CN107375489A - A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology - Google Patents
A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology Download PDFInfo
- Publication number
- CN107375489A CN107375489A CN201710739131.5A CN201710739131A CN107375489A CN 107375489 A CN107375489 A CN 107375489A CN 201710739131 A CN201710739131 A CN 201710739131A CN 107375489 A CN107375489 A CN 107375489A
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- Prior art keywords
- tangerine leaf
- spray
- fresh
- crude slice
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh squeezing spray-dried powders medicine materical crude slice of tangerine leaf and its preparation technology.The technique is cleaned, eluted after the harvesting of tangerine leaf medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried；Condensate liquid separation volatile oil is concentrated, and is mixed with spray-dried product, sieving pack.Tangerine leaf powder decoction pieces prepared by this method, remain the active ingredient in medicinal material to greatest extent.Medicine materical crude slice is easy to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine tangerine leaf medicine materical crude slice.
Background technology
Chinese medicine tangerine leaf is rutaceae tangerineCitrus reticulataBlanco drying blade.This product, which has, dredges
Liver, promoting the circulation of qi, resolving sputum, subside a swelling the effect of malicious.The treatment of hypochondriac pain, lung carbuncle, hernia etc. can be treated.
The processing mode of conventional tangerine leaf medicine materical crude slice is：Impurity is removed after harvesting, is dried, packing storage and transport.In such
Medicine medicine materical crude slice, it is bulky, easily pollute and go mouldy, hygiene condition is poor, quality it is difficult to ensure that, be unfavorable for formula adjust and ensure
Its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of tangerine leaf medicinal material.Because prepared by granule pieces
During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Come.Further, since the tangerine leaf medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of tangerine leaf medicinal material is effective, steady quality, a kind of new tangerine leaf medicine materical crude slice and its preparation technology are urgently
It is to be developed.
The content of the invention
The invention discloses " a kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology ".This technique can be most
Polarity and nonpolar active ingredient in the reservation tangerine leaf medicinal material of limits, medicinal material is avoided in the processing of existing medicine materical crude slice and accumulating
The decline of the loss of caused active ingredient and medical material quanlity in journey, pollution of the medicinal material by mould etc. is reduced, to ensuring that tangerine leaf is drunk
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
After tangerine leaf harvesting, clean, wash, take advantage of fresh pressure extracting juice, the dregs of a decoction add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, sheet frame
Filter press press filtration, the gained dregs of a decoction press extracting juice again, merge concoction and with 80 ~ 200 mesh sieve net filtrations.By the decoction of gained, 40 ~ 80
DEG C it is concentrated under reduced pressure, the concentrate that resulting relative density is 1.02 ~ 1.10 is spray-dried, intake air temperature is 90 ~
120 DEG C, air outlet temperature is 70 ~ 100 DEG C.Collect spray drying product and crush.Collect the tangerine leaf condensation of the above-mentioned gained that is concentrated under reduced pressure
Water, add 1% ~ 5% weight NaCl, be stirred to dissolve, solution is put in oil water separator, under 4 DEG C ~ 10 DEG C environment place 12 ~
48 hours, top oil reservoir is collected, and be charged with the anhydrous Na of 1% ~ 5% weight2SO4, after shaking 5 ~ 10min clocks, less than 25 DEG C
Room temperature is placed 1 ~ 6 hour, filtering, obtains tangerine leaf volatile oil.The volatile oil that this is eliminated to moisture mixes with tangerine leaf spray dried powder
Uniformly, 40 ~ 100 mesh sieves are crossed, vacuum packaging, produce the fresh squeezing spray-dried powders medicine materical crude slice of tangerine leaf.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of tangerine leaf is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Fresh tangerine leaf medicinal material clean washing after directly squeeze, filter, be concentrated under reduced pressure, being spray-dried, separate volatile oil, spray powder and
Volatile oil mixes, and resulting powder decoction pieces, can completely retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice
Volume greatly reduces compared to traditional medicine materical crude slice volume, and quality is more stable, beneficial to accumulating and clinical adjustment, has very notable
Social effect and economic implications.
Embodiment
Embodiment 1
By the tangerine leaf medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, take juice.The gained dregs of a decoction add 2 times of amounts
Drinking water, stir 20min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction squeeze concoction with squeezer again.By above-mentioned 3 medicines
Juice merges, and is concentrated under reduced pressure, temperature is set as 65 DEG C.When concentrate relative density is 1.05, it is spray-dried, intake air temperature is
110 DEG C, air outlet temperature is 80 DEG C, collects dried object and crushes.In addition, the tangerine leaf condensed water that will be collected when being concentrated under reduced pressure, adds
Enter the NaCl of weight 5%, be stirred to dissolve.This solution is positioned in oil water separator, and standing 24 is small in 10 DEG C of environment
When, separate and collect upper strata volatile oil.The anhydrous Na of 2% weight is added into this volatile oil2SO4, shake 10min clocks after, 25 DEG C with
Lower room temperature is placed 6 hours, filtering, obtains tangerine leaf volatile oil.This volatile oil is well mixed with above-mentioned tangerine leaf spray-dried product, crosses 60
Mesh sieve, pack, 1kg/ bags add packed antioxidant and drier, Vacuum Package, and labeling is got product.
Embodiment 2
By the tangerine leaf medicinal material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, take juice.The gained dregs of a decoction add 3 times of amounts
Drinking water, stir 30min, plate and frame filter press pressure extracting juice.The gained dregs of a decoction squeeze concoction with squeezer again.By above-mentioned 3 medicines
Juice merges, and is concentrated under reduced pressure, temperature is set as 60 DEG C.When concentrate relative density is 1.10, it is spray-dried, intake air temperature is
120 DEG C, air outlet temperature is 90 DEG C, collects dried object and crushes.In addition, the tangerine leaf condensed water that will be collected when being concentrated under reduced pressure, adds
Enter the NaCl of weight 3%, be stirred to dissolve.This solution is positioned in oil water separator, and standing 12 is small in 10 DEG C of environment
When, separate and collect upper strata volatile oil.The anhydrous Na of 5% weight is added into this volatile oil2SO4, after shaking 5min clocks, less than 25 DEG C
Room temperature is placed 4 hours, filtering, obtains tangerine leaf volatile oil.This volatile oil is well mixed with above-mentioned tangerine leaf spray-dried product, crosses 80 mesh
Sieve, pack, 1kg/ bags add packed antioxidant and drier, Vacuum Package, and labeling is got product.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (3)
1. a kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：After tangerine leaf harvesting, clean,
Washing, fresh pressure extracting juice is taken advantage of, the dregs of a decoction add the water of 1 ~ 3 times of amount, stir 5 ~ 30min, plate and frame filter press press filtration, and the gained dregs of a decoction are pressed again
Extracting juice, merge concoction and with 80 ~ 200 mesh sieve net filtrations.
2. a kind of tangerine leaf according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
By the decoction of gained in claim 1,40 ~ 80 DEG C are concentrated under reduced pressure, and the concentrate spraying that gained relative density is 1.02 ~ 1.10 is dry
Dry, intake air temperature is 90 ~ 120 DEG C, and air outlet temperature is 70 ~ 100 DEG C, collects spray drying product and crushes.
3. a kind of tangerine leaf according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：
The tangerine leaf condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of 1% ~ 5% weight is added, is stirred to dissolve, solution
Put in oil water separator, placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with 1% ~ 5% weight
The anhydrous Na of amount2SO4, after shaking 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain tangerine leaf volatile oil, and will
It wants the tangerine leaf spray dried powder in 2 to be well mixed with right, crosses 40 ~ 100 mesh sieves, vacuum packaging, produces fresh squeeze of tangerine leaf and spray
Dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739131.5A CN107375489A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739131.5A CN107375489A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375489A true CN107375489A (en) | 2017-11-24 |
Family
ID=60346961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739131.5A Pending CN107375489A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
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| Country | Link |
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| CN (1) | CN107375489A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213473A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213475A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213474A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105520986A (en) * | 2016-02-11 | 2016-04-27 | 徐自升 | Folium artemisiae argyi fresh juice spray-dried decoction powder and preparation process thereof |
| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
-
2017
- 2017-08-25 CN CN201710739131.5A patent/CN107375489A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213473A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213475A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213474A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Menthae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105520986A (en) * | 2016-02-11 | 2016-04-27 | 徐自升 | Folium artemisiae argyi fresh juice spray-dried decoction powder and preparation process thereof |
| CN105560365A (en) * | 2016-02-11 | 2016-05-11 | 徐自升 | Spray-dried particle decoction piece prepared from freshly-squeezed perilla leaves and preparing technology thereof |
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Application publication date: 20171124 |