CN107233377A - A kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology - Google Patents
A kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107233377A CN107233377A CN201710465650.7A CN201710465650A CN107233377A CN 107233377 A CN107233377 A CN 107233377A CN 201710465650 A CN201710465650 A CN 201710465650A CN 107233377 A CN107233377 A CN 107233377A
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- Prior art keywords
- field thistle
- concoction
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- fresh
- squeezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh squeezing spray-dried granules medicine materical crude slice of field thistle and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of field thistle medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, and collects spray drying thing, size-reduced to be vacuum-packed with first squeeze after concoction mixing granulation, whole grain.Field thistle granule pieces prepared by this method, remain the polarity and nonpolar active ingredient in medicinal material to greatest extent.Granule pieces good fluidity, convenient to adjust beneficial to accumulating, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine field thistle medicine materical crude slice.
Background technology
Chinese medicine field thistle is feverfew field thistleCephalanoplos segetum(Bunge) Kitam. dry ground
Upper part.This product sweet, bitter, cold, the thoughts of returning home, Liver Channel.This product has cooling blood and hemostasis, the effect of eliminating stasis to resolve swelling, is mainly used in bleeding from five sense organs or subcutaneous tissue, urine
Blood, have blood in stool, the treatment of metrostaxis etc..
The processing mode of conventional field thistle medicine materical crude slice is：After harvesting, impurity is removed, is dried, then accumulating of packing.Such herbal medicine drink
Piece, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for formula adjust and ensure that it faces
Bed curative effect, or even to patient bring recessiveness harm.
At present, in the market also has the granule pieces sale that field thistle medicinal material is made after extraction.The preparation of granule pieces
Journey, extracts not only time consumption and energy consumption, and is difficult to be extracted because commonly using substantial amounts of water to do the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the field thistle medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is also very big.In order to ensure the clinic of field thistle medicinal material is effective, steady quality, a kind of new field thistle medicine materical crude slice and its preparation technology
Urgently develop.
The content of the invention
The invention discloses " a kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology ".This technique can be most
The polarity and nonpolar active ingredient that retain in field thistle medicinal material of limits, it is to avoid medicinal material is in the processing of existing medicine materical crude slice and accumulating
The loss of active ingredient and the decline of medical material quanlity caused by journey, reduce pollution of the medicinal material by mould etc., to ensuring that field thistle drinks
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in field thistle picking time, is cleaned, after washing, fresh squeezing is taken advantage of, collects and just squeeze concoction, retain 0.5% ~ 5%
First squeezing concoction it is standby, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration takes juice, the remaining dregs of a decoction are again
Press extracting juice, merge it is remaining just squeeze concoction and after squeeze concoction twice, 60 ~ 120 mesh screens obtain field thistle concoction.It will obtain
Field thistle concoction the concentrate that relative density is 1.02 ~ 1.15 is concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C, and this concentrate is sprayed
Mist is dried, and intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects desciccate, excessively 60 after crushing ~
100 mesh sieves.By above-mentioned field thistle spray dried powder, mixed with the first squeezing concoction of retention, prepare softwood, pelletized, 50 ~ 80 DEG C of dryings 4 ~
8 hours, whole grain, vacuum packaging.On the label of product packaging bags, the name of an article, medicinal part, planting site, medicine materical crude slice production in printing
The information such as business, date of manufacture, Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Bag
The thin layer for inside enclosing field thistle differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in product
Packaging bag on, be printed on Quick Response Code, can be linked by scanning obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo,
The information such as character and microscopical characters feature.
The present invention is advantageous in that：
The field thistle medicinal material of fresh collection, cleans and is directly squeezed after washing, filter, be concentrated under reduced pressure, being spray-dried, pelletizing, resulting
Granule pieces, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume is compared to traditional medicine materical crude slice volume
Greatly reduce, good fluidity, be vacuum-packed so that prepared slice quality is more stablized, beneficial to accumulating and clinical adjustment, with very
Significant social effect and economic implications.
Embodiment
Embodiment 1
By the field thistle medicinal material of fresh collection, clean, silt is washed with water, take advantage of using fresh herb squeezer pressure extracting juice, retain 1% weight
Concoction is just squeezed separately to use.The gained dregs of a decoction add the running water of 3 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction
Again extracting juice is pressed with squeezer.The above-mentioned remaining concoction that just squeezes is merged with the follow-up concoction of squeezing twice, with 100 eye mesh screen mistakes
Filter.Filtrate decompression is concentrated, and temperature is set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.05, spray drying, air inlet
Temperature is 140 DEG C, and air outlet temperature is 100 DEG C, collects spray drying thing, and low-temperature grinding crosses 80 mesh sieves.By this spray dried powder with it is upper
The first squeezing concoction for stating retention mixes softwood processed, granulation, 75 DEG C of drying 6 hours, and whole grain is packed, 1kg/ bags, the packed antioxidant of addition
And drier, Vacuum Package, labeling.
Embodiment 2
By the field thistle medicinal material of fresh collection, clean, silt is washed with water, take advantage of using fresh herb squeezer pressure extracting juice, retain 5% weight
Concoction is just squeezed separately to use.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction
Again extracting juice is pressed with squeezer.The above-mentioned remaining concoction that just squeezes is merged with the follow-up concoction of squeezing twice, with 100 eye mesh screen mistakes
Filter.Filtrate decompression is concentrated, and temperature is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.10, spray drying, air inlet
Temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects spray drying thing, and low-temperature grinding crosses 80 mesh sieves.By this spray dried powder with it is upper
The first squeezing concoction for stating retention mixes softwood processed, granulation, 70 DEG C of drying 8 hours, and whole grain is packed, 1kg/ bags, the packed antioxidant of addition
And drier, Vacuum Package, labeling.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (3)
1. a kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, it is characterised in that：It is gathered in field thistle picking time
Aerial part, is cleaned, after washing, takes advantage of fresh squeezing, is collected and is just squeezed concoction, and the first squeezing concoction for retaining 0.5% ~ 5% is standby, and the dregs of a decoction are added
The water of 1 ~ 5 times of amount, stirs 5 ~ 30min, and plate and frame filter press press filtration takes juice, and the remaining dregs of a decoction press extracting juice again, merges remaining just squeezing
Concoction and after squeeze concoction twice, 60 ~ 120 mesh screens obtain field thistle concoction.
2. a kind of field thistle according to claim 1 is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, it is characterised in that：
Obtained field thistle concoction is concentrated under reduced pressure into the concentrate that relative density is 1.02 ~ 1.15 under the conditions of 40 ~ 75 DEG C, and this is dense
Contracting liquid is spray-dried, and intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects desciccate, is crushed
60 ~ 100 mesh sieves are crossed afterwards.
3. a kind of field thistle according to claim 1 is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, it is characterised in that：
By the field thistle spray dried powder in claim 2, mixed with the first squeezing concoction retained in claim 1, prepare softwood, pelletized,
50 ~ 80 DEG C of dryings 4 ~ 8 hours, whole grain, vacuum packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710465650.7A CN107233377A (en) | 2017-06-19 | 2017-06-19 | A kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710465650.7A CN107233377A (en) | 2017-06-19 | 2017-06-19 | A kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107233377A true CN107233377A (en) | 2017-10-10 |
Family
ID=59987575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710465650.7A Pending CN107233377A (en) | 2017-06-19 | 2017-06-19 | A kind of field thistle is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
Country Status (1)
| Country | Link |
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| CN (1) | CN107233377A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106109575A (en) * | 2016-07-24 | 2016-11-16 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106214723A (en) * | 2016-07-23 | 2016-12-14 | 徐漫 | A kind of Herba Lobeliae Chinensis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
-
2017
- 2017-06-19 CN CN201710465650.7A patent/CN107233377A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106214723A (en) * | 2016-07-23 | 2016-12-14 | 徐漫 | A kind of Herba Lobeliae Chinensis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106109575A (en) * | 2016-07-24 | 2016-11-16 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Application publication date: 20171010 |