CN107233384A - A kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology - Google Patents
A kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology Download PDFInfo
- Publication number
- CN107233384A CN107233384A CN201710478604.0A CN201710478604A CN107233384A CN 107233384 A CN107233384 A CN 107233384A CN 201710478604 A CN201710478604 A CN 201710478604A CN 107233384 A CN107233384 A CN 107233384A
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- CN
- China
- Prior art keywords
- motherwort
- crude slice
- materical crude
- medicine materical
- fresh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of fresh squeezing spray-dried granules medicine materical crude slice of motherwort and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of motherwort medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, granulation.Herba Leonuri granule medicine materical crude slice prepared by this method, remains the polarity and nonpolar active ingredient in medicinal material to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine motherwort medicine materical crude slice.
Background technology
Chinese medicine motherwort is labiate motherwortLeonurus japonicusHoutt. on fresh or dry ground
Part.This product is pungent bitter, cool, has effects that to invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water, can be clinically used for treating menoxenia,
Threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle swells sore etc. at hematuria.
The processing mode of conventional motherwort medicine materical crude slice is：Tap, dry when summer cauline leaf is luxuriant, Hua Weikai or first is opened, or
Segment is dried, packing storage and transport.The motherwort medicinal material that these are dried is bulky, is easy to be contaminated in storage and transport process
With go mouldy, quality it is difficult to ensure that, be unfavorable for conditioning agent formulation and ensuring its clinical efficacy.
At present, in the market also has the granule pieces sale that motherwort medicinal material is made after extraction.Due to granule pieces system
During standby, not only time consumption and energy consumption is extracted, and is difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the motherwort medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Mistake is also very big.In order to ensure the clinic of motherwort medicinal material is effective, steady quality, a kind of new motherwort medicine materical crude slice and its system
Standby technique is urgently developed.
The content of the invention
The invention discloses " a kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology ".This technique can be with
Retain the polarity and nonpolar active ingredient in motherwort medicinal material to greatest extent, it is to avoid medicinal material is processed and stored up in existing medicine materical crude slice
The loss of active ingredient and the decline of medical material quanlity caused by during fortune, reduce pollution of the medicinal material by mould etc., to ensuring benefit
The steady quality and clinical safety of Brittle Falsepimpernel Herb medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in motherwort picking time, is cleaned, after washing, the section of 1 ~ 10cm length is cut into, fresh pressure extracting juice is taken advantage of, stays
This first squeezing concoction of 0.5% ~ 5% weight is deposited, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and plate and frame filter press press filtration takes juice,
The dregs of a decoction press extracting juice again, merge 3 concoctions, juice is filtered to take with 60 ~ 120 eye mesh screens.By the concoction of gained, in 40 ~ 75 DEG C of decompressions
Concentration, obtains the concentrate that relative density is 1.02 ~ 1.10, and this concentrate is transferred into spray drying tower spray drying, air intake
Mouth temperature is 90 ~ 140 DEG C, and air outlet temperature is 70 ~ 110 DEG C, collects dried object, and 60 ~ 100 mesh sieves are crossed after crushing.Stayed foregoing
The first squeezing concoction deposited, is well mixed with spray powder, prepares softwood, granulation, and whole grain after drying collects particle, packaging.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of motherwort is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, being printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh motherwort medicinal material clean after washing directly segment squeeze, filter, being concentrated under reduced pressure, being spray-dried, pelletize it is resulting
Granule pieces, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume is big compared to traditional medicine materical crude slice volume
The earth reduces, good fluidity, and quality is more stablized, and is easy to accumulating and clinic to adjust, with very significant social effect and warp
Ji meaning.
Embodiment
Embodiment 1
By the motherwort medicinal material of fresh collection, clean, with water wash, be cut into the section of 5cm length, take advantage of using fresh herb squeezer pressure extracting juice.
Retain this first squeezing concoction 2% standby.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, and plate and frame filter press pressure takes concoction.Institute
Obtain the dregs of a decoction to be squeezed with squeezer again, leaching concoction.Above-mentioned 3 times are squeezed obtained motherwort concoction to merge, cross 100 mesh sieves.Filter
Liquid is concentrated under reduced pressure, and temperature is set as 60 DEG C.When concentrate relative density obtained by concentration is 1.02, it is spray-dried, air intake
Mouth temperature is 140 DEG C, and air outlet temperature is 110 DEG C.Spray-dried product is collected, is crushed, 60 mesh sieves are crossed.Will it is above-mentioned just squeeze concoction in
Spray powder is well mixed, and prepares softwood, is pelletized, and is dried, and is packed after whole grain, 1kg/ bags, adds bagged dryer and antioxidant,
Vacuum seal, labeling.
Embodiment 2
By the motherwort medicinal material of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of using fresh herb squeezer pressure extracting juice.
Retain this first squeezing concoction 5% standby.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, and plate and frame filter press pressure takes concoction.Institute
Obtain the dregs of a decoction to be squeezed with squeezer again, leaching concoction.Above-mentioned 3 times are squeezed obtained motherwort concoction to merge, cross 80 mesh sieves.Filtrate
It is concentrated under reduced pressure, temperature is set as 70 DEG C.When concentrate relative density obtained by concentration is 1.05, it is spray-dried, air inlet
Temperature is 120 DEG C, and air outlet temperature is 90 DEG C.Spray-dried product is collected, is crushed, 60 mesh sieves are crossed.By the above-mentioned concoction that just squeezes in spray
Dry powder blend is uniform, prepares softwood, pelletizes, and dries, and is packed after whole grain, 1kg/ bags, adds bagged dryer and antioxidant, very
Sky sealing, labeling.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (3)
1. a kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, it is characterised in that：Adopted in motherwort picking time
Collect its aerial part, clean, after washing, be cut into the section of 1 ~ 10cm length, take advantage of fresh pressure extracting juice, at the beginning of retaining this of 0.5% ~ 5% weight
Concoction is squeezed, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and plate and frame filter press press filtration takes juice, and the dregs of a decoction press extracting juice again, merge
3 concoctions, juice is filtered to take with 60 ~ 120 eye mesh screens.
2. a kind of motherwort according to claim 1 is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, its feature exists
In：By the concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 75 DEG C, obtains the concentrate that relative density is 1.02 ~ 1.10,
This concentrate is transferred to spray drying tower spray drying, intake air temperature is 90 ~ 140 DEG C, and air outlet temperature is 70 ~ 110 DEG C,
Dried object is collected, 60 ~ 100 mesh sieves are crossed after crushing.
3. a kind of motherwort according to claim 1 is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology, its feature exists
In：By the first squeezing concoction retained in claim 1, with the spray powder in claim 2, it is well mixed, prepares softwood, pelletize,
Whole grain after drying, collects particle, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710478604.0A CN107233384A (en) | 2017-06-22 | 2017-06-22 | A kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710478604.0A CN107233384A (en) | 2017-06-22 | 2017-06-22 | A kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107233384A true CN107233384A (en) | 2017-10-10 |
Family
ID=59987194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710478604.0A Pending CN107233384A (en) | 2017-06-22 | 2017-06-22 | A kind of motherwort is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
Country Status (1)
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| CN (1) | CN107233384A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671196A (en) * | 2018-07-06 | 2018-10-19 | 徐漫 | Radix Curcumae is fresh to carry spray-dried granules medicine materical crude slice |
| CN110680843A (en) * | 2019-09-27 | 2020-01-14 | 山东佳诚动物药业有限公司 | Extraction method and drying device of motherwort extract |
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| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213660A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105232607A (en) * | 2015-11-14 | 2016-01-13 | 芜湖天成普阳中药科技有限公司 | Cactus freshly-squeezed spray dried granule decoction piece and preparation process thereof |
| CN105287858A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried granular decoction piece and preparation technology thereof |
| CN105998151A (en) * | 2016-07-24 | 2016-10-12 | 徐漫 | Euphorbia humifusa freshly-pressed spray dried particulate decoction slices and preparation process thereof |
| CN106038491A (en) * | 2016-07-23 | 2016-10-26 | 徐漫 | Freshly squeezed and spray-dried granular decoction pieces with verbena officinalis and process for preparing freshly squeezed and spray-dried granular decoction pieces |
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Patent Citations (8)
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| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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| CN105287858A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried granular decoction piece and preparation technology thereof |
| CN106038491A (en) * | 2016-07-23 | 2016-10-26 | 徐漫 | Freshly squeezed and spray-dried granular decoction pieces with verbena officinalis and process for preparing freshly squeezed and spray-dried granular decoction pieces |
| CN105998151A (en) * | 2016-07-24 | 2016-10-12 | 徐漫 | Euphorbia humifusa freshly-pressed spray dried particulate decoction slices and preparation process thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671196A (en) * | 2018-07-06 | 2018-10-19 | 徐漫 | Radix Curcumae is fresh to carry spray-dried granules medicine materical crude slice |
| CN110680843A (en) * | 2019-09-27 | 2020-01-14 | 山东佳诚动物药业有限公司 | Extraction method and drying device of motherwort extract |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20171010 |