CN107213187A - A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology - Google Patents
A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107213187A CN107213187A CN201710469083.2A CN201710469083A CN107213187A CN 107213187 A CN107213187 A CN 107213187A CN 201710469083 A CN201710469083 A CN 201710469083A CN 107213187 A CN107213187 A CN 107213187A
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- acalypha copperleaf
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- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a kind of fresh squeezing freeze-dried powder medicine materical crude slice of acalypha copperleaf and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of acalypha copperleaf medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is freeze-dried.Acalypha copperleaf powder decoction pieces prepared by this method, remain the polarity and nonpolar active ingredient in medicinal material to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine acalypha copperleaf medicine materical crude slice.
Background technology
Chinese medicine acalypha copperleaf is Euphorbiaceae Acalypha plantAcalyphaaustralisL. dry aerial parts.This product
With clearing heat and detoxicating, dampness removing, effect of astringing to arrest bleeding, clinic is usually used in enteritis, dysentery, haematemesis, bleeding from five sense organs or subcutaneous tissue, have blood in stool, hematuria, collapse
Leak, carbuncle furuncle sore, the treatment of dermatitis and eczema etc..
The processing mode of conventional acalypha copperleaf medicine materical crude slice is：Summer, autumn tap, and remove impurity, dry, packing storage and fortune
It is defeated.These acalypha copperleaf medicinal materials dried be transported to after prepared slices of Chinese crude drugs factory, it is necessary to clean, segment, and redry.Existing process consumes
When it is laborious, process is repeated, and adds the production cost of medicine materical crude slice.Aqueous soluble active constituent therein is not only resulted in the process
A large amount of losses, and process and such as carried out in high temperature season, easily occur medicinal material and go mouldy, thus cause the decline of medical material quanlity with
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily pollute and go mouldy, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Side and ensure its clinical efficacy.
At present, in the market also has the granule pieces sale that acalypha copperleaf medicinal material is made after extraction.Due to granule pieces system
During standby, not only time consumption and energy consumption is extracted, and is difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the acalypha copperleaf medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Mistake is also very big.In order to ensure the clinic of acalypha copperleaf medicinal material is effective, steady quality, a kind of new acalypha copperleaf medicine materical crude slice and its system
Standby technique is urgently developed.
The content of the invention
The invention discloses " a kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology ".This technique can be with
Retain the polarity and nonpolar active ingredient in acalypha copperleaf medicinal material to greatest extent, it is to avoid medicinal material is processed and stored up in existing medicine materical crude slice
The loss of active ingredient and the decline of medical material quanlity caused by during fortune, reduce pollution of the medicinal material by mould etc., to ensuring iron
The steady quality and clinical safety of three-coloured amaranth medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in acalypha copperleaf picking time, is cleaned, after washing, the section of 1 ~ 10cm length is cut into, fresh pressure extracting juice, medicine is taken advantage of
Slag adds the water of 1 ~ 5 times of amount, stirs 5 ~ 30min, and plate and frame filter press press filtration takes juice, and the dregs of a decoction press extracting juice again, merge 3 concoctions,
Juice is filtered to take with 60 ~ 120 eye mesh screens.
By the concoction of above-mentioned gained, it is concentrated under reduced pressure in 40 ~ 75 DEG C, the medicinal extract that relative density is 1.05 ~ 1.30 is obtained, by this
Medicinal extract, which is transferred in -20 ~ -80 DEG C of refrigerators, to be freezed 6 ~ 24 hours, then is freeze-dried, temperature be -15 ~ -40 DEG C, pressure be 0.06 ~
0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, and 60 ~ 100 mesh sieves, packaging are crossed after crushing.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of acalypha copperleaf is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, being printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh acalypha copperleaf medicinal material cleans direct segment after washing and squeezes, filters, being concentrated under reduced pressure, being freeze-dried resulting powder drink
Piece, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly subtracts compared to traditional medicine materical crude slice volume
Small, quality is more stablized, and is easy to accumulating and clinical adjustment, with very significant social effect and economic implications.
Embodiment
Embodiment 1
By the acalypha copperleaf medicinal material of fresh collection, clean, with water wash, be cut into the section of 5cm length, take advantage of using fresh herb squeezer pressure extracting juice.
The gained dregs of a decoction add after the running water of 2 times of amounts, stirring 20min, are taken concoction with plate and frame filter press pressure.The dregs of a decoction are squeezed with squeezer again,
Leaching concoction.The acalypha copperleaf concoction that above-mentioned 3 times are filtrated to get merges, and crosses 100 mesh sieves, and filtrate decompression concentration, temperature is set as
60℃.When medicinal extract relative density obtained by concentration is 1.10, put after freezing 24 hours in -20 DEG C of refrigerators, taking-up is freeze-dried.
Freeze temperature is set as -20 DEG C, and pressure is 0.09Mpa, and the time is 48 hours.Lyophilized products are collected, are crushed, 60 mesh sieves are crossed, packed,
1kg/ bags, add bagged dryer and antioxidant, vacuum seal, labeling.
Embodiment 2
By the acalypha copperleaf medicinal material of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of using fresh herb squeezer pressure extracting juice.
The gained dregs of a decoction add after the running water of 5 times of amounts, stirring 30min, are taken concoction with plate and frame filter press pressure.The dregs of a decoction are squeezed with squeezer again,
Leaching concoction.The acalypha copperleaf concoction that above-mentioned 3 times are filtrated to get merges, and crosses 100 mesh sieves, and filtrate decompression concentration, temperature is set as
70℃.When medicinal extract relative density obtained by concentration is 1.05, put after freezing 12 hours in -80 DEG C of refrigerators, taking-up is freeze-dried.
Freeze temperature is set as that pressure is 0.07Mpa for -40 DEG C, and the time is 24 hours.Lyophilized products are collected, are crushed, 60 mesh sieves, dress are crossed
Bag, adds bagged dryer and antioxidant, vacuum seal, labeling by 1kg/ bags.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, it is characterised in that：Adopted in acalypha copperleaf picking time
Collect its aerial part, clean, after washing, be cut into the section of 1 ~ 10cm length, take advantage of fresh pressure extracting juice, the dregs of a decoction add the water of 1 ~ 5 times of amount, stirred
5 ~ 30min is mixed, plate and frame filter press press filtration takes juice, and the dregs of a decoction press extracting juice again, merge 3 concoctions, are filtered to take with 60 ~ 120 eye mesh screens
Juice.
2. a kind of acalypha copperleaf according to claim 1 is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology, its feature exists
In：By the concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 75 DEG C, obtains the medicinal extract that relative density is 1.05 ~ 1.30, will
This medicinal extract, which is transferred in -20 ~ -80 DEG C of refrigerators, to be freezed 6 ~ 24 hours, then is freeze-dried, and temperature is -15 ~ -40 DEG C, and pressure is 0.06
~ 0.09MPa, the time is 8 ~ 48 hours, collects lyophilized products, and 60 ~ 100 mesh sieves, packaging are crossed after crushing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710469083.2A CN107213187A (en) | 2017-06-20 | 2017-06-20 | A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710469083.2A CN107213187A (en) | 2017-06-20 | 2017-06-20 | A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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| Publication Number | Publication Date |
|---|---|
| CN107213187A true CN107213187A (en) | 2017-09-29 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710469083.2A Pending CN107213187A (en) | 2017-06-20 | 2017-06-20 | A kind of acalypha copperleaf is fresh to squeeze freeze-dried powder medicine materical crude slice and its preparation technology |
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| CN (1) | CN107213187A (en) |
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| CN105998130A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed lyophilized powdery decoction pieces and preparation process thereof |
| CN106109598A (en) * | 2016-07-23 | 2016-11-16 | 徐自升 | A kind of Herba Plantaginis fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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Application publication date: 20170929 |
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