CN107157939A - A kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology - Google Patents
A kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107157939A CN107157939A CN201710478689.2A CN201710478689A CN107157939A CN 107157939 A CN107157939 A CN 107157939A CN 201710478689 A CN201710478689 A CN 201710478689A CN 107157939 A CN107157939 A CN 107157939A
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- Prior art keywords
- flos magnoliae
- freeze
- magnoliae liliflorae
- fresh
- crude slice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
The invention discloses a kind of fresh squeezing freeze-dried powder medicine materical crude slice of Flos Magnoliae Liliflorae and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of Flos Magnoliae Liliflorae medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Meanwhile, concentration condensate liquid separation volatile oil, and mixed with freeze-drying thing, sieving pack.Flos Magnoliae Liliflorae powder decoction pieces prepared by this method, remain the active ingredient in medicinal material to greatest extent.Medicine materical crude slice is easy to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The processing technology of medicine materical crude slice is spent the invention belongs to Chinese medicine manufacture field, more particularly to Chinese medicinal magnolia flower.
Background technology
Chinese medicinal magnolia flower flower is Magnoliacea plant Magnolia binodiiMagnolia biondiiPamp., yulanMagnolia denudataOr sprenger magnolia bark Desr.Magnolia sprengeriPamp. dry flower.This product has dispersing wind and cold, leads to
Effect of nose key.For anemofrigid headache, runny nose of having a stuffy nose, the treatment of nasosinusitis etc..
The processing mode of conventional Flos Magnoliae Liliflorae medicine materical crude slice is：Harvested when flower is not opened at the beginning of last month of spring in winter, except discarding stalk, dry in the shade, beat
Bag storage and transport.Such prepared slices of Chinese crude drugs, it is bulky, easily pollute and go mouldy, hygiene condition is poor, quality it is difficult to ensure that,
It is unfavorable for formula adjustment and ensures its clinical efficacy.
At present, in the market also has the granule pieces sale that Flos Magnoliae Liliflorae medicinal material is made after extraction.Due to granule pieces system
During standby, not only time consumption and energy consumption is extracted, and is difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the Flos Magnoliae Liliflorae medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Mistake is also very big.In order to ensure the clinic of Flos Magnoliae Liliflorae medicinal material is effective, steady quality, a kind of new Flos Magnoliae Liliflorae medicine materical crude slice and its system
Standby technique is urgently developed.
The content of the invention
The invention discloses " a kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology ".This technique can be with
Retain the polarity and nonpolar active ingredient in Flos Magnoliae Liliflorae medicinal material to greatest extent, it is to avoid medicinal material is processed and stored up in existing medicine materical crude slice
The loss of active ingredient and the decline of medical material quanlity caused by during fortune, reduce pollution of the medicinal material by mould etc., pungent to ensuring
The steady quality and clinical safety of smooth flower medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
After Flos Magnoliae Liliflorae harvesting, clean, wash, take advantage of fresh pressure extracting juice, the dregs of a decoction add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate
Frame filter press press filtration, the gained dregs of a decoction press extracting juice again, merge concoction and with 80 ~ 200 mesh sieve net filtrations.By the decoction of gained, 40 ~
65 DEG C are concentrated under reduced pressure, and gained relative density freezes 6 ~ 24 hours for 1.05 ~ 1.30 medicinal extract in -20 ~ -80 DEG C of refrigerators, then
It is freeze-dried, vacuum is 0.06 ~ 0.09MPa, temperature is -20 ~ -40 DEG C, and freeze-drying time is 12 ~ 48 hours, takes out powder
It is broken.In addition, collecting the Flos Magnoliae Liliflorae condensed water for the gained that is concentrated under reduced pressure, the NaCl of 1% ~ 5% weight is added, rear solution is stirred to dissolve and puts
In oil water separator, in being placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, upper strata oil is collected, and be charged with 1% ~ 5% weight
Anhydrous Na2SO4, after shaking 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain flower bud of lily magnolia flowers volatile oil, and by its
It is well mixed with above-mentioned Flos Magnoliae Liliflorae freeze-dried powder, crosses 40 ~ 100 mesh sieves, vacuum packaging produces the fresh freeze-dried powder of squeezing of Flos Magnoliae Liliflorae and drunk
Piece.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of Flos Magnoliae Liliflorae is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, being printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh Flos Magnoliae Liliflorae medicinal material cleans direct segment after washing and squeezes, filters, being concentrated under reduced pressure, being freeze-dried, separating oil and will wave
Hair oil is mixed with freeze-drying thing, and resulting powder decoction pieces can completely retain the active ingredient in medicinal material to greatest extent.
This medicine materical crude slice volume is greatly reduced compared to traditional medicine materical crude slice volume, and quality is more stablized, and beneficial to accumulating and clinical adjustment, is had
Very significant social effect and economic implications.
Embodiment
Embodiment 1
By the Flos Magnoliae Liliflorae medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, take juice.The gained dregs of a decoction add 2 times
The drinking water of amount, stirs 20min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction squeeze concoction with squeezer again.By above-mentioned 3 times
Concoction merges, and is concentrated under reduced pressure, temperature is set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, puts in -80 DEG C and freeze
After 8 hours, take out, freeze-drying, pressure is 0.09Mpa, temperature is -40 DEG C, and the time is 24 hours.Take out lyophilized products, low temperature
Grind.In addition, by the Flos Magnoliae Liliflorae condensed water collected when being concentrated under reduced pressure, adding the NaCl of weight 5%, being stirred to dissolve.By this
Solution is positioned in oil water separator, and stands 24 hours in 10 DEG C of environment, separates and collects upper strata volatile oil.Toward this volatile oil
The middle anhydrous Na for adding 2% weight2SO4, shake after 10min clocks, less than 25 DEG C room temperatures are placed 6 hours, filtering, obtain Flos Magnoliae Liliflorae volatilization
Oil.This volatile oil is well mixed with above-mentioned Flos Magnoliae Liliflorae freeze-drying thing, 60 mesh sieves are crossed, pack, adds packed antioxygen by 1kg/ bags
Agent and drier, Vacuum Package, labeling are got product.
Embodiment 2
By the Flos Magnoliae Liliflorae medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, take juice.The gained dregs of a decoction add 3 times
The drinking water of amount, stirs 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction squeeze concoction with squeezer again.By above-mentioned 3 times
Concoction merges, and is concentrated under reduced pressure, temperature is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, puts in -80 DEG C and freeze
After 12 hours, take out, freeze-drying, pressure is 0.08Mpa, temperature is -20 DEG C, and the time is 48 hours.Take out lyophilized products, low temperature
Grind.In addition, by the Flos Magnoliae Liliflorae condensed water collected when being concentrated under reduced pressure, adding the NaCl of weight 3%, being stirred to dissolve.By this
Solution is positioned in oil water separator, and stands 24 hours in 10 DEG C of environment, separates and collects upper strata volatile oil.Toward this volatile oil
The middle anhydrous Na for adding 5% weight2SO4, shake after 10min clocks, less than 25 DEG C room temperatures are placed 8 hours, filtering, obtain Flos Magnoliae Liliflorae volatilization
Oil.This volatile oil is well mixed with above-mentioned Flos Magnoliae Liliflorae freeze-drying thing, 80 mesh sieves are crossed, pack, adds packed antioxygen by 1kg/ bags
Agent and drier, Vacuum Package, labeling are got product.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (3)
1. a kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, it is characterised in that：After Flos Magnoliae Liliflorae is harvested, only
Fresh pressure extracting juice is taken advantage of in choosing, washing, and the dregs of a decoction add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration, the gained dregs of a decoction
Press extracting juice again, merge concoction and with 80 ~ 200 mesh sieve net filtrations.
2. a kind of Flos Magnoliae Liliflorae according to claim 1 is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, its feature exists
In：By the decoction of gained in claim 1,40 ~ 65 DEG C are concentrated under reduced pressure, and the medicinal extract that gained relative density is 1.05 ~ 1.30 is in -20
Freeze in ~ -80 DEG C of refrigerators 6 ~ 24 hours, be then freeze-dried, vacuum is 0.06 ~ 0.09MPa, temperature is -20 ~ -40
DEG C, freeze-drying time is 12 ~ 48 hours, takes out and crushes.
3. a kind of Flos Magnoliae Liliflorae according to claim 1 is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, its feature exists
In：The Flos Magnoliae Liliflorae condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of 1% ~ 5% weight is added, is stirred to dissolve
Solution is put in oil water separator afterwards, in being placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collects upper strata oil, and it is charged with 1% ~
The anhydrous Na of 5% weight2SO4, shake after 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain Flos Magnoliae Liliflorae volatilization
Oil, and want the Flos Magnoliae Liliflorae freeze-dried powder in 2 to be well mixed itself and right, 40 ~ 100 mesh sieves are crossed, vacuum packaging produces Flos Magnoliae Liliflorae fresh
Squeeze freeze-dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710478689.2A CN107157939A (en) | 2017-06-22 | 2017-06-22 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710478689.2A CN107157939A (en) | 2017-06-22 | 2017-06-22 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107157939A true CN107157939A (en) | 2017-09-15 |
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ID=59820092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710478689.2A Withdrawn CN107157939A (en) | 2017-06-22 | 2017-06-22 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107157939A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107997168A (en) * | 2017-11-23 | 2018-05-08 | 山东华玫生物科技有限公司 | A kind of extraction process of fresh rose flower liquid |
-
2017
- 2017-06-22 CN CN201710478689.2A patent/CN107157939A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107997168A (en) * | 2017-11-23 | 2018-05-08 | 山东华玫生物科技有限公司 | A kind of extraction process of fresh rose flower liquid |
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Application publication date: 20170915 |