CN107157937A - A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology - Google Patents
A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107157937A CN107157937A CN201710460829.3A CN201710460829A CN107157937A CN 107157937 A CN107157937 A CN 107157937A CN 201710460829 A CN201710460829 A CN 201710460829A CN 107157937 A CN107157937 A CN 107157937A
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- Prior art keywords
- wrinkled giant
- giant hyssop
- fresh
- crude slice
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a kind of fresh squeezing spray-dried granules medicine materical crude slice of wrinkled giant hyssop and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of wrinkled giant hyssop medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried；Condensate liquid separation volatile oil is concentrated, after being included through beta cyclodextrin, mixes, whole grain, packs, Vacuum Package with spray-dried product.Wrinkled giant hyssop granule pieces prepared by this method, remain the active ingredient in medicinal material to greatest extent.Granule pieces good fluidity, is easy to accumulating, convenient to adjust, and quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine wrinkled giant hyssop medicine materical crude slice.
Background technology
Chinese medicine wrinkled giant hyssop is Labiatae wrinkled giant hyssop platymiscium wrinkled giant hyssopAgastache rugosa (Fisch. et Mey.) O.
Ktze. dry aerial parts.This moral character is pungent, tepor.Returns spleen, stomach, lung channel.This product, which has, eliminates dampness with aromatics, and middle preventing or arresting vomiting, delivers
The function of relieving summer-heat.Available for turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome is from the beginning of, burnout of generating heat, and uncomfortable in chest not relax, cold-dampness is closed
Heat, stomachache is vomited and diarrhoea, the treatment of nasosinusitis headache etc..
The processing mode of conventional wrinkled giant hyssop medicine materical crude slice is：Its aerial part is extracted in picking time, shred, dry in the shade or dry into
Medicine；Or it is collated, dry after, packing storage and transport.These dry wrinkled giant hyssop medicinal materials be transported to after prepared slices of Chinese crude drugs factory, it is necessary to
Elution, section, and redry.Existing process time and effort consuming, process is repeated, and adds the production cost of medicine materical crude slice.In this process
In not only result in water miscible a large amount of losses therein, and the also substantial amounts of loss of its abundant volatile effective component, from
And cause the decline of medical material quanlity and the reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily pollute and go mouldy, matter
Amount it is difficult to ensure that, be unfavorable for formula and adjust and ensure its clinical efficacy.
At present, in the market also has the granule pieces sale that wrinkled giant hyssop medicinal material is made after extraction.Because prepared by granule pieces
During, not only time consumption and energy consumption is extracted, and be difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Come.Further, since the wrinkled giant hyssop medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of wrinkled giant hyssop medicinal material is effective, steady quality, a kind of new wrinkled giant hyssop medicine materical crude slice and its preparation technology are urgently
It is to be developed.
The content of the invention
The invention discloses " a kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology ".This technique can be most
The polarity and nonpolar active ingredient that retain in wrinkled giant hyssop medicinal material of limits, it is to avoid medicinal material is in the processing of existing medicine materical crude slice and accumulating
The loss of active ingredient and the decline of medical material quanlity caused by journey, reduce pollution of the medicinal material by mould etc., to ensuring that wrinkled giant hyssop drinks
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in wrinkled giant hyssop picking time, is cleaned, after washing, the section of 1 ~ 10cm length is cut into, fresh pressure extracting juice, the dregs of a decoction is taken advantage of
Add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration, the gained dregs of a decoction press extracting juice again, merge concoction and with 80 ~
200 mesh sieve net filtrations.By the decoction of gained, 40 ~ 80 DEG C are concentrated under reduced pressure, and gained relative density is sprayed for 1.02 ~ 1.10 concentrate
Mist is dried, and intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, is collected spray drying product and is crushed.Meanwhile, collect
Wrinkled giant hyssop condensed water obtained by being concentrated under reduced pressure, adds the NaCl of 1% ~ 5% weight, is stirred to dissolve, solution is put in oil water separator, in
Placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with the anhydrous Na of 1% ~ 5% weight2SO4, shake
Shake after 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering obtains Herba Agastaches Rugosae volatile oil.By obtained Herba Agastaches Rugosae volatile oil, with
The beta-schardinger dextrin equal increments method grinding inclusion of 1 ~ 6 times of weight, and inclusion compound is well mixed with the dry product of above-mentioned spraying, wet method
Pelletize, dried 4 ~ 8 hours at 60 ~ 75 DEG C, whole grain, vacuum packaging.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of wrinkled giant hyssop is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, be used as " identity card " of product.In addition, in the packaging bag of product, being printed on two
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as levy.
The present invention is advantageous in that：
Fresh wrinkled giant hyssop medicinal material cleans direct segment after washing and squeezes, filters, being concentrated under reduced pressure, being spray-dried, separating volatile oil, ring paste
Spermatophore is closed, mixing granulation, and resulting granule pieces can completely retain the active ingredient in medicinal material, especially to greatest extent
Be to retain volatile effective component, it is significant.This medicine materical crude slice volume greatly subtracts compared to traditional medicine materical crude slice volume
Small, quality is more stablized, and mobility of particle is good, beneficial to accumulating and clinical adjustment, with very significant social effect and economy
Meaning.
Embodiment
Embodiment 1
By the wrinkled giant hyssop medicinal material of fresh collection, clean, with water wash, be cut into the section of 5cm length, take advantage of the squeezing of using fresh herb squeezer, take juice.Institute
The drinking water that the dregs of a decoction add 2 times of amounts are obtained, 20min, plate and frame filter press pressure extracting juice is stirred.The gained dregs of a decoction squeeze medicine with squeezer again
Juice.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 65 DEG C.When concentrate relative density is 1.05, spraying is dry
Dry, intake air temperature is 110 DEG C, and air outlet temperature is 80 DEG C, collects dried object and crushes.In addition, being collected when will be concentrated under reduced pressure
Wrinkled giant hyssop condensed water, add weight 5% NaCl, be stirred to dissolve.This solution is positioned in oil water separator, and in 10 DEG C
24 hours are stood in environment, upper strata volatile oil is separated and collected.The anhydrous Na of 2% weight is added into this volatile oil2SO4, shaking
After 10min clocks, less than 25 DEG C room temperatures are placed 6 hours, and filtering obtains Herba Agastaches Rugosae volatile oil.This volatile oil and the β of 2 times of weight-ring are pasted
Smooth grinding is included, then is well mixed with above-mentioned wrinkled giant hyssop spray drying crushed material, softwood processed, and granulation, at 65 DEG C, is dried 8 hours,
Whole grain, sieving, collection can be by 24 mesh sieves, and 1kg/ bags, can not add bagged dryer by 60 particles sieved, pack, resist
Oxidant, Vacuum Package, labeling.
Embodiment 2
By the wrinkled giant hyssop medicinal material of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of the squeezing of using fresh herb squeezer, take juice.
The gained dregs of a decoction add the drinking water of 3 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction squeeze medicine with squeezer again
Juice.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 60 DEG C.When concentrate relative density is 1.08, spraying is dry
Dry, intake air temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects dried object and crushes.In addition, being collected when will be concentrated under reduced pressure
Wrinkled giant hyssop condensed water, add weight 3% NaCl, be stirred to dissolve.This solution is positioned in oil water separator, and in 10 DEG C
12 hours are stood in environment, upper strata volatile oil is separated and collected.The anhydrous Na of 5% weight is added into this volatile oil2SO4, shaking
After 10min clocks, less than 25 DEG C room temperatures are placed 12 hours, and filtering obtains Herba Agastaches Rugosae volatile oil.By this volatile oil and β-ring of 5 times of weight
Dextrin is ground with equal increments method and included, then is well mixed with above-mentioned wrinkled giant hyssop spray drying crushed material, softwood processed, granulation, in 70
At DEG C, dry 6 hours, whole grain, sieving, collection can be by 24 mesh sieves, and can not be packed, 1kg/ bags by 60 particles sieved, plus
Enter bagged dryer, antioxidant, Vacuum Package, labeling.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (4)
1. a kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, it is characterised in that：It is gathered in wrinkled giant hyssop picking time
Aerial part, is cleaned, after washing, is cut into the section of 1 ~ 10cm length, takes advantage of fresh pressure extracting juice, and the dregs of a decoction add the water of 1 ~ 3 times of amount, and stirring 5 ~
30min, plate and frame filter press press filtration, the gained dregs of a decoction press extracting juice again, merge concoction and with 80 ~ 200 mesh sieve net filtrations.
2. a kind of wrinkled giant hyssop according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
By the decoction of gained in claim 1,40 ~ 80 DEG C are concentrated under reduced pressure, and gained relative density is dry for 1.02 ~ 1.10 concentrate spraying
Dry, intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and crushes.
3. a kind of wrinkled giant hyssop according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
The wrinkled giant hyssop condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of 1% ~ 5% weight is added, is stirred to dissolve, solution
Put in oil water separator, in being placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with 1% ~ 5% weight
The anhydrous Na of amount2SO4, shake after 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering obtains Herba Agastaches Rugosae volatile oil.
4. a kind of wrinkled giant hyssop according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
By the Herba Agastaches Rugosae volatile oil obtained in claim 3, grind and include with the beta-schardinger dextrin equal increments method of 1 ~ 6 times of weight, and will bag
Compound is well mixed with the dry product of the spraying in claim 2, wet granulation, is dried 4 ~ 8 hours at 60 ~ 75 DEG C, whole grain, vacuum
Packaging.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710460829.3A CN107157937A (en) | 2017-06-18 | 2017-06-18 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710460829.3A CN107157937A (en) | 2017-06-18 | 2017-06-18 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
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| CN107157937A true CN107157937A (en) | 2017-09-15 |
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| CN201710460829.3A Pending CN107157937A (en) | 2017-06-18 | 2017-06-18 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468735A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eupatorium |
| CN110448593A (en) * | 2018-05-07 | 2019-11-15 | 北京盈科瑞创新医药股份有限公司 | A kind of Pogostemon cablin granule spray drying process |
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| CN106109533A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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2017
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Patent Citations (5)
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| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
| CN105663199A (en) * | 2016-02-11 | 2016-06-15 | 徐自升 | Freshly-squeezed folium artemisiae argyi spray drying granular medicinal slices and preparation technology thereof |
| CN106109533A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468735A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eupatorium |
| CN110448593A (en) * | 2018-05-07 | 2019-11-15 | 北京盈科瑞创新医药股份有限公司 | A kind of Pogostemon cablin granule spray drying process |
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Application publication date: 20170915 |