CN105596416A

CN105596416A - Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof

Info

Publication number: CN105596416A
Application number: CN201610083513.2A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-02-11
Filing date: 2016-02-11
Publication date: 2016-05-25

Abstract

The invention discloses freshly squeezed herba periliae freeze-dried powder decoction pieces and a preparation technology thereof. The technology comprises the following steps: collecting the medicinal material herba periliae and selecting and drip-washing; squeezing when the herba periliae is fresh, and filtering and fetching the juice; adding water into the residue and stirring; filtering and squeezing; merging the obtained juice and performing vacuum concentration and freeze drying; concentrating the condensate and separating volatile oil, and mixing with the freeze-dried product; and screening and bagging. In the herba periliae powder decoction pieces prepared by the method, active ingredients in the medicinal material are maintained to the greatest degree. The decoction pieces are convenient to store, transport and adjust, the quality is controllable, the curative effect is reliable, and the decoction pieces are of great significance to guaranteeing the clinical effect of traditional Chinese medicines. The popularization and implementation of the method bring remarkable social significance and economic benefits.

Description

A kind of Su Ye fresh squeezing freeze drying powder medicine materical crude slice and preparation technology thereof

Technical field

The invention belongs to Chinese medicine manufacture field, relate in particular to the processing technology of Chinese medicine Su Ye medicine materical crude slice.

Background technology

Chinese medicine Su Ye is labiate purple perillaPerillafrutescens(L.) the dry leaf of Britt. (or band spray). It is loose cold that this product mainly has removing toxic substances, effect of relieving QI stagnancy in the stomach, and for anemofrigid cold, the evil of vomitting of coughing, the vomiting of pregnancy, the treatment of the poisoning grade of fish soft-shelled turtle.

The processing mode of conventional Su Ye medicine materical crude slice is: when summer, branches and leaves were luxuriant, gathers, removes impurity, and after drying, packing storage and transport. These type of prepared slices of Chinese crude drugs, bulky, easily to pollute and go mouldy, quality is difficult to ensure, is unfavorable for formula adjustment and guarantees its clinical efficacy.

At present, on market, also there is the granule pieces that Su Ye medicinal material is made after extracting to sell. In granule pieces preparation process, extract not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted. In addition, be to be also dried and to pass through long-time storage owing to extracting the Su Ye medicinal material of use, therefore, the loss of active ingredient is also very large. In order to ensure clinical effective, the steady quality of Su Ye medicinal material, a kind of novel Su Ye medicine materical crude slice and preparation technology thereof urgently develop.

Summary of the invention

The present invention has announced " the fresh squeezing freeze drying of a kind of Su Ye powder medicine materical crude slice and preparation technology thereof ". This technique can retain polarity and the nonpolar active ingredient in Su Ye medicinal material to greatest extent, the loss of active ingredient and the decline of medical material quanlity of avoiding medicinal material to cause in existing medicine materical crude slice processing and storage and transport process, reduce the pollution that medicinal material is subject to mould etc., steady quality and the clinical safety of guaranteeing Su Ye medicine materical crude slice are effectively had great importance.

To achieve these goals, technical scheme of the present invention is:

After Su Ye gathers, clean, washing, takes advantage of fresh pressure extracting juice, and the dregs of a decoction add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration, the gained dregs of a decoction are pressed extracting juice again, merge concoction and also filter with 80 ~ 200 eye mesh screens. By the liquid of gained, 40 ~ 65 DEG C of reduced pressure concentrations, the medicinal extract that gained relative density is 1.05 ~ 1.30 freezes 6 ~ 24 hours in-20 ~-80 DEG C of refrigerators, then carry out freeze drying, vacuum is 0.06 ~ 0.09MPa, and temperature is-20 ~-40 DEG C, freeze-drying time is 12 ~ 48 hours, takes out and pulverizes. In addition, collect the Su Ye condensed water of reduced pressure concentration gained, add the NaCl of 1% ~ 5% weight, be stirred to dissolve rear solution and put in oil water separator, under 4 DEG C ~ 10 DEG C environment, place 12 ~ 48 hours, collect upper strata oil, and toward the anhydrous Na that wherein adds 1% ~ 5% weight₂SO₄, after jolting 5 ~ 10min clock, 25 DEG C of following room temperatures are placed 1 ~ 6 hour, filter, and obtain Soviet Union's leaf volatile oil, and it is mixed with above-mentioned Su Ye freeze-dried powder, cross 40 ~ 100 mesh sieves, vacuum packaging, the i.e. fresh squeezing freeze drying of get Su Ye powder medicine materical crude slice.

On the label of product packaging bags, in printing the name of an article, medicinal part, planting site, manufacturer, date of manufacture, Contents of Main Components, meridian distribution of property and flavor, function cure mainly, the information such as usage and dosage, toxic and side effect and contraindication. In bag, enclose the thin layer of Su Ye and differentiate collection of illustrative plates and/or high efficiency liquid phase characteristic spectrum, as " identity card " of product. In addition, in the packaging bag of product, be printed on Quick Response Code, can link the information such as former plant photo, medicinal material photo, medicine materical crude slice photo, proterties and micro-diagnostic characteristics of obtaining product by scanning.

Usefulness of the present invention is:

Fresh Su Ye medicinal material cleans washing rear directly segment squeezing, filtration, reduced pressure concentration, freeze drying, separating oil and volatile oil is mixed to the powder decoction pieces obtaining, the to greatest extent active ingredient in complete reservation medicinal material with freeze drying thing. This medicine materical crude slice volume compares to traditional medicine materical crude slice volume and reduces widely, and quality is more stable, is beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.

Detailed description of the invention

Embodiment 1

By the Su Ye medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, get juice. The gained dregs of a decoction add the drinking water of 2 times of amounts, stir 20min, and plate and frame filter press is pressed extracting juice. The gained dregs of a decoction squeeze concoction with squeezer again. Above-mentioned 3 concoctions are merged, reduced pressure concentration, Temperature Setting is 65 DEG C. Be 1.15 o'clock in concentrated gained medicinal extract relative density, put in-80 DEG C and freeze after 8 hours, take out, freeze drying, pressure is 0.09Mpa, and temperature is-40 DEG C, and the time is 24 hours. Take out lyophilized products, cryogrinding is pulverized. In addition, the Su Ye condensed water of collecting during by reduced pressure concentration, adds the NaCl of weight 5%, is stirred to dissolve. This solution is positioned in oil water separator, and in 10 DEG C of environment, leaves standstill 24 hours, separated and collected upper strata volatile oil. Toward the anhydrous Na that adds 2% weight in this volatile oil₂SO₄, after jolting 10min clock, 25 DEG C of following room temperatures are placed 6 hours, filter, and obtain Soviet Union's leaf volatile oil. This volatile oil is mixed with above-mentioned Su Ye freeze drying thing, cross 60 mesh sieves, pack, 1kg/ bag, adds packed antioxidant and drier, Vacuum Package, labeling gets product.

Embodiment 2

By the Su Ye medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, get juice. The gained dregs of a decoction add the drinking water of 3 times of amounts, stir 30min, and plate and frame filter press is pressed extracting juice. The gained dregs of a decoction squeeze concoction with squeezer again. Above-mentioned 3 concoctions are merged, reduced pressure concentration, Temperature Setting is 60 DEG C. Be 1.10 o'clock in concentrated gained medicinal extract relative density, put in-80 DEG C and freeze after 12 hours, take out, freeze drying, pressure is 0.08Mpa, and temperature is-20 DEG C, and the time is 48 hours. Take out lyophilized products, cryogrinding is pulverized. In addition, the Su Ye condensed water of collecting during by reduced pressure concentration, adds the NaCl of weight 3%, is stirred to dissolve. This solution is positioned in oil water separator, and in 10 DEG C of environment, leaves standstill 24 hours, separated and collected upper strata volatile oil. Toward the anhydrous Na that adds 5% weight in this volatile oil₂SO₄, after jolting 10min clock, 25 DEG C of following room temperatures are placed 8 hours, filter, and obtain Soviet Union's leaf volatile oil. This volatile oil is mixed with above-mentioned Su Ye freeze drying thing, cross 80 mesh sieves, pack, 1kg/ bag, adds packed antioxidant and drier, Vacuum Package, labeling gets product.

Above embodiment, is only the technological thought of explanation this invention, can not limit whereby the every technological thought proposing according to the present invention of protection scope of the present invention, and any change of doing on technical scheme basis, within all falling into the scope of protection of the invention.

Claims

1. the fresh squeezing freeze drying of a Su Ye powder medicine materical crude slice and preparation technology thereof, it is characterized in that: after Su Ye is gathered, clean, washing, takes advantage of fresh pressure extracting juice, and the dregs of a decoction add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration, the gained dregs of a decoction are pressed extracting juice again, merge concoction and also filter with 80 ~ 200 eye mesh screens.

2. a kind of Su Ye according to claim 1 fresh squeezing freeze drying powder medicine materical crude slice and preparation technology thereof, it is characterized in that: by the liquid of gained in claim 1,40 ~ 65 DEG C of reduced pressure concentrations, gained relative density is that 1.05 ~ 1.30 medicinal extract freezes 6 ~ 24 hours in-20 ~-80 DEG C of refrigerators, then carry out freeze drying, vacuum is 0.06 ~ 0.09MPa, and temperature is-20 ~-40 DEG C, freeze-drying time is 12 ~ 48 hours, takes out and pulverizes.

3. a kind of Su Ye according to claim 1 fresh squeezing freeze drying powder medicine materical crude slice and preparation technology thereof, it is characterized in that: the Su Ye condensed water of collecting the reduced pressure concentration gained in claim 2, add the NaCl of 1% ~ 5% weight, being stirred to dissolve rear solution puts in oil water separator, under 4 DEG C ~ 10 DEG C environment, place 12 ~ 48 hours, collection upper strata oil, and toward the anhydrous Na that wherein adds 1% ~ 5% weight₂SO₄, after jolting 5 ~ 10min clock, 25 DEG C of following room temperatures are placed 1 ~ 6 hour, filter, and obtain Soviet Union's leaf volatile oil, and want the Su Ye freeze-dried powder in 2 to mix itself and right, cross 40 ~ 100 mesh sieves, vacuum packaging, the i.e. fresh squeezing freeze drying of get Su Ye powder medicine materical crude slice.