CN107485642A - A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata - Google Patents
A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata Download PDFInfo
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- CN107485642A CN107485642A CN201710739155.0A CN201710739155A CN107485642A CN 107485642 A CN107485642 A CN 107485642A CN 201710739155 A CN201710739155 A CN 201710739155A CN 107485642 A CN107485642 A CN 107485642A
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- sculellaria barbata
- concoction
- squeezing
- vacuum drying
- fresh
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- 239000000843 powder Substances 0.000 title claims abstract description 10
- 238000005516 engineering process Methods 0.000 title claims abstract description 8
- 238000001291 vacuum drying Methods 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims abstract 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000003306 harvesting Methods 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 230000000192 social effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 241000915604 Scutellaria barbata Species 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000009461 vacuum packaging Methods 0.000 description 2
- 206010003011 Appendicitis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata.The technique is cleaned, eluted, segment after the harvesting of Sculellaria barbata medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is dried in vacuo, is vacuum-packed after crushing.Sculellaria barbata powder decoction pieces prepared by this method, remain the polarity in medicinal material and nonpolar active ingredient to greatest extent.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Scutellaria barbata medicine materical crude slice.
Background technology
Scutellaria barbata is labiate Sculellaria barbataScutellaria barbata D. Don drying herb.This product
There are clearing heat and detoxicating, promoting blood circulation and removing blood stasis, swelling and pain relieving, the work(of anticancer.Clinic is commonly used to treat appendicitis, hepatitis, cervix cancer, mammary gland
Inflammation etc.；External application can treat furuncle pain, treating swelling and pain by traumatic injury etc..
The processing mode of conventional Sculellaria barbata medicine materical crude slice is：Summer, the harvesting of season in autumn two, remove impurity, clean, dry, then pack
Accumulating.Such prepared herbal medicine in small pieces ready for decoction, bulky, Hygienic Index is poor, easily pollutes and goes mouldy, quality it is difficult to ensure that, be unfavorable for matching somebody with somebody
Just adjust and ensure its clinical efficacy, or even the harm of recessiveness is brought to patient.
At present, in the market also has the manufactured granule pieces sale after extraction of Sculellaria barbata medicinal material.The preparation of granule pieces
Process, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be carried
Take out.Further, since the Sculellaria barbata medicinal material of extraction is also to dry and by storage for a long time, therefore, active ingredient
Loss is also very big.In order to ensure the clinic of Sculellaria barbata medicinal material is effective, steady quality, a kind of new Sculellaria barbata medicine materical crude slice is urgently
Exploitation.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata ".This technique can be most
While limits retain Sculellaria barbata medicinal material in polarity and nonpolar active ingredient, avoid medicinal material existing medicine materical crude slice processing and
The decline of the loss of caused active ingredient and medical material quanlity in storage and transport process, pollution of the medicinal material by mould etc. is reduced, to ensuring
The steady quality and clinical safety of Sculellaria barbata medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in Sculellaria barbata picking time, its herb is gathered in Sculellaria barbata picking time, is cleaned, is cut into 1 ~ 2cm section, is added
0.5 ~ 1 times of water measured of medicinal material weight, stirs 15 ~ 30 minutes, takes advantage of fresh squeezing, collects and just squeezes concoction, 1 ~ 5 times of amount of dregs of a decoction addition
Water, 5 ~ 30min is stirred, press extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge and just squeeze concoction and rear two
Secondary squeezing concoction, 100 ~ 200 mesh screens, obtains Sculellaria barbata concoction.Obtained Sculellaria barbata concoction is depressurized under the conditions of 40 ~ 75 DEG C
The medicinal extract that relative density is 1.05 ~ 1.30 is concentrated into, and 60 ~ 120 are crushed after it is dried in vacuo 4 ~ 8 hours in 40 ~ 70 DEG C
Mesh sieve, vacuum packaging, produce fresh squeeze of Sculellaria barbata and be dried in vacuo powder decoction pieces.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture,
The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The included upper Sculellaria barbata of bag
Thin layer differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product,
Quick Response Code is printed on, can be linked by scanning and obtain the former plant photo of product, medicinal material photo, medicine materical crude slice photo, character and micro-
The information such as diagnostic characteristics.
The present invention is advantageous in that：
The Sculellaria barbata medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being dried in vacuo, resulting powder
Last medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume significantly
Ground reduces, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, and there is very significant society to anticipate
Justice and economic implications.
Embodiment
Embodiment 1
By the Sculellaria barbata medicinal material of fresh collection, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stir 15 points
Clock, fresh squeezing is taken advantage of, collect and just squeeze concoction, the dregs of a decoction add the water of 1 times of amount, stir 5min, press extracting juice, and the remaining dregs of a decoction add 3
Times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 mesh screens, obtain Sculellaria barbata concoction.Will
To Sculellaria barbata concoction be concentrated under reduced pressure, temperature is set as 65 DEG C.When medicinal extract relative density obtained by concentration is 1.10, it is transferred to true
In empty drying box, dried 8 hours in 60 DEG C, 60 mesh sieves are crossed after crushing, pack, 1kg/ bags, add packed antioxidant and drying
Agent, Vacuum Package.
Embodiment 2
By the Sculellaria barbata medicinal material of fresh collection, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 20 minutes,
Fresh squeezing is taken advantage of, collects and just squeezes concoction, the dregs of a decoction add the water of 3 times of amounts, stir 10min, press extracting juice, and the remaining dregs of a decoction add 3 times
The water of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 200 mesh screens, obtain Sculellaria barbata concoction.It will obtain
Sculellaria barbata concoction be concentrated under reduced pressure, temperature is set as 70 DEG C.When medicinal extract relative density obtained by concentration is 1.08, vacuum is transferred to
In drying box, dried 6 hours in 65 DEG C, 60 mesh sieves crossed after crushing, pack, 1kg/ bags, add packed antioxidant and drier,
Vacuum Package.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (2)
- A kind of 1. fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata, it is characterised in that：Gathered in Sculellaria barbata picking time Its herb, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, receive Collection just squeeze concoction, the dregs of a decoction add 1 ~ 5 times amount water, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount Water, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain Sculellaria barbata concoction.
- A kind of 2. fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata according to claim 1, it is characterised in that： By obtained Sculellaria barbata concoction be concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C relative density be 1.05 ~ 1.30 medicinal extract, and by its in 40 ~ 70 DEG C vacuum drying 4 ~ 8 hours after crushed 60 ~ 120 mesh sieves, be vacuum-packed, produce Sculellaria barbata it is fresh squeeze vacuum drying powder Medicine materical crude slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739155.0A CN107485642A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739155.0A CN107485642A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107485642A true CN107485642A (en) | 2017-12-19 |
Family
ID=60650732
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739155.0A Pending CN107485642A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Sculellaria barbata |
Country Status (1)
| Country | Link |
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| CN (1) | CN107485642A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963349A (en) * | 2016-07-24 | 2016-09-28 | 徐漫 | Freshly squeezed barbed skullcap herb spray drying powder medicinal slices and preparing process thereof |
| CN105998133A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed vacuum drying powder decoction tablets and preparation process thereof |
| CN106109574A (en) * | 2016-07-24 | 2016-11-16 | 徐漫 | A kind of Herba Scutellariae Barbatae is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710739155.0A patent/CN107485642A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998133A (en) * | 2016-07-23 | 2016-10-12 | 徐漫 | Chinese lobelia freshly-squeezed vacuum drying powder decoction tablets and preparation process thereof |
| CN105963349A (en) * | 2016-07-24 | 2016-09-28 | 徐漫 | Freshly squeezed barbed skullcap herb spray drying powder medicinal slices and preparing process thereof |
| CN106109574A (en) * | 2016-07-24 | 2016-11-16 | 徐漫 | A kind of Herba Scutellariae Barbatae is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof |
| CN106214741A (en) * | 2016-07-24 | 2016-12-14 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing lyophilization powder decoction pieces and preparation technology thereof |
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Application publication date: 20171219 |