CN107243019A - A kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology - Google Patents
A kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology Download PDFInfo
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- CN107243019A CN107243019A CN201710478609.3A CN201710478609A CN107243019A CN 107243019 A CN107243019 A CN 107243019A CN 201710478609 A CN201710478609 A CN 201710478609A CN 107243019 A CN107243019 A CN 107243019A
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- Prior art keywords
- motherwort
- fresh
- crude slice
- materical crude
- medicine materical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh squeezing spray-dried powders medicine materical crude slice of motherwort and its preparation technology.The technique is cleaned, eluted, and take advantage of fresh squeezing, leaching concoction after the harvesting of motherwort medicinal material.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried.Motherwort powder decoction pieces prepared by this method, remain the polarity and nonpolar active ingredient in medicinal material to greatest extent.Medicine materical crude slice is beneficial to accumulating, convenient to adjust, quality controllable, and curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there is significant social effect and economic benefit.
Description
Technical field
The invention belongs to the processing technology of Chinese medicine manufacture field, more particularly to Chinese medicine motherwort medicine materical crude slice.
Background technology
Chinese medicine motherwort is labiate motherwortLeonurus japonicusHoutt. on fresh or dry ground
Part.This product is pungent, bitter, cool, has effects that to invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water, can be clinically used for treating menoxenia,
Threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle swells sore etc. at hematuria.
The processing mode of conventional motherwort medicine materical crude slice is：Tap, dry when summer cauline leaf is luxuriant, Hua Weikai or first is opened, or
Segment is dried, packing storage and transport.The motherwort medicinal material that these are dried is bulky, is easy to be contaminated in storage and transport process
With go mouldy, quality it is difficult to ensure that, be unfavorable for conditioning agent formulation and ensuring its clinical efficacy.
At present, in the market also has the granule pieces sale that motherwort medicinal material is made after extraction.Due to granule pieces system
During standby, not only time consumption and energy consumption is extracted, and is difficult to be extracted because conventional water does the nonpolar active ingredient in solvent, medicinal material
Out.Further, since the motherwort medicinal material of extraction is also to dry and by storage for a long time, therefore, the damage of active ingredient
Mistake is also very big.In order to ensure the clinic of motherwort medicinal material is effective, steady quality, a kind of new motherwort medicine materical crude slice and its system
Standby technique is urgently developed.
The content of the invention
The invention discloses " a kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology ".This technique can be with
Retain the polarity and nonpolar active ingredient in motherwort medicinal material to greatest extent, it is to avoid medicinal material is processed and stored up in existing medicine materical crude slice
The loss of active ingredient and the decline of medical material quanlity caused by during fortune, reduce pollution of the medicinal material by mould etc., to ensuring benefit
The steady quality and clinical safety of Brittle Falsepimpernel Herb medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its aerial part is gathered in motherwort picking time, is cleaned, after washing, the section of 1 ~ 10cm length is cut into, fresh pressure extracting juice is taken advantage of.Institute
The water that 1 ~ 5 times of amount is added in the dregs of a decoction is obtained, 5 ~ 30min is stirred, takes juice with plate and frame filter press press filtration, and extracting juice is pressed again to the dregs of a decoction.
Merge 3 concoctions, juice is filtered to take with 60 ~ 120 eye mesh screens.
By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 75 DEG C, obtains the concentrate that relative density is 1.02 ~ 1.10, this is dense
Contracting liquid is transferred to spray drying tower spray drying, and intake air temperature is 90 ~ 140 DEG C, and air outlet temperature is 70 ~ 110 DEG C, collects dry
Dry thing, crosses 60 ~ 100 mesh sieves, packaging after crushing.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of motherwort is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, is used as " identity card " of product.In addition, in the packaging bag of product, being printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh motherwort medicinal material cleans direct segment after washing and squeezes, filters, being concentrated under reduced pressure, being dried in vacuo resulting powder drink
Piece, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume greatly subtracts compared to traditional medicine materical crude slice volume
Small, quality is more stablized, and is easy to accumulating and clinical adjustment, with very significant social effect and economic implications.
Embodiment
Embodiment 1
By the motherwort medicinal material of fresh collection, clean, with water wash, be cut into the section of 5cm length, take advantage of using fresh herb squeezer pressure extracting juice.
The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, stand Aspirate supernatant after 30min and filter to obtain concoction.The dregs of a decoction are squeezed
Machine is squeezed, leaching concoction.The motherwort concoction that above-mentioned 3 times are filtrated to get merges, and crosses 100 mesh sieves, filtrate decompression concentration, temperature
It is set as 60 DEG C.When concentrate relative density obtained by concentration is 1.02, it is spray-dried, intake air temperature is 140 DEG C, is gone out
Draught temperature is 110 DEG C.Spray-dried product is collected, is crushed, 60 mesh sieves are crossed, pack, adds bagged dryer and antioxygen by 1kg/ bags
Agent, vacuum seal, labeling.
Embodiment 2
By the motherwort medicinal material of fresh collection, clean, with water wash, be cut into the section of 10cm length, take advantage of using fresh herb squeezer pressure extracting juice.
The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, stand Aspirate supernatant after 60min and filter to obtain concoction.The dregs of a decoction are squeezed
Machine is squeezed, leaching concoction.The motherwort concoction that above-mentioned 3 times are filtrated to get merges, and crosses 80 mesh sieves, filtrate decompression concentration, temperature
It is set as 70 DEG C.When concentrate relative density obtained by concentration is 1.05, it is spray-dried, intake air temperature is 120 DEG C, is gone out
Draught temperature is 90 DEG C.Spray-dried product is collected, is crushed, 60 mesh sieves are crossed, pack, adds bagged dryer and antioxygen by 1kg/ bags
Agent, vacuum seal, labeling.
Above example, only illustrates the technological thought of this invention, it is impossible to whereby limit protection scope of the present invention all
It is any change done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention was protected
Within the scope of.
Claims (2)
1. a kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, it is characterised in that：Adopted in motherwort picking time
Collect its aerial part, clean, after washing, be cut into the section of 1 ~ 10cm length, take advantage of fresh pressure extracting juice, the dregs of a decoction add the water of 1 ~ 5 times of amount, stirred
5 ~ 30min is mixed, plate and frame filter press press filtration takes juice, and the dregs of a decoction press extracting juice again, merge 3 concoctions, are filtered to take with 60 ~ 120 eye mesh screens
Juice.
2. a kind of motherwort according to claim 1 is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology, its feature exists
In：By the concoction of gained in claim 2, it is concentrated under reduced pressure in 40 ~ 75 DEG C, obtains the concentrate that relative density is 1.02 ~ 1.10,
This concentrate is transferred to spray drying tower spray drying, intake air temperature is 90 ~ 140 DEG C, and air outlet temperature is 70 ~ 110 DEG C,
Dried object is collected, 60 ~ 100 mesh sieves, packaging are crossed after crushing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710478609.3A CN107243019A (en) | 2017-06-22 | 2017-06-22 | A kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710478609.3A CN107243019A (en) | 2017-06-22 | 2017-06-22 | A kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107243019A true CN107243019A (en) | 2017-10-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710478609.3A Pending CN107243019A (en) | 2017-06-22 | 2017-06-22 | A kind of motherwort is fresh to squeeze spray-dried powders medicine materical crude slice and its preparation technology |
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| CN (1) | CN107243019A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213460A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105287860A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried powdery decoction piece and preparation technology thereof |
| CN105362528A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Folium Aloes fresh-squeezed spray-dried powder decoction pieces and preparation method thereof |
| CN105963349A (en) * | 2016-07-24 | 2016-09-28 | 徐漫 | Freshly squeezed barbed skullcap herb spray drying powder medicinal slices and preparing process thereof |
| CN105998108A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed spray-dried powdery decoction pieces and preparation process thereof |
-
2017
- 2017-06-22 CN CN201710478609.3A patent/CN107243019A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213444A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Portulacae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213450A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213553A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105213460A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Radix et Caulis Opuntiae Dillenii fresh squeezing spray-dried powders decoction pieces and preparation technology thereof |
| CN105362528A (en) * | 2015-11-14 | 2016-03-02 | 芜湖天成普阳中药科技有限公司 | Folium Aloes fresh-squeezed spray-dried powder decoction pieces and preparation method thereof |
| CN105287860A (en) * | 2015-11-22 | 2016-02-03 | 徐漫 | Freshly-squeezed paulownia flower spray-dried powdery decoction piece and preparation technology thereof |
| CN105998108A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Folium Isatidis freshly-pressed spray-dried powdery decoction pieces and preparation process thereof |
| CN105963349A (en) * | 2016-07-24 | 2016-09-28 | 徐漫 | Freshly squeezed barbed skullcap herb spray drying powder medicinal slices and preparing process thereof |
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Application publication date: 20171013 |
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