CN107334849A - A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology - Google Patents
A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology Download PDFInfo
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- CN107334849A CN107334849A CN201710739135.3A CN201710739135A CN107334849A CN 107334849 A CN107334849 A CN 107334849A CN 201710739135 A CN201710739135 A CN 201710739135A CN 107334849 A CN107334849 A CN 107334849A
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- Prior art keywords
- tangerine leaf
- fresh
- vacuum drying
- squeeze
- concoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh squeeze of tangerine leaf to be dried in vacuo powder decoction pieces and its preparation technology.The technique is cleaned, eluted after the harvesting of tangerine leaf medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is dried in vacuo；Condensate liquid separation volatile oil is concentrated, and is mixed with vacuum drying thing, sieving pack.Tangerine leaf powder decoction pieces prepared by this method, remain the active ingredient in medicinal material to greatest extent.Medicine materical crude slice is easy to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine tangerine leaf medicine materical crude slice.
Background technology
Chinese medicine tangerine leaf is rutaceae tangerineCitrus reticulataBlanco drying blade.This product, which has, dredges
Liver, promoting the circulation of qi, resolving sputum, subside a swelling the effect of malicious.The treatment of hypochondriac pain, lung carbuncle, hernia etc. can be treated.
The processing mode of conventional tangerine leaf medicine materical crude slice is：Impurity is removed after harvesting, is dried, packing storage and transport.In such
Medicine medicine materical crude slice, it is bulky, easily pollute and go mouldy, hygiene condition is poor, quality it is difficult to ensure that, be unfavorable for formula adjust and ensure
Its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of tangerine leaf medicinal material.Because prepared by granule pieces
During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Come.Further, since the tangerine leaf medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient
It is very big.In order to ensure the clinic of tangerine leaf medicinal material is effective, steady quality, a kind of new tangerine leaf medicine materical crude slice and its preparation technology are urgently
It is to be developed.
The content of the invention
The invention discloses " a kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology ".This technique can be most
Polarity and nonpolar active ingredient in the reservation tangerine leaf medicinal material of limits, medicinal material is avoided in the processing of existing medicine materical crude slice and accumulating
The decline of the loss of caused active ingredient and medical material quanlity in journey, pollution of the medicinal material by mould etc. is reduced, to ensuring that tangerine leaf is drunk
The steady quality and clinical safety of piece effectively have great importance.
To achieve these goals, the technical scheme is that：
After tangerine leaf is harvested, clean, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stirring 15 ~ 30
Minute, fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction
Add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain
Tangerine leaf concoction.The concoction that will be filtered, be concentrated under reduced pressure in 40 ~ 65 DEG C, obtain relative density be 1.05 ~ 1.30 medicinal extract in 40 ~ 60
DEG C vacuum drying 4 ~ 8 hours after crush.Meanwhile the tangerine leaf condensed water for the gained that is concentrated under reduced pressure is collected, add 1% ~ 5% weight
NaCl, it is stirred to dissolve.This solution is positioned in oil water separator, 12 ~ 48 hours are stood under 4 DEG C ~ 10 DEG C environment.Separation
And top oil reservoir is collected, it is charged with the anhydrous Na of 1% ~ 5% weight2SO4, after shaking 5 ~ 10min clocks, less than 25 DEG C room temperatures are put
Put 1 ~ 6 hour, filter, obtain tangerine leaf volatile oil.The tangerine leaf volatile oil that this is eliminated to moisture is dried in vacuo powder with above-mentioned tangerine leaf
It is well mixed, 40 ~ 100 mesh sieves are crossed, vacuum packaging, fresh squeeze of tangerine leaf is produced and is dried in vacuo powder decoction pieces.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of tangerine leaf is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Fresh tangerine leaf medicinal material directly squeezes after cleaning washing, filters, is concentrated under reduced pressure, being dried in vacuo, separating oil, mixing, resulting
Powder decoction pieces, can completely retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is compared to traditional medicine materical crude slice
Volume greatly reduces, and quality is more stable, is adjusted beneficial to accumulating and clinic, has very significant social effect and economic meaning
Justice.
Embodiment
Embodiment 1
By the tangerine leaf medicinal material of fresh collection, clean, with water wash, be cut into the wide pieces of 1cm, add the water of 0.5 times of amount of medicinal material weight,
Stirring 15 minutes, takes advantage of fresh squeezing.The gained dregs of a decoction add the drinking water of 2 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.Gained
The dregs of a decoction squeeze concoction with squeezer again.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 65 DEG C.In leaching obtained by concentration
When cream relative density is 1.15, it is transferred in vacuum drying chamber, is dried 6 hours in 60 DEG C, obtain vacuum drying thing.In addition, it will subtract
The tangerine leaf condensed water collected during pressure concentration, adds the NaCl of weight 5%, is stirred to dissolve.This solution is positioned over oil water separator
In, and 24 hours are stood in 10 DEG C of environment, separate and collect upper strata volatile oil.The anhydrous of 2% weight is added into this volatile oil
Na2SO4, after shaking 10min clocks, less than 25 DEG C room temperatures are placed 6 hours, filtering, obtain tangerine leaf volatile oil.By this volatile oil with it is above-mentioned
Tangerine leaf vacuum drying thing is well mixed, and is crossed 60 mesh sieves, pack, 1kg/ bags, is added packed antioxidant and drier, vacuum seal
Dress, labeling are got product.
Embodiment 2
By the tangerine leaf medicinal material of fresh collection, clean, with water wash, be cut into the wide pieces of 2cm, add the water of 1 times of amount of medicinal material weight, stir
Mix 30 minutes, take advantage of fresh squeezing.The gained dregs of a decoction add the drinking water of 3 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.Gained medicine
Slag squeezes concoction with squeezer again.Above-mentioned 3 concoctions are merged, are concentrated under reduced pressure, temperature is set as 60 DEG C.In medicinal extract obtained by concentration
When relative density is 1.10, it is transferred in vacuum drying chamber, is dried 8 hours in 60 DEG C, obtain vacuum drying thing.In addition, will decompression
The tangerine leaf condensed water collected during concentration, the NaCl of weight 3% is added, is stirred to dissolve.This solution is positioned over oil water separator
In, and 24 hours are stood in 10 DEG C of environment, separate and collect upper strata volatile oil.The anhydrous of 5% weight is added into this volatile oil
Na2SO4, after shaking 5min clocks, less than 25 DEG C room temperatures are placed 12 hours, filtering, obtain tangerine leaf volatile oil.By this volatile oil with it is above-mentioned
Tangerine leaf vacuum drying thing is well mixed, and is crossed 80 mesh sieves, pack, 1kg/ bags, is added packed antioxidant and drier, vacuum seal
Dress, labeling are got product.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (3)
1. a kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology, it is characterised in that：After tangerine leaf is harvested, clean,
The wide pieces of 1 ~ 2cm are cut into, add the water of 0.5 ~ 1 times of amount of medicinal material weight, are stirred 15 ~ 30 minutes, take advantage of fresh squeezing, collects and just squeezes medicine
Juice, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, and the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, and squeezing takes
Juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain tangerine leaf concoction.
2. a kind of tangerine leaf according to claim 1 is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology, it is characterised in that：
By the concoction of gained in claim 1,40 ~ 65 DEG C are concentrated under reduced pressure, and the medicinal extract that gained relative density is 1.05 ~ 1.30 is in 40 ~ 60
DEG C vacuum drying 4 ~ 8 hours after crush.
3. a kind of tangerine leaf according to claim 1 is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology, it is characterised in that：
The tangerine leaf condensed water of the gained that is concentrated under reduced pressure in claim 2 is collected, the NaCl of 1% ~ 5% weight is added, is stirred to dissolve, solution
Put in oil water separator, placed 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and be charged with 1% ~ 5% weight
The anhydrous Na of amount2SO4, after shaking 5 ~ 10min clocks, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filtering, obtain tangerine leaf volatile oil, and will
It wants the tangerine leaf vacuum drying powder in 2 to be well mixed with right, crosses 40 ~ 100 mesh sieves, vacuum packaging, produces the fresh squeezing vacuum of tangerine leaf
Dried powder medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739135.3A CN107334849A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739135.3A CN107334849A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107334849A true CN107334849A (en) | 2017-11-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739135.3A Pending CN107334849A (en) | 2017-08-25 | 2017-08-25 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
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| Country | Link |
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| CN (1) | CN107334849A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105520987A (en) * | 2016-02-11 | 2016-04-27 | 徐自升 | Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof |
| CN105596417A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae vacuum-dried powder decoction pieces and preparation technology thereof |
| CN105998136A (en) * | 2016-07-23 | 2016-10-12 | 徐自升 | Honeysuckle freshly-squeezed freeze drying powder decoction pieces and preparation process thereof |
| CN106074686A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN107050113A (en) * | 2017-06-19 | 2017-08-18 | 徐漫 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
-
2017
- 2017-08-25 CN CN201710739135.3A patent/CN107334849A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105520987A (en) * | 2016-02-11 | 2016-04-27 | 徐自升 | Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof |
| CN105596417A (en) * | 2016-02-11 | 2016-05-25 | 徐自升 | Freshly squeezed herba periliae vacuum-dried powder decoction pieces and preparation technology thereof |
| CN105998136A (en) * | 2016-07-23 | 2016-10-12 | 徐自升 | Honeysuckle freshly-squeezed freeze drying powder decoction pieces and preparation process thereof |
| CN106074686A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN107050113A (en) * | 2017-06-19 | 2017-08-18 | 徐漫 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171110 |
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| WD01 | Invention patent application deemed withdrawn after publication |