CN107485660A - A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology - Google Patents
A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107485660A CN107485660A CN201710740160.3A CN201710740160A CN107485660A CN 107485660 A CN107485660 A CN 107485660A CN 201710740160 A CN201710740160 A CN 201710740160A CN 107485660 A CN107485660 A CN 107485660A
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- freeze
- tangerine leaf
- concoction
- crude slice
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses a kind of fresh squeezing freeze-dried powder medicine materical crude slice of tangerine leaf and its preparation technology.The technique is cleaned, eluted after the harvesting of tangerine leaf medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Meanwhile condensate liquid separation volatile oil is concentrated, and mixed with freeze-drying thing, sieving pack.Tangerine leaf powder decoction pieces prepared by this method, remain the active ingredient in medicinal material to greatest extent.Medicine materical crude slice is easy to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
Invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine tangerine leaf medicine materical crude slice.
Background technology
Chinese medicine tangerine leaf is rutaceae tangerineCitrus reticulataBlanco drying blade.This product, which has, dredges
Liver, promoting the circulation of qi, resolving sputum, subside a swelling the effect of malicious.The treatment of hypochondriac pain, lung carbuncle, hernia etc. can be treated.
The processing mode of conventional tangerine leaf medicine materical crude slice is：Impurity is removed after harvesting, is dried, packing storage and transport.In such
Medicine medicine materical crude slice, it is bulky, easily pollute and go mouldy, hygiene condition is poor, quality it is difficult to ensure that, be unfavorable for formula adjust and ensure
Its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of tangerine leaf medicinal material.Because prepared by granule pieces
During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Come.Further, since the tangerine leaf medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of tangerine leaf medicinal material is effective, steady quality, a kind of new tangerine leaf medicine materical crude slice and its preparation technology are urgently
It is to be developed.
The content of the invention
The invention discloses " a kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology ".This technique can be most
Polarity and nonpolar active ingredient in the reservation tangerine leaf medicinal material of limits, medicinal material is avoided in the processing of existing medicine materical crude slice and accumulating
The decline of the loss of caused active ingredient and medical material quanlity in journey, pollution of the medicinal material by mould etc. is reduced, to ensuring that tangerine leaf is drunk
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
After tangerine leaf harvesting, after tangerine leaf is harvested, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir
Mix 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, institute
The surplus dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh sieve mistakes twice
Filter, obtains tangerine leaf concoction.By the tangerine leaf concoction of gained, 40 ~ 65 DEG C are concentrated under reduced pressure, and gained relative density is 1.05 ~ 1.30 medicinal extract
Freeze in -20 ~ -80 DEG C of refrigerators 6 ~ 24 hours, be then freeze-dried, vacuum is 0.06 ~ 0.09MPa, and temperature is -20
~ -40 DEG C, freeze-drying time is 12 ~ 48 hours, takes out and crushes, vacuum packaging, produces the fresh squeezing freeze-dried powder medicine materical crude slice of tangerine leaf.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of tangerine leaf is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Directly segment is squeezed, filtered, being concentrated under reduced pressure, being freeze-dried, separating oil and will volatilization after fresh tangerine leaf medicinal material cleans washing
Oil mixes with freeze-drying thing, resulting powder decoction pieces, can completely retain the active ingredient in medicinal material to greatest extent.
This medicine materical crude slice volume greatly reduces compared to traditional medicine materical crude slice volume, and quality is more stable, beneficial to accumulating and clinical adjustment, has
Very significant social effect and economic implications.
Embodiment
Embodiment 1
By the tangerine leaf medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 5 times of amounts, stir 5min, press extracting juice, and the remaining dregs of a decoction add 3 times of amounts
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 mesh screens, obtain tangerine leaf concoction.Depressurized dense
Contracting, temperature are set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, puts after freezing 8 hours in -80 DEG C, take out, it is cold
Dry, pressure 0.09Mpa is freezed, temperature is -40 DEG C, and the time is 24 hours.Lyophilized products are taken out, cryogrinding crushes, and crosses 60 mesh
Sieve, Vacuum Package, labeling are got product.
Embodiment 2
By the tangerine leaf medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 30 minutes, take advantage of
Fresh squeezing, collect and just squeeze concoction, the dregs of a decoction add the water of 4 times of amounts, stir 10min, press extracting juice, and the remaining dregs of a decoction add 3 times of amounts
Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain tangerine leaf concoction.Depressurized dense
Contracting, temperature are set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.15, puts after freezing 8 hours in -80 DEG C, take out, it is cold
Dry, pressure 0.09Mpa is freezed, temperature is -40 DEG C, and the time is 24 hours.Lyophilized products are taken out, cryogrinding crushes, and crosses 60 mesh
Sieve, Vacuum Package, labeling are got product.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
1. a kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, it is characterised in that：After tangerine leaf is harvested, clean,
1 ~ 2cm section is cut into, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, is stirred 15 ~ 30 minutes, takes advantage of fresh squeezing, collects and just squeezes concoction,
The dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice,
Merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain tangerine leaf concoction.
2. a kind of tangerine leaf according to claim 1 is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, it is characterised in that：
By in claim 1 gained tangerine leaf concoction, 40 ~ 65 DEG C are concentrated under reduced pressure, gained relative density be 1.05 ~ 1.30 medicinal extract in-
To freeze in 20 ~ -80 DEG C of refrigerators 6 ~ 24 hours, be then freeze-dried, vacuum is 0.06 ~ 0.09MPa, temperature is -20 ~ -
40 DEG C, freeze-drying time is 12 ~ 48 hours, takes out and crushes, vacuum packaging, produces the fresh squeezing freeze-dried powder medicine materical crude slice of tangerine leaf.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710740160.3A CN107485660A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710740160.3A CN107485660A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107485660A true CN107485660A (en) | 2017-12-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710740160.3A Pending CN107485660A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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| CN (1) | CN107485660A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213661A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105687280A (en) * | 2016-02-11 | 2016-06-22 | 徐自升 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
| CN105998395A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Herba Verbenae freshly squeezed freeze drying powder decoction piece and preparation technology thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710740160.3A patent/CN107485660A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213661A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105687280A (en) * | 2016-02-11 | 2016-06-22 | 徐自升 | Freshly-squeezed freeze-dried Artemisia annua powder decoction pieces and preparation technology thereof |
| CN105998395A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Herba Verbenae freshly squeezed freeze drying powder decoction piece and preparation technology thereof |
| CN106236868A (en) * | 2016-07-31 | 2016-12-21 | 徐漫 | A kind of Herba Potentillae Discoloris fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171219 |
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| WD01 | Invention patent application deemed withdrawn after publication |