CN107375529A - A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet - Google Patents
A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet Download PDFInfo
- Publication number
- CN107375529A CN107375529A CN201710738638.9A CN201710738638A CN107375529A CN 107375529 A CN107375529 A CN 107375529A CN 201710738638 A CN201710738638 A CN 201710738638A CN 107375529 A CN107375529 A CN 107375529A
- Authority
- CN
- China
- Prior art keywords
- bittersweet
- squeezing
- concoction
- spray
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet.The technique is cleaned, eluted after the harvesting of bittersweet medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, then particle is made.Bittersweet granule pieces prepared by this method, not only good fluidity, and to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of studies of Solanum lyratum Thunb medicine materical crude slice.
Background technology
Studies of Solanum lyratum Thunb is the herb of plant of Solanaceae bittersweet.The effect of with clearing heat and promoting diuresis, removing toxicity for detumescence, anticancer.Clinic is main
It is used to treatment cure cold heating, icterepatitis, cholecystitis, cholelithiasis, cancer, uterus erosion, leukorrhea, nephritic dropsy, outer
With controlling carbuncle furuncle poison etc..
The processing mode of conventional bittersweet medicine materical crude slice is：After harvesting, impurity is removed, is dried, directly packing storage and transport.This
Dry bittersweet Hygienic Index can not be up to standard a bit, and medicinal material easily occurs and goes mouldy, so as to cause the decline of medical material quanlity and clinic
The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody
Just and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of bittersweet medicinal material.Because prepared by granule pieces
During, extraction not only time consumption and energy consumption, and because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Come.Further, since the bittersweet medicinal material of extraction be also dry and by for a long time storage, therefore, its raw material easily pollution and it is mould
It is difficult to avoid that the situation of change, which is also,.In order to ensure the clinic of bittersweet medicinal material is effective, steady quality, a kind of new bittersweet medicine materical crude slice
And its preparation technology urgently develops.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet ".This technique can be maximum
The polarity and the nonpolar active ingredient that retain in bittersweet medicinal material of limit, avoid medicinal material from being processed and storage and transport process in existing medicine materical crude slice
In the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring bittersweet medicine materical crude slice
Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in bittersweet picking time, is cleaned, is cut into 1 ~ 2cm section, adds the water of 0.5 ~ 1 times of amount of medicinal material weight, stirring
15 ~ 30 minutes, fresh squeezing is taken advantage of, collects and just squeezes concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add 1 ~ 5 times
The water of amount, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and
Squeeze concoction twice afterwards, 100 ~ 200 mesh screens, obtain bittersweet concoction.By the concoction of gained, it is concentrated under reduced pressure, obtains in 40 ~ 80 DEG C
Relative density is 1.02 ~ 1.10 concentrate.This concentrate is spray-dried, intake air temperature is set as 100 ~ 140 DEG C,
Air outlet temperature is set as 90 ~ 120 DEG C, collects dried object and is crushed, crosses 60 ~ 100 mesh sieves.By the first squeezing concoction of above-mentioned retention
Mixed with obtained spray powder, add appropriate starch and dextrin as one sees fit, prepare softwood, pelletized, dried, whole grain, packaging.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin layer of bittersweet is enclosed in bag
Differentiate collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, two are printed on
Code is tieed up, it is special to link the former plant photo for obtaining product, medicinal material photo, medicine materical crude slice photo, character and microscopical characters by scanning
The information such as sign.
The present invention is advantageous in that：
Fresh bittersweet medicinal material directly squeezes after cleaning washing, filter, be concentrated under reduced pressure, being spray-dried, pelletize after, resulting particle
Medicine materical crude slice, not only good fluidity, moreover it is possible to retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is compared to tradition
Medicine materical crude slice volume greatly reduces, and quality is more stable, beneficial to accumulating and clinical adjustment, has very significant social effect and warp
Ji meaning.
Embodiment
Embodiment 1
By the bittersweet medicinal material of fresh collection, clean, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stirring 15
Minute, fresh squeezing is taken advantage of, retain this first squeezing concoction 0.1% is standby.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, sheet frame
Filter press presses extracting juice.The gained dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 bittersweet concoctions are merged, with 60 mesh sieves
Filtering, filtrate decompression concentration, temperature are set as 60 DEG C.When gained concentrate relative density is 1.03, spray drying is transferred to
Tower is spray-dried, and intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, crushes, mistake
60 mesh sieves.By this spray powder, softwood processed is mixed with the first squeezing concoction of above-mentioned retention, is pelletized, is dried, whole grain, pack, 1kg/ bags,
Add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the bittersweet medicinal material of fresh collection, clean, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stir 30 points
Clock, fresh squeezing is taken advantage of, retain this first squeezing concoction 0.3% is standby.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, sheet frame pressure
Filter presses extracting juice.The gained dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 bittersweet concoctions are merged, with 100 mesh sieves
Filtering, filtrate decompression concentration, temperature are set as 70 DEG C.When gained concentrate relative density is 1.05, spray drying is transferred to
Tower is spray-dried, and intake air temperature is set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, crushes, mistake
60 mesh sieves.By this spray powder, softwood processed is mixed with the first squeezing concoction of above-mentioned retention, is pelletized, is dried, whole grain, pack, 1kg/ bags,
Add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (3)
- A kind of 1. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet, it is characterised in that：It is complete that its is gathered in bittersweet picking time Grass, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect just Concoction is squeezed, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add the water of 1 ~ 5 times of amount, stirs 5 ~ 30min, squeezing takes Juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze concoction, 100 ~ 200 mesh twice Filter is sieved through, obtains bittersweet concoction.
- A kind of 2. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet according to claim 1, it is characterised in that：Will The concoction of gained, is concentrated under reduced pressure in 40 ~ 80 DEG C in claim 1, the concentrate that relative density is 1.02 ~ 1.10 is obtained, to it It is spray-dried, intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects dried object and enters Row crushes, and crosses 60 ~ 100 mesh sieves.
- A kind of 3. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet according to claim 1, it is characterised in that：Will The first squeezing concoction retained in claim 1 mixes with the spray powder obtained in claim 2, prepares softwood, pelletizes, and dries, whole Grain, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738638.9A CN107375529A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738638.9A CN107375529A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375529A true CN107375529A (en) | 2017-11-24 |
Family
ID=60345979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738638.9A Pending CN107375529A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375529A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619412A (en) * | 2018-07-06 | 2018-10-09 | 徐自升 | Rhizoma imperatae is fresh to carry spray-dried granules medicine materical crude slice |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213660A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106109530A (en) * | 2016-07-23 | 2016-11-16 | 徐漫 | A kind of Folium Isatidis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106214723A (en) * | 2016-07-23 | 2016-12-14 | 徐漫 | A kind of Herba Lobeliae Chinensis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738638.9A patent/CN107375529A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213660A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106109530A (en) * | 2016-07-23 | 2016-11-16 | 徐漫 | A kind of Folium Isatidis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106214723A (en) * | 2016-07-23 | 2016-12-14 | 徐漫 | A kind of Herba Lobeliae Chinensis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619412A (en) * | 2018-07-06 | 2018-10-09 | 徐自升 | Rhizoma imperatae is fresh to carry spray-dried granules medicine materical crude slice |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105213660A (en) | A kind of Aloe fresh squeezing spray-dried granules decoction pieces and preparation technology thereof | |
| CN107412303A (en) | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eupatorium | |
| CN107281247A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eclipta | |
| CN107281236A (en) | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology | |
| CN107375529A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of bittersweet | |
| CN107441223A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of cordate houttuynia | |
| CN107397787A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Pogostemon cablin | |
| CN107375389A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of oriental wormwood | |
| CN107375394A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of fringed pink | |
| CN107468831A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese violet | |
| CN107412434A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of black nightshade | |
| CN107375395A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of fringed pink | |
| CN107397774A (en) | A kind of fresh preparation technology for squeezing freeze-dried powder medicine materical crude slice of coriander | |
| CN107375349A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of scouring rush | |
| CN107320568A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of black nightshade | |
| CN107375370A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of coriander | |
| CN107412327A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of elscholtiza | |
| CN107375417A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Herba Lycopi | |
| CN107334796A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of ardisia japonica | |
| CN107320567A (en) | A kind of fresh preparation technology for squeezing spray-dried powders medicine materical crude slice of bittersweet | |
| CN107375379A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gerbera | |
| CN107375403A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla | |
| CN107375566A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of pipewort | |
| CN107375543A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of field pennycress | |
| CN107334790A (en) | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of phoenix-tail fern |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171124 |
|
| WD01 | Invention patent application deemed withdrawn after publication |