CN106074686A - A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof - Google Patents
A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof Download PDFInfo
- Publication number
- CN106074686A CN106074686A CN201610611870.1A CN201610611870A CN106074686A CN 106074686 A CN106074686 A CN 106074686A CN 201610611870 A CN201610611870 A CN 201610611870A CN 106074686 A CN106074686 A CN 106074686A
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- rabdosia rubescens
- spray
- dried
- decoction pieces
- fresh squeezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof.This technique, after Rabdosia rubescens medical material is gathered, cleans, drip washing, and takes advantage of fresh squeezing, leaching medicine juice.Medicinal residues add water stirring, filter squeezing.Concentrating under reduced pressure after the merging of gained medicine juice, is spray-dried；Concentrate condensed fluid separation volatile oil, after beta cyclodextrin inclusion, mix with spray-dried product, granulate, pack, Vacuum Package.Rabdosia rubescens granule pieces prepared by this method, remains the effective ingredient in medical material to greatest extent.Granule pieces good fluidity, it is simple to accumulating, convenient adjustment, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will have significant social meaning and economic benefit.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Rabdosia rubescens decoction pieces.
Background technology
Chinese medicine Rabdosia rubescens is that Labiatae scented tea platymiscium is cracked rice the dry aerial parts of fork.This product has anti-inflammatory analgetic, is good for
Effect that stomach is invigorated blood circulation, can be used for the treatment of laryngopharynx swelling and pain, lump in the abdomen mass in the abdomen and snake bite and insect sting etc..
The processing mode of conventional Rabdosia rubescens decoction pieces is: extract its aerial parts in collection period, chopping, dry in the shade or dry into
Medicine；Or collated, dry after, packing storage and transport.After these Rabdosia rubescens medical materials being dried are transported to prepared slices of Chinese crude drugs factory, need
Want drip washing, section, and redry.Existing technique time and effort consuming, operation repeats, adds the production cost of decoction pieces.In this mistake
Journey not only results in water miscible a large amount of losses therein, and its abundant the most substantial amounts of loss of volatile effective component,
Thus cause the decline of medical material quanlity and the reduction of clinical efficacy.This type of prepared herbal medicine in small pieces ready for decoction, bulky, easily pollute and go mouldy,
Quality it is difficult to ensure that, be unfavorable for formula adjust and guarantee its clinical efficacy.
At present, granule pieces market also having Rabdosia rubescens medical material to make after extracting is sold.Due to granule pieces system
During Bei, extract not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar effective ingredient in medical material is difficult to be extracted
Out.Additionally, due to the Rabdosia rubescens medical material extracted also is to be dried and through long-time storage, therefore, the damage of effective ingredient
It is also the biggest for losing.In order to ensure clinical effective, the steady quality of Rabdosia rubescens medical material, a kind of novel Rabdosia rubescens decoction pieces and system thereof
Standby technique is urgently developed.
Summary of the invention
The invention discloses " a kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof ".This technique is permissible
Retain the polarity in Rabdosia rubescens medical material and nonpolar effective ingredient to greatest extent, it is to avoid medical material is in the processing of existing decoction pieces and storage
The loss of the effective ingredient caused during fortune and the decline of medical material quanlity, reduce the medical material pollution by mycete etc., to guaranteeing the winter
Steady quality and the clinical safety of LINGCAO decoction pieces effectively have great importance.
To achieve these goals, the technical scheme is that
Gather its aerial parts collection period Rabdosia rubescens, clean, after washing, be cut into the section of 1 ~ 10cm length, take advantage of fresh squeezing extracting juice, medicine
Slag adds the water of 1 ~ 3 times amount, stirs 5 ~ 30min, filter press filter pressing, and gained medicinal residues squeeze extracting juice again, merge medicine juice and use
80 ~ 200 eye mesh screens filter.By the medicinal liquid of gained, 40 ~ 80 DEG C of concentrating under reduced pressure, gained relative density is the concentrated solution of 1.02 ~ 1.10
Being spray-dried, intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and pulverizes.Meanwhile, receive
The Rabdosia rubescens condensed water of collection concentrating under reduced pressure gained, adds the NaCl of 1% ~ 5% weight, is stirred to dissolve, and solution puts oil water separator
In, place 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with the anhydrous of 1% ~ 5% weight
Na2SO4, after shaking 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Rabdosia rubescens volatile oil.The winter that will obtain
LINGCAO volatile oil, grinds inclusion with the beta-schardinger dextrin-equal increments method of 1 ~ 6 times of weight, and by clathrate and above-mentioned spray dried product
Mix homogeneously, wet granulation, it is dried 4 ~ 8 hours at 60 ~ 75 DEG C, granulate, is vacuum-packed.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main
The information such as component content, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication.The thin of Rabdosia rubescens is enclosed in Dai
Layer differentiates collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product.Additionally, in the packaging bag of product, be printed on
Quick Response Code, can link former plant photo, medical material photo, decoction pieces photo, character and the microscopical identification obtaining product by scanning
The information such as feature.
The invention have benefit that:
Fresh Rabdosia rubescens medical material clean washing after directly cutting squeezing, filtration, concentrating under reduced pressure, be spray-dried, separate volatile oil, ring
Dextrin inclusion, mixing granulation, obtained granule pieces, can the most completely retain the effective ingredient in medical material, special
It not to retaining volatile effective component, significant.This decoction pieces volume compares to tradition decoction pieces volume and greatly subtracts
Little, quality is more stable, and mobility of particle is good, and beneficially accumulating and clinical adjustment, have the most significant social meaning and economy
Meaning.
Detailed description of the invention
Embodiment 1
By the Rabdosia rubescens medical material of fresh collection, clean, with water wash, be cut into the section of 5cm length, take advantage of the squeezing of using fresh herb squeezer, extracting juice.
Gained medicinal residues add the drinking water of 2 times amount, stir 20min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine with squeezer again
Juice.Being merged by above-mentioned 3 medicine juice, concentrating under reduced pressure, temperature is set as 65 DEG C.When concentrated solution relative density is 1.05, spray dried
Dry, intake air temperature is 110 DEG C, and air outlet temperature is 80 DEG C, collects dried object and pulverizes.It addition, will collect during concentrating under reduced pressure
Rabdosia rubescens condensed water, add weight 5% NaCl, be stirred to dissolve.This solution is positioned in oil water separator, and in 10
DEG C environment stands 24 hours, separates and collects upper strata volatile oil.The anhydrous Na of 2% weight is added in this volatile oil2SO4, shaking
After 10min clock, less than 25 DEG C room temperatures are placed 6 hours, filter, obtain Rabdosia rubescens volatile oil.By this volatile oil and the β-ring of 2 times of weight
Dextrin grinds inclusion, then mixs homogeneously with above-mentioned Rabdosia rubescens spray drying ground product, and soft material processed is pelletized, at 65 DEG C, is dried 8
Hour, granulate, sieves, collects and can pass through 24 mesh sieves, and can not add sack drying by the granule of 60 sieves, pack, 1kg/ bag
Agent, antioxidant, Vacuum Package, labeling.
Embodiment 2
By the Rabdosia rubescens medical material of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of the squeezing of using fresh herb squeezer, take
Juice.Gained medicinal residues add the drinking water of 3 times amount, stir 30min, filter press squeezing extracting juice.Gained medicinal residues squeeze with squeezer again
Take concoction.Being merged by above-mentioned 3 medicine juice, concentrating under reduced pressure, temperature is set as 60 DEG C.When concentrated solution relative density is 1.08, spray
Mist is dried, and intake air temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects dried object and pulverizes.It addition, during by concentrating under reduced pressure
The Rabdosia rubescens condensed water collected, adds the NaCl of weight 3%, is stirred to dissolve.This solution is positioned in oil water separator, and
In 10 DEG C of environment, stand 12 hours, separate and collect upper strata volatile oil.The anhydrous Na of 5% weight is added in this volatile oil2SO4,
After shaking 10min clock, less than 25 DEG C room temperatures are placed 12 hours, filter, obtain Rabdosia rubescens volatile oil.By this volatile oil and 5 times of weight
Beta-schardinger dextrin-with equal increments method grind inclusion, then with above-mentioned Rabdosia rubescens be spray-dried ground product mix homogeneously, soft material processed, make
Grain, at 70 DEG C, is dried 6 hours, granulate, sieves, collect and can pass through 24 mesh sieves, and can not be by the granule of 60 sieves, pack,
1kg/ bag, adds bagged dryer, antioxidant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (4)
1. a Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof, it is characterised in that: adopt collection period Rabdosia rubescens
Collecting its aerial parts, clean, after washing, be cut into the section of 1 ~ 10cm length, take advantage of fresh squeezing extracting juice, medicinal residues add the water of 1 ~ 5 times amount, stir
Mixing 5 ~ 30min, filter press filter pressing, gained medicinal residues squeeze extracting juice again, merge medicine juice and filter with 80 ~ 200 eye mesh screens.
A kind of Rabdosia rubescens fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: by the medicinal liquid of gained in claim 1,40 ~ 80 DEG C of concentrating under reduced pressure, gained relative density is the concentrated solution spray of 1.02 ~ 1.10
Mist is dried, and intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and pulverizes.
A kind of Rabdosia rubescens fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Rabdosia rubescens condensed water of the concentrating under reduced pressure gained in collection claim 2, add the NaCl of 1% ~ 5% weight, stirring makes molten
Solving, solution is put in oil water separator, places 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collects top oil reservoir, and is charged with
The anhydrous Na of 1% ~ 5% weight2SO4, after shaking 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Rabdosia rubescens and wave
Hair oil.
A kind of Rabdosia rubescens fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Rabdosia rubescens volatile oil that will obtain in claim 3, grind inclusion with the beta-schardinger dextrin-equal increments method of 1 ~ 6 times of weight, and
Clathrate is mixed homogeneously with the spray dried product in claim 2, wet granulation, it is dried 4 ~ 8 hours at 60 ~ 75 DEG C, granulate,
It is vacuum-packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610611870.1A CN106074686A (en) | 2016-07-31 | 2016-07-31 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610611870.1A CN106074686A (en) | 2016-07-31 | 2016-07-31 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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| CN106074686A true CN106074686A (en) | 2016-11-09 |
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| CN201610611870.1A Pending CN106074686A (en) | 2016-07-31 | 2016-07-31 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157937A (en) * | 2017-06-18 | 2017-09-15 | 徐漫 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107334833A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf |
| CN107334849A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
| CN107375381A (en) * | 2017-08-25 | 2017-11-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of tussilago |
| CN107412304A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of eclipta |
| CN107468831A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese violet |
| CN112603863A (en) * | 2020-12-21 | 2021-04-06 | 河南省济源市济世药业有限公司 | Rabdosia rubescens low-boiling-point volatile matter, extraction method and application thereof, and mosquito repelling product |
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| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
| CN105708876A (en) * | 2016-02-11 | 2016-06-29 | 徐自升 | Sweet wormwood herb freshly-squeezed spraying drying particle decoction piece and preparation technology thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157937A (en) * | 2017-06-18 | 2017-09-15 | 徐漫 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107334833A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of loguat leaf |
| CN107334849A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
| CN107375381A (en) * | 2017-08-25 | 2017-11-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of tussilago |
| CN107412304A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of eclipta |
| CN107468831A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese violet |
| CN112603863A (en) * | 2020-12-21 | 2021-04-06 | 河南省济源市济世药业有限公司 | Rabdosia rubescens low-boiling-point volatile matter, extraction method and application thereof, and mosquito repelling product |
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Application publication date: 20161109 |