CN106109622A - A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof - Google Patents
A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof Download PDFInfo
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- CN106109622A CN106109622A CN201610582765.XA CN201610582765A CN106109622A CN 106109622 A CN106109622 A CN 106109622A CN 201610582765 A CN201610582765 A CN 201610582765A CN 106109622 A CN106109622 A CN 106109622A
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- herba agrimoniae
- squeezing
- medicine juice
- spray
- dried
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
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Abstract
The invention discloses a kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof.This technique after Herba Agrimoniae medical material is gathered, clean, drip washing, cutting, and take advantage of fresh squeezing, leaching medicine juice.Medicinal residues add water stirring, filter squeezing.Concentrating under reduced pressure after the merging of gained medicine juice, is spray-dried, and collects spray drying product, size-reduced and first squeezing medicine juice mixing granulation, and granulate final vacuum is packed.Herba Agrimoniae granule pieces prepared by this method, remains the polarity in medical material and nonpolar effective ingredient to greatest extent.Granule pieces good fluidity, beneficially accumulating, convenient adjustment, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will have significant social meaning and economic benefit.
Description
Technical field
The invention belongs to Chinese crude drug manufacture field, particularly relate to the processing technique of Chinese medicine Herba Agrimoniae decoction pieces.
Background technology
Chinese medicine Herba Agrimoniae is rosaceous plant Herba AgrimoniaeAgrimonia pilosaLedeb. dry aerial parts.This
Product have the effects such as astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, for the treatment of hemoptysis, haematemesis, dysentery etc..
The processing mode of conventional Herba Agrimoniae decoction pieces is: summer, season in autumn two gather, and removes impurity, dries, then accumulating of packing.
This type of prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for that formula is adjusted
With guarantee its clinical efficacy, even to patient bring recessiveness harm.
At present, granule pieces market also having Herba Agrimoniae medical material to make after extracting is sold.The preparation of granule pieces
Process, extracts not only time consumption and energy consumption, and because conventional substantial amounts of water does solvent, the nonpolar effective ingredient in medical material is difficult to be carried
Take out.Additionally, due to the Herba Agrimoniae medical material extracted also is to be dried and through long-time storage, therefore, effective ingredient
Loss is also the biggest.In order to ensure Herba Agrimoniae medical material clinical effectively, steady quality, a kind of novel Herba Agrimoniae decoction pieces and
Preparation technology urgently develops.
Summary of the invention
The invention discloses " a kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof ".This technique is permissible
Retain the polarity in Herba Agrimoniae medical material and nonpolar effective ingredient to greatest extent, it is to avoid medical material is in the processing of existing decoction pieces and storage
The loss of the effective ingredient caused during fortune and the decline of medical material quanlity, reduce the medical material pollution by mycete etc., to guaranteeing celestial being
Steady quality and the clinical safety of crane grass decoction pieces effectively have great importance.
To achieve these goals, the technical scheme is that
Gather its aerial parts collection period at Herba Agrimoniae, clean, washing, after cutting, take advantage of fresh squeezing, collect and just squeeze medicine juice, retain
The first squeezing medicine juice of 0.5% ~ 5% is standby, the water of medicinal residues addition 1 ~ 5 times amount, stirring 5 ~ 30min, and filter press filter pressing extracting juice is remaining
Medicinal residues squeeze extracting juice again, merge remaining just squeezing medicine juice and rear twice squeezing medicine juice, 60 ~ 120 mesh screen, obtain red crowned crane medical herbs
Juice.The Herba Agrimoniae medicine juice obtained is evaporated under the conditions of 40 ~ 75 DEG C the concentrated solution that relative density is 1.02 ~ 1.15, and
Being spray-dried by this concentrated solution, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects to be dried and produces
Thing, crosses 60 ~ 100 mesh sieves after pulverizing.By above-mentioned Herba Agrimoniae spray drying powder, mix with the first squeezing medicine juice retained, prepare soft material, system
Grain, 50 ~ 80 DEG C are dried 4 ~ 8 hours, granulate, vacuum packaging.On the label of product packaging bags, the name of an article in printing, medicinal part,
Planting site, decoction pieces manufacturer, date of manufacture, Contents of Main Components, meridian distribution of property and flavor, function cure mainly, usage and dosage, toxic and side effects and
The information such as contraindication.The thin layer enclosing Herba Agrimoniae in Dai differentiates collection of illustrative plates and/or high-efficient liquid phase character collection of illustrative plates, as " the body of product
Part card ".Additionally, in the packaging bag of product, be printed on Quick Response Code, by scanning can link obtain product former plant photo,
The information such as medical material photo, decoction pieces photo, character and microscopical identification feature.
The invention have benefit that:
The Herba Agrimoniae medical material of fresh collection, directly squeezes after cleaning washing, filters, concentrating under reduced pressure, is spray-dried, pelletizes, gained
The granule pieces arrived, can retain the effective ingredient in medical material to greatest extent.This decoction pieces volume compares to tradition decoction pieces body
Amass and be greatly reduced, good fluidity, vacuum packaging so that prepared slice quality is more stable, beneficially accumulating and clinical adjustment, have ten
Divide significant social meaning and economic implications.
Detailed description of the invention
Embodiment 1
By the Herba Agrimoniae medical material of fresh collection, clean, wash silt with water, be cut into 3cm section, take advantage of using fresh herb squeezer squeezing extracting juice,
The first squeezing medicine juice retaining 1% weight is separately used.Gained medicinal residues add the tap water of 3 times amount, stir 20min, and filter press squeezing takes
Juice.Remaining medicinal residues squeeze extracting juice with squeezer again.The above-mentioned remaining medicine juice that just squeezes is merged with follow-up twice squeezing medicine juice, uses
100 eye mesh screens filter.Filtrate reduced in volume, temperature is set as 65 DEG C.When concentrating gained extractum relative density and being 1.05, spraying
Being dried, intake air temperature is 140 DEG C, and air outlet temperature is 100 DEG C, collects spray drying thing, low-temperature grinding, crosses 80 mesh sieves.This is sprayed
Mist xeraphium mixes soft material processed with the first squeezing medicine juice of above-mentioned retention, pelletizes, and 75 DEG C are dried 6 hours, granulate, pack, and 1kg/ bag adds
Enter packed antioxidant and desiccant, Vacuum Package, labeling.
Embodiment 2
By the Herba Agrimoniae medical material of fresh collection, clean, wash silt with water, be cut into 5cm section, take advantage of using fresh herb squeezer squeezing extracting juice,
The first squeezing medicine juice retaining 5% weight is separately used.Gained medicinal residues add the tap water of 5 times amount, stir 30min, and filter press squeezing takes
Juice.Remaining medicinal residues squeeze extracting juice with squeezer again.The above-mentioned remaining medicine juice that just squeezes is merged with follow-up twice squeezing medicine juice, uses
100 eye mesh screens filter.Filtrate reduced in volume, temperature is set as 70 DEG C.When concentrating gained extractum relative density and being 1.10, spraying
Being dried, intake air temperature is 120 DEG C, and air outlet temperature is 90 DEG C, collects spray drying thing, low-temperature grinding, crosses 80 mesh sieves.This is sprayed
Xeraphium mixes soft material processed with the first squeezing medicine juice of above-mentioned retention, pelletizes, and 70 DEG C are dried 8 hours, granulate, pack, and 1kg/ bag adds
Packed antioxidant and desiccant, Vacuum Package, labeling.
Above example, is only the technological thought that this invention is described, it is impossible to limit protection scope of the present invention whereby all
It is the technological thought proposed according to the present invention, any change done on the basis of technical scheme, each fall within present invention protection
Within the scope of.
Claims (3)
1. a Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof, it is characterised in that: adopt collection period at Herba Agrimoniae
Collect its aerial parts, clean, washing, after cutting, to take advantage of fresh squeezing, collect and just squeeze medicine juice, the first squeezing medicine juice of retention 0.5% ~ 5% is standby
With, medicinal residues add the water of 1 ~ 5 times amount, stir 5 ~ 30min, filter press filter pressing extracting juice, and remaining medicinal residues squeeze extracting juice again, merge
Remaining just squeezing medicine juice and rear twice squeezing medicine juice, 60 ~ 120 mesh screen, obtain Herba Agrimoniae medicine juice.
A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: the Herba Agrimoniae medicine juice obtained is evaporated under the conditions of 40 ~ 75 DEG C the concentrated solution that relative density is 1.02 ~ 1.15, and
Being spray-dried by this concentrated solution, intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects to be dried and produces
Thing, crosses 60 ~ 100 mesh sieves after pulverizing.
A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces the most according to claim 1 and preparation technology thereof, its feature exists
In: by the Herba Agrimoniae spray drying powder in claim 2, mix with the first squeezing medicine juice retained in claim 1, prepare soft material,
Pelletizing, 50 ~ 80 DEG C are dried 4 ~ 8 hours, and granulate is vacuum-packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582765.XA CN106109622A (en) | 2016-07-23 | 2016-07-23 | A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610582765.XA CN106109622A (en) | 2016-07-23 | 2016-07-23 | A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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| Publication Number | Publication Date |
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| CN106109622A true CN106109622A (en) | 2016-11-16 |
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| CN201610582765.XA Pending CN106109622A (en) | 2016-07-23 | 2016-07-23 | A kind of Herba Agrimoniae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375410A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Canton love-pea vine |
| CN107375566A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of pipewort |
| CN107375385A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Artemisia anomala |
| CN107375389A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of oriental wormwood |
| CN107397787A (en) * | 2017-08-25 | 2017-11-28 | 徐自升 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Pogostemon cablin |
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| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213660A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105232607A (en) * | 2015-11-14 | 2016-01-13 | 芜湖天成普阳中药科技有限公司 | Cactus freshly-squeezed spray dried granule decoction piece and preparation process thereof |
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Patent Citations (6)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375410A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Canton love-pea vine |
| CN107375566A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of pipewort |
| CN107375385A (en) * | 2017-08-25 | 2017-11-24 | 徐漫 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Artemisia anomala |
| CN107375389A (en) * | 2017-08-25 | 2017-11-24 | 徐自升 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of oriental wormwood |
| CN107397787A (en) * | 2017-08-25 | 2017-11-28 | 徐自升 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Pogostemon cablin |
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Application publication date: 20161116 |
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