CN107441155A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb - Google Patents
A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb Download PDFInfo
- Publication number
- CN107441155A CN107441155A CN201710739661.XA CN201710739661A CN107441155A CN 107441155 A CN107441155 A CN 107441155A CN 201710739661 A CN201710739661 A CN 201710739661A CN 107441155 A CN107441155 A CN 107441155A
- Authority
- CN
- China
- Prior art keywords
- ground ivy
- longtube ground
- ivy herb
- materical crude
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb.The technique is cleaned, eluted after the harvesting of Longtube Ground Ivy Herb medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried, and collects lyophilized products, is vacuum-packed after crushed.Longtube Ground Ivy Herb medicine materical crude slice prepared by this method, remain polarity and nonpolar active ingredient in medicinal material simultaneously to greatest extent.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine Longtube Ground Ivy Herb medicine materical crude slice.
Background technology
Chinese medicine Longtube Ground Ivy Herb is labiate blood circulation promoting pillGlechoma longituba (Nakai) Kupr. dry ground
Upper part.This product has that dampness removing is treating stranguria, clearing heat and detoxicating, the effect of eliminating stasis to subdue swelling, is swollen for heat gonorrhea, urolithiasis, jaundice with damp-heat pathogen, sore carbuncle
Bitterly, the treatment of traumatic injury etc..
The processing mode of common Longtube Ground Ivy Herb medicine materical crude slice is：Spring to autumn harvests, and removes impurity, dries, then accumulating of packing.This
Class prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for formula adjust and
Ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.
At present, in the market also has the manufactured granule pieces sale after extraction of Longtube Ground Ivy Herb medicinal material.The preparation of granule pieces
Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried
Take out.Further, since the Longtube Ground Ivy Herb medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient
Loss is also very big.In order to ensure the clinic of Longtube Ground Ivy Herb medicinal material is effective, steady quality, a kind of new Longtube Ground Ivy Herb medicine materical crude slice is urgently
Exploitation.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb ".This technique can be most
The polarity and the nonpolar active ingredient that retain in Longtube Ground Ivy Herb medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensure even money
The steady quality and clinical safety of careless medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in Longtube Ground Ivy Herb picking time, is cleaned, is cut into 1 ~ 2cm section, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs
Mix 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, institute
The surplus dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains Longtube Ground Ivy Herb concoction.By obtained Longtube Ground Ivy Herb concoction be concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C relative density for 1.05 ~
1.25 medicinal extract, and this medicinal extract is freezed 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then be freeze-dried, pressure is 0.06 ~
0.09MPa, temperature are -15 ~ -40 DEG C, and cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, are sieved, packaging is
Can.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Longtube Ground Ivy Herb is enclosed in bag
Thin layer differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product,
Quick Response Code is printed on, can be linked by scanning and obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, character and micro-
The information such as diagnostic characteristics.
The present invention is advantageous in that：
The Longtube Ground Ivy Herb medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being freeze-dried, resulting powder
Last medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, and there is very significant society to anticipate
Justice and economic implications.
Embodiment
Embodiment 1
By the Longtube Ground Ivy Herb medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 3 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Remaining medicine
Slag presses extracting juice with squeezer again.Above-mentioned 3 concoctions are merged, with 100 mesh sieve net filtrations.Filtrate decompression concentrates, temperature setting
For 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, medicinal extract is freezed 6 hours in -80 DEG C of refrigerators.Take out east knot
Thing, freeze-drying, pressure 0.09Mpa, temperature are -20 DEG C, are dried 24 hours.Lyophilized products are taken out, low-temperature grinding, cross 80 mesh
Sieve, moisture are not higher than 12%, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the Longtube Ground Ivy Herb medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 30 minutes,
Take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction
Again extracting juice is pressed with squeezer.Above-mentioned 3 concoctions are merged, with 80 mesh sieve net filtrations.Filtrate decompression concentrates, and temperature is set as 70
℃.When medicinal extract relative density obtained by concentration is 1.10, medicinal extract is freezed 8 hours in -80 DEG C of refrigerators.East knot thing is taken out, it is cold
Dry, pressure 0.08Mpa is freezed, temperature is -40 DEG C, is dried 48 hours.Lyophilized products are taken out, low-temperature grinding, cross 60 mesh sieves, moisture
Content is not higher than 12%, pack, 1kg/ bags, adds packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb, it is characterised in that：Gathered in Longtube Ground Ivy Herb picking time Its herb, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, receive Collection just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain Longtube Ground Ivy Herb concoction.
- A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb according to claim 1, it is characterised in that： Obtained Longtube Ground Ivy Herb concoction is concentrated under reduced pressure into relative density under the conditions of 40 ~ 75 DEG C and is 1.05 ~ 1.25 medicinal extract, and this is soaked Cream freezes 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then is freeze-dried, and pressure is 0.06 ~ 0.09MPa, and temperature is -15 ~ -40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, and sieving, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739661.XA CN107441155A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739661.XA CN107441155A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107441155A true CN107441155A (en) | 2017-12-08 |
Family
ID=60493115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739661.XA Pending CN107441155A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107441155A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105641012A (en) * | 2016-02-11 | 2016-06-08 | 徐自升 | Argy wormwood leaf powdery decoction pieces prepared through freshly pressing and freeze-drying and preparation technology of argy wormwood leaf powdery decoction pieces |
-
2017
- 2017-08-25 CN CN201710739661.XA patent/CN107441155A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105641012A (en) * | 2016-02-11 | 2016-06-08 | 徐自升 | Argy wormwood leaf powdery decoction pieces prepared through freshly pressing and freeze-drying and preparation technology of argy wormwood leaf powdery decoction pieces |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107432883A (en) | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lopseed | |
| CN107362182A (en) | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of phoenix-tail fern | |
| CN107468751A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Longtube Ground Ivy Herb | |
| CN105998395A (en) | Herba Verbenae freshly squeezed freeze drying powder decoction piece and preparation technology thereof | |
| CN107714754A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gynostemma pentaphylla | |
| CN107028998A (en) | A kind of field thistle is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology | |
| CN107375354A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of lycopodium calvatum | |
| CN107441173A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of mulberry leaf | |
| CN107441155A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Longtube Ground Ivy Herb | |
| CN107375401A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gynostemma pentaphylla | |
| CN107375364A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium | |
| CN107441131A (en) | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of desmodium | |
| CN107397774A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander | |
| CN107281237A (en) | A kind of Ilex Latifolia Thunb is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology | |
| CN107375394A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of fringed pink | |
| CN107485694A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of lophatherum gracile | |
| CN107485629A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of desmodium | |
| CN107375512A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of cordate houttuynia | |
| CN107412291A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii | |
| CN107485628A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of geranium wilfordii | |
| CN107334814A (en) | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Longtube Ground Ivy Herb | |
| CN107397786A (en) | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of Longtube Ground Ivy Herb | |
| CN107441153A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Herba Lycopi | |
| CN107320507A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese trumpet creeper | |
| CN107441201A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171208 |
|
| WD01 | Invention patent application deemed withdrawn after publication |