CN107375403A

CN107375403A - A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla

Info

Publication number: CN107375403A
Application number: CN201710738710.8A
Authority: CN
Inventors: 徐漫
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-08-25
Filing date: 2017-08-25
Publication date: 2017-11-24

Abstract

The invention discloses a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla.The technique is cleaned, eluted after Gynostemma pentaphyllum harvesting, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, then particle is made.Gynostemma pentaphylla granule pieces prepared by this method, not only good fluidity, and to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.

Description

A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla

Technical field

The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese Medicine Jiaogulan medicine materical crude slice.

Background technology

Chinese Medicine Jiaogulan is Curcurbitaceae gynostemma pentaphyllaGynostemma pentaphyllum (Thunb.) Makino ground Upper part.With QI invigorating, calm the nerves, hypotensive is clearing heat and detoxicating, the effect of cough-relieving apophlegmatic.

The processing mode of conventional gynostemma pentaphylla medicine materical crude slice is：After harvesting, impurity is removed, is dried, directly packing storage and transport. These dry gynostemma pentaphylla Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy, so as to cause the decline of medical material quanlity and The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting Agent prescription and ensure its clinical efficacy.

At present, in the market also has Gynostemma pentaphyllum manufactured granule pieces sale after extraction.Due to granule pieces system During standby, extraction not only time consumption and energy consumption, and also because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted Out.Further, since the Gynostemma pentaphyllum of extraction is also to dry and stored by long-time, therefore, its raw material easily pollutes It is difficult to avoid to be also with situation about going mouldy.In order to ensure the clinic of Gynostemma pentaphyllum is effective, steady quality, a kind of new strand The blue medicine materical crude slice of stock and its preparation technology urgently develop.

The content of the invention

The invention discloses " a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla ".This technique can be most The polarity and the nonpolar active ingredient that retain in Gynostemma pentaphyllum of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring strand The steady quality and clinical safety of blue medicine materical crude slice effectively have great importance.

To achieve these goals, the technical scheme is that：

Its aerial part is gathered in gynostemma pentaphylla picking time, is cleaned, is cut into 1 ~ 2cm section, adds 0.5 ~ 1 times of amount of medicinal material weight Water, stir 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add Enter the water of 1 ~ 5 times of amount, stir 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just Squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain gynostemma pentaphylla concoction.By the concoction of gained, subtract in 40 ~ 80 DEG C Pressure concentration, obtain the concentrate that relative density is 1.02 ~ 1.10.This concentrate is spray-dried, intake air temperature setting For 100 ~ 140 DEG C, air outlet temperature is set as 90 ~ 120 DEG C, collects dried object and is crushed, crosses 60 ~ 100 mesh sieves.Will be above-mentioned The first squeezing concoction retained mixes with obtained spray powder, adds appropriate starch and dextrin as one sees fit, prepares softwood, pelletizes, and dries, Whole grain, packaging.

It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of gynostemma pentaphylla is enclosed in bag Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, it is printed on Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning The information such as feature.

The present invention is advantageous in that：

Fresh Gynostemma pentaphyllum directly squeezes after cleaning washing, filter, be concentrated under reduced pressure, being spray-dried, pelletize after, resulting Grain medicine materical crude slice, not only good fluidity, moreover it is possible to retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is compared to biography System medicine materical crude slice volume greatly reduces, and quality is more stable, beneficial to accumulating and it is clinical adjust, have very significant social effect and Economic implications.

Embodiment

Embodiment 1

By the Gynostemma pentaphyllum of fresh collection, clean, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stirring 15 minutes, fresh squeezing is taken advantage of, retain this first squeezing concoction 0.1% is standby.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate Frame filter press presses extracting juice.The gained dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 gynostemma pentaphylla concoctions are merged, with 60 Mesh screen, filtrate decompression concentration, temperature are set as 60 DEG C.When gained concentrate relative density is 1.03, spraying is transferred to Drying tower is spray-dried, and intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, powder It is broken, cross 60 mesh sieves.By this spray powder, softwood processed is mixed with the first squeezing concoction of above-mentioned retention, is pelletized, is dried, whole grain, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.

Embodiment 2

By the Gynostemma pentaphyllum of fresh collection, clean, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stirring 30 Minute, fresh squeezing is taken advantage of, retain this first squeezing concoction 0.3% is standby.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, sheet frame Filter press presses extracting juice.The gained dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 gynostemma pentaphylla concoctions are merged, with 100 Mesh screen, filtrate decompression concentration, temperature are set as 70 DEG C.When gained concentrate relative density is 1.05, spraying is transferred to Drying tower is spray-dried, and intake air temperature is set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, powder It is broken, cross 60 mesh sieves.By this spray powder, softwood processed is mixed with the first squeezing concoction of above-mentioned retention, is pelletized, is dried, whole grain, pack, 1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.

Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected Within the scope of.

Claims

A kind of 1. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla, it is characterised in that：Gathered in gynostemma pentaphylla picking time Its aerial part, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh pressure Squeezing, to collect and just squeeze concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, the water of the dregs of a decoction 1 ~ 5 times of amount of addition, stirring 5 ~ 30min, press extracting juice, the remaining dregs of a decoction add 1 ~ 5 times amount water, press extracting juice, merge just squeeze concoction and after squeeze medicine twice Juice, 100 ~ 200 mesh screens, obtain gynostemma pentaphylla concoction.
A kind of 2. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla according to claim 1, it is characterised in that： By the concoction of gained in claim 1, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the concentrate that relative density is 1.02 ~ 1.10, it is right It is spray-dried, and intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects dried object Crushed, cross 60 ~ 100 mesh sieves.
A kind of 3. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of gynostemma pentaphylla according to claim 1, it is characterised in that： The first squeezing concoction retained in claim 1 is mixed with the spray powder obtained in claim 2, prepares softwood, is pelletized, is dried, Whole grain, packaging.