CN105663199A

CN105663199A - Freshly-squeezed folium artemisiae argyi spray drying granular medicinal slices and preparation technology thereof

Info

Publication number: CN105663199A
Application number: CN201610083519.XA
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-02-11
Filing date: 2016-02-11
Publication date: 2016-06-15

Abstract

The invention discloses freshly-squeezed folium artemisiae argyi spray drying granular medicinal slices and a preparation technology thereof. The technology comprises the steps that after folium artemisiae argyi medicinal materials are collected, selection, drip washing and fresh squeezing are performed, and leaching is performed to obtain liquid medicine; water is added into medicine residues for stirring, and filtering and squeezing are performed; the obtained liquid medicine is combined, and decompression concentration and spray drying are performed. The folium artemisiae argyi spray drying granular medicinal slices obtained through the technology reserve effective ingredients in medicine to the maximum extent. The granular medicinal slices are good in flowability, convenient to store and adjust, controllable in quality, and reliable in curative effect and has the important significance in ensuring the traditional Chinese medicine clinical effect, and remarkable social meaning and economic benefits are achieved when the technology is implemented and popularized.

Description

A kind of fresh squeezing spray-dried granules medicine materical crude slice of tarragon and preparation technology thereof

Technical field

The invention belongs to Chinese medicinal materials manufacture field, particularly relate to the complete processing of Chinese medicine tarragon medicine materical crude slice.

Background technology

Chinese medicine tarragon is feverfew Chinese mugwortArtemisiaargyiLevl.EtVant. dry leave. This product warming the meridian for stopping bleeding, dispersing cold for relieving pain, external application removing dampness to relieve itching. It is mainly used in haematemesis, uterine bleeding, menorrhagia, blood under threatened abortion, few abdomen crymodynia, through cold uncomfortable, the treatment of the cold infertile grade in palace.

The processing mode of conventional tarragon medicine materical crude slice is: plucks when summer, flower was not opened, removes impurity, dry, packing storage and transport. These type of prepared slices of Chinese crude drugs, bulky, it is easy to pollute and go mouldy, hygiology condition is poor, and quality is difficult to ensure, is unfavorable for that formula is adjusted and guarantees its clinical efficacy.

At present, particle medicine materical crude slice market also having tarragon medicinal material to make after extracting is sold. Owing to, in particle medicine materical crude slice preparation process, extracting not only time consumption and energy consumption, and doing solvent because commonly using water, the nonpolar effective constituent in medicinal material is difficult to be extracted. In addition, the tarragon medicinal material owing to extracting also is dry and passes through long-time storage, and therefore, the loss of effective constituent is also very big. In order to guarantee clinical effective, the steady quality of tarragon medicinal material, a kind of novel tarragon medicine materical crude slice and preparation technology thereof urgently develop.

Summary of the invention

The present invention discloses " a kind of fresh squeezing spray-dried granules medicine materical crude slice of tarragon and preparation technology thereof ". This technique can retain the polarity in tarragon medicinal material and nonpolar effective constituent to greatest extent, avoid the medicinal material loss of effective constituent that causes and decline of medical material quanlity in the processing of existing medicine materical crude slice and storage and transport process, reduce the pollution of medicinal material by mould etc., the steady quality and clinical safety guaranteeing tarragon medicine materical crude slice is effectively had important meaning.

In order to realize above-mentioned purpose, the technical scheme of the present invention is:

Gathering its over-ground part collection period tarragon, clean, after washing, take advantage of fresh pressure extracting juice, the dregs of a decoction add the water of 1 ~ 3 times amount, stir 5 ~ 30min, plate-and-frame filter press press filtration, and extracting juice pressed again by the gained dregs of a decoction, merge concoction and filter with 80 ~ 200 eye mesh screens. By the liquid of gained, 40 ~ 80 DEG C of concentrating under reduced pressure, gained relative density is the concentrated solution spraying dry of 1.02 ~ 1.10, and intake air temperature is 90 ~ 120 DEG C, and going out draught temperature is 70 ~ 100 DEG C, collects spray dry product and pulverizes. Meanwhile, collecting the tarragon water of condensation of concentrating under reduced pressure gained, add the NaCl of 1% ~ 5% weight, be stirred to dissolve, solution is put in water-and-oil separator, places 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collects top oil reservoir, and toward wherein adding the anhydrous Na of 1% ~ 5% weight₂SO₄, after jolting 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Folium Artemisiae Argyi volatile oil.The Folium Artemisiae Argyi volatile oil that will obtain, closes with the beta-cyclodextrin equivalent incremental method of 1 ~ 6 times of weight grinding bag, and is mixed with above-mentioned spray dried product by inclusion compound, wet granulation, drying 4 ~ 8 hours at 60 ~ 75 DEG C, whole grain, vacuum packaging.

On the label of product packaging bags, the information such as the name of an article in printing, medicinal part, planting site, manufacturer, date manufactured, main component content, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic side effect and contraindication. TLC distinguish collection of illustrative plates and/or the high-efficient liquid phase character collection of illustrative plates of tarragon is enclosed, as " identity card " of product in bag. In addition, in the packing bag of product, it is printed on Quick Response Code, can link, by scanning, information such as obtaining the former plant photo of product, medicinal material photo, medicine materical crude slice photo, proterties and microscopical identification feature.

The usefulness of the present invention is:

Fresh tarragon medicinal material is direct squeezing, filtration, concentrating under reduced pressure, spraying dry, separation volatile oil, cyclodextrin encapsulated, mixing granulation after cleaning washing, the particle medicine materical crude slice obtained, can the effective constituent in complete reservation medicinal material to greatest extent, particularly to reservation volatile effective component, significant. This kind of medicine materical crude slice volume compares to tradition medicine materical crude slice volume and reduces widely, and quality is more stable, and mobility of particle is good, is beneficial to accumulating and clinical adjustment, has very significant social effect and economic implications.

Embodiment

Embodiment 1

By the tarragon medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezing machine, get juice. The tap water of times amount that the gained dregs of a decoction add 2, stirs 20min, plate-and-frame filter press pressure extracting juice. The gained dregs of a decoction squeeze concoction with squeezing machine again. Being merged by above-mentioned 3 concoctions, concentrating under reduced pressure, temperature is set as 65 DEG C. When concentrated solution relative density is 1.05, spraying dry, intake air temperature is 110 DEG C, and going out draught temperature is 80 DEG C, collects dried object and pulverizes. In addition, the tarragon water of condensation will collected during concentrating under reduced pressure, adds the NaCl of weight 5%, is stirred to dissolve. This solution is positioned in water-and-oil separator, and in 10 DEG C of environment, leaves standstill 24 hours, separated and collected upper strata volatile oil. The anhydrous Na of 2% weight is added in this volatile oil₂SO₄, after jolting 10min clock, less than 25 DEG C room temperatures place 6 hours, filter, obtain Folium Artemisiae Argyi volatile oil. The beta-cyclodextrin grinding bag of this volatile oil and 2 times of weight is closed, then mixes with above-mentioned tarragon spraying dry crushed material, softwood processed, granulate, at 65 DEG C, dry 8 hours, whole grain, sieves, and collects by 24 order sieves, and not by the particle of 60 sieves, pack, 1kg/ bag, adds packed siccative, antioxidant, Vacuum Package, labeling.

Embodiment 2

By the tarragon medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezing machine, get juice. The tap water of times amount that the gained dregs of a decoction add 3, stirs 30min, plate-and-frame filter press pressure extracting juice. The gained dregs of a decoction squeeze concoction with squeezing machine again. Being merged by above-mentioned 3 concoctions, concentrating under reduced pressure, temperature is set as 60 DEG C. When concentrated solution relative density is 1.08, spraying dry, intake air temperature is 120 DEG C, and going out draught temperature is 90 DEG C, collects dried object and pulverizes. In addition, the tarragon water of condensation will collected during concentrating under reduced pressure, adds the NaCl of weight 3%, is stirred to dissolve. This solution is positioned in water-and-oil separator, and in 10 DEG C of environment, leaves standstill 12 hours, separated and collected upper strata volatile oil. The anhydrous Na of 5% weight is added in this volatile oil₂SO₄, after jolting 10min clock, less than 25 DEG C room temperatures place 12 hours, filter, obtain Folium Artemisiae Argyi volatile oil.The beta-cyclodextrin of this volatile oil and 5 times of weight is closed with equivalent incremental method grinding bag, then mixes with above-mentioned tarragon spraying dry crushed material, softwood processed, granulate, at 70 DEG C, dry 6 hours, whole grain, sieves, and collects by 24 order sieves, and not by the particle of 60 sieves, pack, 1kg/ bag, adds packed siccative, antioxidant, Vacuum Package, labeling.

Above embodiment, is only the technological thought that this invention is described, can not limit the every technological thought proposed according to the present invention of protection scope of the present invention whereby, and any change done on technical scheme basis, all falls within the scope of protection of the invention.

Claims

1. the fresh squeezing spray-dried granules medicine materical crude slice of tarragon and preparation technology thereof, it is characterized in that: after tarragon is gathered, clean, washing, takes advantage of fresh pressure extracting juice, and the dregs of a decoction add the water of 1 ~ 3 times amount, stir 5 ~ 30min, plate-and-frame filter press press filtration, extracting juice pressed again by the gained dregs of a decoction, merges concoction and filters with 80 ~ 200 eye mesh screens.

2. a kind of fresh squeezing spray-dried powders medicine materical crude slice of tarragon according to claim 1 and preparation technology thereof, it is characterized in that: by the liquid of gained in claim 1,40 ~ 80 DEG C of concentrating under reduced pressure, gained relative density is the concentrated solution spraying dry of 1.02 ~ 1.10, intake air temperature is 90 ~ 120 DEG C, going out draught temperature is 70 ~ 100 DEG C, collects spray dry product and pulverizes.

3. a kind of fresh squeezing spray-dried powders medicine materical crude slice of tarragon according to claim 1 and preparation technology thereof, it is characterized in that: the tarragon water of condensation collecting the concentrating under reduced pressure gained in claim 2, add the NaCl of 1% ~ 5% weight, it is stirred to dissolve, solution is put in water-and-oil separator, place 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and toward wherein adding the anhydrous Na of 1% ~ 5% weight₂SO₄, after jolting 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Folium Artemisiae Argyi volatile oil.

4. a kind of fresh squeezing spray-dried powders medicine materical crude slice of tarragon according to claim 1 and preparation technology thereof, it is characterized in that: the Folium Artemisiae Argyi volatile oil that will obtain in claim 3, close with the beta-cyclodextrin equivalent incremental method of 1 ~ 6 times of weight grinding bag, and inclusion compound is mixed with the spray dried product in claim 2, wet granulation, drying 4 ~ 8 hours at 60 ~ 75 DEG C, whole grain, vacuum packaging.