CN105520987A - Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof - Google Patents
Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof Download PDFInfo
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- CN105520987A CN105520987A CN201610083518.5A CN201610083518A CN105520987A CN 105520987 A CN105520987 A CN 105520987A CN 201610083518 A CN201610083518 A CN 201610083518A CN 105520987 A CN105520987 A CN 105520987A
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- folium artemisiae
- artemisiae argyi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Microbiology (AREA)
- Medical Informatics (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses folium artemisiae argyi fresh juice vacuum-dried decoction powder and a preparation process thereof. The process comprises the following steps: cleaning, selecting and leaching harvested folium artemisiae argyi medicinal materials, squeezing the medicinal materials when the medicinal materials are still fresh, filtering and reserving medicine juice; stirring medicine dregs in water once again, filtering and squeezing; combining obtained medicine juice, decompressing and concentrating, and vacuum-drying; and separating volatile oil from concentrated condensate, mixing the volatile oil with the vacuum-dried material, sieving and bagging. The folium artemisiae argyi decoction powder prepared by the method can reserve active ingredients in the medicinal materials to the greatest extent. The decoction powder is convenient for storage and transportation, convenient for blending, controllable in quality and reliable in treatment effect, and the decoction powder has an important significance for guaranteeing the clinical treatment effect of traditional Chinese medicine. The method, with popularization and implementation, can bring about apparent social significance and economical benefits.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Folium Artemisiae Argyi decoction pieces.
Background technology
Chinese medicine Folium Artemisiae Argyi is feverfew Chinese mugwort
artemisiaargyilevl.EtVant. dried leaves.This product warming the meridian for stopping bleeding, dispersing cold for relieving pain, external removing dampness to relieve itching.Be mainly used in haematemesis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, the treatment of the infertile grade of cold womb.
The processing mode of conventional Folium Artemisiae Argyi decoction pieces is: pluck when summer, flower was not opened, and removing impurity, dries, packing storage and transport.These type of prepared slices of Chinese crude drugs, bulky, easily pollute and go mouldy, hygiology condition is poor, and quality is difficult to ensure, is unfavorable for that formula is adjusted and guarantees its clinical efficacy.
At present, granule pieces market also having Folium Artemisiae Argyi medical material to make after extracting is sold.Due in granule pieces preparation process, extract not only time consumption and energy consumption, and do solvent because commonly using water, the nonpolar effective ingredient in medical material is difficult to be extracted.In addition, because the Folium Artemisiae Argyi medical material extracted also is dry also through long-time storage, therefore, the loss of effective ingredient is also very large.In order to ensure clinical effective, the steady quality of Folium Artemisiae Argyi medical material, a kind of novel Folium Artemisiae Argyi decoction pieces and preparation technology thereof urgently develop.
Summary of the invention
The present invention discloses " a kind of Folium Artemisiae Argyi fresh squeezing vacuum drying powder decoction pieces and preparation technology thereof ".This technique can retain polarity in Folium Artemisiae Argyi medical material and nonpolar effective ingredient to greatest extent, the loss of effective ingredient avoiding medical material to cause in existing decoction pieces processing and storage and transport process and the decline of medical material quanlity, reduce the pollution of medical material by mycete etc., the steady quality and clinical safety guaranteeing Folium Artemisiae Argyi decoction pieces is effectively had great importance.
To achieve these goals, technical scheme of the present invention is:
After being gathered by Folium Artemisiae Argyi, clean, washing, take advantage of fresh squeezing extracting juice, medicinal residues add the water of 1 ~ 3 times amount, and stir 5 ~ 30min, filter press filter pressing, gained medicinal residues squeeze extracting juice again, merge medicine juice and filter with 80 ~ 200 eye mesh screens.By the medicinal liquid filtered, in 40 ~ 65 DEG C of concentrating under reduced pressure, obtain relative density be 1.05 ~ 1.30 extractum pulverize after 4 ~ 8 hours in 40 ~ 60 DEG C of vacuum dryings.Meanwhile, collect the Folium Artemisiae Argyi condensed water of concentrating under reduced pressure gained, add the NaCl of 1% ~ 5% weight, be stirred to dissolve.This solution is positioned in oil water separator, under 4 DEG C ~ 10 DEG C environment, leaves standstill 12 ~ 48 hours.Be separated and collect top oil reservoir, toward the anhydrous Na wherein adding 1% ~ 5% weight
2sO
4, after jolting 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Folium Artemisiae Argyi volatile oil.The Folium Artemisiae Argyi volatile oil this being eliminated moisture is mixed homogeneously with above-mentioned Folium Artemisiae Argyi vacuum drying powder, and cross 40 ~ 100 mesh sieves, vacuum packaging, obtains Folium Artemisiae Argyi fresh squeezing vacuum drying powder decoction pieces.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, manufacturer, date of manufacture, Contents of Main Components, meridian distribution of property and flavor, function cure mainly, the information such as usage and dosage, toxic and side effects and contraindication.TLC distinguish collection of illustrative plates and/or the high-efficient liquid phase character collection of illustrative plates of Folium Artemisiae Argyi is enclosed, as " identity card " of product in bag.In addition, in the packaging bag of product, be printed on Quick Response Code, the information such as former plant photo, medical material photo, decoction pieces photo, character and the microscopical identification feature obtaining product can be linked by scanning.
Usefulness of the present invention is:
Fresh Folium Artemisiae Argyi medical material cleans directly squeezing after washing, filtration, concentrating under reduced pressure, vacuum drying, separating oil, mixing, the powder decoction pieces obtained, can effective ingredient to greatest extent in complete reservation medical material.This decoction pieces volume compares to traditional decoction pieces volume and reduces widely, and quality is more stable, is beneficial to accumulating and clinical adjustment, has very significant social meaning and economic implications.
Detailed description of the invention
Embodiment 1
By the Folium Artemisiae Argyi medical material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, extracting juice.Gained medicinal residues add the drinking water of 2 times amount, stir 20min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine juice with squeezer again.Merged by above-mentioned 3 medicine juice, concentrating under reduced pressure, temperature is set as 65 DEG C.When concentrated gained extractum relative density is 1.15, transfers in vacuum drying oven, in 60 DEG C of dryings 6 hours, obtain vacuum drying thing.In addition, by the Folium Artemisiae Argyi condensed water collected during concentrating under reduced pressure, add the NaCl of weight 5%, be stirred to dissolve.This solution is positioned in oil water separator, and in 10 DEG C of environment, leaves standstill 24 hours, separated and collected upper strata volatile oil.The anhydrous Na of 2% weight is added in this volatile oil
2sO
4, after jolting 10min clock, less than 25 DEG C room temperatures place 6 hours, filter, obtain Folium Artemisiae Argyi volatile oil.Mixed homogeneously with above-mentioned Folium Artemisiae Argyi vacuum drying thing by this volatile oil, cross 60 mesh sieves, pack, 1kg/ bag, add packed antioxidant and desiccant, Vacuum Package, labeling gets product.
Embodiment 2
By the Folium Artemisiae Argyi medical material of fresh collection, clean, with water wash, take advantage of the squeezing of using fresh herb squeezer, extracting juice.Gained medicinal residues add the drinking water of 3 times amount, stir 30min, filter press squeezing extracting juice.Gained medicinal residues squeeze medicine juice with squeezer again.Merged by above-mentioned 3 medicine juice, concentrating under reduced pressure, temperature is set as 60 DEG C.When concentrated gained extractum relative density is 1.10, transfers in vacuum drying oven, in 60 DEG C of dryings 8 hours, obtain vacuum drying thing.In addition, by the Folium Artemisiae Argyi condensed water collected during concentrating under reduced pressure, add the NaCl of weight 3%, be stirred to dissolve.This solution is positioned in oil water separator, and leaves standstill 24 hours in 10 DEG C of environment, separated and collected upper strata volatile oil.The anhydrous Na of 5% weight is added in this volatile oil
2sO
4, after jolting 5min clock, less than 25 DEG C room temperatures place 12 hours, filter, obtain Folium Artemisiae Argyi volatile oil.Mixed homogeneously with above-mentioned Folium Artemisiae Argyi vacuum drying thing by this volatile oil, cross 80 mesh sieves, pack, 1kg/ bag, add packed antioxidant and desiccant, Vacuum Package, labeling gets product.
Above embodiment, is only the technological thought that this invention is described, can not limit the every technological thought proposed according to the present invention of protection scope of the present invention whereby, any change that technical scheme basis is done, all falls within the scope of protection of the invention.
Claims (3)
1. a Folium Artemisiae Argyi fresh squeezing vacuum drying powder decoction pieces and preparation technology thereof, it is characterized in that: after Folium Artemisiae Argyi is gathered, clean, after washing, take advantage of fresh squeezing extracting juice, medicinal residues add the water of 1 ~ 3 times amount, stir 5 ~ 30min, filter press filter pressing, gained medicinal residues squeeze extracting juice again, merge medicine juice and filter with 80 ~ 200 eye mesh screens.
2. a kind of Folium Artemisiae Argyi fresh squeezing vacuum drying powder decoction pieces according to claim 1 and preparation technology thereof, it is characterized in that: by the medicinal liquid of gained in claim 1,40 ~ 65 DEG C of concentrating under reduced pressure, gained relative density be 1.05 ~ 1.30 extractum pulverize after 4 ~ 8 hours in 40 ~ 60 DEG C of vacuum dryings.
3. a kind of Folium Artemisiae Argyi fresh squeezing vacuum drying powder decoction pieces according to claim 1 and preparation technology thereof, it is characterized in that: the Folium Artemisiae Argyi condensed water collecting the concentrating under reduced pressure gained in claim 2, add the NaCl of 1% ~ 5% weight, be stirred to dissolve, solution is put in oil water separator, place 12 ~ 48 hours under 4 DEG C ~ 10 DEG C environment, collect top oil reservoir, and toward wherein adding the anhydrous Na of 1% ~ 5% weight
2sO
4, after jolting 5 ~ 10min clock, less than 25 DEG C room temperatures are placed 1 ~ 6 hour, filter, obtain Folium Artemisiae Argyi volatile oil, and itself and right are wanted the Folium Artemisiae Argyi vacuum drying powder in 2 to mix homogeneously, and cross 40 ~ 100 mesh sieves, vacuum packaging, obtains Folium Artemisiae Argyi fresh squeezing vacuum drying powder decoction pieces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610083518.5A CN105520987A (en) | 2016-02-11 | 2016-02-11 | Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610083518.5A CN105520987A (en) | 2016-02-11 | 2016-02-11 | Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof |
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| CN105520987A true CN105520987A (en) | 2016-04-27 |
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| CN201610083518.5A Pending CN105520987A (en) | 2016-02-11 | 2016-02-11 | Folium artemisiae argyi fresh juice vacuum-dried decoction powder and preparation process thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074687A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
| CN107157938A (en) * | 2017-06-19 | 2017-09-15 | 徐漫 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
| CN107334849A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
| CN107375396A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of fringed pink |
| CN107441137A (en) * | 2017-08-25 | 2017-12-08 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of tussilago |
| CN107456473A (en) * | 2017-08-25 | 2017-12-12 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of gerbera |
| CN107485695A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lophatherum gracile |
| CN107485667A (en) * | 2017-08-25 | 2017-12-19 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of bittersweet |
| CN107485633A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of folium artemisiae argyi |
Citations (3)
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|---|---|---|---|---|
| JPH07206839A (en) * | 1994-01-20 | 1995-08-08 | Japan Tobacco Inc | New sesquiterpene lactone a or b, and antitumor agent containing artemisia argyi levl. et vant. compositae extract or sesquiterpene lactone a, b or c as active ingredient |
| CN102813037A (en) * | 2012-08-30 | 2012-12-12 | 安徽农业大学 | Making method of folium artemisiae argyi tea |
| CN105193920A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed vacuum drying peppermint powdery decoction pieces and preparation process thereof |
-
2016
- 2016-02-11 CN CN201610083518.5A patent/CN105520987A/en active Pending
Patent Citations (3)
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| JPH07206839A (en) * | 1994-01-20 | 1995-08-08 | Japan Tobacco Inc | New sesquiterpene lactone a or b, and antitumor agent containing artemisia argyi levl. et vant. compositae extract or sesquiterpene lactone a, b or c as active ingredient |
| CN102813037A (en) * | 2012-08-30 | 2012-12-12 | 安徽农业大学 | Making method of folium artemisiae argyi tea |
| CN105193920A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed vacuum drying peppermint powdery decoction pieces and preparation process thereof |
Non-Patent Citations (1)
| Title |
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| 胡小勤等: "《中药学》", 31 January 2014, 西安交通大学出版社 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074687A (en) * | 2016-07-31 | 2016-11-09 | 徐漫 | A kind of Rabdosia rubescens is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
| CN107157938A (en) * | 2017-06-19 | 2017-09-15 | 徐漫 | A kind of Flos Magnoliae Liliflorae is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
| CN107334849A (en) * | 2017-08-25 | 2017-11-10 | 芜湖天成普阳中药科技有限公司 | A kind of tangerine leaf is fresh to squeeze vacuum drying powder decoction pieces and its preparation technology |
| CN107375396A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of fringed pink |
| CN107441137A (en) * | 2017-08-25 | 2017-12-08 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of tussilago |
| CN107456473A (en) * | 2017-08-25 | 2017-12-12 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of gerbera |
| CN107485695A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lophatherum gracile |
| CN107485667A (en) * | 2017-08-25 | 2017-12-19 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of bittersweet |
| CN107485633A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of folium artemisiae argyi |
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Application publication date: 20160427 |
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