CN106109533A - A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof - Google Patents
A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof Download PDFInfo
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- CN106109533A CN106109533A CN201610582903.4A CN201610582903A CN106109533A CN 106109533 A CN106109533 A CN 106109533A CN 201610582903 A CN201610582903 A CN 201610582903A CN 106109533 A CN106109533 A CN 106109533A
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- Prior art keywords
- flos lonicerae
- spray
- dried
- decoction pieces
- fresh squeezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof.This technique, after Chinese medicine honeysuckle is gathered, cleans, drip washing, and takes advantage of fresh squeezing, leaching medicine juice.Medicinal residues add water stirring, filter squeezing.Concentrating under reduced pressure after the merging of gained medicine juice, is spray-dried；Concentrate condensed fluid separation volatile oil, after beta cyclodextrin inclusion, mix with spray-dried product, granulate, pack, Vacuum Package.Flos Lonicerae granule pieces prepared by this method, remains the effective ingredient in medical material to greatest extent.Granule pieces good fluidity, it is simple to accumulating, convenient adjustment, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will have significant social meaning and economic benefit.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Flos lonicerae decoction pieces.
Background technology
Flos lonicerae is caprifoliaceae plantLonicera japonicaThunb. dry flower or the first flower opened of band.
Early summer the flowers are in blossom put before gather, be dried.This product is cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat wind
Effect, cures mainly the diseases such as disease under distension, epidemic febrile disease heating, pyretic toxicity carbuncle and ulcer and tumor, hyperhidrosis unhappiness, enteritis, bacillary dysentery dry to thirsty work,
The diseases such as epidemic encephalitis, septicemia, acute mastitis, erysipelas, parotitis, skin infection all have certain curative effect.
The processing mode of conventional Flos Lonicerae decoction pieces is: removes impurity after gathering, dries, packing storage and transport.This type of
The prepared slices of Chinese crude drugs, bulky, easily pollute and go mouldy, hygiology condition is poor, quality it is difficult to ensure that, be unfavorable for that formula is adjusted and really
Protect its clinical efficacy.
At present, granule pieces market also having Chinese medicine honeysuckle to make after extracting is sold.Due to granule pieces system
During Bei, extract not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar effective ingredient in medical material is difficult to be extracted
Out.Additionally, due to the Chinese medicine honeysuckle extracted also is to be dried and through long-time storage, therefore, the damage of effective ingredient
It is also the biggest for losing.In order to ensure clinical effective, the steady quality of Chinese medicine honeysuckle, a kind of novel Flos Lonicerae decoction pieces and system thereof
Standby technique is urgently developed.
Summary of the invention
The invention discloses " a kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof ".This technique is permissible
Retain the polarity in Chinese medicine honeysuckle and nonpolar effective ingredient to greatest extent, it is to avoid medical material is in the processing of existing decoction pieces and storage
The loss of the effective ingredient caused during fortune and the decline of medical material quanlity, reduce the medical material pollution by mycete etc., to guaranteeing gold
Steady quality and the clinical safety of Flos Lonicerae decoction pieces effectively have great importance.
To achieve these goals, the technical scheme is that
Gathering its aerial parts collection period Flos Lonicerae, clean, after washing, take advantage of fresh squeezing extracting juice, medicinal residues add 1 ~ 3 times amount
Water, stirs 5 ~ 30min, filter press filter pressing, and gained medicinal residues squeeze extracting juice again, merges medicine juice and by 80 ~ 200 eye mesh screen mistakes
Filter.By the medicinal liquid of gained, 40 ~ 80 DEG C of concentrating under reduced pressure, gained relative density is the concentrated solution spray drying of 1.02 ~ 1.10, air intake
Mouth temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and also pulverizes.Meanwhile, concentrating under reduced pressure institute is collected
The Flos Lonicerae condensed water obtained, adds the NaCl of 1% ~ 5% weight, is stirred to dissolve, and solution is put in oil water separator, in 4 DEG C ~ 10 DEG C
Place 12 ~ 48 hours under environment, collect top oil reservoir, and be charged with the anhydrous Na of 1% ~ 5% weight2SO4, shake 5 ~ 10min
Zhong Hou, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Flos Lonicerae volatile oil.The Flos Lonicerae volatile oil that will obtain, with 1 ~ 6 times
The beta-schardinger dextrin-equal increments method of weight grinds inclusion, and is mixed homogeneously with above-mentioned spray dried product by clathrate, wet granulation,
It is dried 4 ~ 8 hours at 60 ~ 75 DEG C, granulate, is vacuum-packed.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main
The information such as component content, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication.The thin of Flos Lonicerae is enclosed in Dai
Layer differentiates collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product.Additionally, in the packaging bag of product, be printed on
Quick Response Code, can link former plant photo, medical material photo, decoction pieces photo, character and the microscopical identification obtaining product by scanning
The information such as feature.
The invention have benefit that:
Fresh Chinese medicine honeysuckle directly squeezes after cleaning washing, filters, concentrating under reduced pressure, be spray-dried, separate volatile oil, cyclodextrin
Inclusion, mixing granulation, obtained granule pieces, can the most completely retain the effective ingredient in medical material, particularly
To retaining volatile effective component, significant.This decoction pieces volume compares to tradition decoction pieces volume and is greatly reduced,
Quality is more stable, and mobility of particle is good, beneficially accumulating and clinical adjustment, has the most significant social meaning and economic meaning
Justice.
Detailed description of the invention
Embodiment 1
By the Chinese medicine honeysuckle of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, extracting juice.Gained medicinal residues add 2 times
The drinking water of amount, stirs 20min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine juice with squeezer again.By above-mentioned 3 times
Medicine juice merges, and concentrating under reduced pressure, temperature is set as 65 DEG C.When concentrated solution relative density is 1.05, it is spray-dried, intake air temperature
Being 110 DEG C, air outlet temperature is 80 DEG C, collects dried object and pulverizes.It addition, the Flos Lonicerae condensation will collected during concentrating under reduced pressure
Water, adds the NaCl of weight 5%, is stirred to dissolve.This solution is positioned in oil water separator, and stands in 10 DEG C of environment
24 hours, separate and collect upper strata volatile oil.The anhydrous Na of 2% weight is added in this volatile oil2SO4, after shaking 10min clock, 25
Room temperature below DEG C is placed 6 hours, filters, obtains Flos Lonicerae volatile oil.The beta-schardinger dextrin-of this volatile oil and 2 times of weight is ground bag
Close, then mix homogeneously with above-mentioned Flos Lonicerae spray drying ground product, soft material processed, pelletize, at 65 DEG C, be dried 8 hours, granulate,
Sieve, collect and can pass through 24 mesh sieves, and bagged dryer, antioxidation can not be added by the granule of 60 sieves, pack, 1kg/ bag
Agent, Vacuum Package, labeling.
Embodiment 2
By the Chinese medicine honeysuckle of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, extracting juice.Gained medicinal residues add 3 times
The drinking water of amount, stirs 30min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine juice with squeezer again.By above-mentioned 3 times
Medicine juice merges, and concentrating under reduced pressure, temperature is set as 60 DEG C.When concentrated solution relative density is 1.08, it is spray-dried, intake air temperature
Being 120 DEG C, air outlet temperature is 90 DEG C, collects dried object and pulverizes.It addition, the Flos Lonicerae condensation will collected during concentrating under reduced pressure
Water, adds the NaCl of weight 3%, is stirred to dissolve.This solution is positioned in oil water separator, and stands in 10 DEG C of environment
12 hours, separate and collect upper strata volatile oil.The anhydrous Na of 5% weight is added in this volatile oil2SO4, after shaking 10min clock, 25
Room temperature below DEG C is placed 12 hours, filters, obtains Flos Lonicerae volatile oil.By the beta-schardinger dextrin-equivalent of this volatile oil and 5 times of weight
Incremental method grinds inclusion, then mixs homogeneously with above-mentioned Flos Lonicerae spray drying ground product, and soft material processed is pelletized, at 70 DEG C, is dried
6 hours, granulate, sieves, collects and can pass through 24 mesh sieves, and can not add packed dry by the granule of 60 sieves, pack, 1kg/ bag
Drying prescription, antioxidant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (4)
1. a Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof, it is characterised in that: after Flos Lonicerae is gathered, only
Choosing, washing, take advantage of fresh squeezing extracting juice, medicinal residues add the water of 1 ~ 3 times amount, stir 5 ~ 30min, filter press filter pressing, gained medicinal residues
Squeeze extracting juice again, merge medicine juice and filter with 80 ~ 200 eye mesh screens.
A kind of Flos Lonicerae fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: by the medicinal liquid of gained in claim 1,40 ~ 80 DEG C of concentrating under reduced pressure, gained relative density is the concentrated solution spray of 1.02 ~ 1.10
Mist is dried, and intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and pulverizes.
A kind of Flos Lonicerae fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Flos Lonicerae condensed water of the concentrating under reduced pressure gained in collection claim 2, add the NaCl of 1% ~ 5% weight, stirring makes molten
Solving, solution is put in oil water separator, places 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collects top oil reservoir, and is charged with
The anhydrous Na of 1% ~ 5% weight2SO4, after shaking 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Flos Lonicerae and wave
Hair oil.
A kind of Flos Lonicerae fresh squeezing spray-dried powders decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Flos Lonicerae volatile oil that will obtain in claim 3, grind inclusion with the beta-schardinger dextrin-equal increments method of 1 ~ 6 times of weight, and
Clathrate is mixed homogeneously with the spray dried product in claim 2, wet granulation, it is dried 4 ~ 8 hours at 60 ~ 75 DEG C, granulate,
It is vacuum-packed.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582903.4A CN106109533A (en) | 2016-07-23 | 2016-07-23 | A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582903.4A CN106109533A (en) | 2016-07-23 | 2016-07-23 | A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106109533A true CN106109533A (en) | 2016-11-16 |
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ID=57289878
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610582903.4A Pending CN106109533A (en) | 2016-07-23 | 2016-07-23 | A kind of Flos Lonicerae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157937A (en) * | 2017-06-18 | 2017-09-15 | 徐漫 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107213200A (en) * | 2017-06-19 | 2017-09-29 | 徐漫 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107334814A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Longtube Ground Ivy Herb |
| CN107412301A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eclipta |
| CN107468735A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eupatorium |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
-
2016
- 2016-07-23 CN CN201610582903.4A patent/CN106109533A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157937A (en) * | 2017-06-18 | 2017-09-15 | 徐漫 | A kind of wrinkled giant hyssop is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107213200A (en) * | 2017-06-19 | 2017-09-29 | 徐漫 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107334814A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Longtube Ground Ivy Herb |
| CN107412301A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eclipta |
| CN107468735A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eupatorium |
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Application publication date: 20161116 |
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