CN107441201A

CN107441201A - A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf

Info

Publication number: CN107441201A
Application number: CN201710738996.XA
Authority: CN
Inventors: 黄竹青
Original assignee: Wuhu Tiancheng Puyang Traditional Chinese Medicine Technology Co Ltd
Current assignee: Wuhu Tiancheng Puyang Traditional Chinese Medicine Technology Co Ltd
Priority date: 2017-08-25
Filing date: 2017-08-25
Publication date: 2017-12-08

Abstract

The invention discloses a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf.The technique is cleaned, eluted after the harvesting of loguat leaf medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried, and collects lyophilized products, is vacuum-packed after crushed.Loquat Leaf medicine materical crude slice prepared by this method, remain polarity and nonpolar active ingredient in medicinal material simultaneously to greatest extent.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.

Description

A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf

Technical field

The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine loguat leaf medicine materical crude slice.

Background technology

Chinese medicine loguat leaf is rosaceous plant loquatEriobotrya japonicaThunb. leaf.This product has clearly Lung cough-relieving, stopping nausea and vomiting by lowering the adverse flow of QI, and stomach diuresis, the effect of cough-relieving.Available for cough with lung heat is treated, circulation of vital energy in the wrong direction asthma is anxious, gastropyretic vomiting, the sound of vomiting Inverse, dry is quenched one's thirst.

The processing mode of conventional loguat leaf medicine materical crude slice is：After harvesting, impurity is removed, is dried, accumulating of packing.To medicine materical crude slice factory again Profit, chopping are washed, is dried.Such medicine materical crude slice, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, no Adjusted beneficial to formula and ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.

At present, in the market also has the manufactured granule pieces sale after extraction of loguat leaf medicinal material.The preparation of granule pieces Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried Take out.Further, since the loguat leaf medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient Loss is also very big.In order to ensure the clinic of loguat leaf medicinal material is effective, steady quality, a kind of new loguat leaf medicine materical crude slice is urgently Exploitation.

The content of the invention

The invention discloses " a kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf ".This technique can be most The polarity and the nonpolar active ingredient that retain in loguat leaf medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring loquat The steady quality and clinical safety of leaf medicine materical crude slice effectively have great importance.

To achieve these goals, the technical scheme is that：

After loguat leaf harvesting, clean, be cut into the wide pieces of 1 ~ 2cm, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 points Clock, fresh squeezing is taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction are again Add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain loquat Leaf concoction.Obtained loguat leaf concoction is concentrated under reduced pressure into the medicinal extract that relative density is 1.05 ~ 1.25 under the conditions of 40 ~ 75 DEG C, And this medicinal extract is freezed 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then be freeze-dried, pressure is 0.06 ~ 0.09MPa, temperature for - 15 ~ -40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, and sieving, packaging.

On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture, The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Loguat leaf is enclosed in bag Thin layer differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, Quick Response Code is printed on, can be linked by scanning and obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, character and micro- The information such as diagnostic characteristics.

The present invention is advantageous in that：

The loguat leaf medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being freeze-dried, resulting powder Last medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume significantly Ground reduces, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, and there is very significant society to anticipate Justice and economic implications.

Embodiment

Embodiment 1

By the loguat leaf medicinal material of fresh collection, clean, be cut into the wide pieces of 1cm, add the water of 1 times of amount of medicinal material weight, stir 15 points Clock, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 3 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Remaining medicine Slag presses extracting juice with squeezer again.Above-mentioned 3 concoctions are merged, with 100 mesh sieve net filtrations.Filtrate decompression concentrates, temperature setting For 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, medicinal extract is freezed 6 hours in -80 DEG C of refrigerators.Take out east knot Thing, freeze-drying, pressure 0.09Mpa, temperature are -20 DEG C, are dried 24 hours.Lyophilized products are taken out, low-temperature grinding, cross 80 mesh Sieve, moisture are not higher than 12%, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.

Embodiment 2

By the loguat leaf medicinal material of fresh collection, clean, be cut into the wide pieces of 2cm, add the water of 0.5 times of amount of medicinal material weight, stirring 30 Minute, take advantage of fresh pressure extracting juice.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.It is remaining The dregs of a decoction press extracting juice with squeezer again.Above-mentioned 3 concoctions are merged, with 80 mesh sieve net filtrations.Filtrate decompression concentrates, temperature setting For 70 DEG C.When medicinal extract relative density obtained by concentration is 1.10, medicinal extract is freezed 8 hours in -80 DEG C of refrigerators.Take out east knot Thing, freeze-drying, pressure 0.08Mpa, temperature are -40 DEG C, are dried 48 hours.Lyophilized products are taken out, low-temperature grinding, cross 60 mesh Sieve, moisture are not higher than 12%, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.

Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected Within the scope of.

Claims

A kind of 1. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf, it is characterised in that：After loguat leaf harvesting, wash Only, the wide pieces of 1 ~ 2cm are cut into, add the water of 0.5 ~ 1 times of amount of medicinal material weight, are stirred 15 ~ 30 minutes, take advantage of fresh squeezing, collects and just squeezes Concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, squeezing Take juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain loguat leaf concoction.
A kind of 2. fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf according to claim 1, it is characterised in that： Obtained loguat leaf concoction is concentrated under reduced pressure into relative density under the conditions of 40 ~ 75 DEG C and is 1.05 ~ 1.25 medicinal extract, and this is soaked Cream freezes 6 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, then is freeze-dried, and pressure is 0.06 ~ 0.09MPa, and temperature is -15 ~ -40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, through crushing, and sieving, packaging.