CN107412285A - A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum - Google Patents
A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum Download PDFInfo
- Publication number
- CN107412285A CN107412285A CN201710738850.5A CN201710738850A CN107412285A CN 107412285 A CN107412285 A CN 107412285A CN 201710738850 A CN201710738850 A CN 201710738850A CN 107412285 A CN107412285 A CN 107412285A
- Authority
- CN
- China
- Prior art keywords
- squeezing
- lycopodium calvatum
- concoction
- spray
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum.The technique is cleaned, eluted after the harvesting of lycopodium calvatum medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is spray-dried, then particle is made.Lycopodium calvatum granule pieces prepared by this method, not only good fluidity, and to greatest extent while remain polarity and nonpolar active ingredient in medicinal material.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.
Description
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine lycopodium calvatum medicine materical crude slice.
Background technology
Chinese medicine lycopodium calvatum is the drying herb of lycopsid lycopod.With expelling wind and clearing away cold, dehumidification swelling, relaxing tendons and activating collaterals
Effect.Clinic is mainly used in wind-cold-dampness arthralgia, muscle arteries and veins contraction pain, and bruises and spasms are controlled in external application.
The processing mode of conventional lycopodium calvatum medicine materical crude slice is：After harvesting, impurity is removed, is dried, directly packing storage and transport.
These dry lycopodium calvatum Hygienic Indexes can not be up to standard, easily occur medicinal material go mouldy, so as to cause the decline of medical material quanlity and
The reduction of clinical efficacy.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjusting
Agent prescription and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of lycopodium calvatum medicinal material.Due to granule pieces system
During standby, extraction not only time consumption and energy consumption, and also because conventional water does solvent, the nonpolar active ingredient in medicinal material is difficult to be extracted
Out.Further, since the lycopodium calvatum medicinal material of extraction is also to dry and stored by long-time, therefore, its raw material easily pollutes
It is difficult to avoid to be also with situation about going mouldy.In order to ensure the clinic of lycopodium calvatum medicinal material is effective, steady quality, a kind of new stretches
Muscle grass medicine materical crude slice and its preparation technology urgently develop.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum ".This technique can be most
The polarity and the nonpolar active ingredient that retain in lycopodium calvatum medicinal material of limits, avoid medicinal material from being processed and accumulating in existing medicine materical crude slice
During the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring to stretch muscle
The steady quality and clinical safety of careless medicine materical crude slice effectively have great importance.
To achieve these goals, the technical scheme is that：
Its herb is gathered in lycopodium calvatum picking time, is cleaned, is cut into 1 ~ 2cm section, the water of 0.5 ~ 1 times of amount of medicinal material weight is added, stirs
Mix 15 ~ 30 minutes, take advantage of fresh squeezing, collect and just squeeze concoction, the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add 1 ~ 5
The water of amount again, 5 ~ 30min is stirred, press extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, pressure extracting juice, merge and just squeeze concoction
Concoction is squeezed after and twice, 100 ~ 200 mesh screens, obtains lycopodium calvatum concoction.By the concoction of gained, it is concentrated under reduced pressure in 40 ~ 80 DEG C,
Obtain the concentrate that relative density is 1.02 ~ 1.10.This concentrate is spray-dried, intake air temperature is set as 100 ~
140 DEG C, air outlet temperature is set as 90 ~ 120 DEG C, collects dried object and is crushed, crosses 60 ~ 100 mesh sieves.By above-mentioned retention
Just squeeze concoction to mix with obtained spray powder, add appropriate starch and dextrin as one sees fit, prepare softwood, pelletize, dry, whole grain,
Packaging.
It is the name of an article in printing, medicinal part, planting site, manufacturer, the date of manufacture, main on the label of product packaging bags
The information such as component content, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.The thin of lycopodium calvatum is enclosed in bag
Layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, it is printed on
Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the microscopical characters for obtaining product can be linked by scanning
The information such as feature.
The present invention is advantageous in that：
Fresh lycopodium calvatum medicinal material directly squeezes after cleaning washing, filter, be concentrated under reduced pressure, being spray-dried, pelletize after, resulting
Grain medicine materical crude slice, not only good fluidity, moreover it is possible to retain the active ingredient in medicinal material to greatest extent.This medicine materical crude slice volume is compared to biography
System medicine materical crude slice volume greatly reduces, and quality is more stable, beneficial to accumulating and it is clinical adjust, have very significant social effect and
Economic implications.
Embodiment
Embodiment 1
By the lycopodium calvatum medicinal material of fresh collection, clean, clean, be cut into 1cm section, add the water of 0.5 times of amount of medicinal material weight, stirring
15 minutes, fresh squeezing is taken advantage of, retain this first squeezing concoction 0.1% is standby.The gained dregs of a decoction add the running water of 2 times of amounts, stir 20min, plate
Frame filter press presses extracting juice.The gained dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 lycopodium calvatum concoctions are merged, with 60
Mesh screen, filtrate decompression concentration, temperature are set as 60 DEG C.When gained concentrate relative density is 1.03, spraying is transferred to
Drying tower is spray-dried, and intake air temperature is set as 140 DEG C, and air outlet temperature is set as 110 DEG C, collects dried object, powder
It is broken, cross 60 mesh sieves.By this spray powder, softwood processed is mixed with the first squeezing concoction of above-mentioned retention, is pelletized, is dried, whole grain, pack,
1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Embodiment 2
By the lycopodium calvatum medicinal material of fresh collection, clean, clean, be cut into 2cm section, add the water of 1 times of amount of medicinal material weight, stirring 30
Minute, fresh squeezing is taken advantage of, retain this first squeezing concoction 0.3% is standby.The gained dregs of a decoction add the running water of 5 times of amounts, stir 30min, sheet frame
Filter press presses extracting juice.The gained dregs of a decoction are squeezed with squeezer again, leaching concoction.Above-mentioned 3 lycopodium calvatum concoctions are merged, with 100
Mesh screen, filtrate decompression concentration, temperature are set as 70 DEG C.When gained concentrate relative density is 1.05, spraying is transferred to
Drying tower is spray-dried, and intake air temperature is set as 120 DEG C, and air outlet temperature is set as 90 DEG C, collects dried object, powder
It is broken, cross 60 mesh sieves.By this spray powder, softwood processed is mixed with the first squeezing concoction of above-mentioned retention, is pelletized, is dried, whole grain, pack,
1kg/ bags, add packed antioxidant and drier, Vacuum Package, labeling.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention
It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected
Within the scope of.
Claims (3)
- A kind of 1. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum, it is characterised in that：Gathered in lycopodium calvatum picking time Its herb, clean, be cut into 1 ~ 2cm section, add the water of 0.5 ~ 1 times of amount of medicinal material weight, stir 15 ~ 30 minutes, take advantage of fresh squeezing, receive Collection just squeezes concoction, and the first squeezing concoction of 0.1% ~ 0.5% weight of retention is standby, and the dregs of a decoction add the water of 1 ~ 5 times of amount, stirs 5 ~ 30min, pressure Extracting juice, the remaining dregs of a decoction add the water of 1 ~ 5 times of amount, press extracting juice, merge just squeeze concoction and after squeeze concoction twice, 100 ~ 200 mesh screens, obtain lycopodium calvatum concoction.
- A kind of 2. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum according to claim 1, it is characterised in that： By the concoction of gained in claim 1, it is concentrated under reduced pressure in 40 ~ 80 DEG C, obtains the concentrate that relative density is 1.02 ~ 1.10, it is right It is spray-dried, and intake air temperature is set as 100 ~ 140 DEG C, and air outlet temperature is set as 90 ~ 120 DEG C, collects dried object Crushed, cross 60 ~ 100 mesh sieves.
- A kind of 3. fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum according to claim 1, it is characterised in that： The first squeezing concoction retained in claim 1 is mixed with the spray powder obtained in claim 2, prepares softwood, is pelletized, is dried, Whole grain, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738850.5A CN107412285A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738850.5A CN107412285A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107412285A true CN107412285A (en) | 2017-12-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738850.5A Pending CN107412285A (en) | 2017-08-25 | 2017-08-25 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of lycopodium calvatum |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106109575A (en) * | 2016-07-24 | 2016-11-16 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
-
2017
- 2017-08-25 CN CN201710738850.5A patent/CN107412285A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193883A (en) * | 2015-11-14 | 2015-12-30 | 芜湖天成普阳中药科技有限公司 | Freshly squeezed spray drying parslane herb granular decoction pieces and preparation process thereof |
| CN105213452A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Taraxaci fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN105213551A (en) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | A kind of Herba Hedyotidis Diffusae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN106109575A (en) * | 2016-07-24 | 2016-11-16 | 徐漫 | A kind of Herba Scutellariae Barbatae fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171201 |
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| WD01 | Invention patent application deemed withdrawn after publication |