CN105213475A - A kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof - Google Patents
A kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof Download PDFInfo
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- CN105213475A CN105213475A CN201510774857.3A CN201510774857A CN105213475A CN 105213475 A CN105213475 A CN 105213475A CN 201510774857 A CN201510774857 A CN 201510774857A CN 105213475 A CN105213475 A CN 105213475A
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Abstract
The present invention discloses a kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof.This technique, after Herba Menthae medical material is gathered, to clean, drip washing, and takes advantage of fresh squeezing, leaching medicine juice.Medicinal residues add water stirring again, filter squeezing.Concentrating under reduced pressure after gained medicine juice merges, lyophilization.In addition, concentrated condensed fluid is separated volatile oil, and mixes with lyophilization thing, pack of sieving.The Herba Menthae powder decoction pieces that this legal system is standby, remains the effective ingredient in medical material to greatest extent.Decoction pieces is convenient to accumulating, convenient adjustment, and quality controllable, curative effect is reliable, has great importance to guarantee tcm clinical curative effect.The promotion and implementation of this law, will have significant social meaning and economic benefit.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Herba Menthae decoction pieces.
Background technology
Chinese medicine Herba Menthae is labiate Herba Menthae
menthahaplocalyxbriq. dry aerial parts.This product is pungent, cool, returns lung, Liver Channel.There is dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, the functions such as soothing the liver circulation of qi promoting.Be mainly used in anemopyretic cold, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression etc.
The processing mode of conventional Herba Menthae decoction pieces is: the summer, season in autumn two stem and leaf luxuriant or the flowers are in blossom to three-wheel time, select fine day, gradation is tapped, and dries or dries in the shade, then packing storage and transport.After these Herba Menthae medical materials of packing are transported to prepared slices of Chinese crude drugs factory, need drip washing, section, and redry or dry in the shade.Existing technique time and effort consuming, operation repeats, and adds the production cost of decoction pieces.In this accumulating and the course of processing, the loss that its volatile effective component be rich in is a large amount of, thus cause the decline of medical material quanlity and the reduction of clinical efficacy.This type of prepared herbal medicine in small pieces ready for decoction, bulky, easily pollute and go mouldy, quality is difficult to ensure, is unfavorable for that formula is adjusted and guarantees its clinical efficacy.
At present, granule pieces market also having Herba Menthae medical material to make after extracting is sold.Due in granule pieces preparation process, extract not only time consumption and energy consumption, and do solvent because commonly using water, the nonpolar effective ingredient in medical material is difficult to be extracted.Or collect its volatile oil with steam distillation, due to long-time heating in process, very large to the stability influence of its aqueous soluble active constituent again.In addition, because the Herba Menthae medical material extracted also is dry also through long-time storage, therefore, in this process, the loss of effective ingredient is also very large.In order to ensure clinical effective, the steady quality of Herba Menthae medical material, a kind of novel Herba Menthae decoction pieces and preparation technology thereof urgently develop.
Summary of the invention
The present invention discloses " a kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof ".This technique can retain polarity in Herba Menthae medical material and nonpolar effective ingredient to greatest extent, the loss of effective ingredient avoiding medical material to cause in existing decoction pieces processing and storage and transport process and the decline of medical material quanlity, reduce the pollution of medical material by mycete etc., the steady quality and clinical safety guaranteeing Herba Menthae decoction pieces is effectively had great importance.
To achieve these goals, technical scheme of the present invention is:
Gather its aerial parts collection period Herba Menthae, clean, after robbing water wash, take advantage of fresh squeezing extracting juice, medicinal residues add the water of 1 ~ 3 times amount, and stir 5 ~ 30min, filter press filter pressing, gained medicinal residues squeeze extracting juice again, merge medicine juice and filter with 80 ~ 120 eye mesh screens.By the medicinal liquid of gained, in 40 ~ 75 DEG C of concentrating under reduced pressure, obtain the extractum that relative density is 1.10 ~ 1.25.Be positioned over by extractum in-20 ~-80 DEG C of refrigerators and freeze 4 ~ 12 hours, then carry out lyophilization, temperature is-15 ~-40 DEG C, and pressure is 0.06 ~ 0.09MPa, and the time is 8 ~ 48 hours.Collect east knot thing, pulverize, cross 60 ~ 100 mesh sieves and obtain lyophilized powder.Collect the Herba Menthae condensed water of above-mentioned concentrating under reduced pressure gained, add the NaCl of 1% ~ 5% weight, be stirred to dissolve, solution is put in oil water separator, places 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collects top oil reservoir, and toward wherein adding the anhydrous Na of 1% ~ 5% weight
2sO
4, after jolting 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Herba Menthae Haplocalycis volatile oil.By the Herba Menthae Haplocalycis volatile oil obtained, mix homogeneously with above-mentioned Herba Menthae lyophilized powder, cross 40 ~ 100 mesh sieves, vacuum packaging.
On the label of product packaging bags, the name of an article in printing, medicinal part, medical material planting site, manufacturer, date of manufacture, Contents of Main Components, meridian distribution of property and flavor, function cure mainly, the information such as usage and dosage, toxic and side effects and contraindication.TLC distinguish collection of illustrative plates and/or the high-efficient liquid phase character collection of illustrative plates of Herba Menthae is enclosed, as " identity card " of product in bag.In addition, in the packaging bag of product, be printed on Quick Response Code, the information such as former plant photo, medical material photo, decoction pieces photo, character and the microscopical identification feature obtaining product can be linked by scanning.Herba Menthae fresh squeezing vacuum drying powder decoction pieces, faces before taking and adds after Chinese medicine decoction is decocted, when decreasing decoction decocting, and the trouble under after the Herba Menthae in prescription needs, significant to reservation volatile ingredient.
Usefulness of the present invention is:
Fresh mint medical material cleans directly squeezing after washing, filtration, concentrating under reduced pressure, spraying dry, separation volatile oil, mixing, the powder decoction pieces obtained, can effective ingredient to greatest extent in complete reservation medical material.This decoction pieces volume compares to traditional decoction pieces volume and reduces widely, and volatile ingredient retains complete, and quality is more stable, is beneficial to accumulating and clinical adjustment, has very significant social meaning and economic implications.
Detailed description of the invention
Embodiment 1
By the Herba Menthae medical material of fresh collection, clean, rob water wash, take advantage of the squeezing of using fresh herb squeezer, extracting juice.Gained medicinal residues add the tap water of 2 times amount, stir 20min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine juice with squeezer again.Merged by above-mentioned 3 medicine juice, concentrating under reduced pressure, temperature is set as 65 DEG C.When concentrated solution relative density is 1.10, transfers to-20 DEG C of refrigerators and freeze 12 hours.Taken out by scars, carry out lyophilization, temperature is-20 DEG C, and pressure is 0.08Mpa, and the time is 48 hours.Take out lyophilized products, pulverize, cross 60 mesh sieves.In addition, by the Herba Menthae condensed water collected during concentrating under reduced pressure, add the NaCl of weight 5%, be stirred to dissolve.This solution is positioned in oil water separator, and in 10 DEG C of environment, leaves standstill 24 hours, separated and collected upper strata volatile oil.The anhydrous Na of 2% weight is added in this volatile oil
2sO
4, after jolting 10min clock, less than 25 DEG C room temperatures place 6 hours, filter, obtain Herba Menthae Haplocalycis volatile oil.Mixed homogeneously with above-mentioned Herba Menthae lyophilized powder by this volatile oil, cross 60 mesh sieves, pack, 1kg/ bag, add packed antioxidant and desiccant, Vacuum Package, labeling gets product.
Embodiment 2
By the Herba Menthae medical material of fresh collection, clean, rob water wash, take advantage of the squeezing of using fresh herb squeezer, extracting juice.Gained medicinal residues add the tap water of 5 times amount, stir 30min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine juice with squeezer again.Merged by above-mentioned 3 medicine juice, concentrating under reduced pressure, temperature is set as 70 DEG C.When concentrated solution relative density is 1.15, transfers to-20 DEG C of refrigerators and freeze 10 hours.Taken out by scars, carry out lyophilization, temperature is-40 DEG C, and pressure is 0.07Mpa, and the time is 24 hours.Take out lyophilized products, pulverize, cross 60 mesh sieves.In addition, by the Herba Menthae condensed water collected during concentrating under reduced pressure, add the NaCl of weight 3%, be stirred to dissolve.This solution is positioned in oil water separator, and in 10 DEG C of environment, leaves standstill 12 hours, separated and collected upper strata volatile oil.The anhydrous Na of 5% weight is added in this volatile oil
2sO
4, after jolting 10min clock, less than 25 DEG C room temperatures place 4 hours, filter, obtain Herba Menthae Haplocalycis volatile oil.Mixed homogeneously with above-mentioned Herba Menthae lyophilized powder by this volatile oil, cross 60 mesh sieves, pack, 1kg/ bag, add packed antioxidant and desiccant, Vacuum Package, labeling gets product.
Above embodiment, is only the technological thought that this invention is described, can not limit the every technological thought proposed according to the present invention of protection scope of the present invention whereby, any change that technical scheme basis is done, all falls within the scope of protection of the invention.
Claims (3)
1. a Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof, it is characterized in that: gather its aerial parts collection period Herba Menthae, clean, after robbing water wash, take advantage of fresh squeezing extracting juice, medicinal residues add the water of 1 ~ 3 times amount, stir 5 ~ 30min, filter press filter pressing, gained medicinal residues squeeze extracting juice again, merge medicine juice and filter with 80 ~ 120 eye mesh screens.
2. a kind of Herba Menthae according to claim 1 fresh squeezing lyophilization powder decoction pieces and preparation technology thereof, it is characterized in that: by the medicinal liquid of gained in claim 1, in 40 ~ 75 DEG C of concentrating under reduced pressure, obtain the extractum that relative density is 1.10 ~ 1.25, be positioned in-20 ~-80 DEG C of refrigerators and freezed 4 ~ 12 hours, carry out lyophilization again, temperature is-15 ~-40 DEG C, and pressure is 0.06 ~ 0.09MPa, time is 8 ~ 48 hours, collect east knot thing, pulverize, cross 60 ~ 100 mesh sieves and obtain lyophilized powder.
3. a kind of Herba Menthae fresh squeezing spray-dried powders decoction pieces according to claim 1 and preparation technology thereof, it is characterized in that: the Herba Menthae condensed water collecting the concentrating under reduced pressure gained in claim 2, add the NaCl of 1% ~ 5% weight, be stirred to dissolve, solution is put in oil water separator, place 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and toward wherein adding the anhydrous Na of 1% ~ 5% weight
2sO
4, after jolting 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Herba Menthae Haplocalycis volatile oil, and itself and right are wanted the Herba Menthae lyophilized powder in 2 to mix homogeneously, and cross 40 ~ 100 mesh sieves, vacuum packaging.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105641012A (en) * | 2016-02-11 | 2016-06-08 | 徐自升 | Argy wormwood leaf powdery decoction pieces prepared through freshly pressing and freeze-drying and preparation technology of argy wormwood leaf powdery decoction pieces |
| CN106109566A (en) * | 2016-07-31 | 2016-11-16 | 徐漫 | A kind of Rabdosia rubescens fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106722979A (en) * | 2016-11-18 | 2017-05-31 | 云南金三奇药业有限公司 | The preparation method of pseudo-ginseng food additives |
| CN107320514A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of eupatorium |
| CN107320582A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet |
| CN107375489A (en) * | 2017-08-25 | 2017-11-24 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
| CN107441201A (en) * | 2017-08-25 | 2017-12-08 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf |
| CN107485646A (en) * | 2017-08-25 | 2017-12-19 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of mulberry leaf |
-
2015
- 2015-11-14 CN CN201510774857.3A patent/CN105213475A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 孟胜男等: "《药剂学》", 30 September 2011 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596416A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae freeze-dried powder decoction pieces and preparation technology thereof |
| CN105641012A (en) * | 2016-02-11 | 2016-06-08 | 徐自升 | Argy wormwood leaf powdery decoction pieces prepared through freshly pressing and freeze-drying and preparation technology of argy wormwood leaf powdery decoction pieces |
| CN106109566A (en) * | 2016-07-31 | 2016-11-16 | 徐漫 | A kind of Rabdosia rubescens fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN106722979A (en) * | 2016-11-18 | 2017-05-31 | 云南金三奇药业有限公司 | The preparation method of pseudo-ginseng food additives |
| CN107320514A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of eupatorium |
| CN107320582A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of Chinese violet |
| CN107375489A (en) * | 2017-08-25 | 2017-11-24 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
| CN107441201A (en) * | 2017-08-25 | 2017-12-08 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of loguat leaf |
| CN107485646A (en) * | 2017-08-25 | 2017-12-19 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of mulberry leaf |
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Application publication date: 20160106 |