos segetum(Bunge) Kitam. dry ground
Upper part.This product sweet, bitter, cold, the thoughts of returning home, Liver Channel.This product has cooling blood and hemostasis, the effect of eliminating stasis to resolve swelling, is mainly used in bleeding from five sense organs or subcutaneous tissue, urine
Blood, have blood in stool, the treatment of metrostaxis etc..
The processing mode of conventional field thistle medicine materical crude slice is：After harvesting, impurity is removed, is dried, then accumulating of packing.Such herbal medicine drink
Piece, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for formula adjust and ensure that it faces
Bed curative effect, or even to patient bring recessiveness harm.
At present, in the market also has the granule pieces sale that field thistle medicinal material is made after extraction.The preparation of granule pieces
Journey, extracts not only time consumption and energy consumption, and is difficult to be extracted because commonly using substantial amounts of water to do the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the field thistle medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is also very big.In order to ensure the clinic of field thistle medicinal material is effective, steady quality, a kind of new field thistle medicine materical crude slice and its preparation technology
Urgently develop.
The content of the invention
The invention discloses " a kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology ".This technique can be most
Retain the polarity and nonpolar active ingredient in field thistle medicinal material while limits, it is to avoid medicinal material is processed and stored up in existing medicine materical crude slice
The loss of active ingredient and the decline of medical material quanlity caused by during fortune, reduce pollution of the medicinal material by mould etc., small to ensuring
The steady quality and clinical safety of Ji medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in field thistle picking time, is cleaned, after washing, fresh squeezing is taken advantage of.1 ~ 5 times of amount of addition in the gained dregs of a decoction
Water, stirs 5 ~ 30min, and plate and frame filter press press filtration takes juice.The remaining dregs of a decoction are pressed into extracting juice again.Merge three concoctions, with 40 ~ 120
Mesh screen, obtains field thistle concoction.By obtained field thistle concoction be concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C relative density for 1.02 ~
1.15 concentrate, and this concentrate is spray-dried, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110
DEG C, desciccate is collected, 60 ~ 100 mesh sieves, vacuum packaging are crossed after crushing.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Field thistle is enclosed in bag
Thin layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, print
There is Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the micro- mirror for obtaining product can be linked by scanning
The information such as other feature.
The present invention is advantageous in that：
The field thistle medicinal material of fresh collection, cleans and is directly squeezed after washing, filter, be concentrated under reduced pressure, being spray-dried, resulting powder
Medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume greatly
Reduce, vacuum packaging so that prepared slice quality is more stablized, adjusted beneficial to accumulating and clinic, with very significant social effect
And economic implications.
Embodiment
Embodiment 1
By the field thistle medicinal material of fresh collection, clean, silt is washed with water, take advantage of using fresh herb squeezer pressure extracting juice.The gained dregs of a decoction add 3 times
The running water of amount, stirs 20min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned 3
Secondary concoction merges, with 100 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set as 65 DEG C.In medicinal extract relative density obtained by concentration
For 1.05 when, spray drying, intake air temperature be 140 DEG C, air outlet temperature be 100 DEG C, collect spray drying thing, low-temperature grinding, mistake
80 mesh sieves, moisture is not higher than 12%, and pack 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, labeling is
Can.
Embodiment 2
By the field thistle medicinal material of fresh collection, clean, silt is washed with water, take advantage of using fresh herb squeezer pressure extracting juice.The gained dregs of a decoction add 5 times
The running water of amount, stirs 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned 3
Secondary concoction merges, with 80 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set as 70 DEG C.In medicinal extract relative density obtained by concentration
For 1.10 when, spray drying, intake air temperature be 120 DEG C, air outlet temperature be 90 DEG C, collect spray drying thing, low-temperature grinding, cross 60
Mesh sieve, moisture is not higher than 12%, and pack, adds packed antioxidant and drier, Vacuum Package, labeling by 1kg/ bags.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：It is gathered in field thistle picking time
Aerial part, is cleaned, after washing, takes advantage of fresh squeezing, and the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration
Juice is taken, the remaining dregs of a decoction press extracting juice again, merge three concoctions, and 40 ~ 120 mesh screens obtain field thistle concoction.
2. a kind of field thistle according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
Obtained field thistle concoction is concentrated under reduced pressure into the concentrate that relative density is 1.02 ~ 1.15 under the conditions of 40 ~ 75 DEG C, and this is dense
Contracting liquid is spray-dried, and intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects desciccate, is crushed
60 ~ 100 mesh sieves, vacuum packaging are crossed afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710465357.0A CN107028997A (en) | 2017-06-19 | 2017-06-19 | A kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710465357.0A CN107028997A (en) | 2017-06-19 | 2017-06-19 | A kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107028997A true CN107028997A (en) | 2017-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710465357.0A Pending CN107028997A (en) | 2017-06-19 | 2017-06-19 | A kind of field thistle is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412301A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eclipta |
| CN107441132A (en) * | 2017-08-25 | 2017-12-08 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of geranium wilfordii |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
-
2017
- 2017-06-19 CN CN201710465357.0A patent/CN107028997A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412301A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eclipta |
| CN107441132A (en) * | 2017-08-25 | 2017-12-08 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of geranium wilfordii |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170811 |
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| WD01 | Invention patent application deemed withdrawn after publication |