CN105998130A - Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof - Google Patents
Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof Download PDFInfo
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- CN105998130A CN105998130A CN201610583101.5A CN201610583101A CN105998130A CN 105998130 A CN105998130 A CN 105998130A CN 201610583101 A CN201610583101 A CN 201610583101A CN 105998130 A CN105998130 A CN 105998130A
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- Prior art keywords
- folium isatidis
- decoction pieces
- powdery
- freshly
- pressed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
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- Microbiology (AREA)
- Medical Informatics (AREA)
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- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and a preparation process thereof. The process includes: collecting Folium Isatidis, cleaning for selecting, washing by spraying, pressing when it is fresh, and filtering to obtain decoction; adding water to residue, stirring, filtering and pressing; combining decoctions, concentrating under reduced pressure, lyophilizing, collecting a lyophilized product, crushing, and packaging by vacuum. The Folium Isatidis powdery decoction pieces prepared by the process enable polar and nonpolar effective ingredients in medicinal materials to be maximally retained. The decoction pieces are easy to store and transport, easy to dose, controllable in quality and reliable in therapeutic effect and are of great significance to ensuring clinical therapeutic effect of traditional Chinese medicine. The process can be popularized to provide significant social meaning and economic benefit.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Folium Isatidis decoction pieces.
Background technology
Chinese medicine Folium Isatidis is cruciferae isatisIsatis indigotica Fort. dried leaves.Summer, autumn two
Divide in season 2 ~ 3 times and gather, remove impurity, dry.This product has heat-clearing and toxic substances removing, effect of blood cooling and ecchymoses removing, is mainly used in calentura high heat
Excessive thirst, coma, macule, spit blood, epistaxis, dysentery, erysipelas, aphtha, mumps, the treatment of sore throat etc..
The processing mode of conventional Folium Isatidis decoction pieces is: summer, season in autumn two gather, and removes impurity, dries, then accumulating of packing.
This type of prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for that formula is adjusted
With guarantee its clinical efficacy, even to patient bring recessiveness harm.
At present, granule pieces market also having Folium Isatidis medical material to make after extracting is sold.The preparation of granule pieces
Process, extracts not only time consumption and energy consumption, and because conventional substantial amounts of water does solvent, the nonpolar effective ingredient in medical material is difficult to be carried
Take out.Additionally, due to the Folium Isatidis medical material extracted also is to be dried and through long-time storage, therefore, effective ingredient
Loss is also the biggest.In order to ensure Folium Isatidis medical material clinical effectively, steady quality, a kind of novel Folium Isatidis decoction pieces and
Preparation technology urgently develops.
Summary of the invention
The invention discloses " a kind of Folium Isatidis fresh squeezing lyophilization powder decoction pieces and preparation technology thereof ".This technique is permissible
Retain the polarity in Folium Isatidis medical material and nonpolar effective ingredient to greatest extent, it is to avoid medical material is in the processing of existing decoction pieces and storage
The loss of the effective ingredient caused during fortune and the decline of medical material quanlity, reduce the medical material pollution by mycete etc., big to guaranteeing
Steady quality and the clinical safety of Folium Isatidis decoction pieces effectively have great importance.
To achieve these goals, the technical scheme is that
After Folium Isatidis is gathered, cleaning, washing, take advantage of fresh squeezing, medicinal residues add the water of 1 ~ 5 times amount, stir 5 ~ 30min, sheet frame pressure
Filter filter pressing extracting juice, remaining medicinal residues squeeze extracting juice again, merge three medicine juice, 40 ~ 120 mesh screen, obtain Folium Isatidis medicine juice.Will
To Folium Isatidis medicine juice under the conditions of 40 ~ 75 DEG C, be evaporated to the extractum that relative density is 1.05 ~ 1.25, and by this extractum
Freezing 6 ~ 24 hours, then lyophilization in-20 ~-80 DEG C of refrigerators, pressure is 0.06 ~ 0.09MPa, and temperature is-15 ~-40 DEG C,
Cooling time is 12 ~ 48 hours, after collecting lyophilized products, size-reduced, sieves, packs.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, decoction pieces manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and contraindication.Folium Isatidis is enclosed in Dai
Thin layer differentiate collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " identity card " of product.Additionally, in the packaging bag of product,
It is printed on Quick Response Code, the acquisition former plant photo of product, medical material photo, decoction pieces photo, character and micro-can be linked by scanning
The information such as diagnostic characteristics.
The invention have benefit that:
The Folium Isatidis medical material of fresh collection, directly squeeze after cleaning washing, filter, concentrating under reduced pressure, lyophilization, obtained powder
End decoction pieces, can retain the effective ingredient in medical material to greatest extent.This decoction pieces volume compares to tradition decoction pieces volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stable, and beneficially accumulating and clinic is adjusted, and has very significantly society's meaning
Justice and economic implications.
Detailed description of the invention
Embodiment 1
By the Folium Isatidis medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice.Gained medicinal residues add 3
The tap water of times amount, stirs 20min, filter press squeezing extracting juice.Remaining medicinal residues squeeze extracting juice with squeezer again.By above-mentioned
3 times medicine juice merges, and filters with 100 eye mesh screens.Filtrate reduced in volume, temperature is set as 65 DEG C.Concentrating, gained extractum is the closeest
When degree is 1.15, extractum is freezed in-80 DEG C of refrigerators 6 hours.Taking out east knot thing, lyophilization, pressure is 0.09Mpa, temperature
Degree, for-20 DEG C, is dried 24 hours.Taking out lyophilized products, low-temperature grinding, cross 80 mesh sieves, moisture is not higher than 12%, packs, 1kg/
Bag, adds packed antioxidant and desiccant, Vacuum Package, labeling.
Embodiment 2
By the Folium Isatidis medical material of fresh collection, clean, wash silt with water, take advantage of using fresh herb squeezer squeezing extracting juice.Gained medicinal residues add 5
The tap water of times amount, stirs 30min, filter press squeezing extracting juice.Remaining medicinal residues squeeze extracting juice with squeezer again.By above-mentioned
3 times medicine juice merges, and filters with 80 eye mesh screens.Filtrate reduced in volume, temperature is set as 70 DEG C.Concentrating gained extractum relative density
When being 1.10, extractum is freezed in-80 DEG C of refrigerators 8 hours.Taking out east knot thing, lyophilization, pressure is 0.08Mpa, temperature
For-40 DEG C, it is dried 48 hours.Taking out lyophilized products, low-temperature grinding, cross 60 mesh sieves, moisture is not higher than 12%, packs, 1kg/
Bag, adds packed antioxidant and desiccant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (2)
1. a Folium Isatidis fresh squeezing lyophilization powder decoction pieces and preparation technology thereof, it is characterised in that: after Folium Isatidis is gathered, only
Choosing, washing, take advantage of fresh squeezing, medicinal residues add the water of 1 ~ 5 times amount, stir 5 ~ 30min, filter press filter pressing extracting juice, remaining medicinal residues
Squeeze extracting juice again, merge three medicine juice, 40 ~ 120 mesh screen, obtain Folium Isatidis medicine juice.
A kind of Folium Isatidis fresh squeezing lyophilization powder decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Folium Isatidis medicine juice obtained is evaporated under the conditions of 40 ~ 75 DEG C the extractum that relative density is 1.05 ~ 1.25, and will
This extractum freezes 6 ~ 24 hours in-20 ~-80 DEG C of refrigerators, then lyophilization, and pressure is 0.06 ~ 0.09MPa, and temperature is-15 ~-
40 DEG C, cooling time is 12 ~ 48 hours, after collecting lyophilized products, size-reduced, sieves, packs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610583101.5A CN105998130A (en) | 2016-07-23 | 2016-07-23 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610583101.5A CN105998130A (en) | 2016-07-23 | 2016-07-23 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
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| Publication Number | Publication Date |
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| CN105998130A true CN105998130A (en) | 2016-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610583101.5A Pending CN105998130A (en) | 2016-07-23 | 2016-07-23 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106861381A (en) * | 2017-04-14 | 2017-06-20 | 明光市国星凹土有限公司 | A kind of mineral agent and preparation method with concave convex rod as carrier |
| CN107213187A (en) * | 2017-06-20 | 2017-09-29 | 徐漫 | A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107233385A (en) * | 2017-06-22 | 2017-10-10 | 徐漫 | A kind of motherwort is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107334802A (en) * | 2017-08-25 | 2017-11-10 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera |
| CN107375530A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet |
| CN107485694A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of lophatherum gracile |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213459A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213661A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
-
2016
- 2016-07-23 CN CN201610583101.5A patent/CN105998130A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213459A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213453A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213661A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105213552A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
| CN105362309A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Herba Portulacae freshly-squeezed freeze-dried powder decoction pieces and preparation process thereof |
| CN105287859A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower freeze-dried powdery decoction piece and preparation technology thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106861381A (en) * | 2017-04-14 | 2017-06-20 | 明光市国星凹土有限公司 | A kind of mineral agent and preparation method with concave convex rod as carrier |
| CN107213187A (en) * | 2017-06-20 | 2017-09-29 | 徐漫 | A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107233385A (en) * | 2017-06-22 | 2017-10-10 | 徐漫 | A kind of motherwort is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
| CN107334802A (en) * | 2017-08-25 | 2017-11-10 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of gerbera |
| CN107375530A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of bittersweet |
| CN107485694A (en) * | 2017-08-25 | 2017-12-19 | 徐自升 | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of lophatherum gracile |
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Application publication date: 20161012 |
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