CN107397788A - A kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology - Google Patents
A kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107397788A CN107397788A CN201710739113.7A CN201710739113A CN107397788A CN 107397788 A CN107397788 A CN 107397788A CN 201710739113 A CN201710739113 A CN 201710739113A CN 107397788 A CN107397788 A CN 107397788A
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- schizonepeta
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- dried
- crude slice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a kind of fresh squeezing spray-dried granules medicine materical crude slice of schizonepeta and its preparation technology.The technique is cleaned, eluted after the harvesting of schizonepeta medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried；Condensate liquid separation volatile oil is concentrated, after beta cyclodextrin includes, mixes, whole grain, packs, Vacuum Package with spray-dried product.Schizonepeta granule pieces prepared by this method, remain the active ingredient in medicinal material to greatest extent.Granule pieces good fluidity, it is easy to accumulating, convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine schizonepeta medicine materical crude slice.
Background technology
Chinese medicine schizonepeta is labiate schizonepetaSchizonepeta tenuisfolia Briq. drying overground part
Point.This taste is flat, and warm-natured, nontoxic, faint scent is dense, rich in volatile ingredient.Schizonepeta is sweating, alexipyretic, is the conventional grass of the traditional Chinese medical science
One of medicine, there are town phlegm, wind-dispelling, the effect of cool blood.Clinic is mainly used to control influenza, headache fever and chills sweating, vomiting.
The processing mode of conventional schizonepeta medicine materical crude slice is：Aerial part is extracted, is shredded, is dried in the shade or dry and be used as medicine；Or through whole
After managing, drying, packing storage and transport.These schizonepeta medicinal materials dried are transported to after prepared slices of Chinese crude drugs factory, it is necessary to elute, cut into slices,
And redry.Existing process time and effort consuming, process repeat, and add the production cost of medicine materical crude slice.It can not only lead in the process
Water miscible a large amount of losses therein, and the also substantial amounts of loss of its abundant volatile effective component are caused, so as to cause medicinal material
The decline of quality and the reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily pollute and go mouldy, quality it is difficult to ensure that,
It is unfavorable for formula adjustment and ensures its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of schizonepeta medicinal material.Because prepared by granule pieces
During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Come.Further, since the schizonepeta medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of schizonepeta medicinal material is effective, steady quality, a kind of new schizonepeta medicine materical crude slice and its preparation technology are urgently
It is to be developed.
The content of the invention
The invention discloses " a kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology ".This technique can be most
The polarity and the nonpolar active ingredient that retain in schizonepeta medicinal material of limits, medicinal material is avoided in the processing of existing medicine materical crude slice and accumulating
The decline of the loss of caused active ingredient and medical material quanlity in journey, pollution of the medicinal material by mould etc. is reduced, to ensuring that schizonepeta drinks
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in schizonepeta picking time, is cleaned, is cut into 1 ~ 2cm section, adds the water of 0.5 ~ 1 times of amount of medicinal material weight,
Stirring 15 ~ 30 minutes, fresh squeezing to be taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice,
The remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains schizonepeta concoction.
By the schizonepeta concoction of gained, 40 ~ 80 DEG C are concentrated under reduced pressure, and the concentrate that gained relative density is 1.02 ~ 1.10 is sprayed
Dry, intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and crushes.Meanwhile collection subtracts
The schizonepeta condensed water of pressure concentration gained, adds the NaCl of 1% ~ 5% weight, is stirred to dissolve, solution is put in oil water separator, in 4
DEG C ~ 10 DEG C of environment under place 12 ~ 48 hours, collect top oil reservoir, and be charged with the anhydrous Na of 1% ~ 5% weight2SO4, shaking
After 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain Herba Schizonepetae volatile oil.The Herba Schizonepetae volatile oil that will be obtained, with 1 ~
The beta-schardinger dextrin equal increments method grinding inclusion of 6 times of weight, and inclusion compound is well mixed with the dry product of above-mentioned spraying, wet method system
, dried 4 ~ 8 hours at 60 ~ 75 DEG C, whole grain, vacuum packaging.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of schizonepeta is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Directly segment is squeezed, filtered, being concentrated under reduced pressure, being spray-dried, separating volatile oil, ring paste after fresh schizonepeta medicinal material cleans washing
Spermatophore closes, mixing granulation, resulting granule pieces, can completely retain the active ingredient in medicinal material to greatest extent, especially
Be to retain volatile effective component, it is significant.This medicine materical crude slice volume greatly subtracts compared to traditional medicine materical crude slice volume
Small, quality is more stable, and mobility of particle is good, beneficial to accumulating and clinical adjustment, has very significant social effect and economy
Meaning.
Embodiment
Embodiment 1
By the schizonepeta medicinal material of fresh collection, clean, with water wash, be cut into the section of 1cm length, add 0.5 times of water measured of medicinal material weight,
Stirring 15 minutes, takes advantage of fresh squeezing, takes juice.The gained dregs of a decoction add the drinking water of 2 times of amounts, stir 20min, and plate and frame filter press squeezing takes
Juice.The gained dregs of a decoction squeeze concoction with squeezer again.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 65 DEG C.Dense
When contracting liquid relative density is 1.05, spray drying, intake air temperature is 110 DEG C, and air outlet temperature is 80 DEG C, collects dried object simultaneously
Crush.In addition, the schizonepeta condensed water that will be collected when being concentrated under reduced pressure, adds the NaCl of weight 5%, is stirred to dissolve.This solution is put
It is placed in oil water separator, and 24 hours is stood in 10 DEG C of environment, separates and collects upper strata volatile oil.Added into this volatile oil
The anhydrous Na of 2% weight2SO4, after shaking 10min clocks, less than 25 DEG C room temperatures are placed 6 hours, filtering, obtain Herba Schizonepetae volatile oil.By this
The beta-schardinger dextrin grinding of volatile oil and 2 times of weight includes, then is well mixed with above-mentioned schizonepeta spray drying crushed material, softwood processed,
Granulation, at 65 DEG C, to dry 8 hours, whole grain, sieving, collection can be by 24 mesh sieves, and can not be packed by the particle of 60 sieves,
1kg/ bags, add bagged dryer, antioxidant, Vacuum Package, labeling.
Embodiment 2
By the schizonepeta medicinal material of fresh collection, clean, with water wash, add the water of 1 times of amount of medicinal material weight, stir 30 minutes, take advantage of fresh
Squeezing.The gained dregs of a decoction add the drinking water of 3 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction use squeezer again
Squeeze concoction.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 60 DEG C.When concentrate relative density is 1.08,
Spray drying, intake air temperature are 120 DEG C, and air outlet temperature is 90 DEG C, collect dried object and crush.In addition, it will be concentrated under reduced pressure
When the schizonepeta condensed water collected, add the NaCl of weight 3%, be stirred to dissolve.This solution is positioned in oil water separator, and
12 hours are stood in 10 DEG C of environment, separates and collects upper strata volatile oil.The anhydrous Na of 5% weight is added into this volatile oil2SO4,
After shaking 10min clocks, less than 25 DEG C room temperatures are placed 12 hours, filtering, obtain Herba Schizonepetae volatile oil.By this volatile oil and 5 times of weight
Beta-schardinger dextrin is ground with equal increments method and included, then is well mixed with above-mentioned schizonepeta spray drying crushed material, softwood processed, granulation,
At 70 DEG C, dry 6 hours, whole grain, sieving, collection can be by 24 mesh sieves, and can not pass through the particle of 60 sieves, pack, 1kg/
Bag, add bagged dryer, antioxidant, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (4)
1. a kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, it is characterised in that：It is gathered in schizonepeta picking time
Aerial part, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing,
Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain schizonepeta concoction.
2. a kind of schizonepeta according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
By the schizonepeta concoction of gained in claim 1,40 ~ 80 DEG C are concentrated under reduced pressure, and the concentrate that gained relative density is 1.02 ~ 1.10 sprays
Mist is dried, and intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, is collected spray drying product and is crushed.
3. a kind of schizonepeta according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
The schizonepeta condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of 1% ~ 5% weight is added, is stirred to dissolve, solution
Put in oil water separator, placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with 1% ~ 5% weight
The anhydrous Na of amount2SO4, after shaking 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain Herba Schizonepetae volatile oil.
4. a kind of schizonepeta according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
The Herba Schizonepetae volatile oil that will be obtained in claim 3, grind and include with the beta-schardinger dextrin equal increments method of 1 ~ 6 times of weight, and will bag
Compound is well mixed with the dry product of the spraying in claim 2, wet granulation, is dried 4 ~ 8 hours at 60 ~ 75 DEG C, whole grain, vacuum
Packaging.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739113.7A CN107397788A (en) | 2017-08-25 | 2017-08-25 | A kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739113.7A CN107397788A (en) | 2017-08-25 | 2017-08-25 | A kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
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| Publication Number | Publication Date |
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| CN107397788A true CN107397788A (en) | 2017-11-28 |
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| CN201710739113.7A Pending CN107397788A (en) | 2017-08-25 | 2017-08-25 | A kind of schizonepeta is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
| CN105663199A (en) * | 2016-02-11 | 2016-06-15 | 徐自升 | Freshly-squeezed folium artemisiae argyi spray drying granular medicinal slices and preparation technology thereof |
| CN106038491A (en) * | 2016-07-23 | 2016-10-26 | 徐漫 | Freshly squeezed and spray-dried granular decoction pieces with verbena officinalis and process for preparing freshly squeezed and spray-dried granular decoction pieces |
-
2017
- 2017-08-25 CN CN201710739113.7A patent/CN107397788A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
| CN105663199A (en) * | 2016-02-11 | 2016-06-15 | 徐自升 | Freshly-squeezed folium artemisiae argyi spray drying granular medicinal slices and preparation technology thereof |
| CN106038491A (en) * | 2016-07-23 | 2016-10-26 | 徐漫 | Freshly squeezed and spray-dried granular decoction pieces with verbena officinalis and process for preparing freshly squeezed and spray-dried granular decoction pieces |
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