CN107397774A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander - Google Patents

A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander Download PDF

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Publication number
CN107397774A
CN107397774A CN201710738816.8A CN201710738816A CN107397774A CN 107397774 A CN107397774 A CN 107397774A CN 201710738816 A CN201710738816 A CN 201710738816A CN 107397774 A CN107397774 A CN 107397774A
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China
Prior art keywords
coriander
freeze
squeezing
concoction
crude slice
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CN201710738816.8A
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Chinese (zh)
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徐漫
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Individual
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Individual
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Priority to CN201710738816.8A priority Critical patent/CN107397774A/en
Publication of CN107397774A publication Critical patent/CN107397774A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander.The technique is cleaned, eluted after the harvesting of coriander medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Coriander powder decoction pieces prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.

Description

A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine coriander medicine materical crude slice.
Background technology
Chinese medicine coriander is that samphire brings up SuiCoriandrum sativumL. herb.With sweating promoting eruption, help digestion Lower gas, the effect of being amusing and be middle, cure mainly measles and appear the illnesss such as not smooth, food is stagnant, appetite is not opened, prolapse of the anus initial stage.
The processing mode of conventional coriander medicine materical crude slice is:After harvesting, impurity is removed, is dried, directly packing storage and transport.This Dry coriander Hygienic Index can not be up to standard a bit, and medicinal material easily occurs and goes mouldy, so as to cause the decline of medical material quanlity and clinic The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody Just and ensure its clinical efficacy.
At present, granule pieces made of in the market Chinese medicine are sold.Because in granule pieces preparation process, extraction not only consumes When consume energy, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted.Further, since extraction Coriander medicinal material is also dry and by storage for a long time, and therefore, the loss of active ingredient is also very big.In order to ensure The clinical effective, steady quality of coriander medicinal material, a kind of new coriander medicine materical crude slice are urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander ".This technique can be maximum The polarity and the nonpolar active ingredient that retain in coriander medicinal material of limit, avoid medicinal material from being processed and storage and transport process in existing medicine materical crude slice In the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring coriander medicine materical crude slice Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that:
Its herb is gathered in coriander picking time, is cleaned, is cut into the section of 1 ~ 2cm length, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs Mix 15 ~ 30 minutes, take advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and squeezing takes Juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh twice Filter is sieved through, obtains coriander concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the leaching that relative density is 1.05 ~ 1.25 Cream.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as -15 DEG C ~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, and crosses 60 ~ 100 mesh sieves, bag Dress, produce the fresh squeezing freeze-dried powder medicine materical crude slice of coriander.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of coriander is enclosed in bag Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning The information such as sign.
The present invention is advantageous in that:
Fresh coriander medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being freeze-dried, and resulting powder decoction pieces can To retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume, matter Amount is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By the coriander medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stir 15 points Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction Squeezed again with squeezer, leaching concoction.Above-mentioned 3 coriander concoctions are merged, with 60 mesh screens, filtrate decompression concentration, temperature It is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.By scars It is freeze-dried after taking-up, temperature is set as -18 DEG C, pressure 0.09Mpa, and the time is 24 hours.Collect lyophilized products, powder It is broken, 60 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the coriander medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 minutes, Take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction are again Squeezed with squeezer, leaching concoction.Above-mentioned 3 coriander concoctions are merged, with 100 mesh screens, filtrate decompression concentration, temperature is set It is set to 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.Scars are taken out After be freeze-dried, temperature is set as -40 DEG C, pressure 0.09Mpa, and the time is 48 hours.Lyophilized products are collected, are crushed, mistake 100 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected Within the scope of.

Claims (2)

  1. A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander, it is characterised in that:It is complete that its is gathered in coriander picking time Grass, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect Concoction is just squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, Press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain coriander concoction.
  2. A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander according to claim 1, it is characterised in that:Will The coriander concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 2, obtains the medicinal extract that relative density is 1.05 ~ 1.25, put- Freeze in 20 DEG C ~ -80 DEG C refrigerators 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set as 0.06 ~ 0.09MPa, time are 8 ~ 48 hours, collect lyophilized products, crush, and cross 60 ~ 100 mesh sieves, packaging, it is cold to produce the fresh squeezing of coriander Freeze dry powder decoction pieces.
CN201710738816.8A 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander Pending CN107397774A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710738816.8A CN107397774A (en) 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710738816.8A CN107397774A (en) 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander

Publications (1)

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CN107397774A true CN107397774A (en) 2017-11-28

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113142511A (en) * 2021-04-23 2021-07-23 南京黄教授食品科技有限公司 Method for reducing polycyclic aromatic hydrocarbons in baking process of raw and fresh meat by pickling before baking coriander

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113142511A (en) * 2021-04-23 2021-07-23 南京黄教授食品科技有限公司 Method for reducing polycyclic aromatic hydrocarbons in baking process of raw and fresh meat by pickling before baking coriander
CN113142511B (en) * 2021-04-23 2023-07-11 南京黄教授食品科技有限公司 Method for reducing polycyclic aromatic hydrocarbon in fresh meat baking process by pickling coriander before baking

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Application publication date: 20171128