CN107375530A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet Download PDFInfo
- Publication number
- CN107375530A CN107375530A CN201710738654.8A CN201710738654A CN107375530A CN 107375530 A CN107375530 A CN 107375530A CN 201710738654 A CN201710738654 A CN 201710738654A CN 107375530 A CN107375530 A CN 107375530A
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- China
- Prior art keywords
- bittersweet
- freeze
- squeezing
- concoction
- crude slice
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet.The technique is cleaned, eluted after the harvesting of bittersweet medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Bittersweet powder decoction pieces prepared by this method, to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of studies of Solanum lyratum Thunb medicine materical crude slice.
Background technology
Studies of Solanum lyratum Thunb is the herb of plant of Solanaceae bittersweet.The effect of with clearing heat and promoting diuresis, removing toxicity for detumescence, anticancer.Clinic is main
It is used to treatment cure cold heating, icterepatitis, cholecystitis, cholelithiasis, cancer, uterus erosion, leukorrhea, nephritic dropsy, outer
With controlling carbuncle furuncle poison etc..
The processing mode of conventional bittersweet medicine materical crude slice is：Impurity is removed after harvesting, is dried, directly packing storage and transport.This
Dry bittersweet Hygienic Index can not be up to standard a bit, and medicinal material easily occurs and goes mouldy, so as to cause the decline of medical material quanlity and clinic
The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Just and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of bittersweet medicinal material.Because prepared by granule pieces
During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Come.Further, since the bittersweet medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of bittersweet medicinal material is effective, steady quality, a kind of new bittersweet medicine materical crude slice is urgently developed.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet ".This technique can be maximum
The polarity and the nonpolar active ingredient that retain in bittersweet medicinal material of limit, avoid medicinal material from being processed and storage and transport process in existing medicine materical crude slice
In the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring bittersweet medicine materical crude slice
Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in bittersweet picking time, is cleaned, is cut into the section of 1 ~ 2cm length, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs
Mix 15 ~ 30 minutes, take advantage of fresh pressure extracting juice.Collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and squeezing takes
Juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh twice
Filter is sieved through, obtains bittersweet concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the leaching that relative density is 1.05 ~ 1.25
Cream.This medicinal extract is put in -20 DEG C ~ -80 DEG C refrigerators and freezed 6 ~ 24 hours, is freeze-dried after taking-up.Freeze temperature is set as -15 DEG C
~ 40 DEG C, pressure is set as 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours, collects lyophilized products, crushes, and crosses 60 ~ 100 mesh sieves, bag
Dress, produce the fresh squeezing freeze-dried powder medicine materical crude slice of bittersweet.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of bittersweet is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Fresh bittersweet medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being freeze-dried, and resulting powder decoction pieces can
To retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume, matter
Amount is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.
Embodiment
Embodiment 1
By the bittersweet medicinal material of fresh collection, clean, be cut into the section of 1cm length, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction
Squeezed again with squeezer, leaching concoction.Above-mentioned 3 bittersweet concoctions are merged, with 60 mesh screens, filtrate decompression concentration, temperature
It is set as 60 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to -20 DEG C of refrigerators and freezes 12 hours.By scars
It is freeze-dried after taking-up, temperature is set as -18 DEG C, pressure 0.09Mpa, and the time is 24 hours.Collect lyophilized products, powder
It is broken, 60 mesh sieves are crossed, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the bittersweet medicinal material of fresh collection, clean, be cut into the section of 2cm length, add the water of 1 times of amount of medicinal material weight, stir 30 minutes,
Take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction are again
Squeezed with squeezer, leaching concoction.Above-mentioned 3 bittersweet concoctions are merged, with 100 mesh screens, filtrate decompression concentration, temperature is set
It is set to 70 DEG C.When medicinal extract relative density obtained by concentration is 1.05, it is transferred to -20 DEG C of refrigerators and freezes 8 hours.Scars are taken out
After be freeze-dried, temperature is set as -40 DEG C, pressure 0.09Mpa, and the time is 48 hours.Lyophilized products are collected, are crushed, mistake
100 mesh sieves, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet, it is characterised in that：It is complete that its is gathered in bittersweet picking time Grass, clean, be cut into the section of 1 ~ 2cm length, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect Concoction is just squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, Press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain bittersweet concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet according to claim 1, it is characterised in that：Will The bittersweet concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 2, obtains the medicinal extract that relative density is 1.05 ~ 1.25, put- Freeze in 20 DEG C ~ -80 DEG C refrigerators 6 ~ 24 hours, be freeze-dried after taking-up, temperature is set as -15 DEG C ~ 40 DEG C, and pressure is set as 0.06 ~ 0.09MPa, time are 8 ~ 48 hours, collect lyophilized products, crush, and cross 60 ~ 100 mesh sieves, packaging, it is cold to produce the fresh squeezing of bittersweet Freeze dry powder decoction pieces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738654.8A CN107375530A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738654.8A CN107375530A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375530A true CN107375530A (en) | 2017-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738654.8A Pending CN107375530A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet |
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| CN (1) | CN107375530A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN105998130A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738654.8A patent/CN107375530A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105998132A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed freeze drying powder decoction tablets and preparation process thereof |
| CN105998130A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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Application publication date: 20171124 |
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