CN107375364A

CN107375364A - A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium

Info

Publication number: CN107375364A
Application number: CN201710739154.6A
Authority: CN
Inventors: 徐自升
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-08-25
Filing date: 2017-08-25
Publication date: 2017-11-24

Abstract

The invention discloses a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium.The technique is cleaned, eluted after the harvesting of desmodium medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, and collects spray drying product, through crushing with just squeezing concoction mixing granulation, is vacuum-packed after whole grain.Desmodium granule pieces prepared by this method, remain the polarity in medicinal material and nonpolar active ingredient to greatest extent.Granule pieces good fluidity, beneficial to accumulating, convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.

Description

A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium

Technical field

The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine desmodium medicine materical crude slice.

Background technology

Chinese medicine desmodium is Ofthe Primulaceae Lysimachia christinaeLysimachia christinaeHance drying herb. This product has the effect of promoting diuresis for stranguria, clearing heat and detoxicating, eliminating stasis to subdue swelling, is mainly used in treating liver and gall and calculi in urinary system, ephritis Oedema, jaundice with damp-heat pathogen, snake bite and insect sting, traumatic injury etc..

The processing mode of common desmodium medicine materical crude slice is：Summer, the harvesting of season in autumn two, remove impurity, dry, then accumulating of packing. Such prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for formula adjust With ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.

At present, in the market also has the manufactured granule pieces sale after extraction of desmodium medicinal material.The preparation of granule pieces Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried Take out.Further, since the desmodium medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient Loss is also very big.In order to ensure the clinic of desmodium medicinal material is effective, steady quality, a kind of new desmodium medicine materical crude slice is urgently Exploitation.

The content of the invention

The invention discloses " a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium ".This technique can be most The polarity and the nonpolar active ingredient that retain in money herbal medicine material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring money The steady quality and clinical safety of careless medicine materical crude slice effectively have great importance.

To achieve these goals, the technical scheme is that：

Its aerial part is gathered in desmodium picking time, is cleaned, is cut into 1 ~ 2cm section, adds 0.5 ~ 1 times of amount of medicinal material weight oneself Water, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, the dregs of a decoction The water of 1 ~ 5 times of amount is added, stirs 5 ~ 30min, presses extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge Just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain desmodium concoction.By obtained desmodium concoction in 40 ~ Relative density is concentrated under reduced pressure under the conditions of 75 DEG C and is 1.02 ~ 1.15 concentrate, and this concentrate is spray-dried, air inlet temperature Degree is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects desciccate, and 60 ~ 100 mesh sieves are crossed after crushing.Will be above-mentioned Desmodium spray dried powder, mixed with the first squeezing concoction of retention, prepare softwood, pelletized, 60 ~ 80 DEG C of electric heating forced air dryings 4 ~ 8 are small When, whole grain, vacuum packaging.On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, The information such as date of manufacture, Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.In bag The thin layer for enclosing desmodium differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in product Packaging bag on, be printed on Quick Response Code, can be linked by scanning obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, The information such as character and microscopical characters feature.

The present invention is advantageous in that：

The desmodium medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being spray-dried, pelletizing, gained The granule pieces arrived, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume is compared to traditional medicine materical crude slice body Product greatly reduces, good fluidity, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, has ten Divide significant social effect and economic implications.

Embodiment

Embodiment 1

By the desmodium medicinal material of fresh collection, clean, silt is washed with water, be cut into 1cm section, add 0.5 times of amount of medicinal material weight Running water, stir 15 minutes, take advantage of using fresh herb squeezer pressure extracting juice, retain 0.1% weight first squeezing concoction separately use.The gained dregs of a decoction Add the running water of 3 times of amounts, stir 20min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.Will The above-mentioned remaining concoction that just squeezes merges with the follow-up concoction of squeezing twice, with 100 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set It is set to 65 DEG C.When medicinal extract relative density obtained by concentration is 1.05, spray drying, intake air temperature is 140 DEG C, air outlet temperature For 100 DEG C, spray drying thing is collected, low-temperature grinding, crosses 80 mesh sieves.This spray dried powder is mixed into system with the first squeezing concoction of above-mentioned retention Softwood, granulation, 75 DEG C of drying 6 hours, whole grain, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling .

Embodiment 2

By the desmodium medicinal material of fresh collection, clean, silt is washed with water, be cut into 1 ~ 2cm section, add 1 times of amount of medicinal material weight Running water, stir 30 minutes, take advantage of using fresh herb squeezer pressure extracting juice, retain 0.5% weight first squeezing concoction separately use.The gained dregs of a decoction Add the running water of 5 times of amounts, stir 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.Will The above-mentioned remaining concoction that just squeezes merges with the follow-up concoction of squeezing twice, with 200 mesh sieve net filtrations.Filtrate decompression is concentrated, and temperature is set It is set to 70 DEG C.When medicinal extract relative density obtained by concentration is 1.10, spray drying, intake air temperature is 120 DEG C, air outlet temperature For 90 DEG C, spray drying thing is collected, low-temperature grinding, crosses 80 mesh sieves.This spray dried powder is mixed into system with the first squeezing concoction of above-mentioned retention Softwood, granulation, 70 DEG C of drying 8 hours, whole grain, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling .

Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected Within the scope of.

Claims

A kind of 1. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium, it is characterised in that：Gathered in desmodium picking time Its aerial part, clean, be cut into 1 ~ 2cm section, add the running water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of Fresh squeezing, collect and just squeeze concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add the water of 1 ~ 5 times of amount, stirring 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze medicine twice Juice, 100 ~ 200 mesh screens, obtain desmodium concoction.
A kind of 2. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium according to claim 1, it is characterised in that： By obtained desmodium concoction be concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C relative density be 1.02 ~ 1.15 concentrate, and by this Concentrate is spray-dried, and intake air temperature is set as 90 ~ 140 DEG C, and air outlet temperature is 80 ~ 110 DEG C, collects desciccate, powder 60 ~ 100 mesh sieves are crossed after broken.
A kind of 3. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of desmodium according to claim 1, it is characterised in that： By the desmodium spray dried powder in claim 2, mixed with the first squeezing concoction retained in claim 1, prepare softwood, made Grain, 60 ~ 80 DEG C of electric heating forced air dryings 4 ~ 8 hours, whole grain, vacuum packaging.