CN107397789A - A kind of schizonepeta is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology - Google Patents

A kind of schizonepeta is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology Download PDF

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Publication number
CN107397789A
CN107397789A CN201710739175.8A CN201710739175A CN107397789A CN 107397789 A CN107397789 A CN 107397789A CN 201710739175 A CN201710739175 A CN 201710739175A CN 107397789 A CN107397789 A CN 107397789A
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schizonepeta
spray
crude slice
materical crude
medicine materical
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CN201710739175.8A
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徐自升
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of fresh squeezing spray-dried powders medicine materical crude slice of schizonepeta and its preparation technology.The technique is cleaned, eluted after the harvesting of schizonepeta medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried;Condensate liquid separation volatile oil is concentrated, and is mixed with spray-dried product, sieving pack.Fineleaf Schizonepeta Herb medicine materical crude slice prepared by this method, remains the active ingredient in medicinal material to greatest extent.Medicine materical crude slice is easy to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.

Description

A kind of schizonepeta is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine schizonepeta medicine materical crude slice.
Background technology
Chinese medicine schizonepeta is labiate schizonepetaSchizonepeta tenuisfolia Briq. drying overground part Point.This taste is flat, and warm-natured, nontoxic, faint scent is dense, rich in volatile ingredient.Schizonepeta is sweating, alexipyretic, is the conventional grass of the traditional Chinese medical science One of medicine, there are town phlegm, wind-dispelling, the effect of cool blood.Clinic is mainly used to control influenza, headache fever and chills sweating, vomiting.
The processing mode of conventional schizonepeta medicine materical crude slice is:Aerial part is extracted, is shredded, is dried in the shade or dry and be used as medicine;Or through whole After managing, drying, packing storage and transport.These schizonepeta medicinal materials dried are transported to after prepared slices of Chinese crude drugs factory, it is necessary to elute, cut into slices, And redry.Existing process time and effort consuming, process repeat, and add the production cost of medicine materical crude slice.It can not only lead in the process Water miscible a large amount of losses therein, and the also substantial amounts of loss of its abundant volatile effective component are caused, so as to cause medicinal material The decline of quality and the reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily pollute and go mouldy, quality it is difficult to ensure that, It is unfavorable for formula adjustment and ensures its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of schizonepeta medicinal material.Because prepared by granule pieces During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted Come.Further, since the schizonepeta medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient It is very big.In order to ensure the clinic of schizonepeta medicinal material is effective, steady quality, a kind of new schizonepeta medicine materical crude slice and its preparation technology are urgently It is to be developed.
The content of the invention
The invention discloses " a kind of schizonepeta is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology ".This technique can be most The polarity and the nonpolar active ingredient that retain in schizonepeta medicinal material of limits, medicinal material is avoided in the processing of existing medicine materical crude slice and accumulating The decline of the loss of caused active ingredient and medical material quanlity in journey, pollution of the medicinal material by mould etc. is reduced, to ensuring that schizonepeta drinks The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that:
Its aerial part is gathered in schizonepeta picking time, is cleaned, is cut into 1 ~ 2cm section, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, Stirring 15 ~ 30 minutes, fresh squeezing to be taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, The remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice Filter, obtains schizonepeta concoction.By the schizonepeta concoction of gained, 40 ~ 80 DEG C are concentrated under reduced pressure, and are 1.02 ~ 1.10 to resulting relative density Concentrate be spray-dried, intake air temperature be 90 ~ 120 DEG C, air outlet temperature be 70 ~ 100 DEG C.Collect spray drying product simultaneously Crush.The schizonepeta condensed water of the above-mentioned gained that is concentrated under reduced pressure is collected, the NaCl of water weight 20% ~ 30% is added, is stirred to dissolve, solution Put in oil water separator, placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, obtain Herba Schizonepetae volatile oil, used After the beta-cyclodextrin inclusion compounds of 3 ~ 5 times of Herba Schizonepetae volatile oil weight amount, then it is well mixed with schizonepeta spray dried powder, crosses 40 ~ 100 mesh Sieve, vacuum packaging, produce the fresh squeezing spray-dried powders medicine materical crude slice of schizonepeta.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of schizonepeta is enclosed in bag Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning The information such as sign.
The present invention is advantageous in that:
Directly segment is squeezed, filtered, being concentrated under reduced pressure, being spray-dried, separating volatile oil, spray drying after fresh schizonepeta medicinal material cleans washing Powder mixes with volatile oil, resulting powder decoction pieces, can completely retain the active ingredient in medicinal material to greatest extent.It is this Medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume, and quality is more stable, beneficial to accumulating and clinical adjustment, has very Significant social effect and economic implications.
Embodiment
Embodiment 1
By the schizonepeta medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 minutes, Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 5 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 3 times of amounts Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain schizonepeta concoction.By schizonepeta concoction It is concentrated under reduced pressure, temperature is set as 65 DEG C.When concentrate relative density is 1.05, spray drying, intake air temperature is 110 DEG C, Air outlet temperature is 80 DEG C, collects dried object and crushes.In addition, the schizonepeta condensed water that will be collected when being concentrated under reduced pressure, adds water weight The NaCl of amount 30%, is stirred to dissolve.This solution is positioned in oil water separator, and 24 hours are stood in 10 DEG C of environment, point From collection upper strata volatile oil.Top oil reservoir is collected, obtains Herba Schizonepetae volatile oil, β-ring by it with 3 ~ 5 times of amounts of Herba Schizonepetae volatile oil weight After dextrin inclusion, then with right want the schizonepeta spray dried powder in 2 to be well mixed, cross 40 mesh sieves, vacuum packaging, it is fresh to produce schizonepeta Squeeze spray-dried powders medicine materical crude slice.
Embodiment 2
By the schizonepeta medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 30 minutes, take advantage of Fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 3 times of amounts, stir 10min, press extracting juice, and the remaining dregs of a decoction add 3 times of amounts Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain schizonepeta concoction.By schizonepeta concoction It is concentrated under reduced pressure, temperature is set as 65 DEG C.When concentrate relative density is 1.05, spray drying, intake air temperature is 110 DEG C, Air outlet temperature is 80 DEG C, collects dried object and crushes.In addition, the schizonepeta condensed water that will be collected when being concentrated under reduced pressure, adds water weight The NaCl of amount 20%, is stirred to dissolve.This solution is positioned in oil water separator, and 24 hours are stood in 10 DEG C of environment, point From collection upper strata volatile oil.Top oil reservoir is collected, obtains Herba Schizonepetae volatile oil, β-ring by it with 3 ~ 5 times of amounts of Herba Schizonepetae volatile oil weight After dextrin inclusion, then with right want the schizonepeta spray dried powder in 2 to be well mixed, cross 60 mesh sieves, vacuum packaging, it is fresh to produce schizonepeta Squeeze spray-dried powders medicine materical crude slice.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected Within the scope of.

Claims (3)

1. a kind of schizonepeta is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that:It is gathered in schizonepeta picking time Aerial part, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, Collect just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain schizonepeta concoction.
2. a kind of schizonepeta according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that: By the schizonepeta concoction of gained in claim 1,40 ~ 80 DEG C are concentrated under reduced pressure, and the concentrate that gained relative density is 1.02 ~ 1.10 sprays Mist is dried, and intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, is collected spray drying product and is crushed.
3. a kind of schizonepeta according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that: The schizonepeta condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of water weight 20% ~ 30% is added, is stirred to dissolve, Solution is put in oil water separator, is placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, is collected top oil reservoir, is obtained Herba Schizonepetae volatile oil, will After its beta-cyclodextrin inclusion compound with 3 ~ 5 times of Herba Schizonepetae volatile oil weight amount, then with right the schizonepeta spray dried powder in 2 is wanted to mix It is even, 40 ~ 100 mesh sieves are crossed, vacuum packaging, produce the fresh squeezing spray-dried powders medicine materical crude slice of schizonepeta.
CN201710739175.8A 2017-08-25 2017-08-25 A kind of schizonepeta is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology Pending CN107397789A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113662986A (en) * 2021-09-17 2021-11-19 驻马店市中洋生物科技有限公司 Method for preparing catnip oil from catnip essential oil extracted from catnip plant

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213450A (en) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof
CN105213473A (en) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 A kind of Herba Menthae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof
CN106109559A (en) * 2016-07-23 2016-11-16 徐自升 A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof
CN106138157A (en) * 2016-07-23 2016-11-23 徐自升 A kind of Flos Lonicerae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213450A (en) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof
CN105213473A (en) * 2015-11-14 2016-01-06 芜湖天成普阳中药科技有限公司 A kind of Herba Menthae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof
CN106109559A (en) * 2016-07-23 2016-11-16 徐自升 A kind of Flos Sophorae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof
CN106138157A (en) * 2016-07-23 2016-11-23 徐自升 A kind of Flos Lonicerae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113662986A (en) * 2021-09-17 2021-11-19 驻马店市中洋生物科技有限公司 Method for preparing catnip oil from catnip essential oil extracted from catnip plant

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Application publication date: 20171128